Amino acid dipepetide frequency for Bailinhaonella thermotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.243AlaAla: 24.243 ± 0.191	1.146AlaCys: 1.146 ± 0.022	7.863AlaAsp: 7.863 ± 0.057	9.577AlaGlu: 9.577 ± 0.086	3.759AlaPhe: 3.759 ± 0.042	15.53AlaGly: 15.53 ± 0.099	2.822AlaHis: 2.822 ± 0.037	4.228AlaIle: 4.228 ± 0.04	2.372AlaLys: 2.372 ± 0.034	15.501AlaLeu: 15.501 ± 0.1	2.704AlaMet: 2.704 ± 0.035	1.802AlaAsn: 1.802 ± 0.029	7.713AlaPro: 7.713 ± 0.072	3.156AlaGln: 3.156 ± 0.04	12.464AlaArg: 12.464 ± 0.094	5.559AlaSer: 5.559 ± 0.057	6.371AlaThr: 6.371 ± 0.056	12.409AlaVal: 12.409 ± 0.106	2.126AlaTrp: 2.126 ± 0.032	2.872AlaTyr: 2.872 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.023	0.085CysCys: 0.085 ± 0.006	0.486CysAsp: 0.486 ± 0.015	0.416CysGlu: 0.416 ± 0.013	0.204CysPhe: 0.204 ± 0.008	0.923CysGly: 0.923 ± 0.02	0.194CysHis: 0.194 ± 0.01	0.098CysIle: 0.098 ± 0.006	0.099CysLys: 0.099 ± 0.007	0.75CysLeu: 0.75 ± 0.019	0.123CysMet: 0.123 ± 0.007	0.099CysAsn: 0.099 ± 0.007	0.527CysPro: 0.527 ± 0.015	0.143CysGln: 0.143 ± 0.008	0.633CysArg: 0.633 ± 0.016	0.375CysSer: 0.375 ± 0.011	0.351CysThr: 0.351 ± 0.013	0.686CysVal: 0.686 ± 0.018	0.101CysTrp: 0.101 ± 0.006	0.158CysTyr: 0.158 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.184AspAla: 7.184 ± 0.054	0.362AspCys: 0.362 ± 0.012	3.152AspAsp: 3.152 ± 0.04	3.694AspGlu: 3.694 ± 0.043	1.472AspPhe: 1.472 ± 0.025	5.591AspGly: 5.591 ± 0.053	1.358AspHis: 1.358 ± 0.025	1.533AspIle: 1.533 ± 0.025	0.903AspLys: 0.903 ± 0.023	6.679AspLeu: 6.679 ± 0.054	0.821AspMet: 0.821 ± 0.018	0.733AspAsn: 0.733 ± 0.02	4.922AspPro: 4.922 ± 0.046	1.299AspGln: 1.299 ± 0.028	5.188AspArg: 5.188 ± 0.044	1.943AspSer: 1.943 ± 0.032	2.323AspThr: 2.323 ± 0.03	4.833AspVal: 4.833 ± 0.044	0.924AspTrp: 0.924 ± 0.02	1.073AspTyr: 1.073 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.661GluAla: 7.661 ± 0.07	0.367GluCys: 0.367 ± 0.014	2.865GluAsp: 2.865 ± 0.037	3.625GluGlu: 3.625 ± 0.048	1.556GluPhe: 1.556 ± 0.026	4.333GluGly: 4.333 ± 0.046	1.506GluHis: 1.506 ± 0.027	2.506GluIle: 2.506 ± 0.032	1.149GluLys: 1.149 ± 0.024	6.764GluLeu: 6.764 ± 0.062	0.947GluMet: 0.947 ± 0.021	0.934GluAsn: 0.934 ± 0.024	3.743GluPro: 3.743 ± 0.042	1.639GluGln: 1.639 ± 0.029	6.223GluArg: 6.223 ± 0.053	2.446GluSer: 2.446 ± 0.031	2.97GluThr: 2.97 ± 0.036	4.779GluVal: 4.779 ± 0.05	0.81GluTrp: 0.81 ± 0.019	1.154GluTyr: 1.154 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.988PheAla: 3.988 ± 0.043	0.255PheCys: 0.255 ± 0.009	1.881PheAsp: 1.881 ± 0.028	1.477PheGlu: 1.477 ± 0.025	0.903PhePhe: 0.903 ± 0.023	2.98PheGly: 2.98 ± 0.043	0.603PheHis: 0.603 ± 0.015	0.723PheIle: 0.723 ± 0.017	0.427PheLys: 0.427 ± 0.012	2.737PheLeu: 2.737 ± 0.041	0.415PheMet: 0.415 ± 0.014	0.514PheAsn: 0.514 ± 0.015	1.478PhePro: 1.478 ± 0.027	0.633PheGln: 0.633 ± 0.017	1.95PheArg: 1.95 ± 0.028	1.357PheSer: 1.357 ± 0.026	1.948PheThr: 1.948 ± 0.029	2.206PheVal: 2.206 ± 0.03	0.438PheTrp: 0.438 ± 0.012	0.575PheTyr: 0.575 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.855GlyAla: 11.855 ± 0.081	0.772GlyCys: 0.772 ± 0.022	5.566GlyAsp: 5.566 ± 0.055	5.883GlyGlu: 5.883 ± 0.054	2.942GlyPhe: 2.942 ± 0.035	9.768GlyGly: 9.768 ± 0.092	2.301GlyHis: 2.301 ± 0.032	2.974GlyIle: 2.974 ± 0.036	2.004GlyLys: 2.004 ± 0.037	10.424GlyLeu: 10.424 ± 0.074	1.918GlyMet: 1.918 ± 0.028	1.531GlyAsn: 1.531 ± 0.025	5.981GlyPro: 5.981 ± 0.053	2.361GlyGln: 2.361 ± 0.041	8.954GlyArg: 8.954 ± 0.065	4.62GlySer: 4.62 ± 0.05	5.233GlyThr: 5.233 ± 0.048	8.394GlyVal: 8.394 ± 0.064	1.698GlyTrp: 1.698 ± 0.03	2.249GlyTyr: 2.249 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.807HisAla: 2.807 ± 0.039	0.198HisCys: 0.198 ± 0.009	1.264HisAsp: 1.264 ± 0.025	1.233HisGlu: 1.233 ± 0.024	0.587HisPhe: 0.587 ± 0.014	2.25HisGly: 2.25 ± 0.032	0.624HisHis: 0.624 ± 0.017	0.611HisIle: 0.611 ± 0.016	0.277HisLys: 0.277 ± 0.011	2.446HisLeu: 2.446 ± 0.031	0.297HisMet: 0.297 ± 0.011	0.328HisAsn: 0.328 ± 0.01	1.762HisPro: 1.762 ± 0.026	0.514HisGln: 0.514 ± 0.014	1.986HisArg: 1.986 ± 0.028	0.773HisSer: 0.773 ± 0.018	1.051HisThr: 1.051 ± 0.023	1.839HisVal: 1.839 ± 0.026	0.346HisTrp: 0.346 ± 0.012	0.471HisTyr: 0.471 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.321IleAla: 5.321 ± 0.054	0.305IleCys: 0.305 ± 0.012	2.085IleAsp: 2.085 ± 0.027	1.992IleGlu: 1.992 ± 0.029	0.78IlePhe: 0.78 ± 0.018	3.418IleGly: 3.418 ± 0.037	0.597IleHis: 0.597 ± 0.015	0.956IleIle: 0.956 ± 0.022	0.627IleLys: 0.627 ± 0.017	2.658IleLeu: 2.658 ± 0.038	0.514IleMet: 0.514 ± 0.016	0.624IleAsn: 0.624 ± 0.015	1.97IlePro: 1.97 ± 0.03	0.683IleGln: 0.683 ± 0.019	2.388IleArg: 2.388 ± 0.033	1.662IleSer: 1.662 ± 0.028	2.234IleThr: 2.234 ± 0.032	2.956IleVal: 2.956 ± 0.042	0.401IleTrp: 0.401 ± 0.013	0.55IleTyr: 0.55 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.388LysAla: 2.388 ± 0.037	0.085LysCys: 0.085 ± 0.006	0.984LysAsp: 0.984 ± 0.025	0.911LysGlu: 0.911 ± 0.019	0.372LysPhe: 0.372 ± 0.014	1.436LysGly: 1.436 ± 0.035	0.351LysHis: 0.351 ± 0.011	0.837LysIle: 0.837 ± 0.022	0.528LysLys: 0.528 ± 0.021	1.582LysLeu: 1.582 ± 0.026	0.315LysMet: 0.315 ± 0.011	0.389LysAsn: 0.389 ± 0.015	1.163LysPro: 1.163 ± 0.027	0.446LysGln: 0.446 ± 0.015	1.359LysArg: 1.359 ± 0.026	0.876LysSer: 0.876 ± 0.022	1.063LysThr: 1.063 ± 0.025	1.627LysVal: 1.627 ± 0.029	0.205LysTrp: 0.205 ± 0.01	0.335LysTyr: 0.335 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	17.276LeuAla: 17.276 ± 0.114	0.777LeuCys: 0.777 ± 0.02	6.533LeuAsp: 6.533 ± 0.063	4.724LeuGlu: 4.724 ± 0.049	2.68LeuPhe: 2.68 ± 0.037	9.998LeuGly: 9.998 ± 0.078	2.014LeuHis: 2.014 ± 0.027	3.704LeuIle: 3.704 ± 0.041	1.619LeuLys: 1.619 ± 0.03	11.578LeuLeu: 11.578 ± 0.102	1.702LeuMet: 1.702 ± 0.027	1.581LeuAsn: 1.581 ± 0.024	6.844LeuPro: 6.844 ± 0.066	1.785LeuGln: 1.785 ± 0.029	9.683LeuArg: 9.683 ± 0.072	5.193LeuSer: 5.193 ± 0.049	6.756LeuThr: 6.756 ± 0.058	8.974LeuVal: 8.974 ± 0.067	1.338LeuTrp: 1.338 ± 0.024	1.784LeuTyr: 1.784 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.363MetAla: 2.363 ± 0.034	0.123MetCys: 0.123 ± 0.007	0.877MetAsp: 0.877 ± 0.016	0.768MetGlu: 0.768 ± 0.018	0.515MetPhe: 0.515 ± 0.015	1.376MetGly: 1.376 ± 0.025	0.307MetHis: 0.307 ± 0.011	0.805MetIle: 0.805 ± 0.017	0.358MetLys: 0.358 ± 0.013	1.773MetLeu: 1.773 ± 0.029	0.308MetMet: 0.308 ± 0.013	0.388MetAsn: 0.388 ± 0.013	1.17MetPro: 1.17 ± 0.021	0.318MetGln: 0.318 ± 0.011	1.734MetArg: 1.734 ± 0.028	1.261MetSer: 1.261 ± 0.022	1.476MetThr: 1.476 ± 0.024	1.283MetVal: 1.283 ± 0.024	0.235MetTrp: 0.235 ± 0.01	0.295MetTyr: 0.295 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.991AsnAla: 1.991 ± 0.029	0.14AsnCys: 0.14 ± 0.007	0.75AsnAsp: 0.75 ± 0.02	0.716AsnGlu: 0.716 ± 0.017	0.401AsnPhe: 0.401 ± 0.014	1.564AsnGly: 1.564 ± 0.03	0.353AsnHis: 0.353 ± 0.011	0.516AsnIle: 0.516 ± 0.014	0.299AsnLys: 0.299 ± 0.012	1.654AsnLeu: 1.654 ± 0.028	0.271AsnMet: 0.271 ± 0.012	0.307AsnAsn: 0.307 ± 0.011	1.369AsnPro: 1.369 ± 0.024	0.393AsnGln: 0.393 ± 0.014	1.223AsnArg: 1.223 ± 0.022	0.648AsnSer: 0.648 ± 0.016	0.872AsnThr: 0.872 ± 0.022	1.386AsnVal: 1.386 ± 0.026	0.252AsnTrp: 0.252 ± 0.01	0.323AsnTyr: 0.323 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	10.34ProAla: 10.34 ± 0.092	0.372ProCys: 0.372 ± 0.013	4.354ProAsp: 4.354 ± 0.044	4.68ProGlu: 4.68 ± 0.047	1.532ProPhe: 1.532 ± 0.022	8.406ProGly: 8.406 ± 0.07	1.311ProHis: 1.311 ± 0.024	1.66ProIle: 1.66 ± 0.028	1.039ProLys: 1.039 ± 0.024	5.61ProLeu: 5.61 ± 0.049	1.178ProMet: 1.178 ± 0.021	0.788ProAsn: 0.788 ± 0.02	4.733ProPro: 4.733 ± 0.063	1.324ProGln: 1.324 ± 0.026	4.973ProArg: 4.973 ± 0.048	3.027ProSer: 3.027 ± 0.042	2.575ProThr: 2.575 ± 0.035	5.388ProVal: 5.388 ± 0.049	0.992ProTrp: 0.992 ± 0.019	1.639ProTyr: 1.639 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.428GlnAla: 3.428 ± 0.042	0.134GlnCys: 0.134 ± 0.007	1.055GlnAsp: 1.055 ± 0.024	1.224GlnGlu: 1.224 ± 0.021	0.562GlnPhe: 0.562 ± 0.016	1.9GlnGly: 1.9 ± 0.034	0.47GlnHis: 0.47 ± 0.014	1.032GlnIle: 1.032 ± 0.023	0.425GlnLys: 0.425 ± 0.015	2.111GlnLeu: 2.111 ± 0.028	0.407GlnMet: 0.407 ± 0.013	0.395GlnAsn: 0.395 ± 0.013	1.334GlnPro: 1.334 ± 0.028	0.715GlnGln: 0.715 ± 0.022	2.091GlnArg: 2.091 ± 0.03	0.952GlnSer: 0.952 ± 0.022	1.057GlnThr: 1.057 ± 0.025	2.176GlnVal: 2.176 ± 0.032	0.352GlnTrp: 0.352 ± 0.011	0.434GlnTyr: 0.434 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	12.084ArgAla: 12.084 ± 0.091	0.606ArgCys: 0.606 ± 0.016	5.061ArgAsp: 5.061 ± 0.051	5.786ArgGlu: 5.786 ± 0.055	2.556ArgPhe: 2.556 ± 0.03	6.72ArgGly: 6.72 ± 0.067	2.337ArgHis: 2.337 ± 0.032	2.939ArgIle: 2.939 ± 0.035	1.427ArgLys: 1.427 ± 0.025	10.522ArgLeu: 10.522 ± 0.083	1.914ArgMet: 1.914 ± 0.03	1.261ArgAsn: 1.261 ± 0.021	6.009ArgPro: 6.009 ± 0.061	2.149ArgGln: 2.149 ± 0.03	9.738ArgArg: 9.738 ± 0.077	3.779ArgSer: 3.779 ± 0.041	4.523ArgThr: 4.523 ± 0.05	7.177ArgVal: 7.177 ± 0.058	1.524ArgTrp: 1.524 ± 0.025	1.841ArgTyr: 1.841 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.233SerAla: 6.233 ± 0.06	0.352SerCys: 0.352 ± 0.012	2.139SerAsp: 2.139 ± 0.029	2.079SerGlu: 2.079 ± 0.03	1.347SerPhe: 1.347 ± 0.022	5.469SerGly: 5.469 ± 0.048	0.871SerHis: 0.871 ± 0.02	1.378SerIle: 1.378 ± 0.027	0.755SerLys: 0.755 ± 0.019	4.551SerLeu: 4.551 ± 0.043	1.043SerMet: 1.043 ± 0.018	0.646SerAsn: 0.646 ± 0.02	3.468SerPro: 3.468 ± 0.045	0.99SerGln: 0.99 ± 0.019	3.95SerArg: 3.95 ± 0.039	2.192SerSer: 2.192 ± 0.033	2.278SerThr: 2.278 ± 0.031	3.682SerVal: 3.682 ± 0.041	0.877SerTrp: 0.877 ± 0.021	1.04SerTyr: 1.04 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	7.713ThrAla: 7.713 ± 0.059	0.425ThrCys: 0.425 ± 0.011	2.473ThrAsp: 2.473 ± 0.034	2.574ThrGlu: 2.574 ± 0.036	1.543ThrPhe: 1.543 ± 0.026	6.145ThrGly: 6.145 ± 0.057	1.015ThrHis: 1.015 ± 0.02	1.741ThrIle: 1.741 ± 0.03	0.836ThrLys: 0.836 ± 0.02	5.58ThrLeu: 5.58 ± 0.05	0.963ThrMet: 0.963 ± 0.018	0.752ThrAsn: 0.752 ± 0.017	4.2ThrPro: 4.2 ± 0.049	1.028ThrGln: 1.028 ± 0.021	4.182ThrArg: 4.182 ± 0.037	2.568ThrSer: 2.568 ± 0.034	2.994ThrThr: 2.994 ± 0.042	4.875ThrVal: 4.875 ± 0.047	0.899ThrTrp: 0.899 ± 0.02	1.092ThrTyr: 1.092 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	11.695ValAla: 11.695 ± 0.084	0.709ValCys: 0.709 ± 0.019	4.352ValAsp: 4.352 ± 0.038	4.78ValGlu: 4.78 ± 0.048	2.648ValPhe: 2.648 ± 0.038	6.126ValGly: 6.126 ± 0.059	1.799ValHis: 1.799 ± 0.028	3.403ValIle: 3.403 ± 0.041	1.507ValLys: 1.507 ± 0.029	9.575ValLeu: 9.575 ± 0.067	1.364ValMet: 1.364 ± 0.021	1.644ValAsn: 1.644 ± 0.028	5.558ValPro: 5.558 ± 0.056	1.707ValGln: 1.707 ± 0.026	7.751ValArg: 7.751 ± 0.062	4.374ValSer: 4.374 ± 0.043	5.494ValThr: 5.494 ± 0.043	7.878ValVal: 7.878 ± 0.065	1.189ValTrp: 1.189 ± 0.022	1.684ValTyr: 1.684 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.843TrpAla: 1.843 ± 0.027	0.143TrpCys: 0.143 ± 0.008	0.829TrpAsp: 0.829 ± 0.021	0.768TrpGlu: 0.768 ± 0.017	0.518TrpPhe: 0.518 ± 0.015	1.068TrpGly: 1.068 ± 0.021	0.397TrpHis: 0.397 ± 0.014	0.6TrpIle: 0.6 ± 0.019	0.285TrpLys: 0.285 ± 0.011	1.828TrpLeu: 1.828 ± 0.026	0.283TrpMet: 0.283 ± 0.01	0.365TrpAsn: 0.365 ± 0.014	0.89TrpPro: 0.89 ± 0.02	0.44TrpGln: 0.44 ± 0.015	1.64TrpArg: 1.64 ± 0.027	0.863TrpSer: 0.863 ± 0.021	0.98TrpThr: 0.98 ± 0.022	0.985TrpVal: 0.985 ± 0.019	0.381TrpTrp: 0.381 ± 0.012	0.323TrpTyr: 0.323 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.718TyrAla: 2.718 ± 0.034	0.184TyrCys: 0.184 ± 0.009	1.418TyrAsp: 1.418 ± 0.027	1.068TyrGlu: 1.068 ± 0.023	0.614TyrPhe: 0.614 ± 0.017	2.427TyrGly: 2.427 ± 0.034	0.435TyrHis: 0.435 ± 0.014	0.474TyrIle: 0.474 ± 0.014	0.315TyrLys: 0.315 ± 0.012	2.218TyrLeu: 2.218 ± 0.03	0.244TyrMet: 0.244 ± 0.011	0.349TyrAsn: 0.349 ± 0.012	1.087TyrPro: 1.087 ± 0.022	0.532TyrGln: 0.532 ± 0.017	1.843TyrArg: 1.843 ± 0.027	0.871TyrSer: 0.871 ± 0.02	1.05TyrThr: 1.05 ± 0.022	1.706TyrVal: 1.706 ± 0.026	0.341TyrTrp: 0.341 ± 0.01	0.404TyrTyr: 0.404 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7783 proteins (2495893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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