Amino acid dipepetide frequency for Desulfonatronum thiosulfatophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.391AlaAla: 9.391 ± 0.132	1.138AlaCys: 1.138 ± 0.035	4.623AlaAsp: 4.623 ± 0.072	5.981AlaGlu: 5.981 ± 0.09	3.535AlaPhe: 3.535 ± 0.057	7.486AlaGly: 7.486 ± 0.104	1.894AlaHis: 1.894 ± 0.047	4.184AlaIle: 4.184 ± 0.081	3.64AlaLys: 3.64 ± 0.07	11.002AlaLeu: 11.002 ± 0.13	3.04AlaMet: 3.04 ± 0.06	2.347AlaAsn: 2.347 ± 0.052	3.511AlaPro: 3.511 ± 0.078	3.49AlaGln: 3.49 ± 0.065	6.041AlaArg: 6.041 ± 0.081	4.678AlaSer: 4.678 ± 0.067	3.886AlaThr: 3.886 ± 0.059	7.223AlaVal: 7.223 ± 0.099	1.229AlaTrp: 1.229 ± 0.038	2.222AlaTyr: 2.222 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.034	0.222CysCys: 0.222 ± 0.016	0.533CysAsp: 0.533 ± 0.023	0.519CysGlu: 0.519 ± 0.022	0.47CysPhe: 0.47 ± 0.021	1.12CysGly: 1.12 ± 0.037	0.36CysHis: 0.36 ± 0.029	0.629CysIle: 0.629 ± 0.024	0.429CysLys: 0.429 ± 0.019	1.36CysLeu: 1.36 ± 0.035	0.27CysMet: 0.27 ± 0.017	0.353CysAsn: 0.353 ± 0.017	0.823CysPro: 0.823 ± 0.033	0.309CysGln: 0.309 ± 0.017	0.971CysArg: 0.971 ± 0.031	0.766CysSer: 0.766 ± 0.029	0.597CysThr: 0.597 ± 0.025	0.792CysVal: 0.792 ± 0.027	0.164CysTrp: 0.164 ± 0.012	0.275CysTyr: 0.275 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.534AspAla: 4.534 ± 0.067	0.602AspCys: 0.602 ± 0.026	2.747AspAsp: 2.747 ± 0.059	3.44AspGlu: 3.44 ± 0.066	2.542AspPhe: 2.542 ± 0.051	3.583AspGly: 3.583 ± 0.073	1.376AspHis: 1.376 ± 0.034	3.446AspIle: 3.446 ± 0.066	2.135AspLys: 2.135 ± 0.05	6.509AspLeu: 6.509 ± 0.091	1.544AspMet: 1.544 ± 0.035	1.572AspAsn: 1.572 ± 0.037	3.187AspPro: 3.187 ± 0.057	2.469AspGln: 2.469 ± 0.053	3.438AspArg: 3.438 ± 0.064	2.545AspSer: 2.545 ± 0.052	2.0AspThr: 2.0 ± 0.046	4.081AspVal: 4.081 ± 0.056	0.77AspTrp: 0.77 ± 0.031	1.584AspTyr: 1.584 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.757GluAla: 5.757 ± 0.08	0.571GluCys: 0.571 ± 0.024	3.357GluAsp: 3.357 ± 0.063	4.627GluGlu: 4.627 ± 0.08	2.257GluPhe: 2.257 ± 0.049	3.826GluGly: 3.826 ± 0.063	1.69GluHis: 1.69 ± 0.039	4.178GluIle: 4.178 ± 0.065	3.158GluLys: 3.158 ± 0.06	7.182GluLeu: 7.182 ± 0.101	2.124GluMet: 2.124 ± 0.044	2.29GluAsn: 2.29 ± 0.048	2.558GluPro: 2.558 ± 0.061	3.497GluGln: 3.497 ± 0.065	4.467GluArg: 4.467 ± 0.08	3.448GluSer: 3.448 ± 0.062	3.27GluThr: 3.27 ± 0.056	4.259GluVal: 4.259 ± 0.07	0.715GluTrp: 0.715 ± 0.026	1.659GluTyr: 1.659 