Amino acid dipepetide frequency for Acaromyces ingoldii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.551AlaAla: 13.551 ± 0.114	1.052AlaCys: 1.052 ± 0.017	4.859AlaAsp: 4.859 ± 0.034	5.503AlaGlu: 5.503 ± 0.04	3.284AlaPhe: 3.284 ± 0.032	7.58AlaGly: 7.58 ± 0.053	2.21AlaHis: 2.21 ± 0.022	3.856AlaIle: 3.856 ± 0.035	4.908AlaLys: 4.908 ± 0.041	8.955AlaLeu: 8.955 ± 0.067	2.176AlaMet: 2.176 ± 0.023	2.979AlaAsn: 2.979 ± 0.026	5.923AlaPro: 5.923 ± 0.057	4.212AlaGln: 4.212 ± 0.039	6.872AlaArg: 6.872 ± 0.046	10.632AlaSer: 10.632 ± 0.078	6.195AlaThr: 6.195 ± 0.046	5.671AlaVal: 5.671 ± 0.039	1.276AlaTrp: 1.276 ± 0.021	2.095AlaTyr: 2.095 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.944CysAla: 0.944 ± 0.018	0.218CysCys: 0.218 ± 0.008	0.593CysAsp: 0.593 ± 0.013	0.494CysGlu: 0.494 ± 0.011	0.454CysPhe: 0.454 ± 0.011	0.742CysGly: 0.742 ± 0.014	0.271CysHis: 0.271 ± 0.01	0.523CysIle: 0.523 ± 0.011	0.423CysLys: 0.423 ± 0.012	1.153CysLeu: 1.153 ± 0.018	0.199CysMet: 0.199 ± 0.007	0.325CysAsn: 0.325 ± 0.01	0.572CysPro: 0.572 ± 0.012	0.394CysGln: 0.394 ± 0.01	0.68CysArg: 0.68 ± 0.014	0.808CysSer: 0.808 ± 0.016	0.571CysThr: 0.571 ± 0.012	0.699CysVal: 0.699 ± 0.013	0.153CysTrp: 0.153 ± 0.007	0.27CysTyr: 0.27 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.856AspAla: 5.856 ± 0.04	0.531AspCys: 0.531 ± 0.013	5.604AspAsp: 5.604 ± 0.069	5.885AspGlu: 5.885 ± 0.057	1.912AspPhe: 1.912 ± 0.023	4.865AspGly: 4.865 ± 0.041	1.121AspHis: 1.121 ± 0.018	2.138AspIle: 2.138 ± 0.026	2.316AspLys: 2.316 ± 0.025	4.732AspLeu: 4.732 ± 0.039	1.079AspMet: 1.079 ± 0.016	1.466AspAsn: 1.466 ± 0.021	2.762AspPro: 2.762 ± 0.029	1.823AspGln: 1.823 ± 0.023	3.211AspArg: 3.211 ± 0.029	3.804AspSer: 3.804 ± 0.037	2.355AspThr: 2.355 ± 0.025	4.23AspVal: 4.23 ± 0.032	0.796AspTrp: 0.796 ± 0.013	1.284AspTyr: 1.284 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.046GluAla: 7.046 ± 0.046	0.495GluCys: 0.495 ± 0.011	4.447GluAsp: 4.447 ± 0.05	7.124GluGlu: 7.124 ± 0.084	1.256GluPhe: 1.256 ± 0.018	4.778GluGly: 4.778 ± 0.039	1.363GluHis: 1.363 ± 0.02	2.069GluIle: 2.069 ± 0.026	3.367GluLys: 3.367 ± 0.033	4.798GluLeu: 4.798 ± 0.041	1.378GluMet: 1.378 ± 0.02	1.512GluAsn: 1.512 ± 0.02	2.504GluPro: 2.504 ± 0.027	2.936GluGln: 2.936 ± 0.029	4.723GluArg: 4.723 ± 0.044	3.977GluSer: 3.977 ± 0.033	3.014GluThr: 3.014 ± 0.026	3.512GluVal: 3.512 ± 0.033	0.743GluTrp: 0.743 ± 0.014	1.147GluTyr: 1.147 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.186PheAla: 3.186 ± 0.029	0.465PheCys: 0.465 ± 0.012	2.205PheAsp: 2.205 ± 0.025	1.918PheGlu: 1.918 ± 0.022	1.455PhePhe: 1.455 ± 0.021	2.717PheGly: 2.717 ± 0.033	0.761PheHis: 0.761 ± 0.013	1.259PheIle: 1.259 ± 0.022	1.219PheLys: 1.219 ± 0.019	3.085PheLeu: 3.085 ± 0.032	0.58PheMet: 0.58 ± 0.014	1.059PheAsn: 1.059 ± 0.016	1.544PhePro: 1.544 ± 0.02	1.061PheGln: 1.061 ± 0.018	1.73PheArg: 1.73 ± 0.022	2.826PheSer: 2.826 ± 0.029	1.651PheThr: 1.651 ± 0.02	2.414PheVal: 2.414 ± 0.026	0.497PheTrp: 0.497 ± 0.011	0.891PheTyr: 0.891 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	7.719GlyAla: 7.719 ± 0.054	0.735GlyCys: 0.735 ± 0.015	4.121GlyAsp: 4.121 ± 0.031	4.267GlyGlu: 4.267 ± 0.032	2.465GlyPhe: 2.465 ± 0.031	8.303GlyGly: 8.303 ± 0.089	1.873GlyHis: 1.873 ± 0.025	2.933GlyIle: 2.933 ± 0.033	3.711GlyLys: 3.711 ± 0.04	6.316GlyLeu: 6.316 ± 0.048	1.467GlyMet: 1.467 ± 0.023	2.352GlyAsn: 2.352 ± 0.03	4.045GlyPro: 4.045 ± 0.039	3.417GlyGln: 3.417 ± 0.037	4.772GlyArg: 4.772 ± 0.047	7.015GlySer: 7.015 ± 0.056	4.069GlyThr: 4.069 ± 0.033	4.175GlyVal: 4.175 ± 0.041	1.035GlyTrp: 1.035 ± 0.015	1.685GlyTyr: 1.685 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.196HisAla: 2.196 ± 0.023	0.283HisCys: 0.283 ± 0.008	1.317HisAsp: 1.317 ± 0.019	1.278HisGlu: 1.278 ± 0.017	0.91HisPhe: 0.91 ± 0.014	1.815HisGly: 1.815 ± 0.02	1.054HisHis: 1.054 ± 0.03	0.92HisIle: 0.92 ± 0.015	0.77HisLys: 0.77 ± 0.012	2.444HisLeu: 2.444 ± 0.025	0.425HisMet: 0.425 ± 0.01	0.685HisAsn: 0.685 ± 0.014	1.546HisPro: 1.546 ± 0.022	1.174HisGln: 1.174 ± 0.024	1.672HisArg: 1.672 ± 0.022	1.819HisSer: 1.819 ± 0.027	1.115HisThr: 1.115 ± 0.018	1.475HisVal: 1.475 ± 0.019	0.318HisTrp: 0.318 ± 0.009	0.589HisTyr: 0.589 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.624IleAla: 3.624 ± 0.036	0.515IleCys: 0.515 ± 0.011	2.61IleAsp: 2.61 ± 0.025	2.443IleGlu: 2.443 ± 0.025	1.49IlePhe: 1.49 ± 0.023	2.635IleGly: 2.635 ± 0.03	0.906IleHis: 0.906 ± 0.016	1.647IleIle: 1.647 ± 0.024	1.798IleLys: 1.798 ± 0.022	3.497IleLeu: 3.497 ± 0.038	0.695IleMet: 0.695 ± 0.012	1.302IleAsn: 1.302 ± 0.02	1.916IlePro: 1.916 ± 0.023	1.325IleGln: 1.325 ± 0.018	2.282IleArg: 2.282 ± 0.023	2.854IleSer: 2.854 ± 0.027	1.833IleThr: 1.833 ± 0.021	2.923IleVal: 2.923 ± 0.031	0.52IleTrp: 0.52 ± 0.011	0.952IleTyr: 0.952 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.721LysAla: 4.721 ± 0.043	0.365LysCys: 0.365 ± 0.011	2.613LysAsp: 2.613 ± 0.029	3.344LysGlu: 3.344 ± 0.039	0.989LysPhe: 0.989 ± 0.018	3.433LysGly: 3.433 ± 0.035	0.963LysHis: 0.963 ± 0.017	1.666LysIle: 1.666 ± 0.017	3.157LysLys: 3.157 ± 0.051	3.718LysLeu: 3.718 ± 0.031	0.951LysMet: 0.951 ± 0.016	1.235LysAsn: 1.235 ± 0.019	2.252LysPro: 2.252 ± 0.03	1.877LysGln: 1.877 ± 0.025	4.026LysArg: 4.026 ± 0.038	3.145LysSer: 3.145 ± 0.033	2.593LysThr: 2.593 ± 0.026	2.719LysVal: 2.719 ± 0.025	0.525LysTrp: 0.525 ± 0.011	0.858LysTyr: 0.858 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	9.342LeuAla: 9.342 ± 0.066	1.187LeuCys: 1.187 ± 0.019	5.423LeuAsp: 5.423 ± 0.042	5.121LeuGlu: 5.121 ± 0.046	3.298LeuPhe: 3.298 ± 0.036	6.245LeuGly: 6.245 ± 0.04	2.162LeuHis: 2.162 ± 0.023	3.197LeuIle: 3.197 ± 0.031	3.428LeuLys: 3.428 ± 0.034	8.645LeuLeu: 8.645 ± 0.066	1.584LeuMet: 1.584 ± 0.02	2.479LeuAsn: 2.479 ± 0.028	5.402LeuPro: 5.402 ± 0.041	3.693LeuGln: 3.693 ± 0.036	5.98LeuArg: 5.98 ± 0.043	7.755LeuSer: 7.755 ± 0.049	4.404LeuThr: 4.404 ± 0.032	5.924LeuVal: 5.924 ± 0.046	1.042LeuTrp: 1.042 ± 0.018	2.008LeuTyr: 2.008 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.025	0.203MetCys: 0.203 ± 0.007	1.126MetAsp: 1.126 ± 0.016	1.046MetGlu: 1.046 ± 0.016	0.515MetPhe: 0.515 ± 0.011	1.517MetGly: 1.517 ± 0.023	0.451MetHis: 0.451 ± 0.009	0.686MetIle: 0.686 ± 0.013	0.768MetLys: 0.768 ± 0.013	1.81MetLeu: 1.81 ± 0.02	0.534MetMet: 0.534 ± 0.013	0.564MetAsn: 0.564 ± 0.012	1.27MetPro: 1.27 ± 0.021	0.87MetGln: 0.87 ± 0.017	1.388MetArg: 1.388 ± 0.019	1.865MetSer: 1.865 ± 0.023	1.239MetThr: 1.239 ± 0.018	1.112MetVal: 1.112 ± 0.017	0.211MetTrp: 0.211 ± 0.007	0.387MetTyr: 0.387 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.959AsnAla: 2.959 ± 0.028	0.282AsnCys: 0.282 ± 0.009	1.739AsnAsp: 1.739 ± 0.022	1.796AsnGlu: 1.796 ± 0.021	0.999AsnPhe: 0.999 ± 0.017	2.806AsnGly: 2.806 ± 0.033	0.663AsnHis: 0.663 ± 0.013	1.259AsnIle: 1.259 ± 0.019	1.31AsnLys: 1.31 ± 0.018	2.577AsnLeu: 2.577 ± 0.028	0.564AsnMet: 0.564 ± 0.012	1.161AsnAsn: 1.161 ± 0.024	1.647AsnPro: 1.647 ± 0.021	1.013AsnGln: 1.013 ± 0.017	1.668AsnArg: 1.668 ± 0.022	2.23AsnSer: 2.23 ± 0.027	1.487AsnThr: 1.487 ± 0.017	2.131AsnVal: 2.131 ± 0.028	0.341AsnTrp: 0.341 ± 0.008	0.699AsnTyr: 0.699 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.753ProAla: 5.753 ± 0.053	0.458ProCys: 0.458 ± 0.011	2.673ProAsp: 2.673 ± 0.026	2.743ProGlu: 2.743 ± 0.029	1.949ProPhe: 1.949 ± 0.026	3.88ProGly: 3.88 ± 0.039	1.394ProHis: 1.394 ± 0.022	1.99ProIle: 1.99 ± 0.021	2.278ProLys: 2.278 ± 0.033	5.023ProLeu: 5.023 ± 0.038	1.09ProMet: 1.09 ± 0.019	1.644ProAsn: 1.644 ± 0.019	5.42ProPro: 5.42 ± 0.077	2.321ProGln: 2.321 ± 0.033	3.719ProArg: 3.719 ± 0.037	7.305ProSer: 7.305 ± 0.074	3.799ProThr: 3.799 ± 0.035	3.127ProVal: 3.127 ± 0.033	0.673ProTrp: 0.673 ± 0.013	1.246ProTyr: 1.246 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	4.34GlnAla: 4.34 ± 0.04	0.36GlnCys: 0.36 ± 0.01	2.109GlnAsp: 2.109 ± 0.025	2.662GlnGlu: 2.662 ± 0.029	0.928GlnPhe: 0.928 ± 0.016	3.157GlnGly: 3.157 ± 0.03	1.359GlnHis: 1.359 ± 0.026	1.401GlnIle: 1.401 ± 0.018	1.716GlnLys: 1.716 ± 0.024	3.464GlnLeu: 3.464 ± 0.029	0.868GlnMet: 0.868 ± 0.016	1.06GlnAsn: 1.06 ± 0.017	2.505GlnPro: 2.505 ± 0.036	4.967GlnGln: 4.967 ± 0.13	3.453GlnArg: 3.453 ± 0.031	3.219GlnSer: 3.219 ± 0.029	2.216GlnThr: 2.216 ± 0.025	2.154GlnVal: 2.154 ± 0.023	0.507GlnTrp: 0.507 ± 0.01	0.836GlnTyr: 0.836 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	6.307ArgAla: 6.307 ± 0.046	0.742ArgCys: 0.742 ± 0.015	3.506ArgAsp: 3.506 ± 0.03	4.173ArgGlu: 4.173 ± 0.041	2.244ArgPhe: 2.244 ± 0.026	4.659ArgGly: 4.659 ± 0.046	1.704ArgHis: 1.704 ± 0.023	2.696ArgIle: 2.696 ± 0.028	3.534ArgLys: 3.534 ± 0.037	6.156ArgLeu: 6.156 ± 0.042	1.388ArgMet: 1.388 ± 0.017	1.963ArgAsn: 1.963 ± 0.023	3.956ArgPro: 3.956 ± 0.036	3.162ArgGln: 3.162 ± 0.028	6.563ArgArg: 6.563 ± 0.057	5.871ArgSer: 5.871 ± 0.051	3.456ArgThr: 3.456 ± 0.031	3.317ArgVal: 3.317 ± 0.03	0.948ArgTrp: 0.948 ± 0.016	1.496ArgTyr: 1.496 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	8.847SerAla: 8.847 ± 0.068	0.778SerCys: 0.778 ± 0.014	4.292SerAsp: 4.292 ± 0.037	3.96SerGlu: 3.96 ± 0.037	2.951SerPhe: 2.951 ± 0.028	6.426SerGly: 6.426 ± 0.053	2.079SerHis: 2.079 ± 0.026	3.425SerIle: 3.425 ± 0.034	3.896SerLys: 3.896 ± 0.037	8.0SerLeu: 8.0 ± 0.058	1.893SerMet: 1.893 ± 0.025	2.92SerAsn: 2.92 ± 0.033	6.113SerPro: 6.113 ± 0.078	3.466SerGln: 3.466 ± 0.038	5.676SerArg: 5.676 ± 0.051	14.635SerSer: 14.635 ± 0.152	6.198SerThr: 6.198 ± 0.06	4.638SerVal: 4.638 ± 0.036	1.004SerTrp: 1.004 ± 0.014	1.811SerTyr: 1.811 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.686ThrAla: 5.686 ± 0.038	0.594ThrCys: 0.594 ± 0.014	2.483ThrAsp: 2.483 ± 0.025	2.502ThrGlu: 2.502 ± 0.026	1.982ThrPhe: 1.982 ± 0.023	3.999ThrGly: 3.999 ± 0.035	1.137ThrHis: 1.137 ± 0.018	2.303ThrIle: 2.303 ± 0.027	2.412ThrLys: 2.412 ± 0.025	5.044ThrLeu: 5.044 ± 0.042	1.204ThrMet: 1.204 ± 0.018	1.643ThrAsn: 1.643 ± 0.021	3.923ThrPro: 3.923 ± 0.038	1.822ThrGln: 1.822 ± 0.023	3.223ThrArg: 3.223 ± 0.032	6.01ThrSer: 6.01 ± 0.053	4.152ThrThr: 4.152 ± 0.045	3.304ThrVal: 3.304 ± 0.033	0.675ThrTrp: 0.675 ± 0.014	1.261ThrTyr: 1.261 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	6.201ValAla: 6.201 ± 0.045	0.758ValCys: 0.758 ± 0.014	3.889ValAsp: 3.889 ± 0.029	3.986ValGlu: 3.986 ± 0.035	2.12ValPhe: 2.12 ± 0.025	4.388ValGly: 4.388 ± 0.038	1.412ValHis: 1.412 ± 0.02	2.296ValIle: 2.296 ± 0.027	2.64ValLys: 2.64 ± 0.027	5.53ValLeu: 5.53 ± 0.046	1.129ValMet: 1.129 ± 0.015	1.754ValAsn: 1.754 ± 0.022	3.491ValPro: 3.491 ± 0.032	2.347ValGln: 2.347 ± 0.024	3.839ValArg: 3.839 ± 0.032	4.557ValSer: 4.557 ± 0.037	3.031ValThr: 3.031 ± 0.032	4.454ValVal: 4.454 ± 0.047	0.807ValTrp: 0.807 ± 0.013	1.371ValTyr: 1.371 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.093TrpAla: 1.093 ± 0.016	0.171TrpCys: 0.171 ± 0.006	0.771TrpAsp: 0.771 ± 0.019	0.667TrpGlu: 0.667 ± 0.012	0.422TrpPhe: 0.422 ± 0.011	0.761TrpGly: 0.761 ± 0.016	0.32TrpHis: 0.32 ± 0.009	0.602TrpIle: 0.602 ± 0.012	0.629TrpLys: 0.629 ± 0.012	1.234TrpLeu: 1.234 ± 0.02	0.29TrpMet: 0.29 ± 0.009	0.475TrpAsn: 0.475 ± 0.011	0.58TrpPro: 0.58 ± 0.012	0.545TrpGln: 0.545 ± 0.012	0.953TrpArg: 0.953 ± 0.016	1.09TrpSer: 1.09 ± 0.019	0.852TrpThr: 0.852 ± 0.014	0.636TrpVal: 0.636 ± 0.012	0.236TrpTrp: 0.236 ± 0.008	0.306TrpTyr: 0.306 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.052TyrAla: 2.052 ± 0.025	0.296TyrCys: 0.296 ± 0.009	1.391TyrAsp: 1.391 ± 0.017	1.275TyrGlu: 1.275 ± 0.019	0.898TyrPhe: 0.898 ± 0.016	1.768TyrGly: 1.768 ± 0.028	0.599TyrHis: 0.599 ± 0.012	0.902TyrIle: 0.902 ± 0.014	0.87TyrLys: 0.87 ± 0.014	2.139TyrLeu: 2.139 ± 0.026	0.436TyrMet: 0.436 ± 0.012	0.754TyrAsn: 0.754 ± 0.016	1.115TyrPro: 1.115 ± 0.018	0.856TyrGln: 0.856 ± 0.018	1.412TyrArg: 1.412 ± 0.017	1.594TyrSer: 1.594 ± 0.022	1.128TyrThr: 1.128 ± 0.018	1.382TyrVal: 1.382 ± 0.02	0.325TyrTrp: 0.325 ± 0.009	0.661TyrTyr: 0.661 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 8019 proteins (4210363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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