Amino acid dipepetide frequency for Streptococcus satellite phage Javan479

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.918AlaAla: 0.918 ± 0.45
1.53AlaCys: 1.53 ± 0.594
2.448AlaAsp: 2.448 ± 0.808
5.202AlaGlu: 5.202 ± 1.46
1.836AlaPhe: 1.836 ± 0.613
2.448AlaGly: 2.448 ± 0.729
0.612AlaHis: 0.612 ± 0.714
3.06AlaIle: 3.06 ± 1.201
3.366AlaLys: 3.366 ± 1.116
5.814AlaLeu: 5.814 ± 1.483
1.53AlaMet: 1.53 ± 0.688
3.672AlaAsn: 3.672 ± 1.373
0.306AlaPro: 0.306 ± 0.32
3.978AlaGln: 3.978 ± 1.217
2.754AlaArg: 2.754 ± 0.876
2.142AlaSer: 2.142 ± 0.515
5.202AlaThr: 5.202 ± 0.866
4.284AlaVal: 4.284 ± 1.169
1.224AlaTrp: 1.224 ± 0.658
2.754AlaTyr: 2.754 ± 0.691
0.0AlaXaa: 0.0 ± 0.0
Cys
0.306CysAla: 0.306 ± 0.298
0.306CysCys: 0.306 ± 0.258
0.612CysAsp: 0.612 ± 0.455
0.306CysGlu: 0.306 ± 0.334
0.306CysPhe: 0.306 ± 0.334
0.612CysGly: 0.612 ± 0.367
0.306CysHis: 0.306 ± 0.297
0.306CysIle: 0.306 ± 0.263
0.306CysLys: 0.306 ± 0.27
0.306CysLeu: 0.306 ± 0.27
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.306CysPro: 0.306 ± 0.287
0.0CysGln: 0.0 ± 0.0
0.612CysArg: 0.612 ± 0.413
0.306CysSer: 0.306 ± 0.309
0.0CysThr: 0.0 ± 0.0
0.306CysVal: 0.306 ± 0.258
0.0CysTrp: 0.0 ± 0.0
1.224CysTyr: 1.224 ± 0.757
0.0CysXaa: 0.0 ± 0.0
Asp
1.224AspAla: 1.224 ± 0.588
0.612AspCys: 0.612 ± 0.346
6.12AspAsp: 6.12 ± 1.136
5.508AspGlu: 5.508 ± 1.356
3.366AspPhe: 3.366 ± 1.074
1.53AspGly: 1.53 ± 0.666
1.53AspHis: 1.53 ± 0.63
7.956AspIle: 7.956 ± 1.435
4.284AspLys: 4.284 ± 1.408
7.956AspLeu: 7.956 ± 1.431
3.06AspMet: 3.06 ± 0.961
1.836AspAsn: 1.836 ± 0.66
0.306AspPro: 0.306 ± 0.279
1.53AspGln: 1.53 ± 0.58
2.754AspArg: 2.754 ± 0.924
4.59AspSer: 4.59 ± 1.174
2.142AspThr: 2.142 ± 0.853
3.366AspVal: 3.366 ± 1.092
0.918AspTrp: 0.918 ± 0.44
3.672AspTyr: 3.672 ± 1.151
0.0AspXaa: 0.0 ± 0.0
Glu
5.202GluAla: 5.202 ± 1.196
0.612GluCys: 0.612 ± 0.596
3.366GluAsp: 3.366 ± 1.087
5.508GluGlu: 5.508 ± 1.907
1.836GluPhe: 1.836 ± 1.01
3.978GluGly: 3.978 ± 0.909
2.754GluHis: 2.754 ± 0.746
4.284GluIle: 4.284 ± 0.954
7.344GluLys: 7.344 ± 1.684
10.71GluLeu: 10.71 ± 1.854
3.978GluMet: 3.978 ± 0.959
4.284GluAsn: 4.284 ± 1.217
0.612GluPro: 0.612 ± 0.445
4.59GluGln: 4.59 ± 1.574
2.754GluArg: 2.754 ± 1.04
3.366GluSer: 3.366 ± 1.211
3.978GluThr: 3.978 ± 0.785
5.814GluVal: 5.814 ± 1.013
1.53GluTrp: 1.53 ± 0.597
3.672GluTyr: 3.672 ± 0.869
0.0GluXaa: 0.0 ± 0.0
Phe
1.224PheAla: 1.224 ± 0.497
0.306PheCys: 0.306 ± 0.258
3.366PheAsp: 3.366 ± 0.821
4.284PheGlu: 4.284 ± 0.829
2.142PhePhe: 2.142 ± 0.722
2.142PheGly: 2.142 ± 0.62
1.53PheHis: 1.53 ± 0.593
3.06PheIle: 3.06 ± 1.076
4.284PheLys: 4.284 ± 1.053
3.366PheLeu: 3.366 ± 0.729
0.306PheMet: 0.306 ± 0.357
2.142PheAsn: 2.142 ± 0.822
0.918PhePro: 0.918 ± 0.507
0.918PheGln: 0.918 ± 0.469
3.672PheArg: 3.672 ± 1.163
2.448PheSer: 2.448 ± 0.749
3.366PheThr: 3.366 ± 0.732
1.224PheVal: 1.224 ± 0.5
0.612PheTrp: 0.612 ± 0.484
1.53PheTyr: 1.53 ± 0.625
0.0PheXaa: 0.0 ± 0.0
Gly
1.836GlyAla: 1.836 ± 0.734
0.612GlyCys: 0.612 ± 0.461
2.448GlyAsp: 2.448 ± 0.639
3.978GlyGlu: 3.978 ± 1.182
1.53GlyPhe: 1.53 ± 0.698
3.06GlyGly: 3.06 ± 1.341
0.918GlyHis: 0.918 ± 0.519
4.284GlyIle: 4.284 ± 1.02
3.672GlyLys: 3.672 ± 1.106
4.59GlyLeu: 4.59 ± 1.446
0.612GlyMet: 0.612 ± 0.488
2.448GlyAsn: 2.448 ± 0.798
0.0GlyPro: 0.0 ± 0.0
1.53GlyGln: 1.53 ± 0.72
2.754GlyArg: 2.754 ± 1.457
0.612GlySer: 0.612 ± 0.359
3.06GlyThr: 3.06 ± 0.817
4.284GlyVal: 4.284 ± 1.042
0.306GlyTrp: 0.306 ± 0.258
4.284GlyTyr: 4.284 ± 1.102
0.0GlyXaa: 0.0 ± 0.0
His
1.53HisAla: 1.53 ± 0.863
0.0HisCys: 0.0 ± 0.0
1.224HisAsp: 1.224 ± 0.545
1.224HisGlu: 1.224 ± 0.608
0.306HisPhe: 0.306 ± 0.27
0.918HisGly: 0.918 ± 0.511
0.306HisHis: 0.306 ± 0.263
1.224HisIle: 1.224 ± 0.5
1.224HisLys: 1.224 ± 0.449
1.224HisLeu: 1.224 ± 0.489
0.612HisMet: 0.612 ± 0.37
1.836HisAsn: 1.836 ± 0.572
0.612HisPro: 0.612 ± 0.342
1.224HisGln: 1.224 ± 0.599
1.53HisArg: 1.53 ± 0.586
1.224HisSer: 1.224 ± 0.557
1.224HisThr: 1.224 ± 0.469
1.224HisVal: 1.224 ± 0.738
0.0HisTrp: 0.0 ± 0.0
1.53HisTyr: 1.53 ± 0.729
0.0HisXaa: 0.0 ± 0.0
Ile
4.284IleAla: 4.284 ± 1.328
0.918IleCys: 0.918 ± 0.527
4.896IleAsp: 4.896 ± 0.912
7.956IleGlu: 7.956 ± 1.394
3.366IlePhe: 3.366 ± 0.806
3.366IleGly: 3.366 ± 1.223
1.224IleHis: 1.224 ± 0.571
4.284IleIle: 4.284 ± 0.989
7.038IleLys: 7.038 ± 1.343
3.978IleLeu: 3.978 ± 0.738
1.836IleMet: 1.836 ± 0.735
1.836IleAsn: 1.836 ± 0.553
1.836IlePro: 1.836 ± 0.716
2.754IleGln: 2.754 ± 0.768
2.754IleArg: 2.754 ± 0.831
3.366IleSer: 3.366 ± 0.854
4.896IleThr: 4.896 ± 1.7
2.754IleVal: 2.754 ± 0.763
0.0IleTrp: 0.0 ± 0.0
2.754IleTyr: 2.754 ± 0.844
