Amino acid dipepetide frequency for Legionella drancourtii LLAP12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.719AlaAla: 6.719 ± 0.102	1.027AlaCys: 1.027 ± 0.033	3.577AlaAsp: 3.577 ± 0.064	4.606AlaGlu: 4.606 ± 0.083	3.224AlaPhe: 3.224 ± 0.055	4.806AlaGly: 4.806 ± 0.082	1.97AlaHis: 1.97 ± 0.044	6.068AlaIle: 6.068 ± 0.075	4.971AlaLys: 4.971 ± 0.064	9.728AlaLeu: 9.728 ± 0.113	2.121AlaMet: 2.121 ± 0.053	3.688AlaAsn: 3.688 ± 0.063	2.759AlaPro: 2.759 ± 0.055	4.168AlaGln: 4.168 ± 0.081	3.469AlaArg: 3.469 ± 0.06	4.727AlaSer: 4.727 ± 0.06	4.298AlaThr: 4.298 ± 0.069	4.809AlaVal: 4.809 ± 0.073	0.839AlaTrp: 0.839 ± 0.028	2.685AlaTyr: 2.685 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.895CysAla: 0.895 ± 0.033	0.181CysCys: 0.181 ± 0.011	0.583CysAsp: 0.583 ± 0.022	0.616CysGlu: 0.616 ± 0.023	0.684CysPhe: 0.684 ± 0.025	0.817CysGly: 0.817 ± 0.034	0.337CysHis: 0.337 ± 0.019	0.827CysIle: 0.827 ± 0.028	0.57CysLys: 0.57 ± 0.024	1.329CysLeu: 1.329 ± 0.035	0.295CysMet: 0.295 ± 0.018	0.491CysAsn: 0.491 ± 0.022	0.471CysPro: 0.471 ± 0.022	0.56CysGln: 0.56 ± 0.023	0.466CysArg: 0.466 ± 0.023	0.841CysSer: 0.841 ± 0.031	0.596CysThr: 0.596 ± 0.024	0.657CysVal: 0.657 ± 0.027	0.143CysTrp: 0.143 ± 0.011	0.472CysTyr: 0.472 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.983AspAla: 3.983 ± 0.076	0.559AspCys: 0.559 ± 0.021	2.359AspAsp: 2.359 ± 0.047	3.655AspGlu: 3.655 ± 0.059	2.446AspPhe: 2.446 ± 0.044	2.608AspGly: 2.608 ± 0.051	0.901AspHis: 0.901 ± 0.032	3.491AspIle: 3.491 ± 0.061	3.417AspLys: 3.417 ± 0.058	5.103AspLeu: 5.103 ± 0.074	1.112AspMet: 1.112 ± 0.03	2.37AspAsn: 2.37 ± 0.043	1.823AspPro: 1.823 ± 0.039	1.454AspGln: 1.454 ± 0.038	1.761AspArg: 1.761 ± 0.043	2.859AspSer: 2.859 ± 0.053	2.262AspThr: 2.262 ± 0.037	3.159AspVal: 3.159 ± 0.072	0.674AspTrp: 0.674 ± 0.026	2.024AspTyr: 2.024 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.327GluAla: 4.327 ± 0.076	0.597GluCys: 0.597 ± 0.021	2.389GluAsp: 2.389 ± 0.051	3.949GluGlu: 3.949 ± 0.069	2.305GluPhe: 2.305 ± 0.047	2.862GluGly: 2.862 ± 0.056	1.896GluHis: 1.896 ± 0.044	4.246GluIle: 4.246 ± 0.065	4.374GluLys: 4.374 ± 0.08	6.961GluLeu: 6.961 ± 0.093	1.464GluMet: 1.464 ± 0.033	2.906GluAsn: 2.906 ± 0.06	1.92GluPro: 1.92 ± 0.05	3.963GluGln: 3.963 ± 0.075	3.123GluArg: 3.123 ± 0.061	3.122GluSer: 3.122 ± 0.048	2.817GluThr: 2.817 ± 0.049	3.437GluVal: 3.437 ± 0.068	0.609GluTrp: 0.609 ± 0.023	1.886GluTyr: 1.886 ± 0.04	0.001GluXaa: 0.001 ± 0.001
Phe	3.694PheAla: 3.694 ± 0.058	0.669PheCys: 0.669 ± 0.023	2.381PheAsp: 2.381 ± 0.044	2.128PheGlu: 2.128 ± 0.048	2.409PhePhe: 2.409 ± 0.053	2.473PheGly: 2.473 ± 0.058	1.033PheHis: 1.033 ± 0.032	3.559PheIle: 3.559 ± 0.061	2.563PheLys: 2.563 ± 0.05	4.416PheLeu: 4.416 ± 0.085	1.032PheMet: 1.032 ± 0.03	2.433PheAsn: 2.433 ± 0.045	1.65PhePro: 1.65 ± 0.042	1.43PheGln: 1.43 ± 0.037	1.442PheArg: 1.442 ± 0.034	3.492PheSer: 3.492 ± 0.058	2.407PheThr: 2.407 ± 0.052	2.475PheVal: 2.475 ± 0.049	0.536PheTrp: 0.536 ± 0.023	1.737PheTyr: 1.737 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.365GlyAla: 4.365 ± 0.071	0.801GlyCys: 0.801 ± 0.032	2.713GlyAsp: 2.713 ± 0.05	3.038GlyGlu: 3.038 ± 0.062	3.103GlyPhe: 3.103 ± 0.057	3.789GlyGly: 3.789 ± 0.091	1.555GlyHis: 1.555 ± 0.036	4.764GlyIle: 4.764 ± 0.072	3.625GlyLys: 3.625 ± 0.067	6.317GlyLeu: 6.317 ± 0.085	1.651GlyMet: 1.651 ± 0.045	2.493GlyAsn: 2.493 ± 0.058	1.515GlyPro: 1.515 ± 0.043	2.343GlyGln: 2.343 ± 0.041	2.477GlyArg: 2.477 ± 0.055	3.598GlySer: 3.598 ± 0.06	3.191GlyThr: 3.191 ± 0.064	3.96GlyVal: 3.96 ± 0.075	0.797GlyTrp: 0.797 ± 0.031	2.436GlyTyr: 2.436 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.06HisAla: 2.06 ± 0.04	0.397HisCys: 0.397 ± 0.018	1.233HisAsp: 1.233 ± 0.031	1.545HisGlu: 1.545 ± 0.038	1.311HisPhe: 1.311 ± 0.033	1.667HisGly: 1.667 ± 0.042	0.879HisHis: 0.879 ± 0.032	1.598HisIle: 1.598 ± 0.039	1.263HisLys: 1.263 ± 0.034	2.994HisLeu: 2.994 ± 0.061	0.553HisMet: 0.553 ± 0.024	1.023HisAsn: 1.023 ± 0.03	1.302HisPro: 1.302 ± 0.036	1.399HisGln: 1.399 ± 0.038	1.06HisArg: 1.06 ± 0.032	1.521HisSer: 1.521 ± 0.04	1.211HisThr: 1.211 ± 0.032	1.375HisVal: 1.375 ± 0.039	0.394HisTrp: 0.394 ± 0.019	1.194HisTyr: 1.194 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.404IleAla: 6.404 ± 0.079	0.861IleCys: 0.861 ± 0.028	4.208IleAsp: 4.208 ± 0.067	4.604IleGlu: 4.604 ± 0.073	2.736IlePhe: 2.736 ± 0.058	4.373IleGly: 4.373 ± 0.07	1.822IleHis: 1.822 ± 0.036	5.242IleIle: 5.242 ± 0.073	4.941IleLys: 4.941 ± 0.06	6.702IleLeu: 6.702 ± 0.085	1.529IleMet: 1.529 ± 0.04	4.489IleAsn: 4.489 ± 0.072	3.361IlePro: 3.361 ± 0.055	2.854IleGln: 2.854 ± 0.048	2.915IleArg: 2.915 ± 0.049	5.037IleSer: 5.037 ± 0.077	4.132IleThr: 4.132 ± 0.062	3.901IleVal: 3.901 ± 0.06	0.63IleTrp: 0.63 ± 0.025	2.292IleTyr: 2.292 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.778LysAla: 4.778 ± 0.066	0.45LysCys: 0.45 ± 0.022	2.924LysAsp: 2.924 ± 0.053	4.563LysGlu: 4.563 ± 0.073	1.701LysPhe: 1.701 ± 0.036	3.074LysGly: 3.074 ± 0.056	1.576LysHis: 1.576 ± 0.04	4.904LysIle: 4.904 ± 0.062	5.125LysLys: 5.125 ± 0.071	6.159LysLeu: 6.159 ± 0.078	1.565LysMet: 1.565 ± 0.039	3.814LysAsn: 3.814 ± 0.068	2.737LysPro: 2.737 ± 0.049	3.407LysGln: 3.407 ± 0.055	2.829LysArg: 2.829 ± 0.051	3.738LysSer: 3.738 ± 0.066	3.789LysThr: 3.789 ± 0.064	3.141LysVal: 3.141 ± 0.056	0.545LysTrp: 0.545 ± 0.019	1.737LysTyr: 1.737 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.474LeuAla: 9.474 ± 0.101	1.386LeuCys: 1.386 ± 0.039	5.17LeuAsp: 5.17 ± 0.07	5.697LeuGlu: 5.697 ± 0.087	5.07LeuPhe: 5.07 ± 0.069	6.514LeuGly: 6.514 ± 0.084	2.662LeuHis: 2.662 ± 0.049	8.092LeuIle: 8.092 ± 0.089	6.808LeuLys: 6.808 ± 0.099	11.705LeuLeu: 11.705 ± 0.12	2.736LeuMet: 2.736 ± 0.05	5.878LeuAsn: 5.878 ± 0.08	4.753LeuPro: 4.753 ± 0.066	4.608LeuGln: 4.608 ± 0.077	4.375LeuArg: 4.375 ± 0.07	8.201LeuSer: 8.201 ± 0.081	6.132LeuThr: 6.132 ± 0.083	6.18LeuVal: 6.18 ± 0.073	1.09LeuTrp: 1.09 ± 0.036	3.161LeuTyr: 3.161 ± 0.057	0.001LeuXaa: 0.001 ± 0.001
Met	2.153MetAla: 2.153 ± 0.046	0.197MetCys: 0.197 ± 0.012	1.27MetAsp: 1.27 ± 0.034	1.23MetGlu: 1.23 ± 0.033	0.725MetPhe: 0.725 ± 0.027	1.45MetGly: 1.45 ± 0.039	0.688MetHis: 0.688 ± 0.028	1.619MetIle: 1.619 ± 0.037	1.515MetLys: 1.515 ± 0.035	2.553MetLeu: 2.553 ± 0.043	0.732MetMet: 0.732 ± 0.031	1.321MetAsn: 1.321 ± 0.035	1.159MetPro: 1.159 ± 0.034	1.294MetGln: 1.294 ± 0.033	1.175MetArg: 1.175 ± 0.033	1.671MetSer: 1.671 ± 0.033	1.449MetThr: 1.449 ± 0.036	1.474MetVal: 1.474 ± 0.04	0.171MetTrp: 0.171 ± 0.011	0.539MetTyr: 0.539 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.82AsnAla: 3.82 ± 0.068	0.566AsnCys: 0.566 ± 0.022	2.455AsnAsp: 2.455 ± 0.048	3.163AsnGlu: 3.163 ± 0.051	2.022AsnPhe: 2.022 ± 0.043	2.768AsnGly: 2.768 ± 0.066	1.34AsnHis: 1.34 ± 0.036	3.404AsnIle: 3.404 ± 0.054	3.473AsnLys: 3.473 ± 0.061	4.887AsnLeu: 4.887 ± 0.084	1.008AsnMet: 1.008 ± 0.035	2.785AsnAsn: 2.785 ± 0.064	2.531AsnPro: 2.531 ± 0.053	2.688AsnGln: 2.688 ± 0.053	1.998AsnArg: 1.998 ± 0.051	3.126AsnSer: 3.126 ± 0.058	2.78AsnThr: 2.78 ± 0.049	2.483AsnVal: 2.483 ± 0.047	0.607AsnTrp: 0.607 ± 0.022	1.959AsnTyr: 1.959 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.993ProAla: 2.993 ± 0.053	0.408ProCys: 0.408 ± 0.018	2.066ProAsp: 2.066 ± 0.043	2.933ProGlu: 2.933 ± 0.049	1.791ProPhe: 1.791 ± 0.037	2.516ProGly: 2.516 ± 0.052	0.984ProHis: 0.984 ± 0.031	2.87ProIle: 2.87 ± 0.051	2.32ProLys: 2.32 ± 0.045	4.392ProLeu: 4.392 ± 0.069	0.976ProMet: 0.976 ± 0.028	1.926ProAsn: 1.926 ± 0.047	1.495ProPro: 1.495 ± 0.046	1.952ProGln: 1.952 ± 0.045	1.36ProArg: 1.36 ± 0.035	2.499ProSer: 2.499 ± 0.05	2.15ProThr: 2.15 ± 0.043	2.812ProVal: 2.812 ± 0.053	0.474ProTrp: 0.474 ± 0.017	1.364ProTyr: 1.364 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.977GlnAla: 3.977 ± 0.063	0.555GlnCys: 0.555 ± 0.023	1.977GlnAsp: 1.977 ± 0.038	2.947GlnGlu: 2.947 ± 0.061	2.095GlnPhe: 2.095 ± 0.043	2.7GlnGly: 2.7 ± 0.047	1.372GlnHis: 1.372 ± 0.034	3.28GlnIle: 3.28 ± 0.055	3.042GlnLys: 3.042 ± 0.058	5.546GlnLeu: 5.546 ± 0.081	1.079GlnMet: 1.079 ± 0.029	2.114GlnAsn: 2.114 ± 0.049	1.59GlnPro: 1.59 ± 0.042	3.13GlnGln: 3.13 ± 0.06	2.205GlnArg: 2.205 ± 0.049	2.825GlnSer: 2.825 ± 0.059	2.371GlnThr: 2.371 ± 0.05	2.698GlnVal: 2.698 ± 0.05	0.636GlnTrp: 0.636 ± 0.029	1.555GlnTyr: 1.555 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.138ArgAla: 3.138 ± 0.058	0.516ArgCys: 0.516 ± 0.022	2.04ArgAsp: 2.04 ± 0.048	2.62ArgGlu: 2.62 ± 0.05	2.169ArgPhe: 2.169 ± 0.046	2.214ArgGly: 2.214 ± 0.046	1.175ArgHis: 1.175 ± 0.033	3.108ArgIle: 3.108 ± 0.063	2.457ArgLys: 2.457 ± 0.048	4.924ArgLeu: 4.924 ± 0.076	1.1ArgMet: 1.1 ± 0.032	1.89ArgAsn: 1.89 ± 0.04	1.398ArgPro: 1.398 ± 0.035	2.033ArgGln: 2.033 ± 0.045	1.914ArgArg: 1.914 ± 0.044	2.301ArgSer: 2.301 ± 0.05	2.062ArgThr: 2.062 ± 0.046	2.658ArgVal: 2.658 ± 0.053	0.519ArgTrp: 0.519 ± 0.022	1.726ArgTyr: 1.726 ± 0.047	0.001ArgXaa: 0.001 ± 0.001
Ser	4.823SerAla: 4.823 ± 0.068	0.796SerCys: 0.796 ± 0.028	2.941SerAsp: 2.941 ± 0.051	3.599SerGlu: 3.599 ± 0.053	3.015SerPhe: 3.015 ± 0.049	4.205SerGly: 4.205 ± 0.06	1.593SerHis: 1.593 ± 0.04	4.718SerIle: 4.718 ± 0.064	3.563SerLys: 3.563 ± 0.065	7.66SerLeu: 7.66 ± 0.085	1.724SerMet: 1.724 ± 0.037	2.777SerAsn: 2.777 ± 0.045	2.744SerPro: 2.744 ± 0.048	2.808SerGln: 2.808 ± 0.052	2.525SerArg: 2.525 ± 0.045	4.633SerSer: 4.633 ± 0.073	3.514SerThr: 3.514 ± 0.06	3.745SerVal: 3.745 ± 0.068	0.768SerTrp: 0.768 ± 0.026	2.228SerTyr: 2.228 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.367ThrAla: 4.367 ± 0.074	0.547ThrCys: 0.547 ± 0.024	2.33ThrAsp: 2.33 ± 0.052	2.855ThrGlu: 2.855 ± 0.051	2.06ThrPhe: 2.06 ± 0.048	3.515ThrGly: 3.515 ± 0.061	1.49ThrHis: 1.49 ± 0.039	3.965ThrIle: 3.965 ± 0.069	2.802ThrLys: 2.802 ± 0.05	6.327ThrLeu: 6.327 ± 0.086	1.183ThrMet: 1.183 ± 0.031	2.429ThrAsn: 2.429 ± 0.053	2.835ThrPro: 2.835 ± 0.057	2.656ThrGln: 2.656 ± 0.05	2.25ThrArg: 2.25 ± 0.048	3.29ThrSer: 3.29 ± 0.061	3.226ThrThr: 3.226 ± 0.063	3.46ThrVal: 3.46 ± 0.058	0.541ThrTrp: 0.541 ± 0.021	1.801ThrTyr: 1.801 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.976ValAla: 4.976 ± 0.08	0.677ValCys: 0.677 ± 0.025	3.246ValAsp: 3.246 ± 0.054	3.135ValGlu: 3.135 ± 0.062	2.725ValPhe: 2.725 ± 0.053	3.479ValGly: 3.479 ± 0.066	1.42ValHis: 1.42 ± 0.036	4.502ValIle: 4.502 ± 0.062	3.305ValLys: 3.305 ± 0.057	6.404ValLeu: 6.404 ± 0.082	1.539ValMet: 1.539 ± 0.038	3.006ValAsn: 3.006 ± 0.048	2.316ValPro: 2.316 ± 0.047	2.132ValGln: 2.132 ± 0.048	2.386ValArg: 2.386 ± 0.046	3.997ValSer: 3.997 ± 0.054	3.352ValThr: 3.352 ± 0.055	4.016ValVal: 4.016 ± 0.078	0.558ValTrp: 0.558 ± 0.025	1.8ValTyr: 1.8 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.672TrpAla: 0.672 ± 0.025	0.139TrpCys: 0.139 ± 0.011	0.516TrpAsp: 0.516 ± 0.024	0.521TrpGlu: 0.521 ± 0.021	0.561TrpPhe: 0.561 ± 0.025	0.67TrpGly: 0.67 ± 0.03	0.356TrpHis: 0.356 ± 0.02	0.786TrpIle: 0.786 ± 0.029	0.528TrpLys: 0.528 ± 0.021	1.521TrpLeu: 1.521 ± 0.045	0.31TrpMet: 0.31 ± 0.015	0.536TrpAsn: 0.536 ± 0.023	0.409TrpPro: 0.409 ± 0.02	0.749TrpGln: 0.749 ± 0.026	0.552TrpArg: 0.552 ± 0.023	0.689TrpSer: 0.689 ± 0.027	0.464TrpThr: 0.464 ± 0.024	0.697TrpVal: 0.697 ± 0.026	0.167TrpTrp: 0.167 ± 0.013	0.358TrpTyr: 0.358 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.641TyrAla: 2.641 ± 0.049	0.499TyrCys: 0.499 ± 0.02	1.643TyrAsp: 1.643 ± 0.056	1.753TyrGlu: 1.753 ± 0.038	1.808TyrPhe: 1.808 ± 0.04	2.032TyrGly: 2.032 ± 0.042	0.927TyrHis: 0.927 ± 0.032	1.989TyrIle: 1.989 ± 0.044	1.894TyrLys: 1.894 ± 0.044	4.067TyrLeu: 4.067 ± 0.06	0.677TyrMet: 0.677 ± 0.023	1.494TyrAsn: 1.494 ± 0.034	1.515TyrPro: 1.515 ± 0.042	2.066TyrGln: 2.066 ± 0.044	1.677TyrArg: 1.677 ± 0.043	2.215TyrSer: 2.215 ± 0.043	1.724TyrThr: 1.724 ± 0.043	1.834TyrVal: 1.834 ± 0.042	0.501TyrTrp: 0.501 ± 0.023	1.364TyrTyr: 1.364 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 3959 proteins (1146871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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