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.483PheAla: 3.483 ± 0.056	0.619PheCys: 0.619 ± 0.024	2.174PheAsp: 2.174 ± 0.042	2.193PheGlu: 2.193 ± 0.047	2.283PhePhe: 2.283 ± 0.061	3.219PheGly: 3.219 ± 0.056	0.966PheHis: 0.966 ± 0.027	2.223PheIle: 2.223 ± 0.056	1.356PheLys: 1.356 ± 0.041	4.79PheLeu: 4.79 ± 0.077	1.065PheMet: 1.065 ± 0.033	1.324PheAsn: 1.324 ± 0.036	2.014PhePro: 2.014 ± 0.046	1.685PheGln: 1.685 ± 0.039	2.502PheArg: 2.502 ± 0.044	2.919PheSer: 2.919 ± 0.053	2.196PheThr: 2.196 ± 0.048	2.834PheVal: 2.834 ± 0.055	0.727PheTrp: 0.727 ± 0.03	1.171PheTyr: 1.171 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.871GlyAla: 5.871 ± 0.098	1.094GlyCys: 1.094 ± 0.035	3.586GlyAsp: 3.586 ± 0.071	4.446GlyGlu: 4.446 ± 0.067	3.419GlyPhe: 3.419 ± 0.056	5.23GlyGly: 5.23 ± 0.082	1.847GlyHis: 1.847 ± 0.043	4.632GlyIle: 4.632 ± 0.077	3.615GlyLys: 3.615 ± 0.073	8.895GlyLeu: 8.895 ± 0.112	2.635GlyMet: 2.635 ± 0.054	2.226GlyAsn: 2.226 ± 0.052	2.821GlyPro: 2.821 ± 0.058	2.899GlyGln: 2.899 ± 0.061	5.298GlyArg: 5.298 ± 0.076	3.938GlySer: 3.938 ± 0.064	3.696GlyThr: 3.696 ± 0.065	5.375GlyVal: 5.375 ± 0.085	1.078GlyTrp: 1.078 ± 0.037	2.291GlyTyr: 2.291 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.134HisAla: 2.134 ± 0.046	0.361HisCys: 0.361 ± 0.018	1.341HisAsp: 1.341 ± 0.035	1.387HisGlu: 1.387 ± 0.037	1.092HisPhe: 1.092 ± 0.031	2.021HisGly: 2.021 ± 0.045	0.668HisHis: 0.668 ± 0.029	1.121HisIle: 1.121 ± 0.031	0.786HisLys: 0.786 ± 0.025	2.707HisLeu: 2.707 ± 0.052	0.488HisMet: 0.488 ± 0.024	0.675HisAsn: 0.675 ± 0.025	1.605HisPro: 1.605 ± 0.045	0.912HisGln: 0.912 ± 0.031	1.517HisArg: 1.517 ± 0.038	1.192HisSer: 1.192 ± 0.034	0.874HisThr: 0.874 ± 0.026	1.691HisVal: 1.691 ± 0.047	0.318HisTrp: 0.318 ± 0.019	0.679HisTyr: 0.679 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.876IleAla: 4.876 ± 0.075	0.754IleCys: 0.754 ± 0.03	2.749IleAsp: 2.749 ± 0.048	3.068IleGlu: 3.068 ± 0.062	2.59IlePhe: 2.59 ± 0.057	4.092IleGly: 4.092 ± 0.077	1.337IleHis: 1.337 ± 0.034	3.293IleIle: 3.293 ± 0.073	2.164IleLys: 2.164 ± 0.052	6.628IleLeu: 6.628 ± 0.095	1.417IleMet: 1.417 ± 0.034	1.909IleAsn: 1.909 ± 0.045	3.078IlePro: 3.078 ± 0.064	2.125IleGln: 2.125 ± 0.048	4.004IleArg: 4.004 ± 0.056	3.737IleSer: 3.737 ± 0.065	2.954IleThr: 2.954 ± 0.057	3.896IleVal: 3.896 ± 0.065	0.661IleTrp: 0.661 ± 0.026	1.343IleTyr: 1.343 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.837LysAla: 