Amino acid dipepetide frequency for Tissierella creatinini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.244AlaAla: 4.244 ± 0.102
0.641AlaCys: 0.641 ± 0.031
2.941AlaAsp: 2.941 ± 0.067
3.957AlaGlu: 3.957 ± 0.086
2.526AlaPhe: 2.526 ± 0.064
4.289AlaGly: 4.289 ± 0.08
0.945AlaHis: 0.945 ± 0.039
5.797AlaIle: 5.797 ± 0.099
4.483AlaLys: 4.483 ± 0.074
6.252AlaLeu: 6.252 ± 0.11
1.74AlaMet: 1.74 ± 0.056
2.753AlaAsn: 2.753 ± 0.057
1.561AlaPro: 1.561 ± 0.046
1.545AlaGln: 1.545 ± 0.055
2.444AlaArg: 2.444 ± 0.057
3.405AlaSer: 3.405 ± 0.078
2.933AlaThr: 2.933 ± 0.07
3.974AlaVal: 3.974 ± 0.08
0.382AlaTrp: 0.382 ± 0.021
2.233AlaTyr: 2.233 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.509CysAla: 0.509 ± 0.031
0.134CysCys: 0.134 ± 0.013
0.532CysAsp: 0.532 ± 0.028
0.562CysGlu: 0.562 ± 0.027
0.339CysPhe: 0.339 ± 0.022
0.949CysGly: 0.949 ± 0.043
0.224CysHis: 0.224 ± 0.018
0.773CysIle: 0.773 ± 0.033
0.684CysLys: 0.684 ± 0.035
0.716CysLeu: 0.716 ± 0.034
0.202CysMet: 0.202 ± 0.017
0.529CysAsn: 0.529 ± 0.027
0.523CysPro: 0.523 ± 0.033
0.242CysGln: 0.242 ± 0.017
0.321CysArg: 0.321 ± 0.019
0.661CysSer: 0.661 ± 0.034
0.476CysThr: 0.476 ± 0.028
0.486CysVal: 0.486 ± 0.03
0.081CysTrp: 0.081 ± 0.011
0.305CysTyr: 0.305 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.858AspAla: 2.858 ± 0.06
0.457AspCys: 0.457 ± 0.026
3.093AspAsp: 3.093 ± 0.086
5.194AspGlu: 5.194 ± 0.093
2.961AspPhe: 2.961 ± 0.061
3.761AspGly: 3.761 ± 0.086
0.824AspHis: 0.824 ± 0.036
6.628AspIle: 6.628 ± 0.1
4.999AspLys: 4.999 ± 0.08
6.123AspLeu: 6.123 ± 0.085
1.823AspMet: 1.823 ± 0.046
3.073AspAsn: 3.073 ± 0.079
1.698AspPro: 1.698 ± 0.05
1.112AspGln: 1.112 ± 0.038
2.377AspArg: 2.377 ± 0.058
3.259AspSer: 3.259 ± 0.074
2.551AspThr: 2.551 ± 0.065
3.781AspVal: 3.781 ± 0.065
0.434AspTrp: 0.434 ± 0.025
2.94AspTyr: 2.94 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.639GluAla: 4.639 ± 0.097
0.532GluCys: 0.532 ± 0.03
5.073GluAsp: 5.073 ± 0.088
7.134GluGlu: 7.134 ± 0.107
2.889GluPhe: 2.889 ± 0.064
4.654GluGly: 4.654 ± 0.08
0.908GluHis: 0.908 ± 0.037
7.391GluIle: 7.391 ± 0.109
6.711GluLys: 6.711 ± 0.108
7.074GluLeu: 7.074 ± 0.1
2.081GluMet: 2.081 ± 0.052
4.438GluAsn: 4.438 ± 0.081
1.779GluPro: 1.779 ± 0.05
1.673GluGln: 1.673 ± 0.054
3.024GluArg: 3.024 ± 0.072
3.859GluSer: 3.859 ± 0.08
3.114GluThr: 3.114 ± 0.07
4.938GluVal: 4.938 ± 0.084
0.49GluTrp: 0.49 ± 0.028
3.096GluTyr: 3.096 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.308PheAla: 2.308 ± 0.06
0.434PheCys: 0.434 ± 0.023
2.494PheAsp: 2.494 ± 0.062
2.816PheGlu: 2.816 ± 0.063
1.861PhePhe: 1.861 ± 0.06
2.964PheGly: 2.964 ± 0.075
0.642PheHis: 0.642 ± 0.027
4.239PheIle: 4.239 ± 0.077
3.191PheLys: 3.191 ± 0.074
3.813PheLeu: 3.813 ± 0.084
1.211PheMet: 1.211 ± 0.041
2.48PheAsn: 2.48 ± 0.06
1.37PhePro: 1.37 ± 0.045
0.997PheGln: 0.997 ± 0.037
1.408PheArg: 1.408 ± 0.046
2.889PheSer: 2.889 ± 0.063
2.257PheThr: 2.257 ± 0.059
2.483PheVal: 2.483 ± 0.062
0.306PheTrp: 0.306 ± 0.02
1.662PheTyr: 1.662 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.29GlyAla: 4.29 ± 0.092
0.833GlyCys: 0.833 ± 0.041
3.73GlyAsp: 3.73 ± 0.082
4.424GlyGlu: 4.424 ± 0.089
3.305GlyPhe: 3.305 ± 0.062
4.873GlyGly: 4.873 ± 0.104
1.164GlyHis: 1.164 ± 0.046
7.027GlyIle: 7.027 ± 0.126
5.452GlyLys: 5.452 ± 0.086
6.761GlyLeu: 6.761 ± 0.117
2.009GlyMet: 2.009 ± 0.053
3.339GlyAsn: 3.339 ± 0.068
1.614GlyPro: 1.614 ± 0.053
1.876GlyGln: 1.876 ± 0.053
2.891GlyArg: 2.891 ± 0.065
4.052GlySer: 4.052 ± 0.078
3.607GlyThr: 3.607 ± 0.075
4.752GlyVal: 4.752 ± 0.081
0.517GlyTrp: 0.517 ± 0.026
3.086GlyTyr: 3.086 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
0.77HisAla: 0.77 ± 0.04
0.203HisCys: 0.203 ± 0.017
0.805HisAsp: 0.805 ± 0.034
1.043HisGlu: 1.043 ± 0.037
0.669HisPhe: 0.669 ± 0.03
1.142HisGly: 1.142 ± 0.04
0.369HisHis: 0.369 ± 0.027
1.435HisIle: 1.435 ± 0.044
1.104HisLys: 1.104 ± 0.041
1.408HisLeu: 1.408 ± 0.047
0.407HisMet: 0.407 ± 0.025
0.779HisAsn: 0.779 ± 0.03
0.798HisPro: 0.798 ± 0.034
0.406HisGln: 0.406 ± 0.027
0.672HisArg: 0.672 ± 0.029
0.923HisSer: 0.923 ± 0.04
0.785HisThr: 0.785 ± 0.035
0.821HisVal: 0.821 ± 0.035
0.13HisTrp: 0.13 ± 0.013
0.666HisTyr: 0.666 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.729IleAla: 5.729 ± 0.098
0.93IleCys: 0.93 ± 0.038
6.104IleAsp: 6.104 ± 0.089
7.097IleGlu: 7.097 ± 0.124
3.61IlePhe: 3.61 ± 0.077
6.805IleGly: 6.805 ± 0.102
1.407IleHis: 1.407 ± 0.043
9.275IleIle: 9.275 ± 0.148
7.516IleLys: 7.516 ± 0.101
8.951IleLeu: 8.951 ± 0.141
2.346IleMet: 2.346 ± 0.063
5.189IleAsn: 5.189 ± 0.093
3.465IlePro: 3.465 ± 0.077
2.327IleGln: 2.327 ± 0.05
3.696IleArg: 3.696 ± 0.062
6.714IleSer: 6.714 ± 0.105
4.533IleThr: 4.533 ± 0.077
6.14IleVal: 6.14 ± 0.09
0.537IleTrp: 0.537 ± 0.029
3.46IleTyr: 3.46 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
4.919LysAla: 4.919 ± 0.088
0.57LysCys: 0.57 ± 0.03
5.892LysAsp: 5.892 ± 0.093
7.473LysGlu: 7.473 ± 0.113
2.559LysPhe: 2.559 ± 0.064
5.151LysGly: 5.151 ± 0.088
1.071LysHis: 1.071 ± 0.042
6.704LysIle: 6.704 ± 0.096
6.375LysLys: 6.375 ± 0.096
6.972LysLeu: 6.972 ± 0.102
2.103LysMet: 2.103 ± 0.049
4.833LysAsn: 4.833 ± 0.072
2.183LysPro: 2.183 ± 0.055
1.761LysGln: 1.761 ± 0.054
3.211LysArg: 3.211 ± 0.067
4.741LysSer: 4.741 ± 0.087
3.779LysThr: 3.779 ± 0.077
5.505LysVal: 5.505 ± 0.088
0.55LysTrp: 0.55 ± 0.03
3.508LysTyr: 3.508 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
5.773LeuAla: 5.773 ± 0.094
0.794LeuCys: 0.794 ± 0.034
6.0LeuAsp: 6.0 ± 0.1
7.193LeuGlu: 7.193 ± 0.109
3.801LeuPhe: 3.801 ± 0.09
6.876LeuGly: 6.876 ± 0.103
1.247LeuHis: 1.247 ± 0.041
8.331LeuIle: 8.331 ± 0.122
8.244LeuLys: 8.244 ± 0.124
8.767LeuLeu: 8.767 ± 0.152
2.594LeuMet: 2.594 ± 0.06
5.373LeuAsn: 5.373 ± 0.099
3.227LeuPro: 3.227 ± 0.066
2.186LeuGln: 2.186 ± 0.059
3.839LeuArg: 3.839 ± 0.083
6.733LeuSer: 6.733 ± 0.102
4.412LeuThr: 4.412 ± 0.077
5.939LeuVal: 5.939 ± 0.099
0.572LeuTrp: 0.572 ± 0.028
3.203LeuTyr: 3.203 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
1.939MetAla: 1.939 ± 0.057
0.199MetCys: 0.199 ± 0.017
2.074MetAsp: 2.074 ± 0.052
2.379MetGlu: 2.379 ± 0.057
0.939MetPhe: 0.939 ± 0.035
2.038MetGly: 2.038 ± 0.056
0.335MetHis: 0.335 ± 0.021
2.162MetIle: 2.162 ± 0.058
2.474MetLys: 2.474 ± 0.057
2.283MetLeu: 2.283 ± 0.06
0.711MetMet: 0.711 ± 0.034
1.497MetAsn: 1.497 ± 0.04
0.902MetPro: 0.902 ± 0.034
0.611MetGln: 0.611 ± 0.032
1.018MetArg: 1.018 ± 0.036
1.501MetSer: 1.501 ± 0.043
1.387MetThr: 1.387 ± 0.04
1.908MetVal: 1.908 ± 0.047
0.144MetTrp: 0.144 ± 0.014
0.813MetTyr: 0.813 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.682AsnAla: 2.682 ± 0.06
0.509AsnCys: 0.509 ± 0.03
2.636AsnAsp: 2.636 ± 0.068
3.634AsnGlu: 3.634 ± 0.079
2.131AsnPhe: 2.131 ± 0.059
3.34AsnGly: 3.34 ± 0.077
0.969AsnHis: 0.969 ± 0.035
5.885AsnIle: 5.885 ± 0.099
4.708AsnLys: 4.708 ± 0.079
5.248AsnLeu: 5.248 ± 0.089
1.54AsnMet: 1.54 ± 0.048
3.161AsnAsn: 3.161 ± 0.09
2.429AsnPro: 2.429 ± 0.058
1.688AsnGln: 1.688 ± 0.055
2.335AsnArg: 2.335 ± 0.064
3.165AsnSer: 3.165 ± 0.069
2.629AsnThr: 2.629 ± 0.052
2.969AsnVal: 2.969 ± 0.065
0.388AsnTrp: 0.388 ± 0.025
2.331AsnTyr: 2.331 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
1.812ProAla: 1.812 ± 0.064
0.309ProCys: 0.309 ± 0.022
1.889ProAsp: 1.889 ± 0.054
2.564ProGlu: 2.564 ± 0.059
1.505ProPhe: 1.505 ± 0.048
2.21ProGly: 2.21 ± 0.063
0.605ProHis: 0.605 ± 0.031
2.949ProIle: 2.949 ± 0.064
2.296ProLys: 2.296 ± 0.058
2.989ProLeu: 2.989 ± 0.056
0.845ProMet: 0.845 ± 0.033
1.67ProAsn: 1.67 ± 0.043
0.881ProPro: 0.881 ± 0.036
0.902ProGln: 0.902 ± 0.034
1.118ProArg: 1.118 ± 0.035
1.955ProSer: 1.955 ± 0.05
1.72ProThr: 1.72 ± 0.049
2.295ProVal: 2.295 ± 0.062
0.258ProTrp: 0.258 ± 0.017
1.421ProTyr: 1.421 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.65GlnAla: 1.65 ± 0.048
0.193GlnCys: 0.193 ± 0.017
1.446GlnAsp: 1.446 ± 0.046
1.884GlnGlu: 1.884 ± 0.052
0.954GlnPhe: 0.954 ± 0.03
1.763GlnGly: 1.763 ± 0.057
0.345GlnHis: 0.345 ± 0.02
2.322GlnIle: 2.322 ± 0.059
1.89GlnLys: 1.89 ± 0.052
2.351GlnLeu: 2.351 ± 0.061
0.781GlnMet: 0.781 ± 0.033
1.204GlnAsn: 1.204 ± 0.045
0.696GlnPro: 0.696 ± 0.033
0.642GlnGln: 0.642 ± 0.03
1.184GlnArg: 1.184 ± 0.047
1.354GlnSer: 1.354 ± 0.041
1.064GlnThr: 1.064 ± 0.038
1.638GlnVal: 1.638 ± 0.047
0.232GlnTrp: 0.232 ± 0.018
0.975GlnTyr: 0.975 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.31ArgAla: 2.31 ± 0.063
0.371ArgCys: 0.371 ± 0.024
2.449ArgAsp: 2.449 ± 0.061
3.178ArgGlu: 3.178 ± 0.067
1.733ArgPhe: 1.733 ± 0.048
2.604ArgGly: 2.604 ± 0.065
0.602ArgHis: 0.602 ± 0.026
3.88ArgIle: 3.88 ± 0.073
3.057ArgLys: 3.057 ± 0.069
3.79ArgLeu: 3.79 ± 0.084
1.193ArgMet: 1.193 ± 0.039
2.191ArgAsn: 2.191 ± 0.055
1.229ArgPro: 1.229 ± 0.044
1.137ArgGln: 1.137 ± 0.039
1.815ArgArg: 1.815 ± 0.052
1.976ArgSer: 1.976 ± 0.051
1.88ArgThr: 1.88 ± 0.059
2.709ArgVal: 2.709 ± 0.058
0.274ArgTrp: 0.274 ± 0.022
1.657ArgTyr: 1.657 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.225SerAla: 3.225 ± 0.073
0.574SerCys: 0.574 ± 0.033
3.062SerAsp: 3.062 ± 0.063
3.668SerGlu: 3.668 ± 0.073
2.902SerPhe: 2.902 ± 0.062
4.619SerGly: 4.619 ± 0.084
1.052SerHis: 1.052 ± 0.036
6.26SerIle: 6.26 ± 0.113
4.897SerLys: 4.897 ± 0.08
6.168SerLeu: 6.168 ± 0.096
1.585SerMet: 1.585 ± 0.042
3.324SerAsn: 3.324 ± 0.067
2.017SerPro: 2.017 ± 0.051
1.783SerGln: 1.783 ± 0.048
2.474SerArg: 2.474 ± 0.069
4.157SerSer: 4.157 ± 0.084
3.108SerThr: 3.108 ± 0.061
3.366SerVal: 3.366 ± 0.073
0.453SerTrp: 0.453 ± 0.025
2.529SerTyr: 2.529 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
2.862ThrAla: 2.862 ± 0.067
0.465ThrCys: 0.465 ± 0.024
2.557ThrAsp: 2.557 ± 0.059
2.965ThrGlu: 2.965 ± 0.072
2.134ThrPhe: 2.134 ± 0.055
3.829ThrGly: 3.829 ± 0.063
0.922ThrHis: 0.922 ± 0.035
4.866ThrIle: 4.866 ± 0.081
3.413ThrLys: 3.413 ± 0.07
4.649ThrLeu: 4.649 ± 0.082
1.286ThrMet: 1.286 ± 0.051
2.382ThrAsn: 2.382 ± 0.059
2.061ThrPro: 2.061 ± 0.055
1.161ThrGln: 1.161 ± 0.043
1.945ThrArg: 1.945 ± 0.057
2.928ThrSer: 2.928 ± 0.066
2.74ThrThr: 2.74 ± 0.07
3.09ThrVal: 3.09 ± 0.069
0.292ThrTrp: 0.292 ± 0.021
1.877ThrTyr: 1.877 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.052ValAla: 4.052 ± 0.078
0.613ValCys: 0.613 ± 0.028
4.281ValAsp: 4.281 ± 0.091
5.025ValGlu: 5.025 ± 0.094
2.847ValPhe: 2.847 ± 0.054
4.436ValGly: 4.436 ± 0.086
0.932ValHis: 0.932 ± 0.043
5.695ValIle: 5.695 ± 0.095
4.678ValLys: 4.678 ± 0.075
6.218ValLeu: 6.218 ± 0.093
1.588ValMet: 1.588 ± 0.052
3.347ValAsn: 3.347 ± 0.068
2.134ValPro: 2.134 ± 0.052
1.393ValGln: 1.393 ± 0.044
2.331ValArg: 2.331 ± 0.058
4.028ValSer: 4.028 ± 0.081
3.168ValThr: 3.168 ± 0.063
4.524ValVal: 4.524 ± 0.084
0.34ValTrp: 0.34 ± 0.021
2.214ValTyr: 2.214 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.455TrpAla: 0.455 ± 0.025
0.056TrpCys: 0.056 ± 0.009
0.423TrpAsp: 0.423 ± 0.025
0.489TrpGlu: 0.489 ± 0.026
0.275TrpPhe: 0.275 ± 0.023
0.481TrpGly: 0.481 ± 0.029
0.121TrpHis: 0.121 ± 0.013
0.571TrpIle: 0.571 ± 0.032
0.455TrpLys: 0.455 ± 0.025
0.649TrpLeu: 0.649 ± 0.034
0.23TrpMet: 0.23 ± 0.018
0.43TrpAsn: 0.43 ± 0.025
0.176TrpPro: 0.176 ± 0.016
0.196TrpGln: 0.196 ± 0.017
0.265TrpArg: 0.265 ± 0.022
0.368TrpSer: 0.368 ± 0.019
0.351TrpThr: 0.351 ± 0.022
0.404TrpVal: 0.404 ± 0.023
0.064TrpTrp: 0.064 ± 0.009
0.257TrpTyr: 0.257 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.018TyrAla: 2.018 ± 0.056
0.43TyrCys: 0.43 ± 0.022
2.465TyrAsp: 2.465 ± 0.07
2.819TyrGlu: 2.819 ± 0.071
1.885TyrPhe: 1.885 ± 0.056
2.817TyrGly: 2.817 ± 0.07
0.653TyrHis: 0.653 ± 0.029
3.64TyrIle: 3.64 ± 0.085
3.231TyrLys: 3.231 ± 0.069
3.925TyrLeu: 3.925 ± 0.083
1.039TyrMet: 1.039 ± 0.04
2.386TyrAsn: 2.386 ± 0.061
1.45TyrPro: 1.45 ± 0.042
0.931TyrGln: 0.931 ± 0.036
1.665TyrArg: 1.665 ± 0.045
2.553TyrSer: 2.553 ± 0.06
1.928TyrThr: 1.928 ± 0.05
2.124TyrVal: 2.124 ± 0.059
0.274TyrTrp: 0.274 ± 0.018
1.784TyrTyr: 1.784 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2472 proteins (744290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski