Amino acid dipepetide frequency for Epibacterium ulvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.663AlaAla: 13.663 ± 0.161	1.062AlaCys: 1.062 ± 0.035	6.469AlaAsp: 6.469 ± 0.079	7.528AlaGlu: 7.528 ± 0.103	4.079AlaPhe: 4.079 ± 0.064	8.93AlaGly: 8.93 ± 0.091	2.301AlaHis: 2.301 ± 0.048	5.71AlaIle: 5.71 ± 0.072	4.34AlaLys: 4.34 ± 0.064	12.741AlaLeu: 12.741 ± 0.142	3.252AlaMet: 3.252 ± 0.056	2.914AlaAsn: 2.914 ± 0.053	5.057AlaPro: 5.057 ± 0.079	4.985AlaGln: 4.985 ± 0.075	7.119AlaArg: 7.119 ± 0.092	5.533AlaSer: 5.533 ± 0.073	5.632AlaThr: 5.632 ± 0.069	7.406AlaVal: 7.406 ± 0.084	1.185AlaTrp: 1.185 ± 0.039	2.536AlaTyr: 2.536 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.177CysAla: 1.177 ± 0.036	0.134CysCys: 0.134 ± 0.011	0.678CysAsp: 0.678 ± 0.026	0.491CysGlu: 0.491 ± 0.021	0.387CysPhe: 0.387 ± 0.019	0.952CysGly: 0.952 ± 0.032	0.261CysHis: 0.261 ± 0.013	0.453CysIle: 0.453 ± 0.021	0.255CysLys: 0.255 ± 0.016	0.913CysLeu: 0.913 ± 0.028	0.207CysMet: 0.207 ± 0.014	0.253CysAsn: 0.253 ± 0.014	0.481CysPro: 0.481 ± 0.025	0.283CysGln: 0.283 ± 0.017	0.513CysArg: 0.513 ± 0.022	0.533CysSer: 0.533 ± 0.023	0.502CysThr: 0.502 ± 0.021	0.641CysVal: 0.641 ± 0.024	0.126CysTrp: 0.126 ± 0.009	0.227CysTyr: 0.227 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.624AspAla: 6.624 ± 0.088	0.535AspCys: 0.535 ± 0.025	3.304AspAsp: 3.304 ± 0.078	3.543AspGlu: 3.543 ± 0.057	2.443AspPhe: 2.443 ± 0.048	4.961AspGly: 4.961 ± 0.089	1.478AspHis: 1.478 ± 0.039	3.472AspIle: 3.472 ± 0.053	1.897AspLys: 1.897 ± 0.045	7.025AspLeu: 7.025 ± 0.075	1.627AspMet: 1.627 ± 0.034	1.505AspAsn: 1.505 ± 0.039	3.251AspPro: 3.251 ± 0.061	2.39AspGln: 2.39 ± 0.047	3.603AspArg: 3.603 ± 0.063	2.356AspSer: 2.356 ± 0.052	3.174AspThr: 3.174 ± 0.061	4.368AspVal: 4.368 ± 0.064	1.064AspTrp: 1.064 ± 0.032	1.498AspTyr: 1.498 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.307GluAla: 7.307 ± 0.093	0.393GluCys: 0.393 ± 0.018	3.434GluAsp: 3.434 ± 0.057	3.755GluGlu: 3.755 ± 0.06	2.045GluPhe: 2.045 ± 0.042	4.552GluGly: 4.552 ± 0.059	1.303GluHis: 1.303 ± 0.033	4.107GluIle: 4.107 ± 0.054	2.498GluLys: 2.498 ± 0.057	5.604GluLeu: 5.604 ± 0.07	1.774GluMet: 1.774 ± 0.032	2.181GluAsn: 2.181 ± 0.041	2.229GluPro: 2.229 ± 0.058	2.642GluGln: 2.642 ± 0.051	4.076GluArg: 4.076 ± 0.058	2.345GluSer: 2.345 ± 0.041	4.383GluThr: 4.383 ± 0.073	4.173GluVal: 4.173 ± 0.065	0.681GluTrp: 0.681 ± 0.026	1.086GluTyr: 1.086 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.304PheAla: 4.304 ± 0.063	0.485PheCys: 0.485 ± 0.02	2.951PheAsp: 2.951 ± 0.051	2.547PheGlu: 2.547 ± 0.051	1.559PhePhe: 1.559 ± 0.043	3.657PheGly: 3.657 ± 0.066	0.768PheHis: 0.768 ± 0.031	1.778PheIle: 1.778 ± 0.042	1.249PheLys: 1.249 ± 0.033	3.596PheLeu: 3.596 ± 0.073	0.974PheMet: 0.974 ± 0.03	1.17PheAsn: 1.17 ± 0.033	1.529PhePro: 1.529 ± 0.037	1.269PheGln: 1.269 ± 0.032	1.952PheArg: 1.952 ± 0.039	2.522PheSer: 2.522 ± 0.05	2.179PheThr: 2.179 ± 0.044	2.839PheVal: 2.839 ± 0.055	0.597PheTrp: 0.597 ± 0.023	0.983PheTyr: 0.983 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.677GlyAla: 8.677 ± 0.1	0.84GlyCys: 0.84 ± 0.032	4.474GlyAsp: 4.474 ± 0.087	4.469GlyGlu: 4.469 ± 0.062	3.774GlyPhe: 3.774 ± 0.062	6.624GlyGly: 6.624 ± 0.13	1.918GlyHis: 1.918 ± 0.045	4.326GlyIle: 4.326 ± 0.058	3.311GlyLys: 3.311 ± 0.057	8.535GlyLeu: 8.535 ± 0.103	2.149GlyMet: 2.149 ± 0.045	2.292GlyAsn: 2.292 ± 0.063	2.986GlyPro: 2.986 ± 0.049	3.3GlyGln: 3.3 ± 0.059	4.773GlyArg: 4.773 ± 0.071	4.222GlySer: 4.222 ± 0.064	4.418GlyThr: 4.418 ± 0.067	6.028GlyVal: 6.028 ± 0.084	1.291GlyTrp: 1.291 ± 0.033	2.218GlyTyr: 2.218 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.17HisAla: 2.17 ± 0.044	0.265HisCys: 0.265 ± 0.015	1.242HisAsp: 1.242 ± 0.035	1.123HisGlu: 1.123 ± 0.033	0.905HisPhe: 0.905 ± 0.029	1.749HisGly: 1.749 ± 0.038	0.602HisHis: 0.602 ± 0.028	1.198HisIle: 1.198 ± 0.036	0.789HisLys: 0.789 ± 0.025	2.269HisLeu: 2.269 ± 0.044	0.593HisMet: 0.593 ± 0.022	0.603HisAsn: 0.603 ± 0.027	1.348HisPro: 1.348 ± 0.038	0.782HisGln: 0.782 ± 0.027	1.277HisArg: 1.277 ± 0.033	1.183HisSer: 1.183 ± 0.038	0.962HisThr: 0.962 ± 0.03	1.577HisVal: 1.577 ± 0.042	0.369HisTrp: 0.369 ± 0.02	0.603HisTyr: 0.603 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.878IleAla: 6.878 ± 0.09	0.726IleCys: 0.726 ± 0.028	3.569IleAsp: 3.569 ± 0.051	3.725IleGlu: 3.725 ± 0.055	1.845IlePhe: 1.845 ± 0.045	4.655IleGly: 4.655 ± 0.067	0.996IleHis: 0.996 ± 0.032	2.374IleIle: 2.374 ± 0.055	1.899IleLys: 1.899 ± 0.039	5.202IleLeu: 5.202 ± 0.076	1.162IleMet: 1.162 ± 0.034	1.712IleAsn: 1.712 ± 0.043	2.379IlePro: 2.379 ± 0.038	1.584IleGln: 1.584 ± 0.036	2.964IleArg: 2.964 ± 0.048	3.614IleSer: 3.614 ± 0.055	3.184IleThr: 3.184 ± 0.047	3.734IleVal: 3.734 ± 0.056	0.793IleTrp: 0.793 ± 0.027	1.28IleTyr: 1.28 