Amino acid dipepetide frequency for Pelistega indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.154AlaAla: 7.154 ± 0.15	0.915AlaCys: 0.915 ± 0.041	4.402AlaAsp: 4.402 ± 0.093	5.162AlaGlu: 5.162 ± 0.111	3.49AlaPhe: 3.49 ± 0.079	5.937AlaGly: 5.937 ± 0.117	1.795AlaHis: 1.795 ± 0.053	6.157AlaIle: 6.157 ± 0.112	5.185AlaLys: 5.185 ± 0.107	9.506AlaLeu: 9.506 ± 0.144	2.406AlaMet: 2.406 ± 0.065	3.847AlaAsn: 3.847 ± 0.096	3.068AlaPro: 3.068 ± 0.08	4.303AlaGln: 4.303 ± 0.09	3.976AlaArg: 3.976 ± 0.091	5.184AlaSer: 5.184 ± 0.099	4.536AlaThr: 4.536 ± 0.106	5.617AlaVal: 5.617 ± 0.098	1.097AlaTrp: 1.097 ± 0.042	2.726AlaTyr: 2.726 ± 0.068	0.008AlaXaa: 0.008 ± 0.004
Cys	0.737CysAla: 0.737 ± 0.041	0.151CysCys: 0.151 ± 0.017	0.447CysAsp: 0.447 ± 0.032	0.485CysGlu: 0.485 ± 0.03	0.402CysPhe: 0.402 ± 0.027	0.78CysGly: 0.78 ± 0.038	0.289CysHis: 0.289 ± 0.025	0.655CysIle: 0.655 ± 0.041	0.335CysLys: 0.335 ± 0.025	0.954CysLeu: 0.954 ± 0.039	0.233CysMet: 0.233 ± 0.018	0.279CysAsn: 0.279 ± 0.023	0.478CysPro: 0.478 ± 0.031	0.391CysGln: 0.391 ± 0.026	0.414CysArg: 0.414 ± 0.027	0.618CysSer: 0.618 ± 0.032	0.455CysThr: 0.455 ± 0.028	0.705CysVal: 0.705 ± 0.032	0.126CysTrp: 0.126 ± 0.017	0.276CysTyr: 0.276 ± 0.02	0.002CysXaa: 0.002 ± 0.002
Asp	4.292AspAla: 4.292 ± 0.112	0.473AspCys: 0.473 ± 0.029	2.649AspAsp: 2.649 ± 0.088	3.484AspGlu: 3.484 ± 0.079	2.516AspPhe: 2.516 ± 0.067	3.536AspGly: 3.536 ± 0.085	0.939AspHis: 0.939 ± 0.042	4.116AspIle: 4.116 ± 0.082	3.331AspLys: 3.331 ± 0.088	5.083AspLeu: 5.083 ± 0.102	1.393AspMet: 1.393 ± 0.045	2.314AspAsn: 2.314 ± 0.068	2.058AspPro: 2.058 ± 0.056	1.646AspGln: 1.646 ± 0.052	2.0AspArg: 2.0 ± 0.055	2.736AspSer: 2.736 ± 0.077	2.858AspThr: 2.858 ± 0.072	3.723AspVal: 3.723 ± 0.089	0.764AspTrp: 0.764 ± 0.034	2.14AspTyr: 2.14 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.873GluAla: 4.873 ± 0.108	0.468GluCys: 0.468 ± 0.029	2.845GluAsp: 2.845 ± 0.078	3.86GluGlu: 3.86 ± 0.101	2.24GluPhe: 2.24 ± 0.064	3.741GluGly: 3.741 ± 0.088	1.468GluHis: 1.468 ± 0.055	4.008GluIle: 4.008 ± 0.085	4.113GluLys: 4.113 ± 0.103	5.974GluLeu: 5.974 ± 0.097	1.529GluMet: 1.529 ± 0.049	2.815GluAsn: 2.815 ± 0.076	2.01GluPro: 2.01 ± 0.065	3.72GluGln: 3.72 ± 0.087	3.16GluArg: 3.16 ± 0.078	3.199GluSer: 3.199 ± 0.077	3.019GluThr: 3.019 ± 0.067	4.211GluVal: 4.211 ± 0.098	0.825GluTrp: 0.825 ± 0.04	1.629GluTyr: 1.629 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.518PheAla: 3.518 ± 0.086	