Amino acid dipepetide frequency for Giesbergeria anulus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.196AlaAla: 16.196 ± 0.152
1.226AlaCys: 1.226 ± 0.035
5.832AlaAsp: 5.832 ± 0.082
6.062AlaGlu: 6.062 ± 0.091
3.537AlaPhe: 3.537 ± 0.058
8.966AlaGly: 8.966 ± 0.104
2.986AlaHis: 2.986 ± 0.06
5.198AlaIle: 5.198 ± 0.07
4.194AlaLys: 4.194 ± 0.089
15.156AlaLeu: 15.156 ± 0.164
3.129AlaMet: 3.129 ± 0.053
3.003AlaAsn: 3.003 ± 0.068
6.294AlaPro: 6.294 ± 0.118
7.917AlaGln: 7.917 ± 0.128
7.502AlaArg: 7.502 ± 0.094
6.869AlaSer: 6.869 ± 0.11
6.433AlaThr: 6.433 ± 0.102
8.557AlaVal: 8.557 ± 0.105
1.692AlaTrp: 1.692 ± 0.049
2.372AlaTyr: 2.372 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.128CysAla: 1.128 ± 0.038
0.139CysCys: 0.139 ± 0.013
0.55CysAsp: 0.55 ± 0.023
0.514CysGlu: 0.514 ± 0.023
0.308CysPhe: 0.308 ± 0.017
0.932CysGly: 0.932 ± 0.032
0.326CysHis: 0.326 ± 0.019
0.501CysIle: 0.501 ± 0.023
0.282CysLys: 0.282 ± 0.016
0.925CysLeu: 0.925 ± 0.029
0.22CysMet: 0.22 ± 0.015
0.274CysAsn: 0.274 ± 0.017
0.527CysPro: 0.527 ± 0.025
0.384CysGln: 0.384 ± 0.02
0.493CysArg: 0.493 ± 0.02
0.548CysSer: 0.548 ± 0.021
0.607CysThr: 0.607 ± 0.027
0.665CysVal: 0.665 ± 0.027
0.132CysTrp: 0.132 ± 0.011
0.23CysTyr: 0.23 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.524AspAla: 6.524 ± 0.07
0.478AspCys: 0.478 ± 0.023
2.409AspAsp: 2.409 ± 0.059
2.819AspGlu: 2.819 ± 0.056
2.094AspPhe: 2.094 ± 0.047
4.078AspGly: 4.078 ± 0.074
1.064AspHis: 1.064 ± 0.033
2.747AspIle: 2.747 ± 0.059
1.986AspLys: 1.986 ± 0.056
5.155AspLeu: 5.155 ± 0.065
1.247AspMet: 1.247 ± 0.032
1.36AspAsn: 1.36 ± 0.04
2.483AspPro: 2.483 ± 0.049
1.732AspGln: 1.732 ± 0.038
2.572AspArg: 2.572 ± 0.059
2.458AspSer: 2.458 ± 0.052
2.791AspThr: 2.791 ± 0.057
3.649AspVal: 3.649 ± 0.061
1.029AspTrp: 1.029 ± 0.032
1.34AspTyr: 1.34 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.482GluAla: 6.482 ± 0.098
0.415GluCys: 0.415 ± 0.021
2.139GluAsp: 2.139 ± 0.047
2.738GluGlu: 2.738 ± 0.069
1.742GluPhe: 1.742 ± 0.044
3.458GluGly: 3.458 ± 0.063
1.444GluHis: 1.444 ± 0.043
2.845GluIle: 2.845 ± 0.056
2.275GluLys: 2.275 ± 0.067
5.888GluLeu: 5.888 ± 0.083
1.224GluMet: 1.224 ± 0.038
1.408GluAsn: 1.408 ± 0.034
2.281GluPro: 2.281 ± 0.05
3.368GluGln: 3.368 ± 0.059
4.345GluArg: 4.345 ± 0.086
2.621GluSer: 2.621 ± 0.055
2.487GluThr: 2.487 ± 0.054
4.056GluVal: 4.056 ± 0.064
0.64GluTrp: 0.64 ± 0.025