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.37LysAla: 4.37 ± 0.058	0.211LysCys: 0.211 ± 0.013	2.168LysAsp: 2.168 ± 0.047	2.136LysGlu: 2.136 ± 0.055	1.146LysPhe: 1.146 ± 0.034	3.023LysGly: 3.023 ± 0.051	0.823LysHis: 0.823 ± 0.027	2.174LysIle: 2.174 ± 0.049	1.497LysLys: 1.497 ± 0.042	3.471LysLeu: 3.471 ± 0.06	1.054LysMet: 1.054 ± 0.032	1.175LysAsn: 1.175 ± 0.031	1.964LysPro: 1.964 ± 0.049	1.287LysGln: 1.287 ± 0.036	2.526LysArg: 2.526 ± 0.05	2.306LysSer: 2.306 ± 0.046	2.473LysThr: 2.473 ± 0.056	2.536LysVal: 2.536 ± 0.054	0.434LysTrp: 0.434 ± 0.018	0.757LysTyr: 0.757 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.412LeuAla: 11.412 ± 0.121	1.049LeuCys: 1.049 ± 0.026	5.995LeuAsp: 5.995 ± 0.083	5.835LeuGlu: 5.835 ± 0.077	3.764LeuPhe: 3.764 ± 0.066	7.997LeuGly: 7.997 ± 0.111	1.991LeuHis: 1.991 ± 0.038	5.512LeuIle: 5.512 ± 0.087	4.012LeuLys: 4.012 ± 0.064	9.193LeuLeu: 9.193 ± 0.117	2.756LeuMet: 2.756 ± 0.047	3.46LeuAsn: 3.46 ± 0.047	5.421LeuPro: 5.421 ± 0.073	3.646LeuGln: 3.646 ± 0.06	6.608LeuArg: 6.608 ± 0.088	7.305LeuSer: 7.305 ± 0.091	5.863LeuThr: 5.863 ± 0.074	6.639LeuVal: 6.639 ± 0.086	1.309LeuTrp: 1.309 ± 0.038	2.072LeuTyr: 2.072 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.067MetAla: 3.067 ± 0.05	0.213MetCys: 0.213 ± 0.013	1.348MetAsp: 1.348 ± 0.038	1.336MetGlu: 1.336 ± 0.034	0.844MetPhe: 0.844 ± 0.027	2.127MetGly: 2.127 ± 0.042	0.498MetHis: 0.498 ± 0.017	1.603MetIle: 1.603 ± 0.04	1.139MetLys: 1.139 ± 0.029	2.467MetLeu: 2.467 ± 0.04	0.85MetMet: 0.85 ± 0.026	0.833MetAsn: 0.833 ± 0.027	1.375MetPro: 1.375 ± 0.038	1.091MetGln: 1.091 ± 0.03	1.78MetArg: 1.78 ± 0.039	1.851MetSer: 1.851 ± 0.038	1.905MetThr: 1.905 ± 0.039	1.781MetVal: 1.781 ± 0.046	0.257MetTrp: 0.257 ± 0.015	0.358MetTyr: 0.358 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.471AsnAla: 3.471 ± 0.06	0.302AsnCys: 0.302 ± 0.015	1.752AsnAsp: 1.752 ± 0.058	1.49AsnGlu: 1.49 ± 0.041	1.114AsnPhe: 1.114 ± 0.032	2.652AsnGly: 2.652 ± 0.056	0.676AsnHis: 0.676 ± 0.024	1.69AsnIle: 1.69 ± 0.039	0.971AsnLys: 0.971 ± 0.031	3.031AsnLeu: 3.031 ± 0.051	0.788AsnMet: 0.788 ± 0.027	0.918AsnAsn: 0.918 ± 0.031	1.953AsnPro: 1.953 ± 0.046	1.023AsnGln: 1.023 ± 0.031	1.879AsnArg: 1.879 ± 0.042	1.56AsnSer: 1.56 ± 0.037	1.736AsnThr: 1.736 ± 0.04	2.09AsnVal: 2.09 ± 0.042	0.524AsnTrp: 0.524 ± 0.026	0.754AsnTyr: 0.754 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.693ProAla: 4.693 ± 0.065	0.374ProCys: 0.374 ± 0.017	3.556ProAsp: 3.556 ± 0.059	3.868ProGlu: 3.868 ± 0.058	1.943ProPhe: 1.943 ± 0.043	3.482ProGly: 3.482 ± 0.056	1.08ProHis: 1.08 ± 0.036	2.305ProIle: 2.305 ± 0.04	2.018ProLys: 2.018 ± 0.048	4.428ProLeu: 4.428 ± 0.073	1.188ProMet: 1.188 ± 0.034	1.616ProAsn: 1.616 ± 0.038	1.859ProPro: 1.859 ± 0.054	1.808ProGln: 1.808 ± 0.042	2.324ProArg: 2.324 ± 0.052	2.7ProSer: 2.7 ± 0.049	2.44ProThr: 2.44 ± 0.05	3.826ProVal: 3.826 ± 0.061	0.61ProTrp: 0.61 ± 0.025	1.143ProTyr: 1.143 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.334GlnAla: 4.334 ± 0.067	0.255GlnCys: 0.255 ± 0.015	2.236GlnAsp: 2.236 ± 0.047	1.993GlnGlu: 1.993 ± 0.049	1.345GlnPhe: 1.345 ± 0.038	2.845GlnGly: 2.845 ± 0.046	0.761GlnHis: 0.761 ± 0.026	2.51GlnIle: 2.51 ± 0.044	1.533GlnLys: 1.533 ± 0.038	3.547GlnLeu: 3.547 ± 0.058	1.178GlnMet: 1.178 ± 0.031	1.363GlnAsn: 1.363 ± 0.042	1.728GlnPro: 1.728 ± 0.04	1.499GlnGln: 1.499 ± 0.041	2.535GlnArg: 2.535 ± 0.049	2.423GlnSer: 2.423 ± 0.05	2.233GlnThr: 2.233 ± 0.048	2.615GlnVal: 2.615 ± 0.044	0.455GlnTrp: 0.455 ± 0.02	0.734GlnTyr: 0.734 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.638ArgAla: 6.638 ± 0.081	0.488ArgCys: 0.488 ± 0.023	3.781ArgAsp: 3.781 ± 0.057	3.524ArgGlu: 3.524 ± 0.06	2.547ArgPhe: 2.547 ± 0.052	3.92ArgGly: 3.92 ± 0.066	1.409ArgHis: 1.409 ± 0.035	3.446ArgIle: 3.446 ± 0.05	2.509ArgLys: 2.509 ± 0.047	6.71ArgLeu: 6.71 ± 0.099	1.691ArgMet: 1.691 ± 0.039	1.937ArgAsn: 1.937 ± 0.044	2.785ArgPro: 2.785 ± 0.057	2.285ArgGln: 2.285 ± 0.051	4.02ArgArg: 4.02 ± 0.066	3.449ArgSer: 3.449 ± 0.053	2.801ArgThr: 2.801 ± 0.056	4.235ArgVal: 4.235 ± 0.06	0.831ArgTrp: 0.831 ± 0.027	1.521ArgTyr: 1.521 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.143SerAla: 6.143 ± 0.072	0.535SerCys: 0.535 ± 0.025	3.622SerAsp: 3.622 ± 0.052	3.436SerGlu: 3.436 ± 0.06	2.56SerPhe: 2.56 ± 0.052	5.415SerGly: 5.415 ± 0.074	1.259SerHis: 1.259 ± 0.032	2.916SerIle: 2.916 ± 0.055	2.096SerLys: 2.096 ± 0.047	5.607SerLeu: 5.607 ± 0.079	1.468SerMet: 1.468 ± 0.033	1.715SerAsn: 1.715 ± 0.041	2.559SerPro: 2.559 ± 0.046	2.065SerGln: 2.065 ± 0.041	3.141SerArg: 3.141 ± 0.056	3.18SerSer: 3.18 ± 0.056	2.951SerThr: 2.951 ± 0.048	4.056SerVal: 4.056 ± 0.063	0.727SerTrp: 0.727 ± 0.026	1.479SerTyr: 1.479 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.091ThrAla: 6.091 ± 0.077	0.531ThrCys: 0.531 ± 0.022	3.104ThrAsp: 3.104 ± 0.056	3.13ThrGlu: 3.13 ± 0.062	2.074ThrPhe: 2.074 ± 0.04	5.009ThrGly: 5.009 ± 0.072	1.25ThrHis: 1.25 ± 0.032	2.809ThrIle: 2.809 ± 0.051	1.836ThrLys: 1.836 ± 0.042	6.329ThrLeu: 6.329 ± 0.073	1.221ThrMet: 1.221 ± 0.03	1.507ThrAsn: 1.507 ± 0.041	3.438ThrPro: 3.438 ± 0.061	2.079ThrGln: 2.079 ± 0.043	3.242ThrArg: 3.242 ± 0.05	3.179ThrSer: 3.179 ± 0.055	3.002ThrThr: 3.002 ± 0.059	4.02ThrVal: 4.02 ± 0.058	0.631ThrTrp: 0.631 ± 0.027	1.416ThrTyr: 1.416 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.777ValAla: 7.777 ± 0.087	0.639ValCys: 0.639 ± 0.022	4.073ValAsp: 4.073 ± 0.057	4.561ValGlu: 4.561 ± 0.066	2.96ValPhe: 2.96 ± 0.053	5.074ValGly: 5.074 ± 0.075	1.318ValHis: 1.318 ± 0.034	4.129ValIle: 4.129 ± 0.071	2.471ValLys: 2.471 ± 0.054	7.362ValLeu: 7.362 ± 0.091	1.891ValMet: 1.891 ± 0.039	2.121ValAsn: 2.121 ± 0.045	3.202ValPro: 3.202 ± 0.052	2.534ValGln: 2.534 ± 0.047	3.752ValArg: 3.752 ± 0.056	4.509ValSer: 4.509 ± 0.057	4.266ValThr: 4.266 ± 0.06	5.528ValVal: 5.528 ± 0.09	0.868ValTrp: 0.868 ± 0.029	1.448ValTyr: 1.448 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.234TrpAla: 1.234 ± 0.034	0.158TrpCys: 0.158 ± 0.011	0.775TrpAsp: 0.775 ± 0.026	0.689TrpGlu: 0.689 ± 0.024	0.554TrpPhe: 0.554 ± 0.023	0.93TrpGly: 0.93 ± 0.034	0.336TrpHis: 0.336 ± 0.016	0.672TrpIle: 0.672 ± 0.025	0.475TrpLys: 0.475 ± 0.02	1.52TrpLeu: 1.52 ± 0.041	0.387TrpMet: 0.387 ± 0.018	0.437TrpAsn: 0.437 ± 0.021	0.643TrpPro: 0.643 ± 0.028	0.677TrpGln: 0.677 ± 0.025	0.992TrpArg: 0.992 ± 0.03	0.868TrpSer: 0.868 ± 0.03	0.645TrpThr: 0.645 ± 0.022	0.837TrpVal: 0.837 ± 0.028	0.207TrpTrp: 0.207 ± 0.015	0.277TrpTyr: 0.277 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.412TyrAla: 2.412 ± 0.046	0.272TyrCys: 0.272 ± 0.013	1.585TyrAsp: 1.585 ± 0.037	1.389TyrGlu: 1.389 ± 0.035	1.021TyrPhe: 1.021 ± 0.03	2.07TyrGly: 2.07 ± 0.044	0.58TyrHis: 0.58 ± 0.024	1.091TyrIle: 1.091 ± 0.032	0.735TyrLys: 0.735 ± 0.028	2.292TyrLeu: 2.292 ± 0.04	0.514TyrMet: 0.514 ± 0.022	0.66TyrAsn: 0.66 ± 0.023	1.073TyrPro: 1.073 ± 0.031	0.894TyrGln: 0.894 ± 0.028	1.45TyrArg: 1.45 ± 0.031	1.292TyrSer: 1.292 ± 0.033	1.151TyrThr: 1.151 ± 0.032	1.552TyrVal: 1.552 ± 0.035	0.355TyrTrp: 0.355 ± 0.017	0.594TyrTyr: 0.594 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3832 proteins (1182256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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