Amino acid dipepetide frequency for Myxococcales bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.056AlaAla: 18.056 ± 0.135	1.751AlaCys: 1.751 ± 0.036	5.939AlaAsp: 5.939 ± 0.049	8.502AlaGlu: 8.502 ± 0.072	4.002AlaPhe: 4.002 ± 0.046	10.883AlaGly: 10.883 ± 0.089	2.266AlaHis: 2.266 ± 0.033	4.042AlaIle: 4.042 ± 0.043	3.889AlaLys: 3.889 ± 0.047	15.162AlaLeu: 15.162 ± 0.118	2.142AlaMet: 2.142 ± 0.03	2.142AlaAsn: 2.142 ± 0.034	8.26AlaPro: 8.26 ± 0.088	4.294AlaGln: 4.294 ± 0.055	10.296AlaArg: 10.296 ± 0.084	8.335AlaSer: 8.335 ± 0.069	6.107AlaThr: 6.107 ± 0.055	8.64AlaVal: 8.64 ± 0.072	1.539AlaTrp: 1.539 ± 0.024	2.321AlaTyr: 2.321 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.418CysAla: 1.418 ± 0.03	0.158CysCys: 0.158 ± 0.009	0.776CysAsp: 0.776 ± 0.028	0.766CysGlu: 0.766 ± 0.024	0.372CysPhe: 0.372 ± 0.012	1.37CysGly: 1.37 ± 0.041	0.309CysHis: 0.309 ± 0.013	0.331CysIle: 0.331 ± 0.012	0.318CysLys: 0.318 ± 0.015	0.935CysLeu: 0.935 ± 0.022	0.148CysMet: 0.148 ± 0.008	0.331CysAsn: 0.331 ± 0.017	0.647CysPro: 0.647 ± 0.021	0.386CysGln: 0.386 ± 0.013	0.741CysArg: 0.741 ± 0.02	0.963CysSer: 0.963 ± 0.026	0.666CysThr: 0.666 ± 0.021	0.889CysVal: 0.889 ± 0.023	0.14CysTrp: 0.14 ± 0.009	0.222CysTyr: 0.222 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.011AspAla: 7.011 ± 0.063	0.682AspCys: 0.682 ± 0.024	3.065AspAsp: 3.065 ± 0.047	3.503AspGlu: 3.503 ± 0.043	1.99AspPhe: 1.99 ± 0.027	4.968AspGly: 4.968 ± 0.067	0.971AspHis: 0.971 ± 0.02	1.684AspIle: 1.684 ± 0.029	1.437AspLys: 1.437 ± 0.032	5.331AspLeu: 5.331 ± 0.052	0.789AspMet: 0.789 ± 0.019	1.034AspAsn: 1.034 ± 0.023	3.447AspPro: 3.447 ± 0.041	1.454AspGln: 1.454 ± 0.023	3.47AspArg: 3.47 ± 0.036	2.803AspSer: 2.803 ± 0.035	2.086AspThr: 2.086 ± 0.032	4.345AspVal: 4.345 ± 0.046	0.696AspTrp: 0.696 ± 0.018	1.229AspTyr: 1.229 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.831GluAla: 7.831 ± 0.08	0.609GluCys: 0.609 ± 0.02	2.777GluAsp: 2.777 ± 0.044	3.429GluGlu: 3.429 ± 0.043	1.346GluPhe: 1.346 ± 0.026	4.604GluGly: 4.604 ± 0.045	1.481GluHis: 1.481 ± 0.026	1.975GluIle: 1.975 ± 0.035	1.934GluLys: 1.934 ± 0.036	9.023GluLeu: 9.023 ± 0.084	0.956GluMet: 0.956 ± 0.02	1.156GluAsn: 1.156 ± 0.021	3.984GluPro: 3.984 ± 0.054	2.802GluGln: 2.802 ± 0.038	6.367GluArg: 6.367 ± 0.072	3.404GluSer: 3.404 ± 0.039	2.696GluThr: 2.696 ± 0.033	4.546GluVal: 4.546 ± 0.046	0.658GluTrp: 0.658 ± 0.018	1.096GluTyr: 1.096 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.903PheAla: 3.903 ± 0.04	0.362PheCys: 0.362 ± 0.012	2.281PheAsp: 2.281 ± 0.033	2.4PheGlu: 2.4 ± 0.031	1.198PhePhe: 1.198 ± 0.025	3.4PheGly: 3.4 ± 0.039	0.646PheHis: 0.646 ± 0.017	0.965PheIle: 0.965 ± 0.022	0.905PheLys: 0.905 ± 0.022	2.798PheLeu: 2.798 ± 0.036	0.611PheMet: 0.611 ± 0.017	0.74PheAsn: 0.74 ± 0.015	1.458PhePro: 1.458 ± 0.022	1.037PheGln: 1.037 ± 0.019	2.204PheArg: 2.204 ± 0.031	2.119PheSer: 2.119 ± 0.031	1.757PheThr: 1.757 ± 0.028	2.887PheVal: 2.887 ± 0.032	0.451PheTrp: 0.451 ± 0.016	0.781PheTyr: 0.781 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.453GlyAla: 11.453 ± 0.097	1.308GlyCys: 1.308 ± 0.031	4.515GlyAsp: 4.515 ± 0.051	5.317GlyGlu: 5.317 ± 0.05	3.142GlyPhe: 3.142 ± 0.038	9.117GlyGly: 9.117 ± 0.125	1.574GlyHis: 1.574 ± 0.025	3.118GlyIle: 3.118 ± 0.042	3.463GlyLys: 3.463 ± 0.048	8.022GlyLeu: 8.022 ± 0.06	1.76GlyMet: 1.76 ± 0.03	2.066GlyAsn: 2.066 ± 0.037	3.844GlyPro: 3.844 ± 0.045	2.813GlyGln: 2.813 ± 0.036	5.88GlyArg: 5.88 ± 0.051	6.513GlySer: 6.513 ± 0.074	4.934GlyThr: 4.934 ± 0.062	6.663GlyVal: 6.663 ± 0.063	1.133GlyTrp: 1.133 ± 0.023	2.142GlyTyr: 2.142 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.381HisAla: 2.381 ± 0.032	0.254HisCys: 0.254 ± 0.011	1.059HisAsp: 1.059 ± 0.021	1.237HisGlu: 1.237 ± 0.023	0.796HisPhe: 0.796 ± 0.019	1.831HisGly: 1.831 ± 0.03	0.561HisHis: 0.561 ± 0.018	0.539HisIle: 0.539 ± 0.015	0.35HisLys: 0.35 ± 0.011	1.942HisLeu: 1.942 ± 0.031	0.272HisMet: 0.272 ± 0.009	0.361HisAsn: 0.361 ± 0.013	1.245HisPro: 1.245 ± 0.022	0.582HisGln: 0.582 ± 0.015	1.554HisArg: 1.554 ± 0.027	0.92HisSer: 0.92 ± 0.02	0.812HisThr: 0.812 ± 0.018	1.718HisVal: 1.718 ± 0.029	0.258HisTrp: 0.258 ± 0.01	0.526HisTyr: 0.526 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.562IleAla: 4.562 ± 0.045	0.35IleCys: 0.35 ± 0.014	2.263IleAsp: 2.263 ± 0.031	2.371IleGlu: 2.371 ± 0.037	0.969IlePhe: 0.969 ± 0.02	3.073IleGly: 3.073 ± 0.036	0.63IleHis: 0.63 ± 0.016	1.023IleIle: 1.023 ± 0.023	0.974IleLys: 0.974 ± 0.026	2.629IleLeu: 2.629 ± 0.041	0.417IleMet: 0.417 ± 0.014	0.748IleAsn: 0.748 ± 0.02	1.615IlePro: 1.615 ± 0.026	0.982IleGln: 0.982 ± 0.023	2.04IleArg: 2.04 ± 0.032	1.958IleSer: 1.958 ± 0.031	1.765IleThr: 1.765 ± 0.029	2.867IleVal: 2.867 ± 0.04	0.362IleTrp: 0.362 ± 0.011	0.709IleTyr: 0.709 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.392LysAla: 3.392 ± 0.054	0.251LysCys: 0.251 ± 0.014	1.592LysAsp: 1.592 ± 0.033	1.616LysGlu: 1.616 ± 0.034	0.768LysPhe: 0.768 ± 0.019	2.061LysGly: 2.061 ± 0.032	0.594LysHis: 0.594 ± 0.017	1.103LysIle: 1.103 ± 0.027	1.395LysLys: 1.395 ± 0.039	3.832LysLeu: 3.832 ± 0.042	0.56LysMet: 0.56 ± 0.016	0.855LysAsn: 0.855 ± 0.02	2.153LysPro: 2.153 ± 0.037	1.16LysGln: 1.16 ± 0.025	2.407LysArg: 2.407 ± 0.03	1.904LysSer: 1.904 ± 0.029	1.65LysThr: 1.65 ± 0.03	2.411LysVal: 2.411 ± 0.034	0.283LysTrp: 0.283 ± 0.011	0.613LysTyr: 0.613 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.047LeuAla: 14.047 ± 0.09	1.188LeuCys: 1.188 ± 0.024	5.682LeuAsp: 5.682 ± 0.056	7.089LeuGlu: 7.089 ± 0.069	3.333LeuPhe: 3.333 ± 0.039	10.093LeuGly: 10.093 ± 0.088	1.987LeuHis: 1.987 ± 0.029	3.001LeuIle: 3.001 ± 0.044	3.1LeuLys: 3.1 ± 0.038	11.65LeuLeu: 11.65 ± 0.105	1.637LeuMet: 1.637 ± 0.028	2.054LeuAsn: 2.054 ± 0.031	6.254LeuPro: 6.254 ± 0.053	3.055LeuGln: 3.055 ± 0.041	8.629LeuArg: 8.629 ± 0.075	7.987LeuSer: 7.987 ± 0.083	5.749LeuThr: 5.749 ± 0.049	8.311LeuVal: 8.311 ± 0.061	1.226LeuTrp: 1.226 ± 0.025	2.024LeuTyr: 2.024 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.97MetAla: 1.97 ± 0.03	0.138MetCys: 0.138 ± 0.008	0.71MetAsp: 0.71 ± 0.016	0.744MetGlu: 0.744 ± 0.02	0.456MetPhe: 0.456 ± 0.014	1.287MetGly: 1.287 ± 0.023	0.308MetHis: 0.308 ± 0.012	0.537MetIle: 0.537 ± 0.017	0.762MetLys: 0.762 ± 0.016	1.811MetLeu: 1.811 ± 0.03	0.326MetMet: 0.326 ± 0.012	0.495MetAsn: 0.495 ± 0.016	1.131MetPro: 1.131 ± 0.021	0.603MetGln: 0.603 ± 0.016	1.338MetArg: 1.338 ± 0.023	1.397MetSer: 1.397 ± 0.023	1.081MetThr: 1.081 ± 0.022	1.114MetVal: 1.114 ± 0.025	0.17MetTrp: 0.17 ± 0.008	0.242MetTyr: 0.242 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.51AsnAla: 2.51 ± 0.037	0.286AsnCys: 0.286 ± 0.013	1.253AsnAsp: 1.253 ± 0.026	1.175AsnGlu: 1.175 ± 0.021	0.683AsnPhe: 0.683 ± 0.019	2.087AsnGly: 2.087 ± 0.041	0.421AsnHis: 0.421 ± 0.013	0.756AsnIle: 0.756 ± 0.02	0.567AsnLys: 0.567 ± 0.017	2.116AsnLeu: 2.116 ± 0.034	0.353AsnMet: 0.353 ± 0.013	0.56AsnAsn: 0.56 ± 0.016	1.434AsnPro: 1.434 ± 0.025	0.744AsnGln: 0.744 ± 0.017	1.318AsnArg: 1.318 ± 0.024	0.969AsnSer: 0.969 ± 0.021	0.983AsnThr: 0.983 ± 0.024	1.954AsnVal: 1.954 ± 0.032	0.281AsnTrp: 0.281 ± 0.01	0.505AsnTyr: 0.505 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.582ProAla: 7.582 ± 0.074	0.514ProCys: 0.514 ± 0.014	3.059ProAsp: 3.059 ± 0.039	4.406ProGlu: 4.406 ± 0.049	1.888ProPhe: 1.888 ± 0.028	5.077ProGly: 5.077 ± 0.05	1.101ProHis: 1.101 ± 0.019	1.798ProIle: 1.798 ± 0.025	1.844ProLys: 1.844 ± 0.028	5.59ProLeu: 5.59 ± 0.061	1.048ProMet: 1.048 ± 0.02	1.352ProAsn: 1.352 ± 0.023	4.732ProPro: 4.732 ± 0.08	1.766ProGln: 1.766 ± 0.028	4.001ProArg: 4.001 ± 0.048	4.536ProSer: 4.536 ± 0.043	3.131ProThr: 3.131 ± 0.039	3.994ProVal: 3.994 ± 0.047	0.739ProTrp: 0.739 ± 0.02	1.063ProTyr: 1.063 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.067GlnAla: 4.067 ± 0.044	0.351GlnCys: 0.351 ± 0.015	1.366GlnAsp: 1.366 ± 0.026	1.618GlnGlu: 1.618 ± 0.027	0.837GlnPhe: 0.837 ± 0.019	2.556GlnGly: 2.556 ± 0.029	0.696GlnHis: 0.696 ± 0.017	1.134GlnIle: 1.134 ± 0.023	1.097GlnLys: 1.097 ± 0.024	4.045GlnLeu: 4.045 ± 0.058	0.569GlnMet: 0.569 ± 0.015	0.789GlnAsn: 0.789 ± 0.018	1.838GlnPro: 1.838 ± 0.025	1.292GlnGln: 1.292 ± 0.026	3.015GlnArg: 3.015 ± 0.036	1.98GlnSer: 1.98 ± 0.034	1.601GlnThr: 1.601 ± 0.025	2.598GlnVal: 2.598 ± 0.04	0.365GlnTrp: 0.365 ± 0.01	0.623GlnTyr: 0.623 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.29ArgAla: 10.29 ± 0.096	0.755ArgCys: 0.755 ± 0.021	3.742ArgAsp: 3.742 ± 0.042	4.968ArgGlu: 4.968 ± 0.058	3.044ArgPhe: 3.044 ± 0.039	5.935ArgGly: 5.935 ± 0.054	1.513ArgHis: 1.513 ± 0.027	2.91ArgIle: 2.91 ± 0.035	2.06ArgLys: 2.06 ± 0.031	8.516ArgLeu: 8.516 ± 0.079	1.384ArgMet: 1.384 ± 0.025	1.29ArgAsn: 1.29 ± 0.024	3.776ArgPro: 3.776 ± 0.043	2.36ArgGln: 2.36 ± 0.034	6.571ArgArg: 6.571 ± 0.077	4.722ArgSer: 4.722 ± 0.055	3.292ArgThr: 3.292 ± 0.037	6.224ArgVal: 6.224 ± 0.05	1.067ArgTrp: 1.067 ± 0.02	1.947ArgTyr: 1.947 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	8.725SerAla: 8.725 ± 0.08	0.895SerCys: 0.895 ± 0.024	3.139SerAsp: 3.139 ± 0.037	3.773SerGlu: 3.773 ± 0.041	2.392SerPhe: 2.392 ± 0.029	6.925SerGly: 6.925 ± 0.072	1.11SerHis: 1.11 ± 0.021	2.16SerIle: 2.16 ± 0.033	1.863SerLys: 1.863 ± 0.029	6.818SerLeu: 6.818 ± 0.062	1.066SerMet: 1.066 ± 0.022	1.358SerAsn: 1.358 ± 0.029	4.019SerPro: 4.019 ± 0.049	1.891SerGln: 1.891 ± 0.029	4.599SerArg: 4.599 ± 0.049	4.998SerSer: 4.998 ± 0.053	3.263SerThr: 3.263 ± 0.039	4.884SerVal: 4.884 ± 0.043	0.846SerTrp: 0.846 ± 0.021	1.42SerTyr: 1.42 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.971ThrAla: 5.971 ± 0.056	0.672ThrCys: 0.672 ± 0.022	2.568ThrAsp: 2.568 ± 0.038	2.869ThrGlu: 2.869 ± 0.034	1.884ThrPhe: 1.884 ± 0.029	4.64ThrGly: 4.64 ± 0.055	0.942ThrHis: 0.942 ± 0.02	1.745ThrIle: 1.745 ± 0.031	1.451ThrLys: 1.451 ± 0.029	5.661ThrLeu: 5.661 ± 0.044	0.726ThrMet: 0.726 ± 0.019	1.176ThrAsn: 1.176 ± 0.027	3.482ThrPro: 3.482 ± 0.044	1.585ThrGln: 1.585 ± 0.042	3.475ThrArg: 3.475 ± 0.04	3.413ThrSer: 3.413 ± 0.039	2.927ThrThr: 2.927 ± 0.044	3.683ThrVal: 3.683 ± 0.046	0.712ThrTrp: 0.712 ± 0.018	1.081ThrTyr: 1.081 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	9.832ValAla: 9.832 ± 0.077	0.933ValCys: 0.933 ± 0.022	4.28ValAsp: 4.28 ± 0.039	4.864ValGlu: 4.864 ± 0.044	2.427ValPhe: 2.427 ± 0.036	6.109ValGly: 6.109 ± 0.053	1.422ValHis: 1.422 ± 0.025	2.575ValIle: 2.575 ± 0.036	2.298ValLys: 2.298 ± 0.038	8.244ValLeu: 8.244 ± 0.068	1.302ValMet: 1.302 ± 0.022	1.627ValAsn: 1.627 ± 0.029	4.304ValPro: 4.304 ± 0.042	2.328ValGln: 2.328 ± 0.029	5.694ValArg: 5.694 ± 0.056	5.164ValSer: 5.164 ± 0.047	4.585ValThr: 4.585 ± 0.058	6.81ValVal: 6.81 ± 0.056	0.932ValTrp: 0.932 ± 0.019	1.563ValTyr: 1.563 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.267TrpAla: 1.267 ± 0.023	0.152TrpCys: 0.152 ± 0.008	0.595TrpAsp: 0.595 ± 0.015	0.625TrpGlu: 0.625 ± 0.017	0.486TrpPhe: 0.486 ± 0.015	0.91TrpGly: 0.91 ± 0.02	0.255TrpHis: 0.255 ± 0.011	0.39TrpIle: 0.39 ± 0.012	0.382TrpLys: 0.382 ± 0.014	1.77TrpLeu: 1.77 ± 0.03	0.241TrpMet: 0.241 ± 0.011	0.333TrpAsn: 0.333 ± 0.012	0.572TrpPro: 0.572 ± 0.014	0.522TrpGln: 0.522 ± 0.013	0.933TrpArg: 0.933 ± 0.022	0.887TrpSer: 0.887 ± 0.019	0.61TrpThr: 0.61 ± 0.016	0.97TrpVal: 0.97 ± 0.017	0.184TrpTrp: 0.184 ± 0.009	0.26TrpTyr: 0.26 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.299TyrAla: 2.299 ± 0.034	0.28TyrCys: 0.28 ± 0.012	1.333TyrAsp: 1.333 ± 0.025	1.401TyrGlu: 1.401 ± 0.031	0.89TyrPhe: 0.89 ± 0.019	1.852TyrGly: 1.852 ± 0.027	0.409TyrHis: 0.409 ± 0.014	0.518TyrIle: 0.518 ± 0.019	0.51TyrLys: 0.51 ± 0.019	2.202TyrLeu: 2.202 ± 0.037	0.312TyrMet: 0.312 ± 0.01	0.488TyrAsn: 0.488 ± 0.015	1.027TyrPro: 1.027 ± 0.02	0.779TyrGln: 0.779 ± 0.02	1.835TyrArg: 1.835 ± 0.03	1.173TyrSer: 1.173 ± 0.022	0.965TyrThr: 0.965 ± 0.021	1.79TyrVal: 1.79 ± 0.03	0.3TyrTrp: 0.3 ± 0.011	0.583TyrTyr: 0.583 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7151 proteins (2565783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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