1.049GluTyr: 1.049 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.881PheAla: 3.881 ± 0.072
0.41PheCys: 0.41 ± 0.02
2.279PheAsp: 2.279 ± 0.048
1.85PheGlu: 1.85 ± 0.044
1.341PhePhe: 1.341 ± 0.044
2.754PheGly: 2.754 ± 0.055
0.723PheHis: 0.723 ± 0.026
1.541PheIle: 1.541 ± 0.039
1.216PheLys: 1.216 ± 0.036
3.017PheLeu: 3.017 ± 0.054
0.744PheMet: 0.744 ± 0.026
1.161PheAsn: 1.161 ± 0.035
1.308PhePro: 1.308 ± 0.038
1.216PheGln: 1.216 ± 0.036
1.644PheArg: 1.644 ± 0.04
2.308PheSer: 2.308 ± 0.05
1.804PheThr: 1.804 ± 0.044
2.503PheVal: 2.503 ± 0.052
0.484PheTrp: 0.484 ± 0.022
0.866PheTyr: 0.866 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
7.708GlyAla: 7.708 ± 0.097
0.883GlyCys: 0.883 ± 0.035
3.506GlyAsp: 3.506 ± 0.068
3.743GlyGlu: 3.743 ± 0.07
2.846GlyPhe: 2.846 ± 0.055
5.886GlyGly: 5.886 ± 0.113
1.993GlyHis: 1.993 ± 0.038
3.853GlyIle: 3.853 ± 0.074
3.309GlyLys: 3.309 ± 0.065
8.45GlyLeu: 8.45 ± 0.101
2.138GlyMet: 2.138 ± 0.043
2.297GlyAsn: 2.297 ± 0.073
2.624GlyPro: 2.624 ± 0.054
4.133GlyGln: 4.133 ± 0.067
4.616GlyArg: 4.616 ± 0.079
4.418GlySer: 4.418 ± 0.087
4.348GlyThr: 4.348 ± 0.084
5.923GlyVal: 5.923 ± 0.085
1.387GlyTrp: 1.387 ± 0.04
2.136GlyTyr: 2.136 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.829HisAla: 2.829 ± 0.065
0.369HisCys: 0.369 ± 0.019
1.33HisAsp: 1.33 ± 0.037
1.238HisGlu: 1.238 ± 0.042
0.954HisPhe: 0.954 ± 0.03
2.062HisGly: 2.062 ± 0.044
0.858HisHis: 0.858 ± 0.03
1.242HisIle: 1.242 ± 0.037
0.676HisLys: 0.676 ± 0.028
2.573HisLeu: 2.573 ± 0.058
0.529HisMet: 0.529 ± 0.025
0.657HisAsn: 0.657 ± 0.023
1.566HisPro: 1.566 ± 0.042
1.132HisGln: 1.132 ± 0.035
1.426HisArg: 1.426 ± 0.042
1.406HisSer: 1.406 ± 0.038
1.458HisThr: 1.458 ± 0.039
1.379HisVal: 1.379 ± 0.038
0.533HisTrp: 0.533 ± 0.024
0.721HisTyr: 0.721 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.784IleAla: 5.784 ± 0.095
0.425IleCys: 0.425 ± 0.023
3.127IleAsp: 3.127 ± 0.053
3.307IleGlu: 3.307 ± 0.068
1.438IlePhe: 1.438 ± 0.043
3.745IleGly: 3.745 ± 0.069
1.069IleHis: 1.069 ± 0.031
1.877IleIle: 1.877 ± 0.053
1.754IleLys: 1.754 ± 0.05
3.509IleLeu: 3.509 ± 0.058
0.884IleMet: 0.884 ± 0.031
1.713IleAsn: 1.713 ± 0.049
2.007IlePro: 2.007 ± 0.046
1.668IleGln: 1.668 ± 0.035
2.568IleArg: 2.568 ± 0.051
2.715IleSer: 2.715 ± 0.07
2.95IleThr: 2.95 ± 0.059
3.272IleVal: 3.272 ± 0.06
0.459IleTrp: 0.459 ± 0.021