0.463PheCys: 0.463 ± 0.028	2.687PheAsp: 2.687 ± 0.065	2.401PheGlu: 2.401 ± 0.059	1.912PhePhe: 1.912 ± 0.061	3.155PheGly: 3.155 ± 0.083	0.744PheHis: 0.744 ± 0.034	3.058PheIle: 3.058 ± 0.078	2.281PheLys: 2.281 ± 0.066	3.873PheLeu: 3.873 ± 0.085	1.038PheMet: 1.038 ± 0.046	2.209PheAsn: 2.209 ± 0.074	1.605PhePro: 1.605 ± 0.048	1.256PheGln: 1.256 ± 0.048	1.513PheArg: 1.513 ± 0.051	2.922PheSer: 2.922 ± 0.07	2.449PheThr: 2.449 ± 0.068	2.845PheVal: 2.845 ± 0.072	0.489PheTrp: 0.489 ± 0.031	1.293PheTyr: 1.293 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.574GlyAla: 5.574 ± 0.104	0.759GlyCys: 0.759 ± 0.037	3.349GlyAsp: 3.349 ± 0.085	3.886GlyGlu: 3.886 ± 0.087	3.06GlyPhe: 3.06 ± 0.069	4.758GlyGly: 4.758 ± 0.107	1.501GlyHis: 1.501 ± 0.053	5.32GlyIle: 5.32 ± 0.113	4.193GlyLys: 4.193 ± 0.096	7.404GlyLeu: 7.404 ± 0.132	2.022GlyMet: 2.022 ± 0.052	2.618GlyAsn: 2.618 ± 0.068	1.754GlyPro: 1.754 ± 0.053	2.884GlyGln: 2.884 ± 0.081	3.181GlyArg: 3.181 ± 0.062	4.019GlySer: 4.019 ± 0.1	3.714GlyThr: 3.714 ± 0.081	5.341GlyVal: 5.341 ± 0.11	0.851GlyTrp: 0.851 ± 0.037	2.336GlyTyr: 2.336 ± 0.063	0.005GlyXaa: 0.005 ± 0.002
His	1.729HisAla: 1.729 ± 0.055	0.241HisCys: 0.241 ± 0.022	1.132HisAsp: 1.132 ± 0.044	1.191HisGlu: 1.191 ± 0.05	0.985HisPhe: 0.985 ± 0.042	1.536HisGly: 1.536 ± 0.051	0.741HisHis: 0.741 ± 0.045	1.72HisIle: 1.72 ± 0.056	1.056HisLys: 1.056 ± 0.043	2.184HisLeu: 2.184 ± 0.059	0.568HisMet: 0.568 ± 0.031	0.907HisAsn: 0.907 ± 0.036	1.263HisPro: 1.263 ± 0.049	1.233HisGln: 1.233 ± 0.049	1.027HisArg: 1.027 ± 0.042	1.238HisSer: 1.238 ± 0.048	1.186HisThr: 1.186 ± 0.044	1.166HisVal: 1.166 ± 0.044	0.302HisTrp: 0.302 ± 0.023	0.912HisTyr: 0.912 ± 0.038	0.003HisXaa: 0.003 ± 0.002
Ile	6.568IleAla: 6.568 ± 0.124	0.695IleCys: 0.695 ± 0.035	4.187IleAsp: 4.187 ± 0.084	4.38IleGlu: 4.38 ± 0.08	2.722IlePhe: 2.722 ± 0.071	4.901IleGly: 4.901 ± 0.097	1.491IleHis: 1.491 ± 0.056	4.354IleIle: 4.354 ± 0.093	3.853IleLys: 3.853 ± 0.082	6.087IleLeu: 6.087 ± 0.115	1.508IleMet: 1.508 ± 0.048	3.316IleAsn: 3.316 ± 0.072	3.259IlePro: 3.259 ± 0.078	2.8IleGln: 2.8 ± 0.069	3.112IleArg: 3.112 ± 0.071	4.561IleSer: 4.561 ± 0.086	3.764IleThr: 3.764 ± 0.075	4.599IleVal: 4.599 ± 0.087	0.641IleTrp: 0.641 ± 0.038	2.01IleTyr: 2.01 ± 0.06	0.003IleXaa: 0.003 ± 0.002
Lys	5.261LysAla: 5.261 ± 0.118	0.296LysCys: 0.296 ± 0.021	3.078LysAsp: 3.078 ± 0.074	4.095LysGlu: 4.095 ± 0.09	1.779LysPhe: 1.779 ± 0.055	3.86LysGly: 3.86 ± 0.082	1.299LysHis: 1.299 ± 0.045	3.62LysIle: 3.62 ± 0.07	3.643LysLys: 3.643 ± 0.089	5.05LysLeu: 5.05 ± 0.091	1.562LysMet: 1.562 ± 0.055	2.8LysAsn: 2.8 ± 0.071	2.418LysPro: 2.418 ± 0.071	3.011LysGln: 3.011 ± 0.08	2.731LysArg: 2.731 ± 0.073	3.084LysSer: 3.084 ± 0.075	3.408LysThr: 3.408 ± 0.086	3.814LysVal: 3.814 ± 0.09	0.641LysTrp: 0.641 ± 0.03	1.549LysTyr: 1.549 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	9.74LeuAla: 9.74 ± 0.15	1.058LeuCys: 1.058 ± 0.046	5.3LeuAsp: 5.3 ± 0.104	5.671LeuGlu: 5.671 ± 0.094	4.394LeuPhe: 4.394 ± 0.1	7.184LeuGly: 7.184 ± 0.13	2.014LeuHis: 2.014 ± 0.057	6.465LeuIle: 6.465 ± 0.12	5.946LeuLys: 5.946 ± 0.109	10.352LeuLeu: 10.352 ± 0.192	2.585LeuMet: 2.585 ± 0.074	4.775LeuAsn: 4.775 ± 0.098	4.865LeuPro: 4.865 ± 0.089	3.824LeuGln: 3.824 ± 0.083	4.817LeuArg: 4.817 ± 0.091	7.54LeuSer: 7.54 ± 0.108	5.689LeuThr: 5.689 ± 0.091	6.442LeuVal: 6.442 ± 0.111	1.069LeuTrp: 1.069 ± 0.045	2.643LeuTyr: 2.643 ± 0.076	0.005LeuXaa: 0.005 ± 0.003
Met	2.483MetAla: 2.483 ± 0.065	0.181MetCys: 0.181 ± 0.017	1.215MetAsp: 1.215 ± 0.04	1.073MetGlu: 1.073 ± 0.037	0.916MetPhe: 0.916 ± 0.039	1.82MetGly: 1.82 ± 0.061	0.601MetHis: 0.601 ± 0.034	1.559MetIle: 1.559 ± 0.049	1.454MetLys: 1.454 ± 0.044	2.557MetLeu: 2.557 ± 0.072	0.792MetMet: 0.792 ± 0.035	1.099MetAsn: 1.099 ± 0.041	1.289MetPro: 1.289 ± 0.052	1.352MetGln: 1.352 ± 0.056	1.281MetArg: 1.281 ± 0.042	1.987MetSer: 1.987 ± 0.056	1.562MetThr: 1.562 ± 0.055	1.698MetVal: 1.698 ± 0.05	0.194MetTrp: 0.194 ± 0.017	0.568MetTyr: 0.568 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.75AsnAla: 3.75 ± 0.077	0.36AsnCys: 0.36 ± 0.027	2.109AsnAsp: 2.109 ± 0.059	2.255AsnGlu: 2.255 ± 0.064	1.623AsnPhe: 1.623 ± 0.049	2.859AsnGly: 2.859 ± 0.071	1.107AsnHis: 1.107 ± 0.05	3.009AsnIle: 3.009 ± 0.076	2.588AsnLys: 2.588 ± 0.069	4.211AsnLeu: 4.211 ± 0.097	1.12AsnMet: 1.12 ± 0.043	2.094AsnAsn: 2.094 ± 0.063	2.526AsnPro: 2.526 ± 0.061	2.068AsnGln: 2.068 ± 0.056	2.099AsnArg: 2.099 ± 0.058	2.357AsnSer: 2.357 ± 0.071	2.649AsnThr: 2.649 ± 0.067	2.835AsnVal: 2.835 ± 0.075	0.519AsnTrp: 0.519 ± 0.029	1.421AsnTyr: 1.421 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.237ProAla: 3.237 ± 0.08	0.335ProCys: 0.335 ± 0.027	2.503ProAsp: 2.503 ± 0.065	3.339ProGlu: 3.339 ± 0.077	1.9ProPhe: 1.9 ± 0.061	2.436ProGly: 2.436 ± 0.067	0.925ProHis: 0.925 ± 0.041	3.057ProIle: 3.057 ± 0.07	2.268ProLys: 2.268 ± 0.067	4.09ProLeu: 4.09 ± 0.099	1.025ProMet: 1.025 ± 0.044	1.977ProAsn: 1.977 ± 0.06	1.442ProPro: 1.442 ± 0.061	1.662ProGln: 1.662 ± 0.048	1.49ProArg: 1.49 ± 0.051	2.833ProSer: 2.833 ± 0.081	2.462ProThr: 2.462 ± 0.073	3.112ProVal: 3.112 ± 0.081	0.534ProTrp: 0.534 ± 0.025	1.337ProTyr: 1.337 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	4.628GlnAla: 4.628 ± 0.086	0.335GlnCys: 0.335 ± 0.025	1.997GlnAsp: 1.997 ± 0.057	2.804GlnGlu: 2.804 ± 0.079	1.687GlnPhe: 1.687 ± 0.063	2.795GlnGly: 2.795 ± 0.068	1.194GlnHis: 1.194 ± 0.051	2.71GlnIle: 2.71 ± 0.067	2.653GlnLys: 2.653 ± 0.069	4.909GlnLeu: 4.909 ± 0.095	1.031GlnMet: 1.031 ± 0.037	1.679GlnAsn: 1.679 ± 0.048	1.537GlnPro: 1.537 ± 0.058	3.037GlnGln: 3.037 ± 0.086	2.291GlnArg: 2.291 ± 0.061	2.546GlnSer: 2.546 ± 0.067	2.547GlnThr: 2.547 ± 0.074	3.076GlnVal: 3.076 ± 0.082	0.734GlnTrp: 0.734 ± 0.033	1.444GlnTyr: 1.444 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	3.523ArgAla: 3.523 ± 0.081	0.366ArgCys: 0.366 ± 0.021	2.349ArgAsp: 2.349 ± 0.064	2.925ArgGlu: 2.925 ± 0.077	2.175ArgPhe: 2.175 ± 0.053	2.703ArgGly: 2.703 ± 0.075	1.153ArgHis: 1.153 ± 0.047	3.242ArgIle: 3.242 ± 0.081	2.442ArgLys: 2.442 ± 0.07	5.259ArgLeu: 5.259 ± 0.097	1.201ArgMet: 1.201 ± 0.043	1.69ArgAsn: 1.69 ± 0.059	1.784ArgPro: 1.784 ± 0.057	2.411ArgGln: 2.411 ± 0.075	2.257ArgArg: 2.257 ± 0.067	2.38ArgSer: 2.38 ± 0.057	2.299ArgThr: 2.299 ± 0.074	3.155ArgVal: 3.155 ± 0.079	0.565ArgTrp: 0.565 ± 0.029	1.897ArgTyr: 1.897 ± 0.068	0.002ArgXaa: 0.002 ± 0.001
Ser	4.932SerAla: 4.932 ± 0.103	0.547SerCys: 0.547 ± 0.032	2.981SerAsp: 2.981 ± 0.075	3.221SerGlu: 3.221 ± 0.073	2.792SerPhe: 2.792 ± 0.075	4.536SerGly: 4.536 ± 0.096	1.358SerHis: 1.358 ± 0.044	4.423SerIle: 4.423 ± 0.08	3.264SerLys: 3.264 ± 0.076	7.039SerLeu: 7.039 ± 0.127	1.55SerMet: 1.55 ± 0.051	2.462SerAsn: 2.462 ± 0.067	2.669SerPro: 2.669 ± 0.079	2.621SerGln: 2.621 ± 0.063	2.771SerArg: 2.771 ± 0.065	4.198SerSer: 4.198 ± 0.105	3.676SerThr: 3.676 ± 0.086	4.067SerVal: 4.067 ± 0.09	0.726SerTrp: 0.726 ± 0.035	1.913SerTyr: 1.913 ± 0.058	0.003SerXaa: 0.003 ± 0.002
Thr	4.576ThrAla: 4.576 ± 0.095	0.447ThrCys: 0.447 ± 0.029	2.682ThrAsp: 2.682 ± 0.065	3.152ThrGlu: 3.152 ± 0.074	2.143ThrPhe: 2.143 ± 0.069	4.221ThrGly: 4.221 ± 0.096	1.312ThrHis: 1.312 ± 0.047	3.943ThrIle: 3.943 ± 0.082	2.602ThrLys: 2.602 ± 0.076	6.164ThrLeu: 6.164 ± 0.107	1.248ThrMet: 1.248 ± 0.044	2.014ThrAsn: 2.014 ± 0.068	3.045ThrPro: 3.045 ± 0.075	2.574ThrGln: 2.574 ± 0.076	2.337ThrArg: 2.337 ± 0.061	3.313ThrSer: 3.313 ± 0.081	3.42ThrThr: 3.42 ± 0.092	4.177ThrVal: 4.177 ± 0.1	0.664ThrTrp: 0.664 ± 0.037	1.59ThrTyr: 1.59 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	6.323ValAla: 6.323 ± 0.12	0.642ValCys: 0.642 ± 0.032	3.827ValAsp: 3.827 ± 0.091	4.088ValGlu: 4.088 ± 0.09	2.973ValPhe: 2.973 ± 0.089	4.796ValGly: 4.796 ± 0.098	1.217ValHis: 1.217 ± 0.047	4.706ValIle: 4.706 ± 0.085	3.653ValLys: 3.653 ± 0.09	6.92ValLeu: 6.92 ± 0.118	1.913ValMet: 1.913 ± 0.05	2.991ValAsn: 2.991 ± 0.071	2.976ValPro: 2.976 ± 0.065	2.416ValGln: 2.416 ± 0.064	3.037ValArg: 3.037 ± 0.075	4.474ValSer: 4.474 ± 0.087	3.689ValThr: 3.689 ± 0.079	5.184ValVal: 5.184 ± 0.113	0.805ValTrp: 0.805 ± 0.035	1.915ValTyr: 1.915 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.875TrpAla: 0.875 ± 0.035	0.146TrpCys: 0.146 ± 0.016	0.558TrpAsp: 0.558 ± 0.034	0.601TrpGlu: 0.601 ± 0.033	0.593TrpPhe: 0.593 ± 0.032	0.792TrpGly: 0.792 ± 0.039	0.347TrpHis: 0.347 ± 0.023	0.806TrpIle: 0.806 ± 0.036	0.573TrpLys: 0.573 ± 0.028	1.58TrpLeu: 1.58 ± 0.056	0.292TrpMet: 0.292 ± 0.027	0.511TrpAsn: 0.511 ± 0.027	0.383TrpPro: 0.383 ± 0.024	0.795TrpGln: 0.795 ± 0.034	0.644TrpArg: 0.644 ± 0.029	0.734TrpSer: 0.734 ± 0.038	0.54TrpThr: 0.54 ± 0.028	0.859TrpVal: 0.859 ± 0.039	0.189TrpTrp: 0.189 ± 0.018	0.37TrpTyr: 0.37 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.697TyrAla: 2.697 ± 0.072	0.335TyrCys: 0.335 ± 0.022	1.752TyrAsp: 1.752 ± 0.058	1.634TyrGlu: 1.634 ± 0.049	1.409TyrPhe: 1.409 ± 0.044	2.18TyrGly: 2.18 ± 0.076	0.821TyrHis: 0.821 ± 0.038	1.884TyrIle: 1.884 ± 0.059	1.564TyrLys: 1.564 ± 0.054	3.173TyrLeu: 3.173 ± 0.072	0.659TyrMet: 0.659 ± 0.033	1.161TyrAsn: 1.161 ± 0.047	1.536TyrPro: 1.536 ± 0.052	1.631TyrGln: 1.631 ± 0.049	1.634TyrArg: 1.634 ± 0.055	1.826TyrSer: 1.826 ± 0.062	1.7TyrThr: 1.7 ± 0.052	1.917TyrVal: 1.917 ± 0.06	0.455TyrTrp: 0.455 ± 0.026	1.079TyrTyr: 1.079 ± 0.054	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.003XaaHis: 0.003 ± 0.003	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.005XaaLeu: 0.005 ± 0.003	0.003XaaMet: 0.003 ± 0.002	0.002XaaAsn: 0.002 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.005XaaArg: 0.005 ± 0.003	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.002	0.002XaaVal: 0.002 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 2121 proteins (608854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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