0.0IleXaa: 0.0 ± 0.0
Lys
7.65LysAla: 7.65 ± 1.379
0.306LysCys: 0.306 ± 0.298
5.814LysAsp: 5.814 ± 1.195
8.262LysGlu: 8.262 ± 1.603
3.978LysPhe: 3.978 ± 1.174
4.284LysGly: 4.284 ± 1.101
2.754LysHis: 2.754 ± 1.02
5.814LysIle: 5.814 ± 1.464
9.18LysLys: 9.18 ± 1.919
9.792LysLeu: 9.792 ± 1.54
2.448LysMet: 2.448 ± 0.77
6.12LysAsn: 6.12 ± 1.112
2.754LysPro: 2.754 ± 1.041
4.284LysGln: 4.284 ± 0.733
4.59LysArg: 4.59 ± 1.149
3.672LysSer: 3.672 ± 1.184
3.366LysThr: 3.366 ± 0.919
5.814LysVal: 5.814 ± 1.203
0.612LysTrp: 0.612 ± 0.426
2.448LysTyr: 2.448 ± 0.675
0.0LysXaa: 0.0 ± 0.0
Leu
5.508LeuAla: 5.508 ± 1.461
0.306LeuCys: 0.306 ± 0.263
8.262LeuAsp: 8.262 ± 0.967
11.322LeuGlu: 11.322 ± 2.258
3.06LeuPhe: 3.06 ± 1.118
5.202LeuGly: 5.202 ± 1.318
1.836LeuHis: 1.836 ± 0.667
3.978LeuIle: 3.978 ± 1.23
8.262LeuLys: 8.262 ± 1.3
8.568LeuLeu: 8.568 ± 1.652
3.06LeuMet: 3.06 ± 0.999
6.426LeuAsn: 6.426 ± 1.372
2.142LeuPro: 2.142 ± 0.614
3.366LeuGln: 3.366 ± 1.0
3.06LeuArg: 3.06 ± 0.806
10.098LeuSer: 10.098 ± 1.508
3.672LeuThr: 3.672 ± 1.095
3.978LeuVal: 3.978 ± 1.168
0.918LeuTrp: 0.918 ± 0.488
4.896LeuTyr: 4.896 ± 1.01
0.0LeuXaa: 0.0 ± 0.0
Met
1.836MetAla: 1.836 ± 0.705
0.0MetCys: 0.0 ± 0.0
0.918MetAsp: 0.918 ± 0.478
1.53MetGlu: 1.53 ± 0.556
0.612MetPhe: 0.612 ± 0.378
0.0MetGly: 0.0 ± 0.0
0.306MetHis: 0.306 ± 0.258
1.836MetIle: 1.836 ± 0.729
2.142MetLys: 2.142 ± 0.786
2.754MetLeu: 2.754 ± 0.873
0.306MetMet: 0.306 ± 0.27
2.754MetAsn: 2.754 ± 0.889
0.0MetPro: 0.0 ± 0.0
2.142MetGln: 2.142 ± 0.87
1.224MetArg: 1.224 ± 0.492
0.612MetSer: 0.612 ± 0.368
3.366MetThr: 3.366 ± 0.914
1.836MetVal: 1.836 ± 1.168
0.306MetTrp: 0.306 ± 0.306
0.918MetTyr: 0.918 ± 0.485
0.0MetXaa: 0.0 ± 0.0
Asn
3.06AsnAla: 3.06 ± 0.851
0.0AsnCys: 0.0 ± 0.0
2.754AsnAsp: 2.754 ± 0.975
1.224AsnGlu: 1.224 ± 0.677
2.754AsnPhe: 2.754 ± 0.8
3.06AsnGly: 3.06 ± 0.79
1.224AsnHis: 1.224 ± 0.583
4.896AsnIle: 4.896 ± 1.043
4.59AsnLys: 4.59 ± 1.12
3.06AsnLeu: 3.06 ± 0.859
0.306AsnMet: 0.306 ± 0.373
3.366AsnAsn: 3.366 ± 1.154
2.754AsnPro: 2.754 ± 0.786
4.896AsnGln: 4.896 ± 1.115
3.366AsnArg: 3.366 ± 0.745
3.366AsnSer: 3.366 ± 0.858
3.06AsnThr: 3.06 ± 0.856
1.53AsnVal: 1.53 ± 0.713
0.918AsnTrp: 0.918 ± 0.572
2.448AsnTyr: 2.448 ± 0.862
0.0AsnXaa: 0.0 ± 0.0
Pro
0.918ProAla: 0.918 ± 0.479
0.306ProCys: 0.306 ± 0.309
1.836ProAsp: 1.836 ± 0.646
2.142ProGlu: 2.142 ± 0.701
1.836ProPhe: 1.836 ± 0.567
0.306ProGly: 0.306 ± 0.263
0.0ProHis: 0.0 ± 0.0
0.306ProIle: 0.306 ± 0.339
3.06ProLys: 3.06 ± 0.871
2.142ProLeu: 2.142 ± 0.727
0.918ProMet: 0.918 ± 0.502
0.612ProAsn: 0.612 ± 0.356
1.224ProPro: 1.224 ± 0.706
0.612ProGln: 0.612 ± 0.527
0.918ProArg: 0.918 ± 0.553
2.142ProSer: 2.142 ± 0.831
2.448ProThr: 2.448 ± 0.813
0.918ProVal: 0.918 ± 0.446
0.0ProTrp: 0.0 ± 0.0
0.918ProTyr: 0.918 ± 0.689
0.0ProXaa: 0.0 ± 0.0
Gln
2.448GlnAla: 2.448 ± 0.923
0.0GlnCys: 0.0 ± 0.0
2.754GlnAsp: 2.754 ± 0.817
2.448GlnGlu: 2.448 ± 0.721
2.754GlnPhe: 2.754 ± 0.683
2.448GlnGly: 2.448 ± 1.176
0.612GlnHis: 0.612 ± 0.383
1.53GlnIle: 1.53 ± 0.816
3.978GlnLys: 3.978 ± 1.123
4.896GlnLeu: 4.896 ± 1.304
0.612GlnMet: 0.612 ± 0.39
2.448GlnAsn: 2.448 ± 0.877
2.142GlnPro: 2.142 ± 1.059
2.448GlnGln: 2.448 ± 1.075
0.918GlnArg: 0.918 ± 0.421
2.754GlnSer: 2.754 ± 0.852
3.978GlnThr: 3.978 ± 1.083
4.59GlnVal: 4.59 ± 1.101
0.306GlnTrp: 0.306 ± 0.27
1.836GlnTyr: 1.836 ± 0.784
0.0GlnXaa: 0.0 ± 0.0
Arg
3.366ArgAla: 3.366 ± 0.688
0.0ArgCys: 0.0 ± 0.0
4.284ArgAsp: 4.284 ± 0.972
1.836ArgGlu: 1.836 ± 0.592
1.224ArgPhe: 1.224 ± 0.675
0.918ArgGly: 0.918 ± 0.477
0.612ArgHis: 0.612 ± 0.276
2.754ArgIle: 2.754 ± 0.831
7.956ArgLys: 7.956 ± 1.619
5.508ArgLeu: 5.508 ± 1.139
0.918ArgMet: 0.918 ± 0.479
1.53ArgAsn: 1.53 ± 0.777
0.612ArgPro: 0.612 ± 0.526
3.672ArgGln: 3.672 ± 0.765
1.836ArgArg: 1.836 ± 0.838
2.754ArgSer: 2.754 ± 0.891
3.672ArgThr: 3.672 ± 1.185
2.754ArgVal: 2.754 ± 0.992
0.918ArgTrp: 0.918 ± 0.494
2.448ArgTyr: 2.448 ± 0.818
0.0ArgXaa: 0.0 ± 0.0
Ser
2.754SerAla: 2.754 ± 1.165
0.306SerCys: 0.306 ± 0.334
3.06SerAsp: 3.06 ± 0.721
4.284SerGlu: 4.284 ± 1.15
3.978SerPhe: 3.978 ± 0.989
3.06SerGly: 3.06 ± 1.438
0.306SerHis: 0.306 ± 0.335
3.672SerIle: 3.672 ± 0.875
7.65SerLys: 7.65 ± 1.443
4.59SerLeu: 4.59 ± 1.11
1.224SerMet: 1.224 ± 0.486
2.754SerAsn: 2.754 ± 0.833
1.53SerPro: 1.53 ± 0.776
1.224SerGln: 1.224 ± 0.596
2.448SerArg: 2.448 ± 0.868
1.836SerSer: 1.836 ± 0.534
2.142SerThr: 2.142 ± 0.604
3.672SerVal: 3.672 ± 1.294
0.918SerTrp: 0.918 ± 0.494
3.366SerTyr: 3.366 ± 0.75
0.0SerXaa: 0.0 ± 0.0
Thr
4.284ThrAla: 4.284 ± 1.026
0.306ThrCys: 0.306 ± 0.287
1.53ThrAsp: 1.53 ± 0.519
3.978ThrGlu: 3.978 ± 1.197
3.06ThrPhe: 3.06 ± 1.318
3.978ThrGly: 3.978 ± 0.875
1.53ThrHis: 1.53 ± 0.571
4.896ThrIle: 4.896 ± 1.532
3.978ThrLys: 3.978 ± 1.418
5.814ThrLeu: 5.814 ± 1.099
0.918ThrMet: 0.918 ± 0.407
2.142ThrAsn: 2.142 ± 0.747
3.672ThrPro: 3.672 ± 1.052
1.224ThrGln: 1.224 ± 0.923
2.142ThrArg: 2.142 ± 0.751
2.754ThrSer: 2.754 ± 0.972
3.672ThrThr: 3.672 ± 1.229
2.448ThrVal: 2.448 ± 0.831
0.0ThrTrp: 0.0 ± 0.0
5.202ThrTyr: 5.202 ± 0.93
0.0ThrXaa: 0.0 ± 0.0
Val
1.53ValAla: 1.53 ± 0.688
0.0ValCys: 0.0 ± 0.0
4.896ValAsp: 4.896 ± 0.886
5.814ValGlu: 5.814 ± 1.486
1.836ValPhe: 1.836 ± 0.78
2.754ValGly: 2.754 ± 1.309
0.612ValHis: 0.612 ± 0.346
5.202ValIle: 5.202 ± 0.807
5.202ValLys: 5.202 ± 1.006
6.426ValLeu: 6.426 ± 0.867
0.918ValMet: 0.918 ± 0.499
3.978ValAsn: 3.978 ± 1.034
1.53ValPro: 1.53 ± 0.669
0.918ValGln: 0.918 ± 0.659
3.06ValArg: 3.06 ± 0.784
4.896ValSer: 4.896 ± 1.202
2.754ValThr: 2.754 ± 0.975
2.448ValVal: 2.448 ± 0.871
0.612ValTrp: 0.612 ± 0.427
1.224ValTyr: 1.224 ± 0.478
0.0ValXaa: 0.0 ± 0.0
Trp
0.918TrpAla: 0.918 ± 0.71
0.0TrpCys: 0.0 ± 0.0
1.836TrpAsp: 1.836 ± 0.721
1.224TrpGlu: 1.224 ± 0.756
0.612TrpPhe: 0.612 ± 0.389
0.306TrpGly: 0.306 ± 0.263
0.0TrpHis: 0.0 ± 0.0
0.612TrpIle: 0.612 ± 0.415
0.918TrpLys: 0.918 ± 0.404
0.918TrpLeu: 0.918 ± 0.55
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.918TrpGln: 0.918 ± 0.449
0.612TrpArg: 0.612 ± 0.386
0.306TrpSer: 0.306 ± 0.27
0.306TrpThr: 0.306 ± 0.263
0.612TrpVal: 0.612 ± 0.427
0.306TrpTrp: 0.306 ± 0.27
0.306TrpTyr: 0.306 ± 0.298
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.284TyrAla: 4.284 ± 1.137
0.0TyrCys: 0.0 ± 0.0
1.836TyrAsp: 1.836 ± 0.805
2.142TyrGlu: 2.142 ± 0.687
2.448TyrPhe: 2.448 ± 0.625
2.448TyrGly: 2.448 ± 0.623
1.224TyrHis: 1.224 ± 0.492
2.142TyrIle: 2.142 ± 0.725
5.508TyrLys: 5.508 ± 1.269
5.508TyrLeu: 5.508 ± 0.858
1.53TyrMet: 1.53 ± 0.851
2.448TyrAsn: 2.448 ± 0.841
0.306TyrPro: 0.306 ± 0.258
3.672TyrGln: 3.672 ± 0.793
5.814TyrArg: 5.814 ± 1.248
1.53TyrSer: 1.53 ± 0.597
1.224TyrThr: 1.224 ± 0.547
2.754TyrVal: 2.754 ± 0.751
0.306TyrTrp: 0.306 ± 0.263
2.448TyrTyr: 2.448 ± 0.99
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 25 proteins (3269 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski