Amino acid dipepetide frequency for Streptococcus satellite phage Javan615

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
3.201AlaAsp: 3.201 ± 1.325
5.122AlaGlu: 5.122 ± 1.61
1.28AlaPhe: 1.28 ± 0.82
4.481AlaGly: 4.481 ± 1.542
0.0AlaHis: 0.0 ± 0.0
3.201AlaIle: 3.201 ± 1.206
6.402AlaLys: 6.402 ± 1.747
5.122AlaLeu: 5.122 ± 1.903
0.64AlaMet: 0.64 ± 0.712
7.682AlaAsn: 7.682 ± 2.402
0.64AlaPro: 0.64 ± 0.58
3.201AlaGln: 3.201 ± 1.773
1.28AlaArg: 1.28 ± 0.558
1.921AlaSer: 1.921 ± 1.137
3.201AlaThr: 3.201 ± 1.471
2.561AlaVal: 2.561 ± 1.593
0.0AlaTrp: 0.0 ± 0.0
3.841AlaTyr: 3.841 ± 0.887
0.0AlaXaa: 0.0 ± 0.0
Cys
0.64CysAla: 0.64 ± 0.556
0.0CysCys: 0.0 ± 0.0
0.64CysAsp: 0.64 ± 0.67
0.64CysGlu: 0.64 ± 0.481
0.0CysPhe: 0.0 ± 0.0
0.64CysGly: 0.64 ± 0.556
0.0CysHis: 0.0 ± 0.0
0.64CysIle: 0.64 ± 0.58
0.0CysLys: 0.0 ± 0.0
0.64CysLeu: 0.64 ± 0.556
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.64CysArg: 0.64 ± 0.481
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.64CysVal: 0.64 ± 0.556
0.0CysTrp: 0.0 ± 0.0
0.64CysTyr: 0.64 ± 0.689
0.0CysXaa: 0.0 ± 0.0
Asp
0.64AspAla: 0.64 ± 0.742
1.28AspCys: 1.28 ± 0.847
1.28AspAsp: 1.28 ± 0.678
4.481AspGlu: 4.481 ± 2.145
3.841AspPhe: 3.841 ± 0.977
2.561AspGly: 2.561 ± 1.525
0.64AspHis: 0.64 ± 0.742
5.762AspIle: 5.762 ± 1.274
5.762AspLys: 5.762 ± 1.369
1.921AspLeu: 1.921 ± 0.868
2.561AspMet: 2.561 ± 1.709
6.402AspAsn: 6.402 ± 2.068
1.28AspPro: 1.28 ± 0.678
0.0AspGln: 0.0 ± 0.0
2.561AspArg: 2.561 ± 1.009
5.762AspSer: 5.762 ± 2.005
3.201AspThr: 3.201 ± 0.839
3.841AspVal: 3.841 ± 1.599
0.0AspTrp: 0.0 ± 0.0
5.762AspTyr: 5.762 ± 2.483
0.0AspXaa: 0.0 ± 0.0
Glu
5.762GluAla: 5.762 ± 1.459
1.28GluCys: 1.28 ± 0.82
2.561GluAsp: 2.561 ± 1.476
6.402GluGlu: 6.402 ± 2.491
3.201GluPhe: 3.201 ± 0.753
3.201GluGly: 3.201 ± 1.128
0.0GluHis: 0.0 ± 0.0
6.402GluIle: 6.402 ± 1.665
7.682GluLys: 7.682 ± 2.992
12.164GluLeu: 12.164 ± 2.181
1.28GluMet: 1.28 ± 0.887
4.481GluAsn: 4.481 ± 1.096
1.921GluPro: 1.921 ± 1.097
3.201GluGln: 3.201 ± 0.64
5.122GluArg: 5.122 ± 2.486
3.841GluSer: 3.841 ± 1.323
3.841GluThr: 3.841 ± 1.399
1.28GluVal: 1.28 ± 0.558
0.64GluTrp: 0.64 ± 0.556
1.28GluTyr: 1.28 ± 1.089
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
3.841PheAsp: 3.841 ± 1.756
1.921PheGlu: 1.921 ± 1.057
1.921PhePhe: 1.921 ± 1.357
3.841PheGly: 3.841 ± 0.985
0.64PheHis: 0.64 ± 0.481
2.561PheIle: 2.561 ± 1.525
4.481PheLys: 4.481 ± 1.18
5.762PheLeu: 5.762 ± 1.25
0.0PheMet: 0.0 ± 0.0
1.921PheAsn: 1.921 ± 0.808
1.28PhePro: 1.28 ± 0.678
0.64PheGln: 0.64 ± 0.742
1.921PheArg: 1.921 ± 1.137
1.28PheSer: 1.28 ± 0.799
0.64PheThr: 0.64 ± 0.556
0.64PheVal: 0.64 ± 0.58
0.0PheTrp: 0.0 ± 0.0
1.921PheTyr: 1.921 ± 0.982
0.0PheXaa: 0.0 ± 0.0
Gly
1.28GlyAla: 1.28 ± 0.735
1.28GlyCys: 1.28 ± 0.558
1.921GlyAsp: 1.921 ± 1.133
5.762GlyGlu: 5.762 ± 1.705
3.201GlyPhe: 3.201 ± 1.405
3.841GlyGly: 3.841 ± 1.465
0.64GlyHis: 0.64 ± 0.481
1.28GlyIle: 1.28 ± 0.652
3.201GlyLys: 3.201 ± 2.064
8.963GlyLeu: 8.963 ± 2.625
3.201GlyMet: 3.201 ± 1.06
2.561GlyAsn: 2.561 ± 1.678
0.0GlyPro: 0.0 ± 0.0
0.64GlyGln: 0.64 ± 0.689
2.561GlyArg: 2.561 ± 1.305
1.921GlySer: 1.921 ± 1.09
3.201GlyThr: 3.201 ± 2.301
6.402GlyVal: 6.402 ± 1.74
1.28GlyTrp: 1.28 ± 1.112
4.481GlyTyr: 4.481 ± 2.038
0.0GlyXaa: 0.0 ± 0.0
His
1.28HisAla: 1.28 ± 0.735
0.64HisCys: 0.64 ± 0.556
0.0HisAsp: 0.0 ± 0.0
1.28HisGlu: 1.28 ± 0.886
1.28HisPhe: 1.28 ± 0.962
1.28HisGly: 1.28 ± 0.652
0.0HisHis: 0.0 ± 0.0
1.28HisIle: 1.28 ± 0.558
0.64HisLys: 0.64 ± 0.481
0.64HisLeu: 0.64 ± 0.481
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.921HisPro: 1.921 ± 1.668
0.64HisGln: 0.64 ± 0.712
0.64HisArg: 0.64 ± 0.481
0.64HisSer: 0.64 ± 0.481
2.561HisThr: 2.561 ± 0.802
0.64HisVal: 0.64 ± 0.481
0.0HisTrp: 0.0 ± 0.0
1.28HisTyr: 1.28 ± 0.652
0.0HisXaa: 0.0 ± 0.0
Ile
5.122IleAla: 5.122 ± 2.027
0.0IleCys: 0.0 ± 0.0
6.402IleAsp: 6.402 ± 2.201
6.402IleGlu: 6.402 ± 2.143
0.64IlePhe: 0.64 ± 0.58
3.201IleGly: 3.201 ± 0.805
0.64IleHis: 0.64 ± 0.481
3.841IleIle: 3.841 ± 1.492
5.122IleLys: 5.122 ± 1.817
4.481IleLeu: 4.481 ± 0.913
1.28IleMet: 1.28 ± 0.76
2.561IleAsn: 2.561 ± 1.006
3.201IlePro: 3.201 ± 1.345
5.762IleGln: 5.762 ± 2.687
0.64IleArg: 0.64 ± 0.556
4.481IleSer: 4.481 ± 2.206
5.122IleThr: 5.122 ± 1.143
1.28IleVal: 1.28 ± 0.678
0.0IleTrp: 0.0 ± 0.0
3.201IleTyr: 3.201 ± 1.815
0.0IleXaa: 0.0 ± 0.0
Lys
7.682LysAla: 7.682 ± 1.691
0.0LysCys: 0.0 ± 0.0
2.561LysAsp: 2.561 ± 0.865
8.323LysGlu: 8.323 ± 2.792
3.201LysPhe: 3.201 ± 1.265
5.122LysGly: 5.122 ± 1.487
2.561LysHis: 2.561 ± 0.946
7.042LysIle: 7.042 ± 1.927
11.524LysLys: 11.524 ± 1.906
7.682LysLeu: 7.682 ± 1.697
1.28LysMet: 1.28 ± 0.816
3.841LysAsn: 3.841 ± 1.451
3.201LysPro: 3.201 ± 1.775
7.682LysGln: 7.682 ± 1.709
7.682LysArg: 7.682 ± 1.095
7.042LysSer: 7.042 ± 2.009
4.481LysThr: 4.481 ± 0.713
5.122LysVal: 5.122 ± 1.437
0.0LysTrp: 0.0 ± 0.0
1.921LysTyr: 1.921 ± 0.766
0.0LysXaa: 0.0 ± 0.0
Leu
8.963LeuAla: 8.963 ± 2.563
0.0LeuCys: 0.0 ± 0.0
7.682LeuAsp: 7.682 ± 0.904
10.243LeuGlu: 10.243 ± 4.336
2.561LeuPhe: 2.561 ± 0.56
7.042LeuGly: 7.042 ± 2.437
1.28LeuHis: 1.28 ± 0.652
7.042LeuIle: 7.042 ± 1.632
8.323LeuLys: 8.323 ± 2.213
10.243LeuLeu: 10.243 ± 1.31
3.201LeuMet: 3.201 ± 1.478
5.122LeuAsn: 5.122 ± 2.02
3.841LeuPro: 3.841 ± 1.051
4.481LeuGln: 4.481 ± 1.369
3.201LeuArg: 3.201 ± 2.154
5.122LeuSer: 5.122 ± 1.112
6.402LeuThr: 6.402 ± 1.969
1.921LeuVal: 1.921 ± 1.02
0.64LeuTrp: 0.64 ± 0.556
0.64LeuTyr: 0.64 ± 0.481
0.0LeuXaa: 0.0 ± 0.0
Met
2.561MetAla: 2.561 ± 1.777
0.0MetCys: 0.0 ± 0.0
3.201MetAsp: 3.201 ± 0.839
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.28MetIle: 1.28 ± 0.914
1.921MetLys: 1.921 ± 0.88
1.28MetLeu: 1.28 ± 0.997
0.64MetMet: 0.64 ± 0.481
1.921MetAsn: 1.921 ± 1.076
0.64MetPro: 0.64 ± 0.58
0.64MetGln: 0.64 ± 0.712
1.28MetArg: 1.28 ± 1.159
0.64MetSer: 0.64 ± 0.556
3.841MetThr: 3.841 ± 1.213
1.921MetVal: 1.921 ± 1.373
0.64MetTrp: 0.64 ± 0.689
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.201AsnAla: 3.201 ± 0.812
0.64AsnCys: 0.64 ± 0.481
3.201AsnAsp: 3.201 ± 1.029
5.122AsnGlu: 5.122 ± 0.867
0.64AsnPhe: 0.64 ± 0.67
4.481AsnGly: 4.481 ± 1.375
1.28AsnHis: 1.28 ± 0.558
2.561AsnIle: 2.561 ± 1.089
5.122AsnLys: 5.122 ± 1.011
3.201AsnLeu: 3.201 ± 1.076
0.0AsnMet: 0.0 ± 0.682
3.841AsnAsn: 3.841 ± 1.978
1.921AsnPro: 1.921 ± 0.731
1.28AsnGln: 1.28 ± 0.86
3.201AsnArg: 3.201 ± 1.232
5.122AsnSer: 5.122 ± 1.973
7.682AsnThr: 7.682 ± 2.014
1.28AsnVal: 1.28 ± 0.652
0.0AsnTrp: 0.0 ± 0.0
4.481AsnTyr: 4.481 ± 1.267
0.0AsnXaa: 0.0 ± 0.0
Pro
2.561ProAla: 2.561 ± 0.697
0.0ProCys: 0.0 ± 0.0
0.64ProAsp: 0.64 ± 0.556
0.64ProGlu: 0.64 ± 0.67
1.28ProPhe: 1.28 ± 1.159
0.0ProGly: 0.0 ± 0.0
1.28ProHis: 1.28 ± 0.678
3.201ProIle: 3.201 ± 1.649
1.921ProLys: 1.921 ± 0.868
3.201ProLeu: 3.201 ± 0.963
1.921ProMet: 1.921 ± 1.118
1.921ProAsn: 1.921 ± 1.005
1.28ProPro: 1.28 ± 1.062
0.64ProGln: 0.64 ± 0.689
3.201ProArg: 3.201 ± 1.154
1.28ProSer: 1.28 ± 0.678
2.561ProThr: 2.561 ± 1.001
2.561ProVal: 2.561 ± 1.094
0.64ProTrp: 0.64 ± 0.58
1.921ProTyr: 1.921 ± 0.566
0.0ProXaa: 0.0 ± 0.0
Gln
2.561GlnAla: 2.561 ± 1.002
0.0GlnCys: 0.0 ± 0.0
1.921GlnAsp: 1.921 ± 1.083
3.841GlnGlu: 3.841 ± 1.323
1.921GlnPhe: 1.921 ± 0.88
2.561GlnGly: 2.561 ± 1.094
1.921GlnHis: 1.921 ± 0.88
3.201GlnIle: 3.201 ± 3.105
5.762GlnLys: 5.762 ± 1.056
3.201GlnLeu: 3.201 ± 1.089
0.0GlnMet: 0.0 ± 0.0
1.28GlnAsn: 1.28 ± 0.724
0.64GlnPro: 0.64 ± 0.712
2.561GlnGln: 2.561 ± 1.692
1.921GlnArg: 1.921 ± 1.057
1.921GlnSer: 1.921 ± 0.886
3.841GlnThr: 3.841 ± 1.17
2.561GlnVal: 2.561 ± 1.086
0.0GlnTrp: 0.0 ± 0.0
1.921GlnTyr: 1.921 ± 1.005
0.0GlnXaa: 0.0 ± 0.0
Arg
1.921ArgAla: 1.921 ± 1.124
0.0ArgCys: 0.0 ± 0.0
4.481ArgAsp: 4.481 ± 1.224
1.28ArgGlu: 1.28 ± 1.112
0.64ArgPhe: 0.64 ± 0.556
4.481ArgGly: 4.481 ± 1.716
1.28ArgHis: 1.28 ± 0.558
2.561ArgIle: 2.561 ± 0.926
3.841ArgLys: 3.841 ± 1.26
5.762ArgLeu: 5.762 ± 1.667
0.0ArgMet: 0.0 ± 0.0
4.481ArgAsn: 4.481 ± 1.721
1.28ArgPro: 1.28 ± 1.159
1.28ArgGln: 1.28 ± 0.678
1.921ArgArg: 1.921 ± 1.034
0.64ArgSer: 0.64 ± 0.58
3.201ArgThr: 3.201 ± 1.345
5.122ArgVal: 5.122 ± 1.541
0.64ArgTrp: 0.64 ± 0.712
3.841ArgTyr: 3.841 ± 0.839
0.0ArgXaa: 0.0 ± 0.0
Ser
1.921SerAla: 1.921 ± 0.752
0.0SerCys: 0.0 ± 0.0
6.402SerAsp: 6.402 ± 1.465
2.561SerGlu: 2.561 ± 0.932
2.561SerPhe: 2.561 ± 1.133
2.561SerGly: 2.561 ± 0.802
1.28SerHis: 1.28 ± 0.962
1.921SerIle: 1.921 ± 0.868
7.042SerLys: 7.042 ± 1.329
5.762SerLeu: 5.762 ± 1.461
0.64SerMet: 0.64 ± 0.481
2.561SerAsn: 2.561 ± 1.533
1.28SerPro: 1.28 ± 0.558
3.841SerGln: 3.841 ± 1.263
1.28SerArg: 1.28 ± 0.86
2.561SerSer: 2.561 ± 0.986
3.841SerThr: 3.841 ± 1.636
2.561SerVal: 2.561 ± 1.358
1.921SerTrp: 1.921 ± 1.442
2.561SerTyr: 2.561 ± 0.913
0.0SerXaa: 0.0 ± 0.0
Thr
3.841ThrAla: 3.841 ± 1.387
0.0ThrCys: 0.0 ± 0.0
4.481ThrAsp: 4.481 ± 1.968
1.921ThrGlu: 1.921 ± 0.808
1.28ThrPhe: 1.28 ± 0.678
5.122ThrGly: 5.122 ± 1.68
0.64ThrHis: 0.64 ± 0.481
3.201ThrIle: 3.201 ± 1.613
7.042ThrLys: 7.042 ± 1.579
6.402ThrLeu: 6.402 ± 2.137
3.841ThrMet: 3.841 ± 1.58
1.28ThrAsn: 1.28 ± 0.769
3.201ThrPro: 3.201 ± 1.402
3.201ThrGln: 3.201 ± 1.247
3.201ThrArg: 3.201 ± 1.764
2.561ThrSer: 2.561 ± 1.001
2.561ThrThr: 2.561 ± 1.265
7.042ThrVal: 7.042 ± 1.99
0.64ThrTrp: 0.64 ± 0.58
4.481ThrTyr: 4.481 ± 1.468
0.0ThrXaa: 0.0 ± 0.0
Val
2.561ValAla: 2.561 ± 1.305
0.0ValCys: 0.0 ± 0.0
1.28ValAsp: 1.28 ± 0.558
1.921ValGlu: 1.921 ± 1.25
3.841ValPhe: 3.841 ± 1.229
1.921ValGly: 1.921 ± 1.002
1.28ValHis: 1.28 ± 0.652
3.201ValIle: 3.201 ± 1.619
6.402ValLys: 6.402 ± 1.597
6.402ValLeu: 6.402 ± 1.981
0.64ValMet: 0.64 ± 0.517
3.841ValAsn: 3.841 ± 0.837
1.921ValPro: 1.921 ± 0.818
0.64ValGln: 0.64 ± 0.58
0.64ValArg: 0.64 ± 0.58
2.561ValSer: 2.561 ± 1.227
5.762ValThr: 5.762 ± 1.974
4.481ValVal: 4.481 ± 1.296
0.64ValTrp: 0.64 ± 0.556
2.561ValTyr: 2.561 ± 1.404
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.921TrpAsp: 1.921 ± 1.005
0.64TrpGlu: 0.64 ± 0.712
0.64TrpPhe: 0.64 ± 0.556
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.64TrpLys: 0.64 ± 0.481
0.64TrpLeu: 0.64 ± 0.556
0.64TrpMet: 0.64 ± 0.689
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.64TrpGln: 0.64 ± 0.58
0.64TrpArg: 0.64 ± 0.556
1.28TrpSer: 1.28 ± 0.652
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.64TrpTrp: 0.64 ± 0.481
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.28TyrAla: 1.28 ± 0.997
0.64TyrCys: 0.64 ± 0.58
1.921TyrAsp: 1.921 ± 0.868
7.042TyrGlu: 7.042 ± 1.81
1.28TyrPhe: 1.28 ± 1.112
1.28TyrGly: 1.28 ± 0.769
1.28TyrHis: 1.28 ± 1.112
3.201TyrIle: 3.201 ± 1.745
5.122TyrLys: 5.122 ± 2.561
4.481TyrLeu: 4.481 ± 1.145
0.0TyrMet: 0.0 ± 0.0
3.201TyrAsn: 3.201 ± 1.946
3.201TyrPro: 3.201 ± 0.996
2.561TyrGln: 2.561 ± 1.404
5.122TyrArg: 5.122 ± 1.872
4.481TyrSer: 4.481 ± 0.836
0.0TyrThr: 0.0 ± 0.0
0.64TyrVal: 0.64 ± 0.556
0.0TyrTrp: 0.0 ± 0.0
2.561TyrTyr: 2.561 ± 1.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski