Amino acid dipepetide frequency for Pteropine orthoreovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.429AlaAla: 8.429 ± 1.294
1.017AlaCys: 1.017 ± 0.34
5.086AlaAsp: 5.086 ± 0.821
2.471AlaGlu: 2.471 ± 0.363
2.035AlaPhe: 2.035 ± 0.584
3.924AlaGly: 3.924 ± 0.567
1.453AlaHis: 1.453 ± 0.428
4.069AlaIle: 4.069 ± 0.635
2.761AlaLys: 2.761 ± 0.628
6.83AlaLeu: 6.83 ± 0.894
2.18AlaMet: 2.18 ± 0.497
3.343AlaAsn: 3.343 ± 0.862
5.668AlaPro: 5.668 ± 0.979
3.197AlaGln: 3.197 ± 0.724
5.232AlaArg: 5.232 ± 0.827
8.429AlaSer: 8.429 ± 0.707
5.958AlaThr: 5.958 ± 1.047
5.377AlaVal: 5.377 ± 0.546
1.889AlaTrp: 1.889 ± 0.57
1.889AlaTyr: 1.889 ± 0.291
0.0AlaXaa: 0.0 ± 0.0
Cys
1.163CysAla: 1.163 ± 0.354
0.436CysCys: 0.436 ± 0.385
1.017CysAsp: 1.017 ± 0.328
0.436CysGlu: 0.436 ± 0.429
0.727CysPhe: 0.727 ± 0.248
0.872CysGly: 0.872 ± 0.309
0.436CysHis: 0.436 ± 0.391
0.291CysIle: 0.291 ± 0.161
0.145CysLys: 0.145 ± 0.112
2.471CysLeu: 2.471 ± 0.511
0.291CysMet: 0.291 ± 0.139
0.727CysAsn: 0.727 ± 0.435
0.436CysPro: 0.436 ± 0.25
0.581CysGln: 0.581 ± 0.239
0.872CysArg: 0.872 ± 0.255
1.599CysSer: 1.599 ± 0.345
1.163CysThr: 1.163 ± 0.376
1.163CysVal: 1.163 ± 0.301
0.291CysTrp: 0.291 ± 0.177
0.727CysTyr: 0.727 ± 0.407
0.0CysXaa: 0.0 ± 0.0
Asp
5.522AspAla: 5.522 ± 1.045
1.017AspCys: 1.017 ± 0.396
5.086AspAsp: 5.086 ± 1.098
1.744AspGlu: 1.744 ± 0.593
3.343AspPhe: 3.343 ± 0.521
2.907AspGly: 2.907 ± 0.592
1.744AspHis: 1.744 ± 0.49
1.889AspIle: 1.889 ± 0.515
1.308AspLys: 1.308 ± 0.272
4.941AspLeu: 4.941 ± 0.656
1.163AspMet: 1.163 ± 0.378
1.599AspAsn: 1.599 ± 0.387
3.197AspPro: 3.197 ± 0.623
1.599AspGln: 1.599 ± 0.52
3.633AspArg: 3.633 ± 0.776
5.377AspSer: 5.377 ± 0.746
1.744AspThr: 1.744 ± 0.325
6.54AspVal: 6.54 ± 0.933
1.453AspTrp: 1.453 ± 0.686
2.325AspTyr: 2.325 ± 0.912
0.0AspXaa: 0.0 ± 0.0
Glu
1.889GluAla: 1.889 ± 0.532
0.872GluCys: 0.872 ± 0.32
1.889GluAsp: 1.889 ± 0.398
1.453GluGlu: 1.453 ± 0.826
1.017GluPhe: 1.017 ± 0.299
1.163GluGly: 1.163 ± 0.651
1.308GluHis: 1.308 ± 0.716
1.599GluIle: 1.599 ± 0.638
1.744GluLys: 1.744 ± 0.622
4.505GluLeu: 4.505 ± 0.949
1.163GluMet: 1.163 ± 0.633
1.163GluAsn: 1.163 ± 0.428
1.163GluPro: 1.163 ± 0.542
0.727GluGln: 0.727 ± 0.354
2.035GluArg: 2.035 ± 0.49
3.343GluSer: 3.343 ± 0.647
3.343GluThr: 3.343 ± 1.137
1.889GluVal: 1.889 ± 0.666
0.727GluTrp: 0.727 ± 0.278
2.035GluTyr: 2.035 ± 0.54
0.0GluXaa: 0.0 ± 0.0
Phe
2.18PheAla: 2.18 ± 0.582
0.872PheCys: 0.872 ± 0.354
2.035PheAsp: 2.035 ± 0.56
2.18PheGlu: 2.18 ± 0.672
1.599PhePhe: 1.599 ± 0.648
2.761PheGly: 2.761 ± 0.582
0.436PheHis: 0.436 ± 0.205
1.889PheIle: 1.889 ± 0.484
1.453PheLys: 1.453 ± 0.589
4.069PheLeu: 4.069 ± 0.826
1.017PheMet: 1.017 ± 0.266
1.889PheAsn: 1.889 ± 0.601
3.633PhePro: 3.633 ± 0.89
1.453PheGln: 1.453 ± 0.411
1.599PheArg: 1.599 ± 0.312
4.069PheSer: 4.069 ± 0.739
3.052PheThr: 3.052 ± 0.62
2.907PheVal: 2.907 ± 0.453
0.581PheTrp: 0.581 ± 0.263
0.872PheTyr: 0.872 ± 0.353
0.0PheXaa: 0.0 ± 0.0
Gly
3.488GlyAla: 3.488 ± 0.615
0.436GlyCys: 0.436 ± 0.25
3.488GlyAsp: 3.488 ± 0.798
0.581GlyGlu: 0.581 ± 0.332
1.889GlyPhe: 1.889 ± 0.454
2.035GlyGly: 2.035 ± 0.698
1.017GlyHis: 1.017 ± 0.385
2.471GlyIle: 2.471 ± 0.561
1.889GlyLys: 1.889 ± 0.35
5.232GlyLeu: 5.232 ± 0.94
1.599GlyMet: 1.599 ± 0.405
1.889GlyAsn: 1.889 ± 0.586
1.744GlyPro: 1.744 ± 0.523
1.453GlyGln: 1.453 ± 0.438
2.325GlyArg: 2.325 ± 0.601
5.232GlySer: 5.232 ± 1.01
2.616GlyThr: 2.616 ± 0.977
4.796GlyVal: 4.796 ± 0.547
1.017GlyTrp: 1.017 ± 0.449
1.744GlyTyr: 1.744 ± 0.476
0.0GlyXaa: 0.0 ± 0.0
His
0.872HisAla: 0.872 ± 0.207
0.291HisCys: 0.291 ± 0.306
1.017HisAsp: 1.017 ± 0.504
0.436HisGlu: 0.436 ± 0.228
1.017HisPhe: 1.017 ± 0.284
1.453HisGly: 1.453 ± 0.352
0.727HisHis: 0.727 ± 0.414
1.017HisIle: 1.017 ± 0.694
0.727HisLys: 0.727 ± 0.289
1.453HisLeu: 1.453 ± 0.369
0.436HisMet: 0.436 ± 0.227
0.436HisAsn: 0.436 ± 0.279
1.453HisPro: 1.453 ± 0.534
1.163HisGln: 1.163 ± 0.642
0.872HisArg: 0.872 ± 0.448
1.599HisSer: 1.599 ± 0.308
0.872HisThr: 0.872 ± 0.559
3.052HisVal: 3.052 ± 0.758
0.291HisTrp: 0.291 ± 0.183
0.872HisTyr: 0.872 ± 0.357
0.0HisXaa: 0.0 ± 0.0
Ile
4.215IleAla: 4.215 ± 0.849
1.017IleCys: 1.017 ± 0.296
3.197IleAsp: 3.197 ± 0.496
1.163IleGlu: 1.163 ± 0.297
1.889IlePhe: 1.889 ± 0.606
2.035IleGly: 2.035 ± 0.499
1.017IleHis: 1.017 ± 0.323
1.599IleIle: 1.599 ± 0.576
1.163IleLys: 1.163 ± 0.253
3.779IleLeu: 3.779 ± 0.706
1.017IleMet: 1.017 ± 0.436
1.744IleAsn: 1.744 ± 0.328
2.761IlePro: 2.761 ± 0.838
2.471IleGln: 2.471 ± 0.677
4.505IleArg: 4.505 ± 0.817
4.941IleSer: 4.941 ± 0.775
2.471IleThr: 2.471 ± 0.404
3.343IleVal: 3.343 ± 0.6
0.436IleTrp: 0.436 ± 0.148
1.017IleTyr: 1.017 ± 0.48
0.0IleXaa: 0.0 ± 0.0
Lys
2.325LysAla: 2.325 ± 0.408
0.581LysCys: 0.581 ± 0.203
2.035LysAsp: 2.035 ± 0.432
1.599LysGlu: 1.599 ± 0.539
1.599LysPhe: 1.599 ± 0.476
1.744LysGly: 1.744 ± 0.643
0.872LysHis: 0.872 ± 0.244
1.163LysIle: 1.163 ± 0.284
0.436LysLys: 0.436 ± 0.198
3.343LysLeu: 3.343 ± 0.877
0.727LysMet: 0.727 ± 0.355
1.163LysAsn: 1.163 ± 0.378
2.18LysPro: 2.18 ± 0.542
1.017LysGln: 1.017 ± 0.349
1.453LysArg: 1.453 ± 0.762
2.471LysSer: 2.471 ± 0.67
2.616LysThr: 2.616 ± 0.544
2.325LysVal: 2.325 ± 0.509
0.436LysTrp: 0.436 ± 0.251
1.163LysTyr: 1.163 ± 0.612
0.0LysXaa: 0.0 ± 0.0
Leu
9.01LeuAla: 9.01 ± 1.123
1.308LeuCys: 1.308 ± 0.384
5.668LeuAsp: 5.668 ± 0.923
3.197LeuGlu: 3.197 ± 0.59
4.069LeuPhe: 4.069 ± 0.499
3.052LeuGly: 3.052 ± 0.518
1.163LeuHis: 1.163 ± 0.337
3.343LeuIle: 3.343 ± 0.647
3.924LeuLys: 3.924 ± 0.573
12.934LeuLeu: 12.934 ± 1.497
2.325LeuMet: 2.325 ± 0.426
5.086LeuAsn: 5.086 ± 0.525
6.394LeuPro: 6.394 ± 0.818
3.488LeuGln: 3.488 ± 0.65
6.685LeuArg: 6.685 ± 0.81
12.934LeuSer: 12.934 ± 1.501
8.72LeuThr: 8.72 ± 1.219
6.394LeuVal: 6.394 ± 0.983
1.163LeuTrp: 1.163 ± 0.308
1.889LeuTyr: 1.889 ± 0.552
0.0LeuXaa: 0.0 ± 0.0
Met
2.035MetAla: 2.035 ± 0.577
0.436MetCys: 0.436 ± 0.285
1.308MetAsp: 1.308 ± 0.617
0.872MetGlu: 0.872 ± 0.419
1.308MetPhe: 1.308 ± 0.344
1.163MetGly: 1.163 ± 0.318
0.291MetHis: 0.291 ± 0.149
1.163MetIle: 1.163 ± 0.412
0.727MetLys: 0.727 ± 0.312
2.471MetLeu: 2.471 ± 0.612
1.744MetMet: 1.744 ± 0.629
1.453MetAsn: 1.453 ± 0.36
1.744MetPro: 1.744 ± 0.453
1.453MetGln: 1.453 ± 0.369
1.017MetArg: 1.017 ± 0.382
2.761MetSer: 2.761 ± 0.61
2.325MetThr: 2.325 ± 0.652
1.744MetVal: 1.744 ± 0.332
0.291MetTrp: 0.291 ± 0.264
1.163MetTyr: 1.163 ± 0.372
0.0MetXaa: 0.0 ± 0.0
Asn
2.907AsnAla: 2.907 ± 0.691
0.581AsnCys: 0.581 ± 0.211
2.325AsnAsp: 2.325 ± 0.616
1.017AsnGlu: 1.017 ± 0.515
1.308AsnPhe: 1.308 ± 0.372
2.907AsnGly: 2.907 ± 0.468
0.727AsnHis: 0.727 ± 0.233
2.616AsnIle: 2.616 ± 0.946
0.872AsnLys: 0.872 ± 0.447
2.907AsnLeu: 2.907 ± 0.656
0.872AsnMet: 0.872 ± 0.407
1.308AsnAsn: 1.308 ± 0.511
3.052AsnPro: 3.052 ± 0.737
2.18AsnGln: 2.18 ± 0.665
2.325AsnArg: 2.325 ± 0.626
3.633AsnSer: 3.633 ± 1.04
2.471AsnThr: 2.471 ± 0.79
3.488AsnVal: 3.488 ± 0.743
0.436AsnTrp: 0.436 ± 0.283
1.163AsnTyr: 1.163 ± 0.6
0.0AsnXaa: 0.0 ± 0.0
Pro
4.65ProAla: 4.65 ± 0.745
0.436ProCys: 0.436 ± 0.148
3.488ProAsp: 3.488 ± 0.637
3.052ProGlu: 3.052 ± 0.887
3.343ProPhe: 3.343 ± 0.59
2.761ProGly: 2.761 ± 0.457
1.308ProHis: 1.308 ± 0.566
3.924ProIle: 3.924 ± 0.375
1.163ProLys: 1.163 ± 0.55
7.266ProLeu: 7.266 ± 0.972
1.744ProMet: 1.744 ± 0.623
3.052ProAsn: 3.052 ± 0.647
4.069ProPro: 4.069 ± 0.905
1.889ProGln: 1.889 ± 0.355
2.18ProArg: 2.18 ± 0.693
7.993ProSer: 7.993 ± 1.04
4.215ProThr: 4.215 ± 0.598
4.941ProVal: 4.941 ± 0.771
1.453ProTrp: 1.453 ± 0.28
1.599ProTyr: 1.599 ± 0.539
0.0ProXaa: 0.0 ± 0.0
Gln
3.197GlnAla: 3.197 ± 0.885
1.453GlnCys: 1.453 ± 0.413
1.017GlnAsp: 1.017 ± 0.288
0.581GlnGlu: 0.581 ± 0.179
1.163GlnPhe: 1.163 ± 0.347
1.453GlnGly: 1.453 ± 0.325
0.727GlnHis: 0.727 ± 0.307
1.889GlnIle: 1.889 ± 0.325
1.453GlnLys: 1.453 ± 0.459
4.505GlnLeu: 4.505 ± 0.605
1.163GlnMet: 1.163 ± 0.389
1.744GlnAsn: 1.744 ± 0.655
1.889GlnPro: 1.889 ± 0.58
1.744GlnGln: 1.744 ± 0.334
2.471GlnArg: 2.471 ± 0.759
4.505GlnSer: 4.505 ± 0.987
2.325GlnThr: 2.325 ± 0.475
3.343GlnVal: 3.343 ± 0.514
0.581GlnTrp: 0.581 ± 0.257
1.308GlnTyr: 1.308 ± 0.388
0.0GlnXaa: 0.0 ± 0.0
Arg
4.796ArgAla: 4.796 ± 0.556
1.017ArgCys: 1.017 ± 0.398
3.343ArgAsp: 3.343 ± 0.391
2.471ArgGlu: 2.471 ± 0.865
1.453ArgPhe: 1.453 ± 0.447
2.761ArgGly: 2.761 ± 0.722
1.453ArgHis: 1.453 ± 0.304
2.616ArgIle: 2.616 ± 0.535
1.163ArgLys: 1.163 ± 0.422
6.104ArgLeu: 6.104 ± 0.952
1.308ArgMet: 1.308 ± 0.583
1.453ArgAsn: 1.453 ± 0.277
3.197ArgPro: 3.197 ± 0.48
2.907ArgGln: 2.907 ± 0.456
5.086ArgArg: 5.086 ± 1.197
5.522ArgSer: 5.522 ± 1.223
2.471ArgThr: 2.471 ± 0.677
5.086ArgVal: 5.086 ± 0.784
1.308ArgTrp: 1.308 ± 0.312
1.453ArgTyr: 1.453 ± 0.346
0.0ArgXaa: 0.0 ± 0.0
Ser
9.882SerAla: 9.882 ± 1.257
1.308SerCys: 1.308 ± 0.451
5.522SerAsp: 5.522 ± 0.728
5.086SerGlu: 5.086 ± 0.904
4.941SerPhe: 4.941 ± 0.798
5.668SerGly: 5.668 ± 1.042
1.308SerHis: 1.308 ± 0.559
4.796SerIle: 4.796 ± 0.792
2.761SerLys: 2.761 ± 0.453
9.737SerLeu: 9.737 ± 1.516
2.471SerMet: 2.471 ± 0.525
2.761SerAsn: 2.761 ± 0.548
7.702SerPro: 7.702 ± 1.447
4.36SerGln: 4.36 ± 0.491
4.941SerArg: 4.941 ± 0.851
11.481SerSer: 11.481 ± 1.11
7.412SerThr: 7.412 ± 0.588
7.702SerVal: 7.702 ± 1.528
1.889SerTrp: 1.889 ± 0.426
3.343SerTyr: 3.343 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
5.668ThrAla: 5.668 ± 0.818
1.017ThrCys: 1.017 ± 0.453
2.907ThrAsp: 2.907 ± 0.564
2.471ThrGlu: 2.471 ± 0.461
3.197ThrPhe: 3.197 ± 1.013
3.052ThrGly: 3.052 ± 0.444
1.599ThrHis: 1.599 ± 0.298
2.035ThrIle: 2.035 ± 0.413
2.907ThrLys: 2.907 ± 0.384
6.394ThrLeu: 6.394 ± 1.495
1.744ThrMet: 1.744 ± 0.596
2.761ThrAsn: 2.761 ± 0.807
5.668ThrPro: 5.668 ± 1.318
2.761ThrGln: 2.761 ± 0.532
2.616ThrArg: 2.616 ± 0.631
7.557ThrSer: 7.557 ± 0.666
4.215ThrThr: 4.215 ± 1.142
5.958ThrVal: 5.958 ± 1.267
1.453ThrTrp: 1.453 ± 0.343
1.308ThrTyr: 1.308 ± 0.524
0.0ThrXaa: 0.0 ± 0.0
Val
6.104ValAla: 6.104 ± 0.968
1.308ValCys: 1.308 ± 0.428
4.65ValAsp: 4.65 ± 0.722
2.471ValGlu: 2.471 ± 0.73
2.471ValPhe: 2.471 ± 0.56
3.197ValGly: 3.197 ± 0.431
2.035ValHis: 2.035 ± 0.652
5.232ValIle: 5.232 ± 1.117
2.907ValLys: 2.907 ± 0.542
7.702ValLeu: 7.702 ± 1.636
2.761ValMet: 2.761 ± 0.484
3.488ValAsn: 3.488 ± 0.394
5.522ValPro: 5.522 ± 0.721
2.325ValGln: 2.325 ± 0.42
4.65ValArg: 4.65 ± 0.354
7.557ValSer: 7.557 ± 0.956
6.54ValThr: 6.54 ± 0.897
4.65ValVal: 4.65 ± 0.462
0.872ValTrp: 0.872 ± 0.367
1.163ValTyr: 1.163 ± 0.319
0.0ValXaa: 0.0 ± 0.0
Trp
1.308TrpAla: 1.308 ± 0.536
0.145TrpCys: 0.145 ± 0.154
1.017TrpAsp: 1.017 ± 0.23
0.727TrpGlu: 0.727 ± 0.367
1.163TrpPhe: 1.163 ± 0.312
0.436TrpGly: 0.436 ± 0.3
0.145TrpHis: 0.145 ± 0.206
0.581TrpIle: 0.581 ± 0.262
0.872TrpLys: 0.872 ± 0.354
2.18TrpLeu: 2.18 ± 0.336
0.872TrpMet: 0.872 ± 0.254
0.581TrpAsn: 0.581 ± 0.221
1.163TrpPro: 1.163 ± 0.266
0.872TrpGln: 0.872 ± 0.253
1.163TrpArg: 1.163 ± 0.334
0.727TrpSer: 0.727 ± 0.236
1.889TrpThr: 1.889 ± 0.693
1.017TrpVal: 1.017 ± 0.355
0.145TrpTrp: 0.145 ± 0.114
0.436TrpTyr: 0.436 ± 0.198
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.599TyrAla: 1.599 ± 0.522
0.291TyrCys: 0.291 ± 0.267
2.035TyrAsp: 2.035 ± 0.419
1.017TyrGlu: 1.017 ± 0.189
1.017TyrPhe: 1.017 ± 0.404
1.599TyrGly: 1.599 ± 0.352
0.291TyrHis: 0.291 ± 0.2
1.599TyrIle: 1.599 ± 0.516
0.872TyrLys: 0.872 ± 0.308
3.924TyrLeu: 3.924 ± 0.721
0.727TyrMet: 0.727 ± 0.323
1.453TyrAsn: 1.453 ± 0.387
1.889TyrPro: 1.889 ± 0.367
0.872TyrGln: 0.872 ± 0.271
1.308TyrArg: 1.308 ± 0.503
3.343TyrSer: 3.343 ± 0.757
0.872TyrThr: 0.872 ± 0.371
2.035TyrVal: 2.035 ± 0.469
0.727TyrTrp: 0.727 ± 0.302
1.017TyrTyr: 1.017 ± 0.317
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (6882 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski