Amino acid dipepetide frequency for Faecalibaculum rodentium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.173AlaAla: 10.173 ± 0.184	1.382AlaCys: 1.382 ± 0.049	5.751AlaAsp: 5.751 ± 0.109	4.691AlaGlu: 4.691 ± 0.1	3.26AlaPhe: 3.26 ± 0.069	8.192AlaGly: 8.192 ± 0.156	1.323AlaHis: 1.323 ± 0.047	4.496AlaIle: 4.496 ± 0.081	3.77AlaLys: 3.77 ± 0.085	8.28AlaLeu: 8.28 ± 0.131	2.936AlaMet: 2.936 ± 0.069	2.356AlaAsn: 2.356 ± 0.06	2.47AlaPro: 2.47 ± 0.079	3.221AlaGln: 3.221 ± 0.086	4.96AlaArg: 4.96 ± 0.091	4.552AlaSer: 4.552 ± 0.088	3.222AlaThr: 3.222 ± 0.075	6.789AlaVal: 6.789 ± 0.11	1.107AlaTrp: 1.107 ± 0.043	2.222AlaTyr: 2.222 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.092CysAla: 1.092 ± 0.041	0.222CysCys: 0.222 ± 0.019	0.717CysAsp: 0.717 ± 0.03	0.742CysGlu: 0.742 ± 0.032	0.616CysPhe: 0.616 ± 0.031	1.184CysGly: 1.184 ± 0.05	0.367CysHis: 0.367 ± 0.023	0.899CysIle: 0.899 ± 0.037	0.436CysLys: 0.436 ± 0.026	1.489CysLeu: 1.489 ± 0.048	0.418CysMet: 0.418 ± 0.025	0.347CysAsn: 0.347 ± 0.022	0.761CysPro: 0.761 ± 0.033	0.531CysGln: 0.531 ± 0.025	1.198CysArg: 1.198 ± 0.042	0.971CysSer: 0.971 ± 0.04	0.804CysThr: 0.804 ± 0.029	0.785CysVal: 0.785 ± 0.032	0.161CysTrp: 0.161 ± 0.014	0.36CysTyr: 0.36 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.827AspAla: 4.827 ± 0.081	0.834AspCys: 0.834 ± 0.035	3.025AspAsp: 3.025 ± 0.075	4.053AspGlu: 4.053 ± 0.095	2.473AspPhe: 2.473 ± 0.054	4.702AspGly: 4.702 ± 0.095	1.307AspHis: 1.307 ± 0.045	3.731AspIle: 3.731 ± 0.076	2.918AspLys: 2.918 ± 0.068	6.416AspLeu: 6.416 ± 0.109	1.997AspMet: 1.997 ± 0.055	1.728AspAsn: 1.728 ± 0.048	3.526AspPro: 3.526 ± 0.079	2.286AspGln: 2.286 ± 0.057	3.946AspArg: 3.946 ± 0.078	3.479AspSer: 3.479 ± 0.074	3.326AspThr: 3.326 ± 0.072	4.046AspVal: 4.046 ± 0.081	0.913AspTrp: 0.913 ± 0.035	2.148AspTyr: 2.148 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	6.13GluAla: 6.13 ± 0.109	0.634GluCys: 0.634 ± 0.031	4.203GluAsp: 4.203 ± 0.082	5.776GluGlu: 5.776 ± 0.114	2.272GluPhe: 2.272 ± 0.061	4.146GluGly: 4.146 ± 0.086	1.178GluHis: 1.178 ± 0.041	4.229GluIle: 4.229 ± 0.086	4.746GluLys: 4.746 ± 0.08	5.863GluLeu: 5.863 ± 0.108	2.02GluMet: 2.02 ± 0.055	3.091GluAsn: 3.091 ± 0.069	2.452GluPro: 2.452 ± 0.061	3.101GluGln: 3.101 ± 0.071	3.137GluArg: 3.137 ± 0.079	3.631GluSer: 3.631 ± 0.067	4.428GluThr: 4.428 ± 0.093	3.878GluVal: 3.878 ± 0.085	0.7GluTrp: 0.7 ± 0.036	2.34GluTyr: 2.34 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.196PheAla: 3.196 ± 0.077	0.716PheCys: 0.716 ± 0.033	2.639PheAsp: 2.639 ± 0.059	2.423PheGlu: 2.423 ± 0.055	1.838PhePhe: 1.838 ± 0.065	3.104PheGly: 3.104 ± 0.074	0.853PheHis: 0.853 ± 0.034	1.997PheIle: 1.997 ± 0.054	1.278PheLys: 1.278 ± 0.045	4.139PheLeu: 4.139 ± 0.091	1.06PheMet: 1.06 ± 0.034	1.223PheAsn: 1.223 ± 0.041	1.571PhePro: 1.571 ± 0.051	1.394PheGln: 1.394 ± 0.044	2.275PheArg: 2.275 ± 0.054	2.901PheSer: 2.901 ± 0.066	2.318PheThr: 2.318 ± 0.058	2.965PheVal: 2.965 ± 0.078	0.514PheTrp: 0.514 ± 0.03	1.209PheTyr: 1.209 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.905GlyAla: 4.905 ± 0.106	1.28GlyCys: 1.28 ± 0.044	3.514GlyAsp: 3.514 ± 0.072	3.871GlyGlu: 3.871 ± 0.078	3.364GlyPhe: 3.364 ± 0.081	4.562GlyGly: 4.562 ± 0.105	1.542GlyHis: 1.542 ± 0.065	5.303GlyIle: 5.303 ± 0.091	4.181GlyLys: 4.181 ± 0.081	7.424GlyLeu: 7.424 ± 0.122	2.504GlyMet: 2.504 ± 0.055	2.504GlyAsn: 2.504 ± 0.074	2.102GlyPro: 2.102 ± 0.054	2.976GlyGln: 2.976 ± 0.074	3.959GlyArg: 3.959 ± 0.089	4.699GlySer: 4.699 ± 0.09	4.826GlyThr: 4.826 ± 0.098	4.442GlyVal: 4.442 ± 0.08	1.078GlyTrp: 1.078 ± 0.042	2.872GlyTyr: 2.872 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.402HisAla: 1.402 ± 0.045	0.356HisCys: 0.356 ± 0.025	1.237HisAsp: 1.237 ± 0.045	1.221HisGlu: 1.221 ± 0.042	0.803HisPhe: 0.803 ± 0.035	1.598HisGly: 1.598 ± 0.052	0.522HisHis: 0.522 ± 0.029	1.228HisIle: 1.228 ± 0.048	0.795HisLys: 0.795 ± 0.034	1.774HisLeu: 1.774 ± 0.046	0.564HisMet: 0.564 ± 0.029	0.629HisAsn: 0.629 ± 0.029	1.362HisPro: 1.362 ± 0.046	0.664HisGln: 0.664 ± 0.031	1.231HisArg: 1.231 ± 0.043	1.102HisSer: 1.102 ± 0.035	1.062HisThr: 1.062 ± 0.039	1.225HisVal: 1.225 ± 0.046	0.246HisTrp: 0.246 ± 0.022	0.663HisTyr: 0.663 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.932IleAla: 4.932 ± 0.1	1.021IleCys: 1.021 ± 0.041	3.275IleAsp: 3.275 ± 0.076	3.569IleGlu: 3.569 ± 0.081	2.113IlePhe: 2.113 ± 0.069	4.036IleGly: 4.036 ± 0.092	1.338IleHis: 1.338 ± 0.045	2.978IleIle: 2.978 ± 0.071	1.915IleLys: 1.915 ± 0.059	6.886IleLeu: 6.886 ± 0.111	1.431IleMet: 1.431 ± 0.043	1.854IleAsn: 1.854 ± 0.055	3.304IlePro: 3.304 ± 0.073	2.443IleGln: 2.443 ± 0.06	4.603IleArg: 4.603 ± 0.087	3.738IleSer: 3.738 ± 0.077	3.346IleThr: 3.346 ± 0.076	3.722IleVal: 3.722 ± 0.084	0.667IleTrp: 0.667 ± 0.031	1.772IleTyr: 1.772 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.866LysAla: 4.866 ± 0.103	0.389LysCys: 0.389 ± 0.021	3.71LysAsp: 3.71 ± 0.081	4.392LysGlu: 4.392 ± 0.094	1.332LysPhe: 1.332 ± 0.046	3.401LysGly: 3.401 ± 0.063	0.92LysHis: 0.92 ± 0.035	2.755LysIle: 2.755 ± 0.063	4.04LysLys: 4.04 ± 0.097	4.191LysLeu: 4.191 ± 0.082	1.446LysMet: 1.446 ± 0.049	2.233LysAsn: 2.233 ± 0.058	2.329LysPro: 2.329 ± 0.05	2.13LysGln: 2.13 ± 0.066	2.754LysArg: 2.754 ± 0.065	2.823LysSer: 2.823 ± 0.067	3.544LysThr: 3.544 ± 0.07	3.043LysVal: 3.043 ± 0.084	0.486LysTrp: 0.486 ± 0.026	1.777LysTyr: 1.777 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	8.469LeuAla: 8.469 ± 0.135	1.565LeuCys: 1.565 ± 0.053	6.323LeuAsp: 6.323 ± 0.089	7.368LeuGlu: 7.368 ± 0.135	4.142LeuPhe: 4.142 ± 0.091	5.884LeuGly: 5.884 ± 0.102	2.036LeuHis: 2.036 ± 0.057	5.169LeuIle: 5.169 ± 0.101	5.698LeuLys: 5.698 ± 0.087	9.179LeuLeu: 9.179 ± 0.166	2.836LeuMet: 2.836 ± 0.068	3.325LeuAsn: 3.325 ± 0.077	4.318LeuPro: 4.318 ± 0.082	4.068LeuGln: 4.068 ± 0.083	4.81LeuArg: 4.81 ± 0.087	6.382LeuSer: 6.382 ± 0.098	5.347LeuThr: 5.347 ± 0.089	6.219LeuVal: 6.219 ± 0.101	1.081LeuTrp: 1.081 ± 0.046	3.267LeuTyr: 3.267 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	2.776MetAla: 2.776 ± 0.066	0.281MetCys: 0.281 ± 0.019	2.134MetAsp: 2.134 ± 0.062	2.391MetGlu: 2.391 ± 0.064	0.898MetPhe: 0.898 ± 0.036	1.762MetGly: 1.762 ± 0.054	0.563MetHis: 0.563 ± 0.025	1.992MetIle: 1.992 ± 0.057	2.508MetLys: 2.508 ± 0.057	2.45MetLeu: 2.45 ± 0.064	0.946MetMet: 0.946 ± 0.043	1.567MetAsn: 1.567 ± 0.047	1.31MetPro: 1.31 ± 0.043	1.202MetGln: 1.202 ± 0.042	1.332MetArg: 1.332 ± 0.038	1.584MetSer: 1.584 ± 0.049	2.041MetThr: 2.041 ± 0.058	1.809MetVal: 1.809 ± 0.05	0.199MetTrp: 0.199 ± 0.015	0.717MetTyr: 0.717 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.001AsnAla: 3.001 ± 0.075	0.459AsnCys: 0.459 ± 0.022	1.966AsnAsp: 1.966 ± 0.066	2.159AsnGlu: 2.159 ± 0.065	1.084AsnPhe: 1.084 ± 0.035	3.053AsnGly: 3.053 ± 0.08	0.736AsnHis: 0.736 ± 0.034	2.143AsnIle: 2.143 ± 0.063	1.498AsnLys: 1.498 ± 0.056	3.148AsnLeu: 3.148 ± 0.078	1.038AsnMet: 1.038 ± 0.038	1.124AsnAsn: 1.124 ± 0.049	1.967AsnPro: 1.967 ± 0.061	1.252AsnGln: 1.252 ± 0.042	2.462AsnArg: 2.462 ± 0.061	1.883AsnSer: 1.883 ± 0.058	1.88AsnThr: 1.88 ± 0.057	2.227AsnVal: 2.227 ± 0.066	0.475AsnTrp: 0.475 ± 0.027	1.194AsnTyr: 1.194 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	4.582ProAla: 4.582 ± 0.088	0.538ProCys: 0.538 ± 0.034	3.55ProAsp: 3.55 ± 0.077	4.51ProGlu: 4.51 ± 0.09	1.842ProPhe: 1.842 ± 0.054	3.699ProGly: 3.699 ± 0.074	0.702ProHis: 0.702 ± 0.032	1.633ProIle: 1.633 ± 0.048	1.628ProLys: 1.628 ± 0.047	3.383ProLeu: 3.383 ± 0.071	1.112ProMet: 1.112 ± 0.038	1.178ProAsn: 1.178 ± 0.042	0.952ProPro: 0.952 ± 0.037	1.364ProGln: 1.364 ± 0.042	1.666ProArg: 1.666 ± 0.049	1.997ProSer: 1.997 ± 0.055	1.478ProThr: 1.478 ± 0.046	4.5ProVal: 4.5 ± 0.083	0.585ProTrp: 0.585 ± 0.03	1.33ProTyr: 1.33 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	4.029GlnAla: 4.029 ± 0.078	0.407GlnCys: 0.407 ± 0.02	2.719GlnAsp: 2.719 ± 0.061	3.303GlnGlu: 3.303 ± 0.078	1.288GlnPhe: 1.288 ± 0.041	2.7GlnGly: 2.7 ± 0.065	0.524GlnHis: 0.524 ± 0.027	2.477GlnIle: 2.477 ± 0.062	2.462GlnLys: 2.462 ± 0.058	3.471GlnLeu: 3.471 ± 0.08	1.237GlnMet: 1.237 ± 0.039	1.42GlnAsn: 1.42 ± 0.043	1.635GlnPro: 1.635 ± 0.045	1.435GlnGln: 1.435 ± 0.054	1.769GlnArg: 1.769 ± 0.052	2.28GlnSer: 2.28 ± 0.059	2.526GlnThr: 2.526 ± 0.065	2.591GlnVal: 2.591 ± 0.066	0.435GlnTrp: 0.435 ± 0.028	1.232GlnTyr: 1.232 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	3.292ArgAla: 3.292 ± 0.069	0.688ArgCys: 0.688 ± 0.035	3.329ArgAsp: 3.329 ± 0.068	4.374ArgGlu: 4.374 ± 0.078	2.469ArgPhe: 2.469 ± 0.059	2.833ArgGly: 2.833 ± 0.068	1.38ArgHis: 1.38 ± 0.049	3.943ArgIle: 3.943 ± 0.085	4.081ArgLys: 4.081 ± 0.081	5.731ArgLeu: 5.731 ± 0.104	1.873ArgMet: 1.873 ± 0.054	2.256ArgAsn: 2.256 ± 0.06	2.212ArgPro: 2.212 ± 0.064	3.239ArgGln: 3.239 ± 0.073	3.747ArgArg: 3.747 ± 0.088	2.958ArgSer: 2.958 ± 0.069	3.272ArgThr: 3.272 ± 0.065	2.969ArgVal: 2.969 ± 0.065	0.557ArgTrp: 0.557 ± 0.031	1.991ArgTyr: 1.991 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.67SerAla: 4.67 ± 0.084	0.877SerCys: 0.877 ± 0.038	3.271SerAsp: 3.271 ± 0.072	3.168SerGlu: 3.168 ± 0.069	2.651SerPhe: 2.651 ± 0.065	5.16SerGly: 5.16 ± 0.096	1.22SerHis: 1.22 ± 0.047	3.103SerIle: 3.103 ± 0.065	2.248SerLys: 2.248 ± 0.062	6.415SerLeu: 6.415 ± 0.113	1.954SerMet: 1.954 ± 0.057	1.715SerAsn: 1.715 ± 0.06	2.255SerPro: 2.255 ± 0.045	2.249SerGln: 2.249 ± 0.061	4.145SerArg: 4.145 ± 0.088	3.615SerSer: 3.615 ± 0.076	2.726SerThr: 2.726 ± 0.064	4.275SerVal: 4.275 ± 0.082	0.843SerTrp: 0.843 ± 0.034	1.81SerTyr: 1.81 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	5.341ThrAla: 5.341 ± 0.09	0.65ThrCys: 0.65 ± 0.028	3.661ThrAsp: 3.661 ± 0.078	3.604ThrGlu: 3.604 ± 0.082	2.105ThrPhe: 2.105 ± 0.054	5.542ThrGly: 5.542 ± 0.1	0.909ThrHis: 0.909 ± 0.039	3.328ThrIle: 3.328 ± 0.075	2.326ThrLys: 2.326 ± 0.068	5.281ThrLeu: 5.281 ± 0.08	1.508ThrMet: 1.508 ± 0.043	1.674ThrAsn: 1.674 ± 0.057	2.697ThrPro: 2.697 ± 0.069	1.712ThrGln: 1.712 ± 0.042	2.818ThrArg: 2.818 ± 0.075	2.796ThrSer: 2.796 ± 0.06	2.618ThrThr: 2.618 ± 0.075	4.894ThrVal: 4.894 ± 0.096	0.774ThrTrp: 0.774 ± 0.041	1.599ThrTyr: 1.599 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.299ValAla: 4.299 ± 0.088	1.184ValCys: 1.184 ± 0.043	3.856ValAsp: 3.856 ± 0.078	3.578ValGlu: 3.578 ± 0.082	3.212ValPhe: 3.212 ± 0.083	3.269ValGly: 3.269 ± 0.073	1.305ValHis: 1.305 ± 0.041	4.712ValIle: 4.712 ± 0.09	3.581ValLys: 3.581 ± 0.079	7.383ValLeu: 7.383 ± 0.112	2.325ValMet: 2.325 ± 0.058	2.64ValAsn: 2.64 ± 0.066	3.115ValPro: 3.115 ± 0.07	2.848ValGln: 2.848 ± 0.06	3.831ValArg: 3.831 ± 0.082	4.459ValSer: 4.459 ± 0.071	4.46ValThr: 4.46 ± 0.094	4.427ValVal: 4.427 ± 0.09	0.817ValTrp: 0.817 ± 0.035	2.266ValTyr: 2.266 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.668TrpAla: 0.668 ± 0.034	0.197TrpCys: 0.197 ± 0.016	0.563TrpAsp: 0.563 ± 0.023	0.646TrpGlu: 0.646 ± 0.034	0.568TrpPhe: 0.568 ± 0.028	0.593TrpGly: 0.593 ± 0.027	0.276TrpHis: 0.276 ± 0.019	0.927TrpIle: 0.927 ± 0.042	0.932TrpLys: 0.932 ± 0.038	1.524TrpLeu: 1.524 ± 0.054	0.467TrpMet: 0.467 ± 0.025	0.634TrpAsn: 0.634 ± 0.032	0.388TrpPro: 0.388 ± 0.024	0.663TrpGln: 0.663 ± 0.034	0.504TrpArg: 0.504 ± 0.028	0.671TrpSer: 0.671 ± 0.036	0.688TrpThr: 0.688 ± 0.034	0.67TrpVal: 0.67 ± 0.03	0.149TrpTrp: 0.149 ± 0.014	0.445TrpTyr: 0.445 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.502TyrAla: 2.502 ± 0.055	0.424TyrCys: 0.424 ± 0.025	2.24TyrAsp: 2.24 ± 0.065	2.119TyrGlu: 2.119 ± 0.051	1.281TyrPhe: 1.281 ± 0.042	2.486TyrGly: 2.486 ± 0.056	0.684TyrHis: 0.684 ± 0.036	1.901TyrIle: 1.901 ± 0.054	1.521TyrLys: 1.521 ± 0.051	3.055TyrLeu: 3.055 ± 0.076	0.791TyrMet: 0.791 ± 0.033	1.249TyrAsn: 1.249 ± 0.052	1.501TyrPro: 1.501 ± 0.048	1.163TyrGln: 1.163 ± 0.044	2.048TyrArg: 2.048 ± 0.054	1.851TyrSer: 1.851 ± 0.05	1.924TyrThr: 1.924 ± 0.062	2.088TyrVal: 2.088 ± 0.053	0.385TyrTrp: 0.385 ± 0.025	1.185TyrTyr: 1.185 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2740 proteins (719718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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