3.837 ± 0.066	0.387LysCys: 0.387 ± 0.02	2.276LysAsp: 2.276 ± 0.051	2.681LysGlu: 2.681 ± 0.057	1.291LysPhe: 1.291 ± 0.037	2.811LysGly: 2.811 ± 0.054	0.897LysHis: 0.897 ± 0.035	2.595LysIle: 2.595 ± 0.061	2.266LysLys: 2.266 ± 0.057	3.754LysLeu: 3.754 ± 0.064	1.228LysMet: 1.228 ± 0.035	1.622LysAsn: 1.622 ± 0.044	1.99LysPro: 1.99 ± 0.044	1.517LysGln: 1.517 ± 0.039	2.38LysArg: 2.38 ± 0.049	2.414LysSer: 2.414 ± 0.051	2.34LysThr: 2.34 ± 0.05	2.757LysVal: 2.757 ± 0.067	0.409LysTrp: 0.409 ± 0.02	1.014LysTyr: 1.014 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.471LeuAla: 11.471 ± 0.126	1.265LeuCys: 1.265 ± 0.039	6.536LeuAsp: 6.536 ± 0.087	7.908LeuGlu: 7.908 ± 0.103	4.639LeuPhe: 4.639 ± 0.084	8.574LeuGly: 8.574 ± 0.097	2.604LeuHis: 2.604 ± 0.042	5.738LeuIle: 5.738 ± 0.091	4.226LeuLys: 4.226 ± 0.077	12.384LeuLeu: 12.384 ± 0.134	2.452LeuMet: 2.452 ± 0.051	3.453LeuAsn: 3.453 ± 0.068	5.841LeuPro: 5.841 ± 0.088	4.14LeuGln: 4.14 ± 0.065	7.863LeuArg: 7.863 ± 0.095	6.547LeuSer: 6.547 ± 0.09	5.448LeuThr: 5.448 ± 0.072	7.643LeuVal: 7.643 ± 0.095	1.206LeuTrp: 1.206 ± 0.036	2.272LeuTyr: 2.272 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.995MetAla: 2.995 ± 0.057	0.213MetCys: 0.213 ± 0.014	1.76MetAsp: 1.76 ± 0.043	1.862MetGlu: 1.862 ± 0.041	0.938MetPhe: 0.938 ± 0.029	2.019MetGly: 2.019 ± 0.044	0.653MetHis: 0.653 ± 0.023	1.687MetIle: 1.687 ± 0.045	1.12MetLys: 1.12 ± 0.033	2.828MetLeu: 2.828 ± 0.054	0.622MetMet: 0.622 ± 0.029	1.129MetAsn: 1.129 ± 0.032	1.49MetPro: 1.49 ± 0.04	1.126MetGln: 1.126 ± 0.037	1.741MetArg: 1.741 ± 0.041	1.706MetSer: 1.706 ± 0.041	1.639MetThr: 1.639 ± 0.041	2.025MetVal: 2.025 ± 0.043	0.189MetTrp: 0.189 ± 0.012	0.527MetTyr: 0.527 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.724AsnAla: 2.724 ± 0.054	0.431AsnCys: 0.431 ± 0.02	1.407AsnAsp: 1.407 ± 0.038	1.647AsnGlu: 1.647 ± 0.041	1.299AsnPhe: 1.299 ± 0.035	2.032AsnGly: 2.032 ± 0.048	0.744AsnHis: 0.744 ± 0.025	2.179AsnIle: 2.179 ± 0.049	1.251AsnLys: 1.251 ± 0.039	3.818AsnLeu: 3.818 ± 0.062	0.979AsnMet: 0.979 ± 0.03	1.094AsnAsn: 1.094 ± 0.037	2.114AsnPro: 2.114 ± 0.047	1.3AsnGln: 1.3 ± 0.036	1.997AsnArg: 1.997 ± 0.052	1.599AsnSer: 1.599 ± 0.041	1.402AsnThr: 1.402 ± 0.04	2.271AsnVal: 2.271 ± 0.044	0.43AsnTrp: 0.43 ± 0.02	0.91AsnTyr: 0.91 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.214ProAla: 4.214 ± 0.073	0.57ProCys: 0.57 ± 0.024	3.455ProAsp: 3.455 ± 0.069	4.554ProGlu: 4.554 ± 0.068	1.978ProPhe: 1.978 ± 0.044	4.262ProGly: 4.262 ± 0.082	1.103ProHis: 1.103 ± 0.027	2.059ProIle: 2.059 ± 0.047	1.83ProLys: 1.83 ± 0.044	4.906ProLeu: 4.906 ± 0.077	1.278ProMet: 1.278 ± 0.035	1.339ProAsn: 1.339 ± 0.04	2.133ProPro: 2.133 ± 0.06	1.702ProGln: 1.702 ± 0.036	2.734ProArg: 2.734 ± 0.059	2.584ProSer: 2.584 ± 0.051	2.109ProThr: 2.109 ± 0.046	3.836ProVal: 3.836 ± 0.065	0.746ProTrp: 0.746 ± 0.033	1.141ProTyr: 1.141 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.692GlnAla: 4.692 ± 0.077	0.416GlnCys: 0.416 ± 0.022	2.342GlnAsp: 2.342 ± 0.044	2.832GlnGlu: 2.832 ± 0.055	1.259GlnPhe: 1.259 ± 0.034	3.277GlnGly: 3.277 ± 0.062	0.805GlnHis: 0.805 ± 0.026	2.144GlnIle: 2.144 ± 0.046	1.653GlnLys: 1.653 ± 0.045	3.379GlnLeu: 3.379 ± 0.065	1.033GlnMet: 1.033 ± 0.03	1.285GlnAsn: 1.285 ± 0.034	1.79GlnPro: 1.79 ± 0.05	1.545GlnGln: 1.545 ± 0.048	2.856GlnArg: 2.856 ± 0.063	2.193GlnSer: 2.193 ± 0.047	2.05GlnThr: 2.05 ± 0.04	2.918GlnVal: 2.918 ± 0.056	0.52GlnTrp: 0.52 ± 0.021	0.795GlnTyr: 0.795 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.836ArgAla: 4.836 ± 0.071	0.685ArgCys: 0.685 ± 0.025	3.702ArgAsp: 3.702 ± 0.06	5.14ArgGlu: 5.14 ± 0.082	2.975ArgPhe: 2.975 ± 0.061	4.039ArgGly: 4.039 ± 0.071	1.673ArgHis: 1.673 ± 0.037	4.758ArgIle: 4.758 ± 0.068	3.307ArgLys: 3.307 ± 0.066	7.484ArgLeu: 7.484 ± 0.101	2.078ArgMet: 2.078 ± 0.046	2.496ArgAsn: 2.496 ± 0.053	2.864ArgPro: 2.864 ± 0.058	2.896ArgGln: 2.896 ± 0.055	4.588ArgArg: 4.588 ± 0.084	3.507ArgSer: 3.507 ± 0.059	3.416ArgThr: 3.416 ± 0.056	4.243ArgVal: 4.243 ± 0.07	0.762ArgTrp: 0.762 ± 0.025	1.728ArgTyr: 1.728 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.708SerAla: 4.708 ± 0.075	0.725SerCys: 0.725 ± 0.031	2.763SerAsp: 2.763 ± 0.048	3.374SerGlu: 3.374 ± 0.058	2.408SerPhe: 2.408 ± 0.049	5.254SerGly: 5.254 ± 0.078	1.225SerHis: 1.225 ± 0.034	3.099SerIle: 3.099 ± 0.057	2.057SerLys: 2.057 ± 0.049	6.286SerLeu: 6.286 ± 0.084	1.77SerMet: 1.77 ± 0.042	1.484SerAsn: 1.484 ± 0.04	2.931SerPro: 2.931 ± 0.053	2.028SerGln: 2.028 ± 0.046	4.22SerArg: 4.22 ± 0.072	3.539SerSer: 3.539 ± 0.069	2.714SerThr: 2.714 ± 0.055	3.693SerVal: 3.693 ± 0.06	0.852SerTrp: 0.852 ± 0.029	1.304SerTyr: 1.304 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.462ThrAla: 4.462 ± 0.071	0.538ThrCys: 0.538 ± 0.023	2.567ThrAsp: 2.567 ± 0.058	2.686ThrGlu: 2.686 ± 0.058	1.941ThrPhe: 1.941 ± 0.045	4.295ThrGly: 4.295 ± 0.064	1.051ThrHis: 1.051 ± 0.031	2.797ThrIle: 2.797 ± 0.046	1.759ThrLys: 1.759 ± 0.04	5.396ThrLeu: 5.396 ± 0.086	1.418ThrMet: 1.418 ± 0.038	1.413ThrAsn: 1.413 ± 0.035	2.799ThrPro: 2.799 ± 0.057	1.631ThrGln: 1.631 ± 0.04	2.833ThrArg: 2.833 ± 0.055	2.775ThrSer: 2.775 ± 0.053	2.5ThrThr: 2.5 ± 0.057	3.524ThrVal: 3.524 ± 0.061	0.605ThrTrp: 0.605 ± 0.026	1.274ThrTyr: 1.274 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.363ValAla: 6.363 ± 0.087	0.889ValCys: 0.889 ± 0.03	4.111ValAsp: 4.111 ± 0.064	4.417ValGlu: 4.417 ± 0.074	3.066ValPhe: 3.066 ± 0.057	4.959ValGly: 4.959 ± 0.084	1.731ValHis: 1.731 ± 0.042	3.996ValIle: 3.996 ± 0.075	2.324ValLys: 2.324 ± 0.059	8.385ValLeu: 8.385 ± 0.098	1.924ValMet: 1.924 ± 0.045	2.273ValAsn: 2.273 ± 0.05	3.113ValPro: 3.113 ± 0.051	2.935ValGln: 2.935 ± 0.057	5.078ValArg: 5.078 ± 0.071	4.057ValSer: 4.057 ± 0.065	3.398ValThr: 3.398 ± 0.055	5.55ValVal: 5.55 ± 0.101	0.812ValTrp: 0.812 ± 0.034	1.683ValTyr: 1.683 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.01TrpAla: 1.01 ± 0.03	0.126TrpCys: 0.126 ± 0.01	0.684TrpAsp: 0.684 ± 0.026	0.757TrpGlu: 0.757 ± 0.03	0.504TrpPhe: 0.504 ± 0.023	0.822TrpGly: 0.822 ± 0.029	0.3TrpHis: 0.3 ± 0.016	0.738TrpIle: 0.738 ± 0.026	0.599TrpLys: 0.599 ± 0.024	1.465TrpLeu: 1.465 ± 0.041	0.387TrpMet: 0.387 ± 0.021	0.533TrpAsn: 0.533 ± 0.023	0.628TrpPro: 0.628 ± 0.031	0.581TrpGln: 0.581 ± 0.024	0.921TrpArg: 0.921 ± 0.03	0.801TrpSer: 0.801 ± 0.027	0.629TrpThr: 0.629 ± 0.024	0.803TrpVal: 0.803 ± 0.026	0.22TrpTrp: 0.22 ± 0.015	0.307TrpTyr: 0.307 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.201TyrAla: 2.201 ± 0.045	0.339TyrCys: 0.339 ± 0.02	1.39TyrAsp: 1.39 ± 0.039	1.37TyrGlu: 1.37 ± 0.034	1.258TyrPhe: 1.258 ± 0.037	1.969TyrGly: 1.969 ± 0.042	0.642TyrHis: 0.642 ± 0.026	1.178TyrIle: 1.178 ± 0.037	0.793TyrLys: 0.793 ± 0.03	3.051TyrLeu: 3.051 ± 0.058	0.516TyrMet: 0.516 ± 0.023	0.813TyrAsn: 0.813 ± 0.034	1.245TyrPro: 1.245 ± 0.032	0.995TyrGln: 0.995 ± 0.033	1.729TyrArg: 1.729 ± 0.045	1.493TyrSer: 1.493 ± 0.043	1.146TyrThr: 1.146 ± 0.035	1.651TyrVal: 1.651 ± 0.04	0.401TyrTrp: 0.401 ± 0.023	0.826TyrTyr: 0.826 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3184 proteins (1035802 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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