1.029IleTyr: 1.029 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.188LysAla: 4.188 ± 0.099
0.189LysCys: 0.189 ± 0.014
1.747LysAsp: 1.747 ± 0.048
1.963LysGlu: 1.963 ± 0.057
1.006LysPhe: 1.006 ± 0.034
2.424LysGly: 2.424 ± 0.053
0.737LysHis: 0.737 ± 0.028
1.868LysIle: 1.868 ± 0.049
1.772LysLys: 1.772 ± 0.061
3.599LysLeu: 3.599 ± 0.071
0.904LysMet: 0.904 ± 0.036
1.254LysAsn: 1.254 ± 0.038
2.085LysPro: 2.085 ± 0.057
1.41LysGln: 1.41 ± 0.039
2.067LysArg: 2.067 ± 0.051
1.942LysSer: 1.942 ± 0.047
2.261LysThr: 2.261 ± 0.05
2.731LysVal: 2.731 ± 0.064
0.354LysTrp: 0.354 ± 0.017
0.717LysTyr: 0.717 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
14.42LeuAla: 14.42 ± 0.156
1.163LeuCys: 1.163 ± 0.032
5.65LeuAsp: 5.65 ± 0.071
5.806LeuGlu: 5.806 ± 0.096
3.144LeuPhe: 3.144 ± 0.065
8.392LeuGly: 8.392 ± 0.116
3.101LeuHis: 3.101 ± 0.055
4.379LeuIle: 4.379 ± 0.068
3.559LeuLys: 3.559 ± 0.064
12.157LeuLeu: 12.157 ± 0.178
2.501LeuMet: 2.501 ± 0.047
3.003LeuAsn: 3.003 ± 0.057
6.417LeuPro: 6.417 ± 0.1
5.804LeuGln: 5.804 ± 0.089
7.541LeuArg: 7.541 ± 0.12
6.197LeuSer: 6.197 ± 0.097
5.465LeuThr: 5.465 ± 0.078
7.758LeuVal: 7.758 ± 0.1
1.456LeuTrp: 1.456 ± 0.042
2.095LeuTyr: 2.095 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.13MetAla: 3.13 ± 0.058
0.164MetCys: 0.164 ± 0.013
1.167MetAsp: 1.167 ± 0.038
1.147MetGlu: 1.147 ± 0.034
0.641MetPhe: 0.641 ± 0.026
1.897MetGly: 1.897 ± 0.045
0.526MetHis: 0.526 ± 0.022
0.836MetIle: 0.836 ± 0.027
0.923MetLys: 0.923 ± 0.032
2.557MetLeu: 2.557 ± 0.054
0.544MetMet: 0.544 ± 0.023
0.799MetAsn: 0.799 ± 0.026
1.451MetPro: 1.451 ± 0.038
1.212MetGln: 1.212 ± 0.038
1.417MetArg: 1.417 ± 0.04
1.564MetSer: 1.564 ± 0.037
1.385MetThr: 1.385 ± 0.035
1.89MetVal: 1.89 ± 0.04
0.187MetTrp: 0.187 ± 0.013
0.366MetTyr: 0.366 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.484AsnAla: 3.484 ± 0.063
0.249AsnCys: 0.249 ± 0.016
1.464AsnAsp: 1.464 ± 0.041
1.305AsnGlu: 1.305 ± 0.039
1.037AsnPhe: 1.037 ± 0.034
2.229AsnGly: 2.229 ± 0.054
0.668AsnHis: 0.668 ± 0.026
1.45AsnIle: 1.45 ± 0.039
1.03AsnLys: 1.03 ± 0.037
2.91AsnLeu: 2.91 ± 0.06
0.631AsnMet: 0.631 ± 0.025
0.9AsnAsn: 0.9 ± 0.034
1.957AsnPro: 1.957 ± 0.044
1.226AsnGln: 1.226 ± 0.041
1.642AsnArg: 1.642 ± 0.044
1.446AsnSer: 1.446 ± 0.051
1.697AsnThr: 1.697 ± 0.047
1.955AsnVal: 1.955 ± 0.051
0.412AsnTrp: 0.412 ± 0.019
0.733AsnTyr: 0.733 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
6.918ProAla: 6.918 ± 0.116
0.423ProCys: 0.423 ± 0.02
2.902ProAsp: 2.902 ± 0.061
3.461ProGlu: 3.461 ± 0.062
1.582ProPhe: 1.582 ± 0.039
3.706ProGly: 3.706 ± 0.064
1.209ProHis: 1.209 ± 0.035
1.946ProIle: 1.946 ± 0.053
1.54ProLys: 1.54 ± 0.047
5.439ProLeu: 5.439 ± 0.087
1.258ProMet: 1.258 ± 0.034
1.335ProAsn: 1.335 ± 0.038
2.932ProPro: 2.932 ± 0.089
2.551ProGln: 2.551 ± 0.047
2.496ProArg: 2.496 ± 0.056
3.008ProSer: 3.008 ± 0.058
2.911ProThr: 2.911 ± 0.056
4.302ProVal: 4.302 ± 0.075
0.786ProTrp: 0.786 ± 0.031
1.107ProTyr: 1.107 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
7.469GlnAla: 7.469 ± 0.117
0.443GlnCys: 0.443 ± 0.021
2.05GlnAsp: 2.05 ± 0.051
2.517GlnGlu: 2.517 ± 0.055
1.474GlnPhe: 1.474 ± 0.032
3.859GlnGly: 3.859 ± 0.068
1.384GlnHis: 1.384 ± 0.036
2.192GlnIle: 2.192 ± 0.057
1.53GlnLys: 1.53 ± 0.04
5.372GlnLeu: 5.372 ± 0.086
1.116GlnMet: 1.116 ± 0.033
1.255GlnAsn: 1.255 ± 0.035
2.767GlnPro: 2.767 ± 0.051
3.232GlnGln: 3.232 ± 0.078
4.188GlnArg: 4.188 ± 0.076
2.568GlnSer: 2.568 ± 0.057
2.638GlnThr: 2.638 ± 0.057
3.674GlnVal: 3.674 ± 0.066
0.949GlnTrp: 0.949 ± 0.033
0.964GlnTyr: 0.964 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
6.699ArgAla: 6.699 ± 0.08
0.572ArgCys: 0.572 ± 0.024
3.091ArgAsp: 3.091 ± 0.055
3.492ArgGlu: 3.492 ± 0.067
2.35ArgPhe: 2.35 ± 0.052
3.869ArgGly: 3.869 ± 0.068
1.685ArgHis: 1.685 ± 0.046
3.202ArgIle: 3.202 ± 0.062
2.176ArgLys: 2.176 ± 0.052
7.407ArgLeu: 7.407 ± 0.11
1.742ArgMet: 1.742 ± 0.044
1.871ArgAsn: 1.871 ± 0.046
2.826ArgPro: 2.826 ± 0.05
3.433ArgGln: 3.433 ± 0.067
3.903ArgArg: 3.903 ± 0.082
3.354ArgSer: 3.354 ± 0.062
3.2ArgThr: 3.2 ± 0.06
4.278ArgVal: 4.278 ± 0.068
1.126ArgTrp: 1.126 ± 0.034
1.741ArgTyr: 1.741 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.63SerAla: 6.63 ± 0.099
0.495SerCys: 0.495 ± 0.024
2.727SerAsp: 2.727 ± 0.06
2.595SerGlu: 2.595 ± 0.051
2.028SerPhe: 2.028 ± 0.048
5.094SerGly: 5.094 ± 0.091
1.432SerHis: 1.432 ± 0.04
2.69SerIle: 2.69 ± 0.061
1.881SerLys: 1.881 ± 0.053
5.705SerLeu: 5.705 ± 0.076
1.32SerMet: 1.32 ± 0.037
1.676SerAsn: 1.676 ± 0.042
2.815SerPro: 2.815 ± 0.059
2.369SerGln: 2.369 ± 0.056
3.179SerArg: 3.179 ± 0.051
3.78SerSer: 3.78 ± 0.083
3.579SerThr: 3.579 ± 0.078
4.141SerVal: 4.141 ± 0.066
0.677SerTrp: 0.677 ± 0.027
1.376SerTyr: 1.376 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
6.484ThrAla: 6.484 ± 0.113
0.43ThrCys: 0.43 ± 0.022
2.715ThrAsp: 2.715 ± 0.056
2.832ThrGlu: 2.832 ± 0.061
1.674ThrPhe: 1.674 ± 0.046
4.712ThrGly: 4.712 ± 0.087
1.252ThrHis: 1.252 ± 0.039
2.434ThrIle: 2.434 ± 0.065
1.597ThrLys: 1.597 ± 0.049
6.824ThrLeu: 6.824 ± 0.104
1.154ThrMet: 1.154 ± 0.033
1.381ThrAsn: 1.381 ± 0.04
3.76ThrPro: 3.76 ± 0.065
2.568ThrGln: 2.568 ± 0.058
2.874ThrArg: 2.874 ± 0.056
2.969ThrSer: 2.969 ± 0.062
3.182ThrThr: 3.182 ± 0.066
4.452ThrVal: 4.452 ± 0.077
0.617ThrTrp: 0.617 ± 0.026
0.977ThrTyr: 0.977 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.193ValAla: 9.193 ± 0.101
0.744ValCys: 0.744 ± 0.024
3.606ValAsp: 3.606 ± 0.056
3.8ValGlu: 3.8 ± 0.063
2.475ValPhe: 2.475 ± 0.049
5.351ValGly: 5.351 ± 0.08
1.6ValHis: 1.6 ± 0.042
3.05ValIle: 3.05 ± 0.06
2.323ValLys: 2.323 ± 0.052
8.718ValLeu: 8.718 ± 0.121
1.683ValMet: 1.683 ± 0.039
2.012ValAsn: 2.012 ± 0.046
3.881ValPro: 3.881 ± 0.062
4.083ValGln: 4.083 ± 0.073
4.895ValArg: 4.895 ± 0.069
3.988ValSer: 3.988 ± 0.063
3.849ValThr: 3.849 ± 0.07
6.254ValVal: 6.254 ± 0.085
0.987ValTrp: 0.987 ± 0.03
1.516ValTyr: 1.516 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.446TrpAla: 1.446 ± 0.04
0.21TrpCys: 0.21 ± 0.014
0.59TrpAsp: 0.59 ± 0.021
0.573TrpGlu: 0.573 ± 0.024
0.497TrpPhe: 0.497 ± 0.023
0.949TrpGly: 0.949 ± 0.029
0.384TrpHis: 0.384 ± 0.02
0.62TrpIle: 0.62 ± 0.028
0.431TrpLys: 0.431 ± 0.022
2.217TrpLeu: 2.217 ± 0.056
0.428TrpMet: 0.428 ± 0.022
0.422TrpAsn: 0.422 ± 0.023
0.726TrpPro: 0.726 ± 0.028
1.002TrpGln: 1.002 ± 0.034
1.079TrpArg: 1.079 ± 0.031
0.736TrpSer: 0.736 ± 0.026
0.624TrpThr: 0.624 ± 0.024
1.045TrpVal: 1.045 ± 0.035
0.295TrpTrp: 0.295 ± 0.02
0.289TrpTyr: 0.289 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.528TyrAla: 2.528 ± 0.048
0.26TyrCys: 0.26 ± 0.016
1.131TyrAsp: 1.131 ± 0.036
1.141TyrGlu: 1.141 ± 0.036
0.879TyrPhe: 0.879 ± 0.032
1.834TyrGly: 1.834 ± 0.047
0.499TyrHis: 0.499 ± 0.02
0.829TyrIle: 0.829 ± 0.03
0.767TyrLys: 0.767 ± 0.031
2.429TyrLeu: 2.429 ± 0.044
0.404TyrMet: 0.404 ± 0.02
0.639TyrAsn: 0.639 ± 0.03
1.107TyrPro: 1.107 ± 0.031
1.201TyrGln: 1.201 ± 0.034
1.573TyrArg: 1.573 ± 0.042
1.294TyrSer: 1.294 ± 0.034
1.219TyrThr: 1.219 ± 0.032
1.527TyrVal: 1.527 ± 0.043
0.364TyrTrp: 0.364 ± 0.019
0.582TyrTyr: 0.582 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3181 proteins (1039527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski