Amino acid dipepetide frequency for Yonghaparkia sp. Root332

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.055AlaAla: 22.055 ± 0.274	0.65AlaCys: 0.65 ± 0.031	8.412AlaAsp: 8.412 ± 0.124	8.9AlaGlu: 8.9 ± 0.123	3.778AlaPhe: 3.778 ± 0.085	12.408AlaGly: 12.408 ± 0.148	2.686AlaHis: 2.686 ± 0.062	6.706AlaIle: 6.706 ± 0.096	2.289AlaLys: 2.289 ± 0.076	15.971AlaLeu: 15.971 ± 0.185	2.601AlaMet: 2.601 ± 0.065	2.177AlaAsn: 2.177 ± 0.056	7.673AlaPro: 7.673 ± 0.147	3.507AlaGln: 3.507 ± 0.077	10.786AlaArg: 10.786 ± 0.129	7.725AlaSer: 7.725 ± 0.098	7.711AlaThr: 7.711 ± 0.119	12.08AlaVal: 12.08 ± 0.161	1.807AlaTrp: 1.807 ± 0.053	2.23AlaTyr: 2.23 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.614CysAla: 0.614 ± 0.03	0.039CysCys: 0.039 ± 0.006	0.291CysAsp: 0.291 ± 0.02	0.275CysGlu: 0.275 ± 0.025	0.14CysPhe: 0.14 ± 0.015	0.518CysGly: 0.518 ± 0.03	0.103CysHis: 0.103 ± 0.011	0.159CysIle: 0.159 ± 0.015	0.044CysLys: 0.044 ± 0.008	0.429CysLeu: 0.429 ± 0.024	0.067CysMet: 0.067 ± 0.009	0.097CysAsn: 0.097 ± 0.011	0.289CysPro: 0.289 ± 0.019	0.104CysGln: 0.104 ± 0.01	0.294CysArg: 0.294 ± 0.022	0.299CysSer: 0.299 ± 0.02	0.278CysThr: 0.278 ± 0.022	0.383CysVal: 0.383 ± 0.022	0.057CysTrp: 0.057 ± 0.01	0.093CysTyr: 0.093 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.59AspAla: 9.59 ± 0.136	0.224AspCys: 0.224 ± 0.018	4.477AspAsp: 4.477 ± 0.089	4.651AspGlu: 4.651 ± 0.08	1.677AspPhe: 1.677 ± 0.05	5.882AspGly: 5.882 ± 0.103	1.223AspHis: 1.223 ± 0.043	2.245AspIle: 2.245 ± 0.054	0.755AspLys: 0.755 ± 0.043	6.028AspLeu: 6.028 ± 0.091	0.767AspMet: 0.767 ± 0.036	0.79AspAsn: 0.79 ± 0.032	4.234AspPro: 4.234 ± 0.089	1.368AspGln: 1.368 ± 0.04	5.018AspArg: 5.018 ± 0.091	2.624AspSer: 2.624 ± 0.068	2.399AspThr: 2.399 ± 0.059	5.12AspVal: 5.12 ± 0.078	0.844AspTrp: 0.844 ± 0.04	1.219AspTyr: 1.219 ± 0.045	0.001AspXaa: 0.001 ± 0.001
Glu	7.731GluAla: 7.731 ± 0.114	0.238GluCys: 0.238 ± 0.021	2.289GluAsp: 2.289 ± 0.063	3.191GluGlu: 3.191 ± 0.082	1.718GluPhe: 1.718 ± 0.051	4.63GluGly: 4.63 ± 0.077	1.592GluHis: 1.592 ± 0.045	2.74GluIle: 2.74 ± 0.063	1.306GluLys: 1.306 ± 0.052	7.618GluLeu: 7.618 ± 0.111	0.833GluMet: 0.833 ± 0.037	1.208GluAsn: 1.208 ± 0.04	3.502GluPro: 3.502 ± 0.066	2.342GluGln: 2.342 ± 0.055	6.083GluArg: 6.083 ± 0.114	3.347GluSer: 3.347 ± 0.07	2.963GluThr: 2.963 ± 0.061	4.962GluVal: 4.962 ± 0.088	0.934GluTrp: 0.934 ± 0.033	1.096GluTyr: 1.096 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.138PheAla: 4.138 ± 0.069	0.161PheCys: 0.161 ± 0.014	2.185PheAsp: 2.185 ± 0.053	1.794PheGlu: 1.794 ± 0.055	0.974PhePhe: 0.974 ± 0.039	3.211PheGly: 3.211 ± 0.073	0.512PheHis: 0.512 ± 0.023	1.145PheIle: 1.145 ± 0.04	0.362PheLys: 0.362 ± 0.023	2.76PheLeu: 2.76 ± 0.067	0.398PheMet: 0.398 ± 0.024	0.516PheAsn: 0.516 ± 0.027	1.338PhePro: 1.338 ± 0.038	0.693PheGln: 0.693 ± 0.029	1.694PheArg: 1.694 ± 0.047	1.64PheSer: 1.64 ± 0.047	1.935PheThr: 1.935 ± 0.057	2.716PheVal: 2.716 ± 0.061	0.424PheTrp: 0.424 ± 0.025	0.621PheTyr: 0.621 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	12.044GlyAla: 12.044 ± 0.159	0.53GlyCys: 0.53 ± 0.027	5.22GlyAsp: 5.22 ± 0.093	5.278GlyGlu: 5.278 ± 0.082	3.182GlyPhe: 3.182 ± 0.07	7.904GlyGly: 7.904 ± 0.139	1.73GlyHis: 1.73 ± 0.043	4.919GlyIle: 4.919 ± 0.084	1.734GlyLys: 1.734 ± 0.053	9.105GlyLeu: 9.105 ± 0.116	1.981GlyMet: 1.981 ± 0.056	1.401GlyAsn: 1.401 ± 0.045	4.011GlyPro: 4.011 ± 0.079	2.275GlyGln: 2.275 ± 0.061	6.672GlyArg: 6.672 ± 0.103	5.439GlySer: 5.439 ± 0.087	4.975GlyThr: 4.975 ± 0.082	8.042GlyVal: 8.042 ± 0.112	1.511GlyTrp: 1.511 ± 0.048	2.037GlyTyr: 2.037 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.508HisAla: 2.508 ± 0.064	0.121HisCys: 0.121 ± 0.013	1.357HisAsp: 1.357 ± 0.043	1.293HisGlu: 1.293 ± 0.043	0.495HisPhe: 0.495 ± 0.026	1.94HisGly: 1.94 ± 0.056	0.544HisHis: 0.544 ± 0.032	0.634HisIle: 0.634 ± 0.03	0.214HisLys: 0.214 ± 0.016	1.923HisLeu: 1.923 ± 0.054	0.281HisMet: 0.281 ± 0.019	0.28HisAsn: 0.28 ± 0.018	1.583HisPro: 1.583 ± 0.052	0.437HisGln: 0.437 ± 0.024	1.74HisArg: 1.74 ± 0.048	0.906HisSer: 0.906 ± 0.038	0.807HisThr: 0.807 ± 0.034	1.646HisVal: 1.646 ± 0.041	0.28HisTrp: 0.28 ± 0.018	0.438HisTyr: 0.438 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.796IleAla: 7.796 ± 0.109	0.208IleCys: 0.208 ± 0.018	3.686IleAsp: 3.686 ± 0.06	3.175IleGlu: 3.175 ± 0.061	1.043IlePhe: 1.043 ± 0.041	4.8IleGly: 4.8 ± 0.095	0.717IleHis: 0.717 ± 0.032	1.957IleIle: 1.957 ± 0.059	0.69IleLys: 0.69 ± 0.032	3.671IleLeu: 3.671 ± 0.071	0.655IleMet: 0.655 ± 0.032	0.798IleAsn: 0.798 ± 0.034	2.52IlePro: 2.52 ± 0.057	0.919IleGln: 0.919 ± 0.034	2.739IleArg: 2.739 ± 0.066	2.12IleSer: 2.12 ± 0.055	2.803IleThr: 2.803 ± 0.063	5.019IleVal: 5.019 ± 0.092	0.44IleTrp: 0.44 ± 0.024	0.674IleTyr: 0.674 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.99LysAla: 1.99 ± 0.067	0.057LysCys: 0.057 ± 0.008	0.846LysAsp: 0.846 ± 0.036	0.874LysGlu: 0.874 ± 0.041	0.418LysPhe: 0.418 ± 0.023	1.303LysGly: 1.303 ± 0.05	0.388LysHis: 0.388 ± 0.023	0.732LysIle: 0.732 ± 0.038	0.673LysLys: 0.673 ± 0.041	1.539LysLeu: 1.539 ± 0.056	0.326LysMet: 0.326 ± 0.022	0.429LysAsn: 0.429 ± 0.026	1.012LysPro: 1.012 ± 0.042	0.554LysGln: 0.554 ± 0.034	1.404LysArg: 1.404 ± 0.049	0.964LysSer: 0.964 ± 0.034	1.071LysThr: 1.071 ± 0.038	1.331LysVal: 1.331 ± 0.059	0.184LysTrp: 0.184 ± 0.015	0.344LysTyr: 0.344 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.301LeuAla: 16.301 ± 0.184	0.437LeuCys: 0.437 ± 0.026	7.172LeuAsp: 7.172 ± 0.108	6.048LeuGlu: 6.048 ± 0.091	2.575LeuPhe: 2.575 ± 0.07	9.595LeuGly: 9.595 ± 0.125	1.817LeuHis: 1.817 ± 0.048	4.411LeuIle: 4.411 ± 0.094	1.515LeuLys: 1.515 ± 0.053	10.741LeuLeu: 10.741 ± 0.16	1.618LeuMet: 1.618 ± 0.048	1.556LeuAsn: 1.556 ± 0.047	5.579LeuPro: 5.579 ± 0.092	2.483LeuGln: 2.483 ± 0.062	7.526LeuArg: 7.526 ± 0.102	5.53LeuSer: 5.53 ± 0.079	5.995LeuThr: 5.995 ± 0.092	10.265LeuVal: 10.265 ± 0.148	1.182LeuTrp: 1.182 ± 0.04	1.583LeuTyr: 1.583 ± 0.045	0.003LeuXaa: 0.003 ± 0.002
Met	2.067MetAla: 2.067 ± 0.049	0.063MetCys: 0.063 ± 0.009	0.754MetAsp: 0.754 ± 0.033	0.654MetGlu: 0.654 ± 0.027	0.385MetPhe: 0.385 ± 0.023	1.292MetGly: 1.292 ± 0.038	0.33MetHis: 0.33 ± 0.021	0.865MetIle: 0.865 ± 0.036	0.349MetLys: 0.349 ± 0.022	1.9MetLeu: 1.9 ± 0.051	0.278MetMet: 0.278 ± 0.019	0.362MetAsn: 0.362 ± 0.027	1.257MetPro: 1.257 ± 0.041	0.472MetGln: 0.472 ± 0.027	1.444MetArg: 1.444 ± 0.046	1.334MetSer: 1.334 ± 0.04	1.752MetThr: 1.752 ± 0.044	1.295MetVal: 1.295 ± 0.044	0.179MetTrp: 0.179 ± 0.016	0.26MetTyr: 0.26 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.16AsnAla: 2.16 ± 0.055	0.112AsnCys: 0.112 ± 0.012	1.017AsnAsp: 1.017 ± 0.037	0.891AsnGlu: 0.891 ± 0.036	0.549AsnPhe: 0.549 ± 0.028	1.752AsnGly: 1.752 ± 0.053	0.315AsnHis: 0.315 ± 0.019	0.744AsnIle: 0.744 ± 0.037	0.299AsnLys: 0.299 ± 0.024	1.634AsnLeu: 1.634 ± 0.05	0.276AsnMet: 0.276 ± 0.022	0.369AsnAsn: 0.369 ± 0.026	1.471AsnPro: 1.471 ± 0.044	0.465AsnGln: 0.465 ± 0.026	1.219AsnArg: 1.219 ± 0.037	0.82AsnSer: 0.82 ± 0.032	0.807AsnThr: 0.807 ± 0.036	1.415AsnVal: 1.415 ± 0.041	0.245AsnTrp: 0.245 ± 0.02	0.425AsnTyr: 0.425 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.901ProAla: 7.901 ± 0.135	0.178ProCys: 0.178 ± 0.014	3.859ProAsp: 3.859 ± 0.074	4.159ProGlu: 4.159 ± 0.083	1.695ProPhe: 1.695 ± 0.053	5.316ProGly: 5.316 ± 0.093	1.111ProHis: 1.111 ± 0.037	2.251ProIle: 2.251 ± 0.05	0.84ProLys: 0.84 ± 0.039	5.329ProLeu: 5.329 ± 0.082	0.853ProMet: 0.853 ± 0.033	0.95ProAsn: 0.95 ± 0.044	2.542ProPro: 2.542 ± 0.081	1.419ProGln: 1.419 ± 0.043	3.706ProArg: 3.706 ± 0.078	3.318ProSer: 3.318 ± 0.069	3.293ProThr: 3.293 ± 0.071	5.129ProVal: 5.129 ± 0.089	0.821ProTrp: 0.821 ± 0.038	1.02ProTyr: 1.02 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.097GlnAla: 3.097 ± 0.064	0.103GlnCys: 0.103 ± 0.011	0.965GlnAsp: 0.965 ± 0.031	1.237GlnGlu: 1.237 ± 0.04	0.794GlnPhe: 0.794 ± 0.034	2.031GlnGly: 2.031 ± 0.047	0.594GlnHis: 0.594 ± 0.029	1.168GlnIle: 1.168 ± 0.039	0.584GlnLys: 0.584 ± 0.03	3.109GlnLeu: 3.109 ± 0.069	0.415GlnMet: 0.415 ± 0.023	0.562GlnAsn: 0.562 ± 0.03	1.462GlnPro: 1.462 ± 0.048	1.061GlnGln: 1.061 ± 0.038	2.386GlnArg: 2.386 ± 0.057	1.52GlnSer: 1.52 ± 0.05	1.276GlnThr: 1.276 ± 0.041	2.163GlnVal: 2.163 ± 0.052	0.442GlnTrp: 0.442 ± 0.021	0.624GlnTyr: 0.624 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	10.308ArgAla: 10.308 ± 0.145	0.309ArgCys: 0.309 ± 0.022	4.514ArgAsp: 4.514 ± 0.086	4.794ArgGlu: 4.794 ± 0.097	2.499ArgPhe: 2.499 ± 0.061	5.871ArgGly: 5.871 ± 0.103	1.529ArgHis: 1.529 ± 0.046	3.953ArgIle: 3.953 ± 0.081	1.114ArgLys: 1.114 ± 0.046	7.899ArgLeu: 7.899 ± 0.115	1.658ArgMet: 1.658 ± 0.047	1.167ArgAsn: 1.167 ± 0.042	3.997ArgPro: 3.997 ± 0.085	1.942ArgGln: 1.942 ± 0.052	6.835ArgArg: 6.835 ± 0.117	4.46ArgSer: 4.46 ± 0.105	4.225ArgThr: 4.225 ± 0.08	6.46ArgVal: 6.46 ± 0.108	1.264ArgTrp: 1.264 ± 0.041	1.493ArgTyr: 1.493 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	7.689SerAla: 7.689 ± 0.107	0.241SerCys: 0.241 ± 0.019	2.899SerAsp: 2.899 ± 0.065	2.805SerGlu: 2.805 ± 0.063	1.701SerPhe: 1.701 ± 0.047	5.767SerGly: 5.767 ± 0.089	0.922SerHis: 0.922 ± 0.031	2.856SerIle: 2.856 ± 0.063	0.907SerLys: 0.907 ± 0.034	5.451SerLeu: 5.451 ± 0.093	1.237SerMet: 1.237 ± 0.043	0.902SerAsn: 0.902 ± 0.035	3.298SerPro: 3.298 ± 0.067	1.221SerGln: 1.221 ± 0.035	3.836SerArg: 3.836 ± 0.078	3.478SerSer: 3.478 ± 0.084	3.822SerThr: 3.822 ± 0.075	4.647SerVal: 4.647 ± 0.076	0.813SerTrp: 0.813 ± 0.032	1.021SerTyr: 1.021 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.832ThrAla: 7.832 ± 0.111	0.258ThrCys: 0.258 ± 0.027	3.316ThrAsp: 3.316 ± 0.072	3.103ThrGlu: 3.103 ± 0.065	1.609ThrPhe: 1.609 ± 0.05	5.67ThrGly: 5.67 ± 0.085	0.985ThrHis: 0.985 ± 0.035	3.038ThrIle: 3.038 ± 0.058	0.913ThrLys: 0.913 ± 0.039	5.639ThrLeu: 5.639 ± 0.091	0.937ThrMet: 0.937 ± 0.033	1.031ThrAsn: 1.031 ± 0.036	3.639ThrPro: 3.639 ± 0.079	1.243ThrGln: 1.243 ± 0.043	3.568ThrArg: 3.568 ± 0.069	3.149ThrSer: 3.149 ± 0.068	3.623ThrThr: 3.623 ± 0.08	5.456ThrVal: 5.456 ± 0.099	0.737ThrTrp: 0.737 ± 0.034	1.035ThrTyr: 1.035 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	12.369ValAla: 12.369 ± 0.144	0.437ValCys: 0.437 ± 0.025	6.054ValAsp: 6.054 ± 0.095	5.512ValGlu: 5.512 ± 0.088	2.718ValPhe: 2.718 ± 0.06	7.351ValGly: 7.351 ± 0.098	1.754ValHis: 1.754 ± 0.05	4.66ValIle: 4.66 ± 0.088	1.321ValLys: 1.321 ± 0.054	9.513ValLeu: 9.513 ± 0.15	1.496ValMet: 1.496 ± 0.048	1.638ValAsn: 1.638 ± 0.049	4.602ValPro: 4.602 ± 0.083	2.069ValGln: 2.069 ± 0.053	6.487ValArg: 6.487 ± 0.107	4.848ValSer: 4.848 ± 0.08	5.352ValThr: 5.352 ± 0.108	9.252ValVal: 9.252 ± 0.147	1.066ValTrp: 1.066 ± 0.038	1.504ValTyr: 1.504 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.597TrpAla: 1.597 ± 0.047	0.088TrpCys: 0.088 ± 0.011	0.634TrpAsp: 0.634 ± 0.032	0.663TrpGlu: 0.663 ± 0.031	0.537TrpPhe: 0.537 ± 0.025	0.983TrpGly: 0.983 ± 0.04	0.308TrpHis: 0.308 ± 0.021	0.637TrpIle: 0.637 ± 0.03	0.25TrpLys: 0.25 ± 0.019	1.612TrpLeu: 1.612 ± 0.051	0.396TrpMet: 0.396 ± 0.024	0.361TrpAsn: 0.361 ± 0.02	0.687TrpPro: 0.687 ± 0.033	0.5TrpGln: 0.5 ± 0.025	1.222TrpArg: 1.222 ± 0.045	0.934TrpSer: 0.934 ± 0.041	0.726TrpThr: 0.726 ± 0.035	1.121TrpVal: 1.121 ± 0.042	0.348TrpTrp: 0.348 ± 0.023	0.247TrpTyr: 0.247 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.365TyrAla: 2.365 ± 0.057	0.119TyrCys: 0.119 ± 0.011	1.188TyrAsp: 1.188 ± 0.041	1.03TyrGlu: 1.03 ± 0.033	0.726TyrPhe: 0.726 ± 0.029	1.767TyrGly: 1.767 ± 0.041	0.268TyrHis: 0.268 ± 0.019	0.61TyrIle: 0.61 ± 0.03	0.281TyrLys: 0.281 ± 0.02	2.058TyrLeu: 2.058 ± 0.051	0.218TyrMet: 0.218 ± 0.02	0.392TyrAsn: 0.392 ± 0.026	0.995TyrPro: 0.995 ± 0.039	0.519TyrGln: 0.519 ± 0.028	1.632TyrArg: 1.632 ± 0.05	1.057TyrSer: 1.057 ± 0.036	0.967TyrThr: 0.967 ± 0.033	1.499TyrVal: 1.499 ± 0.048	0.273TyrTrp: 0.273 ± 0.019	0.414TyrTyr: 0.414 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2389 proteins (775821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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