Amino acid dipepetide frequency for Desulfosarcina widdelii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.947AlaAla: 9.947 ± 0.106	1.319AlaCys: 1.319 ± 0.03	5.456AlaAsp: 5.456 ± 0.061	5.48AlaGlu: 5.48 ± 0.056	3.835AlaPhe: 3.835 ± 0.045	7.564AlaGly: 7.564 ± 0.081	1.71AlaHis: 1.71 ± 0.032	5.885AlaIle: 5.885 ± 0.057	4.059AlaLys: 4.059 ± 0.045	8.999AlaLeu: 8.999 ± 0.071	2.957AlaMet: 2.957 ± 0.038	2.676AlaAsn: 2.676 ± 0.035	3.22AlaPro: 3.22 ± 0.042	2.566AlaGln: 2.566 ± 0.037	5.365AlaArg: 5.365 ± 0.055	4.607AlaSer: 4.607 ± 0.052	4.362AlaThr: 4.362 ± 0.046	7.333AlaVal: 7.333 ± 0.079	1.032AlaTrp: 1.032 ± 0.024	2.525AlaTyr: 2.525 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.002CysAla: 1.002 ± 0.024	0.252CysCys: 0.252 ± 0.011	0.697CysAsp: 0.697 ± 0.019	0.658CysGlu: 0.658 ± 0.021	0.512CysPhe: 0.512 ± 0.016	1.336CysGly: 1.336 ± 0.032	0.406CysHis: 0.406 ± 0.02	0.746CysIle: 0.746 ± 0.023	0.538CysLys: 0.538 ± 0.016	1.192CysLeu: 1.192 ± 0.024	0.329CysMet: 0.329 ± 0.012	0.421CysAsn: 0.421 ± 0.012	0.81CysPro: 0.81 ± 0.023	0.386CysGln: 0.386 ± 0.013	1.016CysArg: 1.016 ± 0.022	0.751CysSer: 0.751 ± 0.02	0.659CysThr: 0.659 ± 0.019	0.752CysVal: 0.752 ± 0.02	0.145CysTrp: 0.145 ± 0.008	0.359CysTyr: 0.359 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.289AspAla: 5.289 ± 0.059	0.675AspCys: 0.675 ± 0.021	3.218AspAsp: 3.218 ± 0.051	3.646AspGlu: 3.646 ± 0.048	2.615AspPhe: 2.615 ± 0.04	4.415AspGly: 4.415 ± 0.055	1.346AspHis: 1.346 ± 0.025	3.944AspIle: 3.944 ± 0.046	2.47AspLys: 2.47 ± 0.037	6.192AspLeu: 6.192 ± 0.059	1.48AspMet: 1.48 ± 0.028	1.763AspAsn: 1.763 ± 0.032	3.182AspPro: 3.182 ± 0.045	1.932AspGln: 1.932 ± 0.028	4.355AspArg: 4.355 ± 0.053	2.708AspSer: 2.708 ± 0.036	2.761AspThr: 2.761 ± 0.04	3.751AspVal: 3.751 ± 0.047	0.738AspTrp: 0.738 ± 0.021	1.833AspTyr: 1.833 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.004GluAla: 6.004 ± 0.058	0.544GluCys: 0.544 ± 0.016	3.282GluAsp: 3.282 ± 0.041	4.098GluGlu: 4.098 ± 0.051	1.943GluPhe: 1.943 ± 0.03	3.83GluGly: 3.83 ± 0.042	1.091GluHis: 1.091 ± 0.025	4.616GluIle: 4.616 ± 0.048	5.099GluLys: 5.099 ± 0.056	5.414GluLeu: 5.414 ± 0.06	2.012GluMet: 2.012 ± 0.03	2.788GluAsn: 2.788 ± 0.042	2.254GluPro: 2.254 ± 0.037	2.226GluGln: 2.226 ± 0.034	3.907GluArg: 3.907 ± 0.048	3.423GluSer: 3.423 ± 0.039	3.871GluThr: 3.871 ± 0.051	3.797GluVal: 3.797 ± 0.048	0.566GluTrp: 0.566 ± 0.017	1.514GluTyr: 1.514 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.287PheAla: 3.287 ± 0.045	0.618PheCys: 0.618 ± 0.019	2.73PheAsp: 2.73 ± 0.042	2.445PheGlu: 2.445 ± 0.035	2.238PhePhe: 2.238 ± 0.037	3.275PheGly: 3.275 ± 0.044	0.875PheHis: 0.875 ± 0.024	2.5PheIle: 2.5 ± 0.038	2.034PheLys: 2.034 ± 0.031	3.955PheLeu: 3.955 ± 0.049	1.065PheMet: 1.065 ± 0.026	1.577PheAsn: 1.577 ± 0.029	1.726PhePro: 1.726 ± 0.028	1.296PheGln: 1.296 ± 0.024	2.17PheArg: 2.17 ± 0.037	3.08PheSer: 3.08 ± 0.046	2.292PheThr: 2.292 ± 0.032	2.842PheVal: 2.842 ± 0.039	0.548PheTrp: 0.548 ± 0.019	1.339PheTyr: 1.339 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	5.952GlyAla: 5.952 ± 0.067	1.236GlyCys: 1.236 ± 0.027	3.787GlyAsp: 3.787 ± 0.045	4.177GlyGlu: 4.177 ± 0.046	3.403GlyPhe: 3.403 ± 0.04	5.764GlyGly: 5.764 ± 0.074	1.619GlyHis: 1.619 ± 0.029	5.708GlyIle: 5.708 ± 0.058	4.512GlyLys: 4.512 ± 0.052	7.36GlyLeu: 7.36 ± 0.074	2.49GlyMet: 2.49 ± 0.037	2.469GlyAsn: 2.469 ± 0.036	2.569GlyPro: 2.569 ± 0.037	2.633GlyGln: 2.633 ± 0.042	4.744GlyArg: 4.744 ± 0.054	4.29GlySer: 4.29 ± 0.053	4.157GlyThr: 4.157 ± 0.054	5.291GlyVal: 5.291 ± 0.054	1.024GlyTrp: 1.024 ± 0.023	2.647GlyTyr: 2.647 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	1.617HisAla: 1.617 ± 0.029	0.344HisCys: 0.344 ± 0.013	1.045HisAsp: 1.045 ± 0.024	1.127HisGlu: 1.127 ± 0.024	0.956HisPhe: 0.956 ± 0.022	1.555HisGly: 1.555 ± 0.031	0.605HisHis: 0.605 ± 0.017	1.264HisIle: 1.264 ± 0.024	0.769HisLys: 0.769 ± 0.02	2.252HisLeu: 2.252 ± 0.034	0.517HisMet: 0.517 ± 0.016	0.638HisAsn: 0.638 ± 0.02	1.346HisPro: 1.346 ± 0.03	0.732HisGln: 0.732 ± 0.019	1.549HisArg: 1.549 ± 0.027	1.044HisSer: 1.044 ± 0.023	1.064HisThr: 1.064 ± 0.025	1.306HisVal: 1.306 ± 0.022	0.29HisTrp: 0.29 ± 0.013	0.685HisTyr: 0.685 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.035IleAla: 6.035 ± 0.051	0.909IleCys: 0.909 ± 0.025	4.558IleAsp: 4.558 ± 0.049	4.467IleGlu: 4.467 ± 0.054	2.62IlePhe: 2.62 ± 0.04	5.099IleGly: 5.099 ± 0.049	1.508IleHis: 1.508 ± 0.027	3.433IleIle: 3.433 ± 0.046	3.06IleLys: 3.06 ± 0.046	5.977IleLeu: 5.977 ± 0.055	1.474IleMet: 1.474 ± 0.027	2.285IleAsn: 2.285 ± 0.042	3.131IlePro: 3.131 ± 0.038	2.294IleGln: 2.294 ± 0.033	4.231IleArg: 4.231 ± 0.051	3.796IleSer: 3.796 ± 0.049	3.198IleThr: 3.198 ± 0.044	4.832IleVal: 4.832 ± 0.056	0.602IleTrp: 0.602 ± 0.018	1.767IleTyr: 1.767 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.866LysAla: 4.866 ± 0.052	0.462LysCys: 0.462 ± 0.016	2.873LysAsp: 2.873 ± 0.041	3.652LysGlu: 3.652 ± 0.051	1.452LysPhe: 1.452 ± 0.028	3.914LysGly: 3.914 ± 0.046	0.9LysHis: 0.9 ± 0.022	3.678LysIle: 3.678 ± 0.051	4.085LysLys: 4.085 ± 0.062	4.109LysLeu: 4.109 ± 0.05	1.595LysMet: 1.595 ± 0.029	2.283LysAsn: 2.283 ± 0.037	2.345LysPro: 2.345 ± 0.039	1.824LysGln: 1.824 ± 0.034	3.306LysArg: 3.306 ± 0.041	2.861LysSer: 2.861 ± 0.04	3.292LysThr: 3.292 ± 0.043	3.155LysVal: 3.155 ± 0.05	0.594LysTrp: 0.594 ± 0.018	1.332LysTyr: 1.332 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	9.391LeuAla: 9.391 ± 0.083	1.204LeuCys: 1.204 ± 0.026	5.803LeuAsp: 5.803 ± 0.058	6.243LeuGlu: 6.243 ± 0.059	4.294LeuPhe: 4.294 ± 0.05	6.801LeuGly: 6.801 ± 0.064	1.688LeuHis: 1.688 ± 0.03	5.883LeuIle: 5.883 ± 0.059	5.758LeuLys: 5.758 ± 0.058	9.158LeuLeu: 9.158 ± 0.098	2.538LeuMet: 2.538 ± 0.039	3.539LeuAsn: 3.539 ± 0.05	4.65LeuPro: 4.65 ± 0.044	2.971LeuGln: 2.971 ± 0.037	4.946LeuArg: 4.946 ± 0.05	6.401LeuSer: 6.401 ± 0.061	5.213LeuThr: 5.213 ± 0.054	6.657LeuVal: 6.657 ± 0.065	0.943LeuTrp: 0.943 ± 0.023	2.527LeuTyr: 2.527 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.303MetAla: 3.303 ± 0.039	0.253MetCys: 0.253 ± 0.014	1.807MetAsp: 1.807 ± 0.034	1.849MetGlu: 1.849 ± 0.03	0.823MetPhe: 0.823 ± 0.019	2.295MetGly: 2.295 ± 0.036	0.484MetHis: 0.484 ± 0.014	1.802MetIle: 1.802 ± 0.029	1.647MetLys: 1.647 ± 0.026	2.433MetLeu: 2.433 ± 0.035	0.754MetMet: 0.754 ± 0.02	1.096MetAsn: 1.096 ± 0.022	1.346MetPro: 1.346 ± 0.027	0.921MetGln: 0.921 ± 0.019	1.419MetArg: 1.419 ± 0.026	1.382MetSer: 1.382 ± 0.026	1.674MetThr: 1.674 ± 0.027	2.201MetVal: 2.201 ± 0.032	0.203MetTrp: 0.203 ± 0.008	0.454MetTyr: 0.454 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.939AsnAla: 2.939 ± 0.042	0.485AsnCys: 0.485 ± 0.016	1.807AsnAsp: 1.807 ± 0.03	1.835AsnGlu: 1.835 ± 0.032	1.355AsnPhe: 1.355 ± 0.026	2.667AsnGly: 2.667 ± 0.035	0.759AsnHis: 0.759 ± 0.023	2.317AsnIle: 2.317 ± 0.038	1.432AsnLys: 1.432 ± 0.03	3.661AsnLeu: 3.661 ± 0.05	0.881AsnMet: 0.881 ± 0.02	1.147AsnAsn: 1.147 ± 0.026	2.135AsnPro: 2.135 ± 0.031	1.227AsnGln: 1.227 ± 0.026	2.743AsnArg: 2.743 ± 0.035	1.569AsnSer: 1.569 ± 0.027	1.607AsnThr: 1.607 ± 0.027	2.283AsnVal: 2.283 ± 0.031	0.464AsnTrp: 0.464 ± 0.015	1.047AsnTyr: 1.047 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	4.028ProAla: 4.028 ± 0.053	0.51ProCys: 0.51 ± 0.017	3.378ProAsp: 3.378 ± 0.042	3.821ProGlu: 3.821 ± 0.046	2.004ProPhe: 2.004 ± 0.032	3.606ProGly: 3.606 ± 0.039	0.923ProHis: 0.923 ± 0.022	2.479ProIle: 2.479 ± 0.036	2.04ProLys: 2.04 ± 0.034	4.116ProLeu: 4.116 ± 0.05	1.214ProMet: 1.214 ± 0.024	1.31ProAsn: 1.31 ± 0.024	2.043ProPro: 2.043 ± 0.045	1.408ProGln: 1.408 ± 0.025	2.039ProArg: 2.039 ± 0.037	2.381ProSer: 2.381 ± 0.034	2.084ProThr: 2.084 ± 0.034	3.923ProVal: 3.923 ± 0.041	0.574ProTrp: 0.574 ± 0.019	1.254ProTyr: 1.254 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.489GlnAla: 3.489 ± 0.047	0.402GlnCys: 0.402 ± 0.015	1.569GlnAsp: 1.569 ± 0.029	1.922GlnGlu: 1.922 ± 0.029	1.215GlnPhe: 1.215 ± 0.027	2.209GlnGly: 2.209 ± 0.035	0.588GlnHis: 0.588 ± 0.018	2.235GlnIle: 2.235 ± 0.031	1.913GlnLys: 1.913 ± 0.033	3.198GlnLeu: 3.198 ± 0.044	1.033GlnMet: 1.033 ± 0.022	1.119GlnAsn: 1.119 ± 0.022	1.485GlnPro: 1.485 ± 0.028	1.342GlnGln: 1.342 ± 0.028	2.327GlnArg: 2.327 ± 0.037	1.847GlnSer: 1.847 ± 0.033	1.895GlnThr: 1.895 ± 0.034	2.397GlnVal: 2.397 ± 0.034	0.497GlnTrp: 0.497 ± 0.015	0.91GlnTyr: 0.91 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.236ArgAla: 4.236 ± 0.049	0.871ArgCys: 0.871 ± 0.021	3.062ArgAsp: 3.062 ± 0.041	3.927ArgGlu: 3.927 ± 0.047	3.068ArgPhe: 3.068 ± 0.038	3.226ArgGly: 3.226 ± 0.043	1.492ArgHis: 1.492 ± 0.025	4.639ArgIle: 4.639 ± 0.057	3.595ArgLys: 3.595 ± 0.044	6.797ArgLeu: 6.797 ± 0.076	1.968ArgMet: 1.968 ± 0.029	2.01ArgAsn: 2.01 ± 0.032	2.627ArgPro: 2.627 ± 0.039	2.866ArgGln: 2.866 ± 0.043	4.225ArgArg: 4.225 ± 0.056	3.42ArgSer: 3.42 ± 0.039	2.971ArgThr: 2.971 ± 0.041	4.033ArgVal: 4.033 ± 0.051	0.857ArgTrp: 0.857 ± 0.02	2.135ArgTyr: 2.135 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.665SerAla: 4.665 ± 0.047	0.648SerCys: 0.648 ± 0.02	3.286SerAsp: 3.286 ± 0.041	3.276SerGlu: 3.276 ± 0.044	2.332SerPhe: 2.332 ± 0.037	5.34SerGly: 5.34 ± 0.057	1.226SerHis: 1.226 ± 0.021	3.615SerIle: 3.615 ± 0.049	2.477SerLys: 2.477 ± 0.041	5.549SerLeu: 5.549 ± 0.058	1.621SerMet: 1.621 ± 0.031	1.677SerAsn: 1.677 ± 0.03	2.578SerPro: 2.578 ± 0.035	1.838SerGln: 1.838 ± 0.028	3.628SerArg: 3.628 ± 0.042	3.166SerSer: 3.166 ± 0.04	2.685SerThr: 2.685 ± 0.036	3.904SerVal: 3.904 ± 0.043	0.66SerTrp: 0.66 ± 0.02	1.548SerTyr: 1.548 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.088ThrAla: 5.088 ± 0.05	0.642ThrCys: 0.642 ± 0.018	3.025ThrAsp: 3.025 ± 0.037	2.823ThrGlu: 2.823 ± 0.04	2.129ThrPhe: 2.129 ± 0.033	4.901ThrGly: 4.901 ± 0.048	1.104ThrHis: 1.104 ± 0.027	3.81ThrIle: 3.81 ± 0.04	1.782ThrLys: 1.782 ± 0.027	5.3ThrLeu: 5.3 ± 0.047	1.319ThrMet: 1.319 ± 0.026	1.498ThrAsn: 1.498 ± 0.031	2.688ThrPro: 2.688 ± 0.036	1.449ThrGln: 1.449 ± 0.026	3.037ThrArg: 3.037 ± 0.044	2.521ThrSer: 2.521 ± 0.037	2.766ThrThr: 2.766 ± 0.043	4.506ThrVal: 4.506 ± 0.053	0.565ThrTrp: 0.565 ± 0.019	1.459ThrTyr: 1.459 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	6.625ValAla: 6.625 ± 0.071	1.018ValCys: 1.018 ± 0.023	4.578ValAsp: 4.578 ± 0.049	4.473ValGlu: 4.473 ± 0.042	3.188ValPhe: 3.188 ± 0.041	5.044ValGly: 5.044 ± 0.055	1.414ValHis: 1.414 ± 0.027	4.403ValIle: 4.403 ± 0.039	3.492ValLys: 3.492 ± 0.047	6.741ValLeu: 6.741 ± 0.058	1.869ValMet: 1.869 ± 0.031	2.644ValAsn: 2.644 ± 0.035	3.058ValPro: 3.058 ± 0.037	2.09ValGln: 2.09 ± 0.028	4.001ValArg: 4.001 ± 0.045	4.283ValSer: 4.283 ± 0.051	3.788ValThr: 3.788 ± 0.053	5.74ValVal: 5.74 ± 0.058	0.711ValTrp: 0.711 ± 0.018	1.923ValTyr: 1.923 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.861TrpAla: 0.861 ± 0.022	0.148TrpCys: 0.148 ± 0.009	0.62TrpAsp: 0.62 ± 0.02	0.689TrpGlu: 0.689 ± 0.019	0.539TrpPhe: 0.539 ± 0.017	0.753TrpGly: 0.753 ± 0.02	0.27TrpHis: 0.27 ± 0.01	0.806TrpIle: 0.806 ± 0.021	0.637TrpLys: 0.637 ± 0.016	1.208TrpLeu: 1.208 ± 0.027	0.375TrpMet: 0.375 ± 0.013	0.438TrpAsn: 0.438 ± 0.015	0.514TrpPro: 0.514 ± 0.016	0.548TrpGln: 0.548 ± 0.016	0.695TrpArg: 0.695 ± 0.018	0.627TrpSer: 0.627 ± 0.02	0.589TrpThr: 0.589 ± 0.018	0.783TrpVal: 0.783 ± 0.019	0.181TrpTrp: 0.181 ± 0.01	0.316TrpTyr: 0.316 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.271TyrAla: 2.271 ± 0.029	0.426TyrCys: 0.426 ± 0.016	1.736TyrAsp: 1.736 ± 0.033	1.668TyrGlu: 1.668 ± 0.028	1.37TyrPhe: 1.37 ± 0.026	2.237TyrGly: 2.237 ± 0.033	0.698TyrHis: 0.698 ± 0.021	1.514TyrIle: 1.514 ± 0.026	1.178TyrLys: 1.178 ± 0.025	2.998TyrLeu: 2.998 ± 0.045	0.653TyrMet: 0.653 ± 0.016	0.983TyrAsn: 0.983 ± 0.023	1.429TyrPro: 1.429 ± 0.026	1.046TyrGln: 1.046 ± 0.022	2.321TyrArg: 2.321 ± 0.032	1.56TyrSer: 1.56 ± 0.032	1.486TyrThr: 1.486 ± 0.029	1.596TyrVal: 1.596 ± 0.031	0.405TyrTrp: 0.405 ± 0.013	1.001TyrTyr: 1.001 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6679 proteins (2063912 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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