Amino acid dipepetide frequency for Prevotella sp. P5-92

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.884AlaAla: 5.884 ± 0.09
1.061AlaCys: 1.061 ± 0.037
5.258AlaAsp: 5.258 ± 0.083
4.776AlaGlu: 4.776 ± 0.077
3.196AlaPhe: 3.196 ± 0.063
4.754AlaGly: 4.754 ± 0.085
1.281AlaHis: 1.281 ± 0.033
5.087AlaIle: 5.087 ± 0.077
4.625AlaLys: 4.625 ± 0.071
6.519AlaLeu: 6.519 ± 0.095
2.231AlaMet: 2.231 ± 0.058
3.385AlaAsn: 3.385 ± 0.067
2.22AlaPro: 2.22 ± 0.052
2.688AlaGln: 2.688 ± 0.059
3.227AlaArg: 3.227 ± 0.059
4.29AlaSer: 4.29 ± 0.071
4.447AlaThr: 4.447 ± 0.073
4.871AlaVal: 4.871 ± 0.072
0.903AlaTrp: 0.903 ± 0.033
2.806AlaTyr: 2.806 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.869CysAla: 0.869 ± 0.027
0.25CysCys: 0.25 ± 0.016
0.88CysAsp: 0.88 ± 0.032
0.797CysGlu: 0.797 ± 0.031
0.62CysPhe: 0.62 ± 0.026
1.26CysGly: 1.26 ± 0.042
0.387CysHis: 0.387 ± 0.02
0.962CysIle: 0.962 ± 0.034
0.781CysLys: 0.781 ± 0.028
1.201CysLeu: 1.201 ± 0.034
0.387CysMet: 0.387 ± 0.022
0.674CysAsn: 0.674 ± 0.028
0.609CysPro: 0.609 ± 0.028
0.457CysGln: 0.457 ± 0.022
0.834CysArg: 0.834 ± 0.031
1.023CysSer: 1.023 ± 0.051
0.771CysThr: 0.771 ± 0.034
0.86CysVal: 0.86 ± 0.032
0.167CysTrp: 0.167 ± 0.012
0.681CysTyr: 0.681 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
4.37AspAla: 4.37 ± 0.064
0.869AspCys: 0.869 ± 0.034
3.738AspAsp: 3.738 ± 0.081
4.277AspGlu: 4.277 ± 0.075
3.138AspPhe: 3.138 ± 0.058
4.755AspGly: 4.755 ± 0.092
1.005AspHis: 1.005 ± 0.031
4.857AspIle: 4.857 ± 0.065
4.042AspLys: 4.042 ± 0.067
4.35AspLeu: 4.35 ± 0.068
1.824AspMet: 1.824 ± 0.042
3.608AspAsn: 3.608 ± 0.062
1.922AspPro: 1.922 ± 0.045
1.252AspGln: 1.252 ± 0.036
2.677AspArg: 2.677 ± 0.058
3.305AspSer: 3.305 ± 0.066
3.047AspThr: 3.047 ± 0.054
3.976AspVal: 3.976 ± 0.067
0.894AspTrp: 0.894 ± 0.031
3.125AspTyr: 3.125 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.943GluAla: 4.943 ± 0.083
0.83GluCys: 0.83 ± 0.032
3.235GluAsp: 3.235 ± 0.054
4.772GluGlu: 4.772 ± 0.083
2.199GluPhe: 2.199 ± 0.048
4.38GluGly: 4.38 ± 0.074
1.202GluHis: 1.202 ± 0.037
4.279GluIle: 4.279 ± 0.089
4.733GluLys: 4.733 ± 0.087
5.274GluLeu: 5.274 ± 0.085
2.244GluMet: 2.244 ± 0.055
3.187GluAsn: 3.187 ± 0.065
1.729GluPro: 1.729 ± 0.046
2.414GluGln: 2.414 ± 0.056
3.46GluArg: 3.46 ± 0.075
3.011GluSer: 3.011 ± 0.051
3.321GluThr: 3.321 ± 0.062
4.026GluVal: 4.026 ± 0.073
0.87GluTrp: 0.87 ± 0.03
2.727GluTyr: 2.727 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.029PheAla: 3.029 ± 0.055
0.734PheCys: 0.734 ± 0.027
3.025PheAsp: 3.025 ± 0.053
2.327PheGlu: 2.327 ± 0.05
2.036PhePhe: 2.036 ± 0.057
3.199PheGly: 3.199 ± 0.062
0.839PheHis: 0.839 ± 0.031
2.759PheIle: 2.759 ± 0.053
2.357PheLys: 2.357 ± 0.058
3.302PheLeu: 3.302 ± 0.064
1.19PheMet: 1.19 ± 0.04
2.338PheAsn: 2.338 ± 0.049
1.504PhePro: 1.504 ± 0.048
1.116PheGln: 1.116 ± 0.035
1.967PheArg: 1.967 ± 0.038
3.232PheSer: 3.232 ± 0.062
2.747PheThr: 2.747 ± 0.052
2.973PheVal: 2.973 ± 0.057
0.544PheTrp: 0.544 ± 0.025
1.754PheTyr: 1.754 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.428GlyAla: 4.428 ± 0.083
1.213GlyCys: 1.213 ± 0.042
3.921GlyAsp: 3.921 ± 0.072
4.137GlyGlu: 4.137 ± 0.078
2.943GlyPhe: 2.943 ± 0.059
4.984GlyGly: 4.984 ± 0.101
1.385GlyHis: 1.385 ± 0.038
5.07GlyIle: 5.07 ± 0.079
5.247GlyLys: 5.247 ± 0.082
5.475GlyLeu: 5.475 ± 0.091
2.208GlyMet: 2.208 ± 0.049
3.682GlyAsn: 3.682 ± 0.076
1.288GlyPro: 1.288 ± 0.042
2.093GlyGln: 2.093 ± 0.044
3.199GlyArg: 3.199 ± 0.06
3.97GlySer: 3.97 ± 0.082
4.125GlyThr: 4.125 ± 0.083
4.786GlyVal: 4.786 ± 0.086
0.951GlyTrp: 0.951 ± 0.038
3.251GlyTyr: 3.251 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.198HisAla: 1.198 ± 0.034
0.383HisCys: 0.383 ± 0.023
1.229HisAsp: 1.229 ± 0.034
1.056HisGlu: 1.056 ± 0.034
1.049HisPhe: 1.049 ± 0.037
1.358HisGly: 1.358 ± 0.035
0.555HisHis: 0.555 ± 0.026
1.393HisIle: 1.393 ± 0.045
1.044HisLys: 1.044 ± 0.031
1.743HisLeu: 1.743 ± 0.043
0.342HisMet: 0.342 ± 0.02
1.062HisAsn: 1.062 ± 0.034
0.951HisPro: 0.951 ± 0.037
0.616HisGln: 0.616 ± 0.026
0.943HisArg: 0.943 ± 0.033
1.182HisSer: 1.182 ± 0.033
1.038HisThr: 1.038 ± 0.031
1.182HisVal: 1.182 ± 0.035
0.254HisTrp: 0.254 ± 0.017
0.956HisTyr: 0.956 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.239IleAla: 5.239 ± 0.076
1.035IleCys: 1.035 ± 0.034
5.101IleAsp: 5.101 ± 0.081
4.431IleGlu: 4.431 ± 0.076
2.554IlePhe: 2.554 ± 0.065
4.592IleGly: 4.592 ± 0.081
1.277IleHis: 1.277 ± 0.036
4.516IleIle: 4.516 ± 0.075
4.08IleLys: 4.08 ± 0.069
5.082IleLeu: 5.082 ± 0.078
1.676IleMet: 1.676 ± 0.042
3.497IleAsn: 3.497 ± 0.059
2.827IlePro: 2.827 ± 0.06
1.918IleGln: 1.918 ± 0.044
3.253IleArg: 3.253 ± 0.059
4.467IleSer: 4.467 ± 0.073
3.977IleThr: 3.977 ± 0.07
4.718IleVal: 4.718 ± 0.079
0.622IleTrp: 0.622 ± 0.022
2.6IleTyr: 2.6 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.376LysAla: 5.376 ± 0.094
0.683LysCys: 0.683 ± 0.025
3.913LysAsp: 3.913 ± 0.067
4.888LysGlu: 4.888 ± 0.086
2.118LysPhe: 2.118 ± 0.048
4.399LysGly: 4.399 ± 0.078
1.168LysHis: 1.168 ± 0.034
3.96LysIle: 3.96 ± 0.068
4.943LysLys: 4.943 ± 0.09
4.832LysLeu: 4.832 ± 0.071
2.315LysMet: 2.315 ± 0.047
3.277LysAsn: 3.277 ± 0.053
2.178LysPro: 2.178 ± 0.051
2.382LysGln: 2.382 ± 0.06
3.249LysArg: 3.249 ± 0.063
3.429LysSer: 3.429 ± 0.064
3.991LysThr: 3.991 ± 0.065
4.415LysVal: 4.415 ± 0.077
0.845LysTrp: 0.845 ± 0.03
2.944LysTyr: 2.944 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
6.298LeuAla: 6.298 ± 0.09
1.403LeuCys: 1.403 ± 0.042
4.924LeuAsp: 4.924 ± 0.073
4.519LeuGlu: 4.519 ± 0.091
3.858LeuPhe: 3.858 ± 0.081
5.196LeuGly: 5.196 ± 0.082
1.754LeuHis: 1.754 ± 0.046
4.661LeuIle: 4.661 ± 0.085
5.68LeuLys: 5.68 ± 0.086
7.457LeuLeu: 7.457 ± 0.132
2.586LeuMet: 2.586 ± 0.059
4.143LeuAsn: 4.143 ± 0.065
3.716LeuPro: 3.716 ± 0.069
2.833LeuGln: 2.833 ± 0.056
4.249LeuArg: 4.249 ± 0.074
6.201LeuSer: 6.201 ± 0.086
5.494LeuThr: 5.494 ± 0.094
5.216LeuVal: 5.216 ± 0.073
1.0LeuTrp: 1.0 ± 0.031
3.377LeuTyr: 3.377 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.636MetAla: 2.636 ± 0.054
0.334MetCys: 0.334 ± 0.017
1.476MetAsp: 1.476 ± 0.044
1.824MetGlu: 1.824 ± 0.05
1.217MetPhe: 1.217 ± 0.053
1.868MetGly: 1.868 ± 0.048
0.527MetHis: 0.527 ± 0.021
1.703MetIle: 1.703 ± 0.046
2.592MetLys: 2.592 ± 0.058
2.756MetLeu: 2.756 ± 0.052
1.055MetMet: 1.055 ± 0.037
1.559MetAsn: 1.559 ± 0.04
1.376MetPro: 1.376 ± 0.033
1.134MetGln: 1.134 ± 0.037
1.504MetArg: 1.504 ± 0.041
1.809MetSer: 1.809 ± 0.041
1.943MetThr: 1.943 ± 0.046
1.867MetVal: 1.867 ± 0.045
0.258MetTrp: 0.258 ± 0.019
0.828MetTyr: 0.828 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.727AsnAla: 3.727 ± 0.065
0.673AsnCys: 0.673 ± 0.032
3.05AsnAsp: 3.05 ± 0.059
2.967AsnGlu: 2.967 ± 0.054
2.077AsnPhe: 2.077 ± 0.041
4.072AsnGly: 4.072 ± 0.079
0.953AsnHis: 0.953 ± 0.035
4.013AsnIle: 4.013 ± 0.062
3.05AsnLys: 3.05 ± 0.051
3.827AsnLeu: 3.827 ± 0.063
1.448AsnMet: 1.448 ± 0.041
2.831AsnAsn: 2.831 ± 0.073
2.396AsnPro: 2.396 ± 0.048
1.379AsnGln: 1.379 ± 0.04
2.236AsnArg: 2.236 ± 0.05
2.941AsnSer: 2.941 ± 0.073
3.02AsnThr: 3.02 ± 0.066
3.607AsnVal: 3.607 ± 0.064
0.587AsnTrp: 0.587 ± 0.025
2.153AsnTyr: 2.153 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.611ProAla: 2.611 ± 0.061
0.427ProCys: 0.427 ± 0.023
2.467ProAsp: 2.467 ± 0.057
3.012ProGlu: 3.012 ± 0.059
1.606ProPhe: 1.606 ± 0.041
2.178ProGly: 2.178 ± 0.051
0.743ProHis: 0.743 ± 0.032
2.097ProIle: 2.097 ± 0.041
2.031ProLys: 2.031 ± 0.048
3.062ProLeu: 3.062 ± 0.055
1.077ProMet: 1.077 ± 0.038
1.646ProAsn: 1.646 ± 0.049
0.688ProPro: 0.688 ± 0.025
1.394ProGln: 1.394 ± 0.04
1.407ProArg: 1.407 ± 0.04
2.321ProSer: 2.321 ± 0.049
2.023ProThr: 2.023 ± 0.046
2.729ProVal: 2.729 ± 0.054
0.483ProTrp: 0.483 ± 0.025
1.66ProTyr: 1.66 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
2.23GlnAla: 2.23 ± 0.045
0.4GlnCys: 0.4 ± 0.019
1.463GlnAsp: 1.463 ± 0.037
1.948GlnGlu: 1.948 ± 0.05
1.232GlnPhe: 1.232 ± 0.034
1.971GlnGly: 1.971 ± 0.045
0.704GlnHis: 0.704 ± 0.026
2.098GlnIle: 2.098 ± 0.052
2.163GlnLys: 2.163 ± 0.056
3.388GlnLeu: 3.388 ± 0.064
1.169GlnMet: 1.169 ± 0.04
1.613GlnAsn: 1.613 ± 0.041
1.272GlnPro: 1.272 ± 0.035
1.751GlnGln: 1.751 ± 0.048
1.869GlnArg: 1.869 ± 0.042
1.777GlnSer: 1.777 ± 0.041
2.032GlnThr: 2.032 ± 0.045
1.938GlnVal: 1.938 ± 0.05
0.508GlnTrp: 0.508 ± 0.024
1.49GlnTyr: 1.49 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.796ArgAla: 2.796 ± 0.058
0.624ArgCys: 0.624 ± 0.027
2.504ArgAsp: 2.504 ± 0.051
3.032ArgGlu: 3.032 ± 0.06
2.121ArgPhe: 2.121 ± 0.046
2.713ArgGly: 2.713 ± 0.055
1.29ArgHis: 1.29 ± 0.04
3.421ArgIle: 3.421 ± 0.059
3.32ArgLys: 3.32 ± 0.068
4.844ArgLeu: 4.844 ± 0.08
1.668ArgMet: 1.668 ± 0.041
2.417ArgAsn: 2.417 ± 0.054
1.655ArgPro: 1.655 ± 0.048
2.268ArgGln: 2.268 ± 0.052
2.968ArgArg: 2.968 ± 0.074
2.338ArgSer: 2.338 ± 0.054
2.395ArgThr: 2.395 ± 0.054
2.908ArgVal: 2.908 ± 0.062
0.722ArgTrp: 0.722 ± 0.032
2.303ArgTyr: 2.303 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.275SerAla: 4.275 ± 0.065
0.97SerCys: 0.97 ± 0.03
3.593SerAsp: 3.593 ± 0.055
3.399SerGlu: 3.399 ± 0.058
2.986SerPhe: 2.986 ± 0.054
4.369SerGly: 4.369 ± 0.077
1.247SerHis: 1.247 ± 0.035
4.211SerIle: 4.211 ± 0.071
3.472SerLys: 3.472 ± 0.066
5.853SerLeu: 5.853 ± 0.109
1.649SerMet: 1.649 ± 0.043
2.812SerAsn: 2.812 ± 0.06
2.315SerPro: 2.315 ± 0.057
2.127SerGln: 2.127 ± 0.048
2.849SerArg: 2.849 ± 0.054
3.956SerSer: 3.956 ± 0.086
3.277SerThr: 3.277 ± 0.064
4.157SerVal: 4.157 ± 0.082
0.853SerTrp: 0.853 ± 0.035
2.543SerTyr: 2.543 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.578ThrAla: 4.578 ± 0.08
0.707ThrCys: 0.707 ± 0.025
3.677ThrAsp: 3.677 ± 0.066
3.168ThrGlu: 3.168 ± 0.049
2.634ThrPhe: 2.634 ± 0.055
4.157ThrGly: 4.157 ± 0.069
1.065ThrHis: 1.065 ± 0.037
4.538ThrIle: 4.538 ± 0.07
3.092ThrLys: 3.092 ± 0.059
5.643ThrLeu: 5.643 ± 0.08
1.615ThrMet: 1.615 ± 0.044
2.546ThrAsn: 2.546 ± 0.061
2.581ThrPro: 2.581 ± 0.041
1.722ThrGln: 1.722 ± 0.038
2.474ThrArg: 2.474 ± 0.052
3.735ThrSer: 3.735 ± 0.091
3.796ThrThr: 3.796 ± 0.078
4.062ThrVal: 4.062 ± 0.068
0.666ThrTrp: 0.666 ± 0.026
2.363ThrTyr: 2.363 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.253ValAla: 5.253 ± 0.078
1.028ValCys: 1.028 ± 0.033
3.856ValAsp: 3.856 ± 0.058
4.51ValGlu: 4.51 ± 0.076
2.944ValPhe: 2.944 ± 0.054
4.214ValGly: 4.214 ± 0.073
0.961ValHis: 0.961 ± 0.031
4.385ValIle: 4.385 ± 0.067
4.699ValLys: 4.699 ± 0.069
5.239ValLeu: 5.239 ± 0.074
2.015ValMet: 2.015 ± 0.046
3.472ValAsn: 3.472 ± 0.061
2.467ValPro: 2.467 ± 0.044
1.592ValGln: 1.592 ± 0.043
3.08ValArg: 3.08 ± 0.057
4.438ValSer: 4.438 ± 0.074
4.314ValThr: 4.314 ± 0.082
5.061ValVal: 5.061 ± 0.077
0.762ValTrp: 0.762 ± 0.03
2.449ValTyr: 2.449 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.031
0.198TrpCys: 0.198 ± 0.014
0.732TrpAsp: 0.732 ± 0.029
0.677TrpGlu: 0.677 ± 0.03
0.539TrpPhe: 0.539 ± 0.026
0.945TrpGly: 0.945 ± 0.038
0.317TrpHis: 0.317 ± 0.019
0.787TrpIle: 0.787 ± 0.03
0.872TrpLys: 0.872 ± 0.034
1.188TrpLeu: 1.188 ± 0.037
0.448TrpMet: 0.448 ± 0.025
0.782TrpAsn: 0.782 ± 0.032
0.316TrpPro: 0.316 ± 0.017
0.521TrpGln: 0.521 ± 0.025
0.624TrpArg: 0.624 ± 0.028
0.73TrpSer: 0.73 ± 0.028
0.744TrpThr: 0.744 ± 0.027
0.658TrpVal: 0.658 ± 0.027
0.21TrpTrp: 0.21 ± 0.016
0.527TrpTyr: 0.527 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.932TyrAla: 2.932 ± 0.056
0.648TyrCys: 0.648 ± 0.028
2.988TyrAsp: 2.988 ± 0.062
2.319TyrGlu: 2.319 ± 0.051
1.909TyrPhe: 1.909 ± 0.052
2.99TyrGly: 2.99 ± 0.063
0.873TyrHis: 0.873 ± 0.035
2.665TyrIle: 2.665 ± 0.055
2.483TyrLys: 2.483 ± 0.05
3.528TyrLeu: 3.528 ± 0.062
1.115TyrMet: 1.115 ± 0.038
2.479TyrAsn: 2.479 ± 0.052
1.651TyrPro: 1.651 ± 0.04
1.365TyrGln: 1.365 ± 0.042
2.236TyrArg: 2.236 ± 0.048
2.757TyrSer: 2.757 ± 0.057
2.316TyrThr: 2.316 ± 0.054
2.728TyrVal: 2.728 ± 0.047
0.555TyrTrp: 0.555 ± 0.023
2.04TyrTyr: 2.04 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2803 proteins (1003906 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski