Amino acid dipepetide frequency for Motiliproteus coralliicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.84AlaAla: 9.84 ± 0.138	1.034AlaCys: 1.034 ± 0.029	5.846AlaAsp: 5.846 ± 0.082	7.077AlaGlu: 7.077 ± 0.093	3.271AlaPhe: 3.271 ± 0.06	7.112AlaGly: 7.112 ± 0.081	1.665AlaHis: 1.665 ± 0.039	5.21AlaIle: 5.21 ± 0.072	3.866AlaLys: 3.866 ± 0.064	11.196AlaLeu: 11.196 ± 0.107	2.808AlaMet: 2.808 ± 0.05	3.005AlaAsn: 3.005 ± 0.053	3.526AlaPro: 3.526 ± 0.071	4.411AlaGln: 4.411 ± 0.061	5.041AlaArg: 5.041 ± 0.075	5.302AlaSer: 5.302 ± 0.077	4.293AlaThr: 4.293 ± 0.062	6.537AlaVal: 6.537 ± 0.079	1.013AlaTrp: 1.013 ± 0.031	2.275AlaTyr: 2.275 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.939CysAla: 0.939 ± 0.036	0.196CysCys: 0.196 ± 0.014	0.66CysAsp: 0.66 ± 0.027	0.59CysGlu: 0.59 ± 0.019	0.435CysPhe: 0.435 ± 0.021	0.996CysGly: 0.996 ± 0.033	0.394CysHis: 0.394 ± 0.02	0.539CysIle: 0.539 ± 0.021	0.309CysLys: 0.309 ± 0.015	1.142CysLeu: 1.142 ± 0.029	0.223CysMet: 0.223 ± 0.014	0.324CysAsn: 0.324 ± 0.018	0.521CysPro: 0.521 ± 0.024	0.51CysGln: 0.51 ± 0.02	0.779CysArg: 0.779 ± 0.028	0.725CysSer: 0.725 ± 0.021	0.449CysThr: 0.449 ± 0.018	0.662CysVal: 0.662 ± 0.023	0.179CysTrp: 0.179 ± 0.014	0.331CysTyr: 0.331 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.903AspAla: 4.903 ± 0.07	0.67AspCys: 0.67 ± 0.024	3.23AspAsp: 3.23 ± 0.063	3.809AspGlu: 3.809 ± 0.07	2.156AspPhe: 2.156 ± 0.042	4.324AspGly: 4.324 ± 0.078	1.338AspHis: 1.338 ± 0.037	3.043AspIle: 3.043 ± 0.048	2.315AspLys: 2.315 ± 0.04	5.805AspLeu: 5.805 ± 0.073	1.187AspMet: 1.187 ± 0.033	2.141AspAsn: 2.141 ± 0.047	3.064AspPro: 3.064 ± 0.051	3.42AspGln: 3.42 ± 0.055	3.544AspArg: 3.544 ± 0.063	3.779AspSer: 3.779 ± 0.06	2.525AspThr: 2.525 ± 0.045	3.064AspVal: 3.064 ± 0.058	0.987AspTrp: 0.987 ± 0.028	1.981AspTyr: 1.981 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.477GluAla: 6.477 ± 0.079	0.449GluCys: 0.449 ± 0.019	2.667GluAsp: 2.667 ± 0.049	3.472GluGlu: 3.472 ± 0.07	2.165GluPhe: 2.165 ± 0.041	3.975GluGly: 3.975 ± 0.057	1.493GluHis: 1.493 ± 0.04	3.464GluIle: 3.464 ± 0.06	2.436GluLys: 2.436 ± 0.059	8.341GluLeu: 8.341 ± 0.1	1.494GluMet: 1.494 ± 0.033	1.685GluAsn: 1.685 ± 0.039	2.79GluPro: 2.79 ± 0.06	5.382GluGln: 5.382 ± 0.081	4.321GluArg: 4.321 ± 0.067	3.459GluSer: 3.459 ± 0.06	2.951GluThr: 2.951 ± 0.051	4.273GluVal: 4.273 ± 0.072	0.677GluTrp: 0.677 ± 0.025	1.377GluTyr: 1.377 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.06	0.528PheCys: 0.528 ± 0.021	2.758PheAsp: 2.758 ± 0.047	2.551PheGlu: 2.551 ± 0.043	1.43PhePhe: 1.43 ± 0.04	3.135PheGly: 3.135 ± 0.053	0.773PheHis: 0.773 ± 0.029	2.034PheIle: 2.034 ± 0.047	1.418PheLys: 1.418 ± 0.031	3.131PheLeu: 3.131 ± 0.055	0.827PheMet: 0.827 ± 0.027	1.51PheAsn: 1.51 ± 0.032	1.347PhePro: 1.347 ± 0.034	1.36PheGln: 1.36 ± 0.037	1.764PheArg: 1.764 ± 0.037	2.744PheSer: 2.744 ± 0.057	1.772PheThr: 1.772 ± 0.044	2.53PheVal: 2.53 ± 0.052	0.518PheTrp: 0.518 ± 0.024	1.134PheTyr: 1.134 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.147GlyAla: 6.147 ± 0.08	1.032GlyCys: 1.032 ± 0.033	4.052GlyAsp: 4.052 ± 0.08	4.494GlyGlu: 4.494 ± 0.064	3.273GlyPhe: 3.273 ± 0.06	5.535GlyGly: 5.535 ± 0.103	1.709GlyHis: 1.709 ± 0.043	4.465GlyIle: 4.465 ± 0.06	3.146GlyLys: 3.146 ± 0.058	8.478GlyLeu: 8.478 ± 0.092	2.26GlyMet: 2.26 ± 0.047	2.354GlyAsn: 2.354 ± 0.055	2.25GlyPro: 2.25 ± 0.044	3.504GlyGln: 3.504 ± 0.062	4.376GlyArg: 4.376 ± 0.072	4.585GlySer: 4.585 ± 0.071	3.472GlyThr: 3.472 ± 0.059	5.453GlyVal: 5.453 ± 0.071	1.178GlyTrp: 1.178 ± 0.032	2.578GlyTyr: 2.578 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.691HisAla: 1.691 ± 0.04	0.363HisCys: 0.363 ± 0.018	1.13HisAsp: 1.13 ± 0.037	1.098HisGlu: 1.098 ± 0.028	0.979HisPhe: 0.979 ± 0.027	1.642HisGly: 1.642 ± 0.043	0.71HisHis: 0.71 ± 0.029	1.059HisIle: 1.059 ± 0.031	0.736HisLys: 0.736 ± 0.027	2.339HisLeu: 2.339 ± 0.041	0.447HisMet: 0.447 ± 0.019	0.725HisAsn: 0.725 ± 0.023	1.426HisPro: 1.426 ± 0.034	1.446HisGln: 1.446 ± 0.034	1.526HisArg: 1.526 ± 0.038	1.446HisSer: 1.446 ± 0.036	0.893HisThr: 0.893 ± 0.025	1.006HisVal: 1.006 ± 0.032	0.419HisTrp: 0.419 ± 0.02	0.827HisTyr: 0.827 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.578IleAla: 5.578 ± 0.079	0.655IleCys: 0.655 ± 0.022	4.17IleAsp: 4.17 ± 0.062	4.402IleGlu: 4.402 ± 0.064	1.604IlePhe: 1.604 ± 0.044	4.495IleGly: 4.495 ± 0.069	1.15IleHis: 1.15 ± 0.027	2.474IleIle: 2.474 ± 0.053	2.306IleLys: 2.306 ± 0.047	4.678IleLeu: 4.678 ± 0.078	0.995IleMet: 0.995 ± 0.03	2.323IleAsn: 2.323 ± 0.051	2.503IlePro: 2.503 ± 0.041	2.152IleGln: 2.152 ± 0.038	3.281IleArg: 3.281 ± 0.052	3.796IleSer: 3.796 ± 0.058	2.687IleThr: 2.687 ± 0.046	3.279IleVal: 3.279 ± 0.057	0.573IleTrp: 0.573 ± 0.026	1.422IleTyr: 1.422 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.929LysAla: 3.929 ± 0.07	0.211LysCys: 0.211 ± 0.013	1.84LysAsp: 1.84 ± 0.046	2.17LysGlu: 2.17 ± 0.051	0.988LysPhe: 0.988 ± 0.028	2.673LysGly: 2.673 ± 0.049	0.837LysHis: 0.837 ± 0.029	1.998LysIle: 1.998 ± 0.043	1.709LysLys: 1.709 ± 0.047	4.446LysLeu: 4.446 ± 0.059	0.906LysMet: 0.906 ± 0.032	1.149LysAsn: 1.149 ± 0.03	2.275LysPro: 2.275 ± 0.043	2.482LysGln: 2.482 ± 0.043	2.541LysArg: 2.541 ± 0.052	2.153LysSer: 2.153 ± 0.056	2.052LysThr: 2.052 ± 0.043	2.787LysVal: 2.787 ± 0.05	0.351LysTrp: 0.351 ± 0.018	0.841LysTyr: 0.841 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.501LeuAla: 11.501 ± 0.12	1.26LeuCys: 1.26 ± 0.035	6.695LeuAsp: 6.695 ± 0.072	7.343LeuGlu: 7.343 ± 0.088	4.256LeuPhe: 4.256 ± 0.08	8.238LeuGly: 8.238 ± 0.102	2.112LeuHis: 2.112 ± 0.044	6.513LeuIle: 6.513 ± 0.077	4.804LeuLys: 4.804 ± 0.067	13.316LeuLeu: 13.316 ± 0.148	2.862LeuMet: 2.862 ± 0.054	4.009LeuAsn: 4.009 ± 0.054	5.517LeuPro: 5.517 ± 0.075	5.419LeuGln: 5.419 ± 0.079	6.074LeuArg: 6.074 ± 0.072	8.083LeuSer: 8.083 ± 0.078	5.446LeuThr: 5.446 ± 0.072	7.744LeuVal: 7.744 ± 0.086	1.264LeuTrp: 1.264 ± 0.036	2.617LeuTyr: 2.617 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.693MetAla: 2.693 ± 0.048	0.159MetCys: 0.159 ± 0.013	1.178MetAsp: 1.178 ± 0.03	1.415MetGlu: 1.415 ± 0.037	0.676MetPhe: 0.676 ± 0.022	1.859MetGly: 1.859 ± 0.04	0.445MetHis: 0.445 ± 0.017	1.398MetIle: 1.398 ± 0.039	1.097MetLys: 1.097 ± 0.032	2.871MetLeu: 2.871 ± 0.052	0.72MetMet: 0.72 ± 0.028	0.893MetAsn: 0.893 ± 0.031	1.223MetPro: 1.223 ± 0.028	1.101MetGln: 1.101 ± 0.027	1.299MetArg: 1.299 ± 0.035	1.702MetSer: 1.702 ± 0.038	1.392MetThr: 1.392 ± 0.033	1.707MetVal: 1.707 ± 0.044	0.173MetTrp: 0.173 ± 0.011	0.37MetTyr: 0.37 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.938AsnAla: 2.938 ± 0.051	0.388AsnCys: 0.388 ± 0.019	1.833AsnAsp: 1.833 ± 0.045	1.884AsnGlu: 1.884 ± 0.04	1.131AsnPhe: 1.131 ± 0.031	2.587AsnGly: 2.587 ± 0.053	0.802AsnHis: 0.802 ± 0.024	1.732AsnIle: 1.732 ± 0.041	1.226AsnLys: 1.226 ± 0.034	3.6AsnLeu: 3.6 ± 0.054	0.705AsnMet: 0.705 ± 0.026	1.31AsnAsn: 1.31 ± 0.036	2.224AsnPro: 2.224 ± 0.045	1.801AsnGln: 1.801 ± 0.044	2.349AsnArg: 2.349 ± 0.038	2.065AsnSer: 2.065 ± 0.046	1.525AsnThr: 1.525 ± 0.034	1.782AsnVal: 1.782 ± 0.036	0.501AsnTrp: 0.501 ± 0.018	0.952AsnTyr: 0.952 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.168ProAla: 4.168 ± 0.068	0.418ProCys: 0.418 ± 0.031	2.97ProAsp: 2.97 ± 0.054	3.746ProGlu: 3.746 ± 0.053	1.719ProPhe: 1.719 ± 0.035	3.374ProGly: 3.374 ± 0.063	0.891ProHis: 0.891 ± 0.029	2.338ProIle: 2.338 ± 0.043	1.805ProLys: 1.805 ± 0.041	5.122ProLeu: 5.122 ± 0.075	1.182ProMet: 1.182 ± 0.032	1.475ProAsn: 1.475 ± 0.035	1.692ProPro: 1.692 ± 0.038	2.395ProGln: 2.395 ± 0.051	1.993ProArg: 1.993 ± 0.04	2.801ProSer: 2.801 ± 0.051	2.208ProThr: 2.208 ± 0.042	3.516ProVal: 3.516 ± 0.057	0.608ProTrp: 0.608 ± 0.024	1.235ProTyr: 1.235 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.73GlnAla: 5.73 ± 0.073	0.414GlnCys: 0.414 ± 0.019	2.102GlnAsp: 2.102 ± 0.042	2.196GlnGlu: 2.196 ± 0.046	1.634GlnPhe: 1.634 ± 0.037	3.761GlnGly: 3.761 ± 0.061	1.419GlnHis: 1.419 ± 0.04	2.845GlnIle: 2.845 ± 0.052	1.498GlnLys: 1.498 ± 0.034	7.666GlnLeu: 7.666 ± 0.112	1.194GlnMet: 1.194 ± 0.036	1.289GlnAsn: 1.289 ± 0.033	2.819GlnPro: 2.819 ± 0.054	5.347GlnGln: 5.347 ± 0.107	3.916GlnArg: 3.916 ± 0.068	2.942GlnSer: 2.942 ± 0.053	2.262GlnThr: 2.262 ± 0.049	3.63GlnVal: 3.63 ± 0.062	0.656GlnTrp: 0.656 ± 0.023	1.111GlnTyr: 1.111 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.859ArgAla: 4.859 ± 0.071	0.695ArgCys: 0.695 ± 0.027	3.219ArgAsp: 3.219 ± 0.05	3.569ArgGlu: 3.569 ± 0.064	2.711ArgPhe: 2.711 ± 0.046	3.548ArgGly: 3.548 ± 0.056	1.482ArgHis: 1.482 ± 0.034	3.663ArgIle: 3.663 ± 0.059	2.129ArgLys: 2.129 ± 0.043	7.302ArgLeu: 7.302 ± 0.102	1.499ArgMet: 1.499 ± 0.035	1.907ArgAsn: 1.907 ± 0.038	2.318ArgPro: 2.318 ± 0.049	3.655ArgGln: 3.655 ± 0.063	3.745ArgArg: 3.745 ± 0.066	3.565ArgSer: 3.565 ± 0.059	2.467ArgThr: 2.467 ± 0.038	4.037ArgVal: 4.037 ± 0.071	1.011ArgTrp: 1.011 ± 0.026	2.098ArgTyr: 2.098 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.694SerAla: 5.694 ± 0.075	0.75SerCys: 0.75 ± 0.028	3.692SerAsp: 3.692 ± 0.057	3.636SerGlu: 3.636 ± 0.064	2.427SerPhe: 2.427 ± 0.048	5.339SerGly: 5.339 ± 0.079	1.414SerHis: 1.414 ± 0.035	3.303SerIle: 3.303 ± 0.057	2.261SerLys: 2.261 ± 0.046	7.135SerLeu: 7.135 ± 0.084	1.59SerMet: 1.59 ± 0.039	2.123SerAsn: 2.123 ± 0.04	2.727SerPro: 2.727 ± 0.051	2.948SerGln: 2.948 ± 0.047	3.833SerArg: 3.833 ± 0.058	4.135SerSer: 4.135 ± 0.072	3.082SerThr: 3.082 ± 0.055	4.05SerVal: 4.05 ± 0.056	0.893SerTrp: 0.893 ± 0.026	1.809SerTyr: 1.809 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.396ThrAla: 4.396 ± 0.064	0.382ThrCys: 0.382 ± 0.02	2.93ThrAsp: 2.93 ± 0.061	3.188ThrGlu: 3.188 ± 0.051	1.524ThrPhe: 1.524 ± 0.033	3.994ThrGly: 3.994 ± 0.052	0.98ThrHis: 0.98 ± 0.029	2.387ThrIle: 2.387 ± 0.047	1.424ThrLys: 1.424 ± 0.039	6.215ThrLeu: 6.215 ± 0.076	0.889ThrMet: 0.889 ± 0.028	1.469ThrAsn: 1.469 ± 0.041	2.7ThrPro: 2.7 ± 0.048	2.058ThrGln: 2.058 ± 0.048	2.569ThrArg: 2.569 ± 0.048	2.682ThrSer: 2.682 ± 0.052	2.441ThrThr: 2.441 ± 0.051	3.179ThrVal: 3.179 ± 0.052	0.446ThrTrp: 0.446 ± 0.021	1.16ThrTyr: 1.16 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	6.781ValAla: 6.781 ± 0.079	0.765ValCys: 0.765 ± 0.025	4.09ValAsp: 4.09 ± 0.054	4.838ValGlu: 4.838 ± 0.07	2.317ValPhe: 2.317 ± 0.046	4.802ValGly: 4.802 ± 0.077	1.257ValHis: 1.257 ± 0.035	4.067ValIle: 4.067 ± 0.059	2.543ValLys: 2.543 ± 0.049	7.067ValLeu: 7.067 ± 0.075	1.775ValMet: 1.775 ± 0.04	2.314ValAsn: 2.314 ± 0.049	2.776ValPro: 2.776 ± 0.055	2.43ValGln: 2.43 ± 0.045	3.52ValArg: 3.52 ± 0.054	4.392ValSer: 4.392 ± 0.067	3.457ValThr: 3.457 ± 0.062	5.204ValVal: 5.204 ± 0.085	0.745ValTrp: 0.745 ± 0.026	1.614ValTyr: 1.614 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.895TrpAla: 0.895 ± 0.028	0.161TrpCys: 0.161 ± 0.012	0.63TrpAsp: 0.63 ± 0.024	0.546TrpGlu: 0.546 ± 0.022	0.546TrpPhe: 0.546 ± 0.023	0.875TrpGly: 0.875 ± 0.028	0.344TrpHis: 0.344 ± 0.016	0.725TrpIle: 0.725 ± 0.026	0.455TrpLys: 0.455 ± 0.019	1.885TrpLeu: 1.885 ± 0.044	0.344TrpMet: 0.344 ± 0.018	0.478TrpAsn: 0.478 ± 0.021	0.572TrpPro: 0.572 ± 0.023	0.873TrpGln: 0.873 ± 0.027	0.809TrpArg: 0.809 ± 0.027	0.788TrpSer: 0.788 ± 0.026	0.472TrpThr: 0.472 ± 0.021	0.886TrpVal: 0.886 ± 0.026	0.186TrpTrp: 0.186 ± 0.014	0.322TrpTyr: 0.322 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.069TyrAla: 2.069 ± 0.04	0.376TyrCys: 0.376 ± 0.018	1.594TyrAsp: 1.594 ± 0.065	1.321TyrGlu: 1.321 ± 0.038	1.117TyrPhe: 1.117 ± 0.03	2.077TyrGly: 2.077 ± 0.043	0.69TyrHis: 0.69 ± 0.025	1.267TyrIle: 1.267 ± 0.031	0.853TyrLys: 0.853 ± 0.029	3.339TyrLeu: 3.339 ± 0.057	0.462TyrMet: 0.462 ± 0.023	0.852TyrAsn: 0.852 ± 0.028	1.386TyrPro: 1.386 ± 0.033	1.739TyrGln: 1.739 ± 0.041	2.197TyrArg: 2.197 ± 0.043	1.698TyrSer: 1.698 ± 0.041	1.165TyrThr: 1.165 ± 0.031	1.431TyrVal: 1.431 ± 0.036	0.419TyrTrp: 0.419 ± 0.017	0.872TyrTyr: 0.872 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3762 proteins (1227948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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