Amino acid dipepetide frequency for Dictyocaulus viviparus (Bovine lungworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.843AlaAla: 4.843 ± 0.052	1.199AlaCys: 1.199 ± 0.016	3.1AlaAsp: 3.1 ± 0.025	3.87AlaGlu: 3.87 ± 0.036	2.615AlaPhe: 2.615 ± 0.024	3.136AlaGly: 3.136 ± 0.035	1.437AlaHis: 1.437 ± 0.018	4.047AlaIle: 4.047 ± 0.031	3.492AlaLys: 3.492 ± 0.031	5.939AlaLeu: 5.939 ± 0.042	1.642AlaMet: 1.642 ± 0.02	2.653AlaAsn: 2.653 ± 0.024	2.588AlaPro: 2.588 ± 0.025	2.285AlaGln: 2.285 ± 0.026	3.36AlaArg: 3.36 ± 0.031	4.673AlaSer: 4.673 ± 0.032	3.44AlaThr: 3.44 ± 0.028	4.696AlaVal: 4.696 ± 0.036	0.576AlaTrp: 0.576 ± 0.011	1.774AlaTyr: 1.774 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.305CysAla: 1.305 ± 0.02	0.651CysCys: 0.651 ± 0.016	1.356CysAsp: 1.356 ± 0.02	1.39CysGlu: 1.39 ± 0.023	1.031CysPhe: 1.031 ± 0.015	1.477CysGly: 1.477 ± 0.021	0.598CysHis: 0.598 ± 0.013	1.329CysIle: 1.329 ± 0.023	1.111CysLys: 1.111 ± 0.018	1.938CysLeu: 1.938 ± 0.025	0.531CysMet: 0.531 ± 0.012	0.981CysAsn: 0.981 ± 0.015	1.092CysPro: 1.092 ± 0.022	0.827CysGln: 0.827 ± 0.016	1.363CysArg: 1.363 ± 0.02	2.044CysSer: 2.044 ± 0.027	1.158CysThr: 1.158 ± 0.016	1.474CysVal: 1.474 ± 0.021	0.235CysTrp: 0.235 ± 0.007	0.711CysTyr: 0.711 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.139AspAla: 3.139 ± 0.029	1.133AspCys: 1.133 ± 0.021	3.934AspAsp: 3.934 ± 0.036	4.425AspGlu: 4.425 ± 0.044	2.395AspPhe: 2.395 ± 0.026	3.373AspGly: 3.373 ± 0.041	1.228AspHis: 1.228 ± 0.015	3.497AspIle: 3.497 ± 0.026	2.756AspLys: 2.756 ± 0.028	4.62AspLeu: 4.62 ± 0.035	1.348AspMet: 1.348 ± 0.018	2.28AspAsn: 2.28 ± 0.024	2.188AspPro: 2.188 ± 0.024	1.811AspGln: 1.811 ± 0.019	3.017AspArg: 3.017 ± 0.032	4.187AspSer: 4.187 ± 0.039	2.442AspThr: 2.442 ± 0.023	4.031AspVal: 4.031 ± 0.032	0.652AspTrp: 0.652 ± 0.013	1.816AspTyr: 1.816 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	3.909GluAla: 3.909 ± 0.038	1.319GluCys: 1.319 ± 0.024	3.494GluAsp: 3.494 ± 0.032	5.207GluGlu: 5.207 ± 0.054	2.412GluPhe: 2.412 ± 0.023	2.764GluGly: 2.764 ± 0.028	1.516GluHis: 1.516 ± 0.018	3.995GluIle: 3.995 ± 0.034	4.992GluLys: 4.992 ± 0.045	5.678GluLeu: 5.678 ± 0.044	1.91GluMet: 1.91 ± 0.021	3.476GluAsn: 3.476 ± 0.031	2.061GluPro: 2.061 ± 0.025	2.733GluGln: 2.733 ± 0.029	4.065GluArg: 4.065 ± 0.036	4.359GluSer: 4.359 ± 0.038	3.209GluThr: 3.209 ± 0.034	3.8GluVal: 3.8 ± 0.028	0.779GluTrp: 0.779 ± 0.015	1.94GluTyr: 1.94 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.637PheAla: 2.637 ± 0.027	1.116PheCys: 1.116 ± 0.016	2.556PheAsp: 2.556 ± 0.025	2.523PheGlu: 2.523 ± 0.022	2.209PhePhe: 2.209 ± 0.025	2.624PheGly: 2.624 ± 0.029	1.17PheHis: 1.17 ± 0.016	2.862PheIle: 2.862 ± 0.029	1.973PheLys: 1.973 ± 0.022	4.236PheLeu: 4.236 ± 0.038	1.107PheMet: 1.107 ± 0.015	1.922PheAsn: 1.922 ± 0.021	1.824PhePro: 1.824 ± 0.023	1.44PheGln: 1.44 ± 0.018	2.337PheArg: 2.337 ± 0.024	3.593PheSer: 3.593 ± 0.029	2.368PheThr: 2.368 ± 0.023	3.168PheVal: 3.168 ± 0.028	0.514PheTrp: 0.514 ± 0.011	1.593PheTyr: 1.593 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	3.089GlyAla: 3.089 ± 0.03	1.219GlyCys: 1.219 ± 0.02	2.91GlyAsp: 2.91 ± 0.03	3.162GlyGlu: 3.162 ± 0.036	2.432GlyPhe: 2.432 ± 0.028	3.5GlyGly: 3.5 ± 0.047	1.266GlyHis: 1.266 ± 0.016	3.354GlyIle: 3.354 ± 0.03	3.235GlyLys: 3.235 ± 0.031	4.257GlyLeu: 4.257 ± 0.04	1.367GlyMet: 1.367 ± 0.02	2.486GlyAsn: 2.486 ± 0.023	2.159GlyPro: 2.159 ± 0.04	1.901GlyGln: 1.901 ± 0.028	3.251GlyArg: 3.251 ± 0.034	4.25GlySer: 4.25 ± 0.038	2.943GlyThr: 2.943 ± 0.028	3.605GlyVal: 3.605 ± 0.028	0.63GlyTrp: 0.63 ± 0.012	1.894GlyTyr: 1.894 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.326HisAla: 1.326 ± 0.017	0.648HisCys: 0.648 ± 0.011	1.243HisAsp: 1.243 ± 0.018	1.458HisGlu: 1.458 ± 0.019	1.197HisPhe: 1.197 ± 0.015	1.384HisGly: 1.384 ± 0.019	0.815HisHis: 0.815 ± 0.016	1.528HisIle: 1.528 ± 0.019	1.174HisLys: 1.174 ± 0.016	2.442HisLeu: 2.442 ± 0.023	0.65HisMet: 0.65 ± 0.012	1.092HisAsn: 1.092 ± 0.016	1.237HisPro: 1.237 ± 0.017	0.96HisGln: 0.96 ± 0.015	1.545HisArg: 1.545 ± 0.019	2.08HisSer: 2.08 ± 0.023	1.203HisThr: 1.203 ± 0.015	1.616HisVal: 1.616 ± 0.022	0.292HisTrp: 0.292 ± 0.008	0.917HisTyr: 0.917 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.107IleAla: 4.107 ± 0.03	1.559IleCys: 1.559 ± 0.023	3.717IleAsp: 3.717 ± 0.033	3.949IleGlu: 3.949 ± 0.03	2.784IlePhe: 2.784 ± 0.027	3.525IleGly: 3.525 ± 0.029	1.582IleHis: 1.582 ± 0.019	3.791IleIle: 3.791 ± 0.032	3.08IleLys: 3.08 ± 0.026	5.526IleLeu: 5.526 ± 0.042	1.483IleMet: 1.483 ± 0.018	2.763IleAsn: 2.763 ± 0.027	3.03IlePro: 3.03 ± 0.026	2.222IleGln: 2.222 ± 0.021	3.735IleArg: 3.735 ± 0.028	5.268IleSer: 5.268 ± 0.037	3.593IleThr: 3.593 ± 0.028	4.303IleVal: 4.303 ± 0.036	0.674IleTrp: 0.674 ± 0.014	1.981IleTyr: 1.981 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.447LysAla: 3.447 ± 0.032	1.294LysCys: 1.294 ± 0.019	2.997LysAsp: 2.997 ± 0.03	4.174LysGlu: 4.174 ± 0.042	2.165LysPhe: 2.165 ± 0.021	2.612LysGly: 2.612 ± 0.026	1.392LysHis: 1.392 ± 0.018	3.6LysIle: 3.6 ± 0.033	4.789LysLys: 4.789 ± 0.049	5.265LysLeu: 5.265 ± 0.04	1.676LysMet: 1.676 ± 0.019	2.956LysAsn: 2.956 ± 0.024	2.353LysPro: 2.353 ± 0.027	2.413LysGln: 2.413 ± 0.024	3.84LysArg: 3.84 ± 0.037	4.326LysSer: 4.326 ± 0.037	3.156LysThr: 3.156 ± 0.029	3.374LysVal: 3.374 ± 0.031	0.696LysTrp: 0.696 ± 0.011	1.919LysTyr: 1.919 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	5.725LeuAla: 5.725 ± 0.034	2.153LeuCys: 2.153 ± 0.027	4.645LeuAsp: 4.645 ± 0.036	5.445LeuGlu: 5.445 ± 0.047	4.217LeuPhe: 4.217 ± 0.038	4.071LeuGly: 4.071 ± 0.033	2.445LeuHis: 2.445 ± 0.027	5.54LeuIle: 5.54 ± 0.043	5.364LeuLys: 5.364 ± 0.038	9.363LeuLeu: 9.363 ± 0.066	2.41LeuMet: 2.41 ± 0.024	4.305LeuAsn: 4.305 ± 0.035	4.64LeuPro: 4.64 ± 0.038	3.754LeuGln: 3.754 ± 0.035	5.729LeuArg: 5.729 ± 0.041	7.85LeuSer: 7.85 ± 0.051	4.957LeuThr: 4.957 ± 0.033	5.453LeuVal: 5.453 ± 0.04	1.025LeuTrp: 1.025 ± 0.019	2.845LeuTyr: 2.845 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.739MetAla: 1.739 ± 0.021	0.548MetCys: 0.548 ± 0.011	1.417MetAsp: 1.417 ± 0.018	1.718MetGlu: 1.718 ± 0.019	1.148MetPhe: 1.148 ± 0.016	1.243MetGly: 1.243 ± 0.018	0.602MetHis: 0.602 ± 0.012	1.574MetIle: 1.574 ± 0.017	1.81MetLys: 1.81 ± 0.02	2.446MetLeu: 2.446 ± 0.024	0.804MetMet: 0.804 ± 0.015	1.356MetAsn: 1.356 ± 0.018	1.078MetPro: 1.078 ± 0.016	1.013MetGln: 1.013 ± 0.016	1.574MetArg: 1.574 ± 0.021	2.162MetSer: 2.162 ± 0.019	1.534MetThr: 1.534 ± 0.022	1.617MetVal: 1.617 ± 0.019	0.284MetTrp: 0.284 ± 0.008	0.738MetTyr: 0.738 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.852AsnAla: 2.852 ± 0.026	1.035AsnCys: 1.035 ± 0.017	2.756AsnAsp: 2.756 ± 0.027	3.342AsnGlu: 3.342 ± 0.029	1.937AsnPhe: 1.937 ± 0.023	2.947AsnGly: 2.947 ± 0.029	1.091AsnHis: 1.091 ± 0.016	3.077AsnIle: 3.077 ± 0.025	2.502AsnLys: 2.502 ± 0.024	3.962AsnLeu: 3.962 ± 0.034	1.222AsnMet: 1.222 ± 0.016	2.297AsnAsn: 2.297 ± 0.025	2.072AsnPro: 2.072 ± 0.025	1.621AsnGln: 1.621 ± 0.02	2.689AsnArg: 2.689 ± 0.023	3.735AsnSer: 3.735 ± 0.032	2.529AsnThr: 2.529 ± 0.023	3.359AsnVal: 3.359 ± 0.027	0.49AsnTrp: 0.49 ± 0.011	1.545AsnTyr: 1.545 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	2.437ProAla: 2.437 ± 0.027	0.851ProCys: 0.851 ± 0.017	2.164ProAsp: 2.164 ± 0.022	2.594ProGlu: 2.594 ± 0.028	1.968ProPhe: 1.968 ± 0.024	2.707ProGly: 2.707 ± 0.083	1.143ProHis: 1.143 ± 0.019	2.764ProIle: 2.764 ± 0.028	2.278ProLys: 2.278 ± 0.026	4.06ProLeu: 4.06 ± 0.033	1.016ProMet: 1.016 ± 0.017	2.034ProAsn: 2.034 ± 0.022	3.255ProPro: 3.255 ± 0.047	1.798ProGln: 1.798 ± 0.029	2.327ProArg: 2.327 ± 0.027	4.254ProSer: 4.254 ± 0.039	2.772ProThr: 2.772 ± 0.027	2.832ProVal: 2.832 ± 0.028	0.442ProTrp: 0.442 ± 0.011	1.477ProTyr: 1.477 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.249GlnAla: 2.249 ± 0.028	0.957GlnCys: 0.957 ± 0.021	1.402GlnAsp: 1.402 ± 0.019	2.071GlnGlu: 2.071 ± 0.024	1.663GlnPhe: 1.663 ± 0.018	1.538GlnGly: 1.538 ± 0.023	1.065GlnHis: 1.065 ± 0.017	2.43GlnIle: 2.43 ± 0.025	2.396GlnLys: 2.396 ± 0.025	4.133GlnLeu: 4.133 ± 0.037	1.226GlnMet: 1.226 ± 0.018	1.844GlnAsn: 1.844 ± 0.018	1.792GlnPro: 1.792 ± 0.028	2.257GlnGln: 2.257 ± 0.041	2.471GlnArg: 2.471 ± 0.025	2.936GlnSer: 2.936 ± 0.029	2.004GlnThr: 2.004 ± 0.022	2.105GlnVal: 2.105 ± 0.021	0.502GlnTrp: 0.502 ± 0.011	1.291GlnTyr: 1.291 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	3.289ArgAla: 3.289 ± 0.03	1.345ArgCys: 1.345 ± 0.023	2.942ArgAsp: 2.942 ± 0.031	3.598ArgGlu: 3.598 ± 0.036	2.586ArgPhe: 2.586 ± 0.025	2.821ArgGly: 2.821 ± 0.034	1.541ArgHis: 1.541 ± 0.017	3.764ArgIle: 3.764 ± 0.026	4.15ArgLys: 4.15 ± 0.033	5.566ArgLeu: 5.566 ± 0.034	1.593ArgMet: 1.593 ± 0.02	3.063ArgAsn: 3.063 ± 0.029	2.419ArgPro: 2.419 ± 0.026	2.383ArgGln: 2.383 ± 0.025	4.668ArgArg: 4.668 ± 0.04	4.781ArgSer: 4.781 ± 0.043	3.102ArgThr: 3.102 ± 0.031	3.394ArgVal: 3.394 ± 0.026	0.657ArgTrp: 0.657 ± 0.013	1.893ArgTyr: 1.893 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	4.878SerAla: 4.878 ± 0.037	1.77SerCys: 1.77 ± 0.025	4.548SerAsp: 4.548 ± 0.041	4.701SerGlu: 4.701 ± 0.032	3.564SerPhe: 3.564 ± 0.031	4.477SerGly: 4.477 ± 0.034	1.944SerHis: 1.944 ± 0.022	5.069SerIle: 5.069 ± 0.036	4.353SerLys: 4.353 ± 0.036	7.401SerLeu: 7.401 ± 0.046	2.044SerMet: 2.044 ± 0.024	3.847SerAsn: 3.847 ± 0.034	3.801SerPro: 3.801 ± 0.042	2.983SerGln: 2.983 ± 0.03	4.653SerArg: 4.653 ± 0.038	8.789SerSer: 8.789 ± 0.087	5.443SerThr: 5.443 ± 0.05	5.251SerVal: 5.251 ± 0.037	0.799SerTrp: 0.799 ± 0.012	2.438SerTyr: 2.438 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	3.66ThrAla: 3.66 ± 0.035	1.188ThrCys: 1.188 ± 0.018	2.74ThrAsp: 2.74 ± 0.028	3.131ThrGlu: 3.131 ± 0.028	2.364ThrPhe: 2.364 ± 0.025	2.895ThrGly: 2.895 ± 0.031	1.222ThrHis: 1.222 ± 0.016	3.661ThrIle: 3.661 ± 0.031	3.026ThrLys: 3.026 ± 0.027	4.986ThrLeu: 4.986 ± 0.036	1.44ThrMet: 1.44 ± 0.024	2.611ThrAsn: 2.611 ± 0.026	2.825ThrPro: 2.825 ± 0.028	1.911ThrGln: 1.911 ± 0.02	2.738ThrArg: 2.738 ± 0.025	5.071ThrSer: 5.071 ± 0.044	3.89ThrThr: 3.89 ± 0.044	4.081ThrVal: 4.081 ± 0.034	0.556ThrTrp: 0.556 ± 0.013	1.607ThrTyr: 1.607 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	4.265ValAla: 4.265 ± 0.035	1.524ValCys: 1.524 ± 0.021	3.982ValAsp: 3.982 ± 0.03	4.259ValGlu: 4.259 ± 0.034	3.029ValPhe: 3.029 ± 0.032	3.313ValGly: 3.313 ± 0.032	1.616ValHis: 1.616 ± 0.019	4.145ValIle: 4.145 ± 0.034	3.58ValLys: 3.58 ± 0.03	6.165ValLeu: 6.165 ± 0.04	1.706ValMet: 1.706 ± 0.019	3.013ValAsn: 3.013 ± 0.029	2.963ValPro: 2.963 ± 0.027	2.407ValGln: 2.407 ± 0.028	3.504ValArg: 3.504 ± 0.029	4.982ValSer: 4.982 ± 0.036	3.608ValThr: 3.608 ± 0.03	4.901ValVal: 4.901 ± 0.037	0.684ValTrp: 0.684 ± 0.013	2.019ValTyr: 2.019 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.592TrpAla: 0.592 ± 0.013	0.247TrpCys: 0.247 ± 0.008	0.545TrpAsp: 0.545 ± 0.013	0.606TrpGlu: 0.606 ± 0.012	0.501TrpPhe: 0.501 ± 0.011	0.444TrpGly: 0.444 ± 0.011	0.267TrpHis: 0.267 ± 0.008	0.784TrpIle: 0.784 ± 0.012	0.763TrpLys: 0.763 ± 0.014	1.1TrpLeu: 1.1 ± 0.017	0.397TrpMet: 0.397 ± 0.009	0.602TrpAsn: 0.602 ± 0.012	0.411TrpPro: 0.411 ± 0.01	0.448TrpGln: 0.448 ± 0.01	0.721TrpArg: 0.721 ± 0.012	0.885TrpSer: 0.885 ± 0.015	0.646TrpThr: 0.646 ± 0.013	0.554TrpVal: 0.554 ± 0.011	0.171TrpTrp: 0.171 ± 0.007	0.371TrpTyr: 0.371 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.877TyrAla: 1.877 ± 0.02	0.849TyrCys: 0.849 ± 0.014	1.822TyrAsp: 1.822 ± 0.022	1.994TyrGlu: 1.994 ± 0.021	1.554TyrPhe: 1.554 ± 0.019	2.059TyrGly: 2.059 ± 0.024	0.868TyrHis: 0.868 ± 0.014	1.861TyrIle: 1.861 ± 0.023	1.617TyrLys: 1.617 ± 0.017	2.854TyrLeu: 2.854 ± 0.033	0.834TyrMet: 0.834 ± 0.013	1.478TyrAsn: 1.478 ± 0.017	1.384TyrPro: 1.384 ± 0.023	1.167TyrGln: 1.167 ± 0.017	1.97TyrArg: 1.97 ± 0.021	2.526TyrSer: 2.526 ± 0.024	1.604TyrThr: 1.604 ± 0.021	2.053TyrVal: 2.053 ± 0.024	0.397TyrTrp: 0.397 ± 0.01	1.238TyrTyr: 1.238 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 14161 proteins (4630289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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