Amino acid dipepetide frequency for Fontimonas thermophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.709AlaAla: 17.709 ± 0.221	1.43AlaCys: 1.43 ± 0.043	7.083AlaAsp: 7.083 ± 0.092	7.428AlaGlu: 7.428 ± 0.113	3.856AlaPhe: 3.856 ± 0.072	9.981AlaGly: 9.981 ± 0.125	3.131AlaHis: 3.131 ± 0.065	5.562AlaIle: 5.562 ± 0.09	2.862AlaLys: 2.862 ± 0.076	15.446AlaLeu: 15.446 ± 0.211	2.769AlaMet: 2.769 ± 0.057	2.435AlaAsn: 2.435 ± 0.053	6.124AlaPro: 6.124 ± 0.096	5.939AlaGln: 5.939 ± 0.093	11.046AlaArg: 11.046 ± 0.128	5.555AlaSer: 5.555 ± 0.098	5.551AlaThr: 5.551 ± 0.093	9.257AlaVal: 9.257 ± 0.118	1.867AlaTrp: 1.867 ± 0.055	2.998AlaTyr: 2.998 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.566CysAla: 1.566 ± 0.049	0.139CysCys: 0.139 ± 0.013	0.512CysAsp: 0.512 ± 0.024	0.532CysGlu: 0.532 ± 0.025	0.305CysPhe: 0.305 ± 0.019	1.121CysGly: 1.121 ± 0.038	0.299CysHis: 0.299 ± 0.027	0.488CysIle: 0.488 ± 0.027	0.209CysLys: 0.209 ± 0.016	0.929CysLeu: 0.929 ± 0.031	0.159CysMet: 0.159 ± 0.012	0.238CysAsn: 0.238 ± 0.018	0.581CysPro: 0.581 ± 0.033	0.231CysGln: 0.231 ± 0.016	0.772CysArg: 0.772 ± 0.031	0.472CysSer: 0.472 ± 0.024	0.58CysThr: 0.58 ± 0.026	0.759CysVal: 0.759 ± 0.034	0.142CysTrp: 0.142 ± 0.014	0.261CysTyr: 0.261 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.743AspAla: 7.743 ± 0.115	0.538AspCys: 0.538 ± 0.03	2.893AspAsp: 2.893 ± 0.069	3.301AspGlu: 3.301 ± 0.064	2.011AspPhe: 2.011 ± 0.047	5.071AspGly: 5.071 ± 0.098	1.145AspHis: 1.145 ± 0.04	2.534AspIle: 2.534 ± 0.051	1.382AspLys: 1.382 ± 0.05	5.592AspLeu: 5.592 ± 0.08	0.882AspMet: 0.882 ± 0.034	1.104AspAsn: 1.104 ± 0.038	3.768AspPro: 3.768 ± 0.075	1.509AspGln: 1.509 ± 0.048	4.145AspArg: 4.145 ± 0.076	1.908AspSer: 1.908 ± 0.05	2.689AspThr: 2.689 ± 0.066	3.904AspVal: 3.904 ± 0.071	1.0AspTrp: 1.0 ± 0.035	1.745AspTyr: 1.745 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.87GluAla: 6.87 ± 0.111	0.466GluCys: 0.466 ± 0.024	2.613GluAsp: 2.613 ± 0.051	2.622GluGlu: 2.622 ± 0.076	1.784GluPhe: 1.784 ± 0.043	3.571GluGly: 3.571 ± 0.069	1.445GluHis: 1.445 ± 0.04	3.23GluIle: 3.23 ± 0.06	1.726GluLys: 1.726 ± 0.061	6.286GluLeu: 6.286 ± 0.11	1.179GluMet: 1.179 ± 0.039	1.374GluAsn: 1.374 ± 0.042	2.776GluPro: 2.776 ± 0.061	2.623GluGln: 2.623 ± 0.063	5.708GluArg: 5.708 ± 0.09	2.403GluSer: 2.403 ± 0.052	2.899GluThr: 2.899 ± 0.062	3.828GluVal: 3.828 ± 0.08	0.759GluTrp: 0.759 ± 0.029	1.326GluTyr: 1.326 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.364PheAla: 4.364 ± 0.087	0.405PheCys: 0.405 ± 0.028	2.48PheAsp: 2.48 ± 0.053	2.124PheGlu: 2.124 ± 0.045	1.33PhePhe: 1.33 ± 0.045	3.186PheGly: 3.186 ± 0.068	0.733PheHis: 0.733 ± 0.029	1.471PheIle: 1.471 ± 0.041	0.945PheLys: 0.945 ± 0.039	2.832PheLeu: 2.832 ± 0.061	0.688PheMet: 0.688 ± 0.03	0.982PheAsn: 0.982 ± 0.033	1.477PhePro: 1.477 ± 0.04	0.906PheGln: 0.906 ± 0.03	2.238PheArg: 2.238 ± 0.047	1.711PheSer: 1.711 ± 0.047	1.802PheThr: 1.802 ± 0.048	2.71PheVal: 2.71 ± 0.067	0.478PheTrp: 0.478 ± 0.024	0.91PheTyr: 0.91 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.836GlyAla: 8.836 ± 0.12	1.073GlyCys: 1.073 ± 0.037	4.082GlyAsp: 4.082 ± 0.077	4.661GlyGlu: 4.661 ± 0.072	3.211GlyPhe: 3.211 ± 0.067	6.758GlyGly: 6.758 ± 0.121	2.116GlyHis: 2.116 ± 0.051	4.446GlyIle: 4.446 ± 0.079	2.605GlyLys: 2.605 ± 0.063	8.856GlyLeu: 8.856 ± 0.125	1.984GlyMet: 1.984 ± 0.049	1.878GlyAsn: 1.878 ± 0.056	3.194GlyPro: 3.194 ± 0.067	2.713GlyGln: 2.713 ± 0.061	6.362GlyArg: 6.362 ± 0.096	4.022GlySer: 4.022 ± 0.072	4.413GlyThr: 4.413 ± 0.09	6.445GlyVal: 6.445 ± 0.083	1.397GlyTrp: 1.397 ± 0.046	2.534GlyTyr: 2.534 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.996HisAla: 2.996 ± 0.07	0.311HisCys: 0.311 ± 0.019	1.16HisAsp: 1.16 ± 0.041	1.188HisGlu: 1.188 ± 0.043	0.92HisPhe: 0.92 ± 0.035	2.261HisGly: 2.261 ± 0.056	0.768HisHis: 0.768 ± 0.035	0.989HisIle: 0.989 ± 0.035	0.595HisLys: 0.595 ± 0.026	2.591HisLeu: 2.591 ± 0.057	0.419HisMet: 0.419 ± 0.022	0.518HisAsn: 0.518 ± 0.027	1.755HisPro: 1.755 ± 0.045	0.614HisGln: 0.614 ± 0.027	1.977HisArg: 1.977 ± 0.055	0.897HisSer: 0.897 ± 0.037	1.145HisThr: 1.145 ± 0.039	1.608HisVal: 1.608 ± 0.049	0.471HisTrp: 0.471 ± 0.023	0.747HisTyr: 0.747 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.921IleAla: 6.921 ± 0.103	0.47IleCys: 0.47 ± 0.024	3.528IleAsp: 3.528 ± 0.073	3.758IleGlu: 3.758 ± 0.083	1.278IlePhe: 1.278 ± 0.042	4.595IleGly: 4.595 ± 0.082	1.061IleHis: 1.061 ± 0.036	1.749IleIle: 1.749 ± 0.053	1.373IleLys: 1.373 ± 0.048	3.872IleLeu: 3.872 ± 0.069	0.663IleMet: 0.663 ± 0.026	1.273IleAsn: 1.273 ± 0.039	2.485IlePro: 2.485 ± 0.06	1.458IleGln: 1.458 ± 0.044	3.43IleArg: 3.43 ± 0.06	1.943IleSer: 1.943 ± 0.048	2.407IleThr: 2.407 ± 0.058	4.063IleVal: 4.063 ± 0.08	0.534IleTrp: 0.534 ± 0.028	1.048IleTyr: 1.048 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.232LysAla: 3.232 ± 0.085	0.176LysCys: 0.176 ± 0.018	1.358LysAsp: 1.358 ± 0.042	1.208LysGlu: 1.208 ± 0.049	0.706LysPhe: 0.706 ± 0.029	1.915LysGly: 1.915 ± 0.057	0.589LysHis: 0.589 ± 0.029	1.429LysIle: 1.429 ± 0.048	1.132LysLys: 1.132 ± 0.05	2.985LysLeu: 2.985 ± 0.066	0.572LysMet: 0.572 ± 0.03	0.77LysAsn: 0.77 ± 0.032	1.904LysPro: 1.904 ± 0.05	0.989LysGln: 0.989 ± 0.044	2.088LysArg: 2.088 ± 0.053	1.227LysSer: 1.227 ± 0.04	1.774LysThr: 1.774 ± 0.051	1.79LysVal: 1.79 ± 0.063	0.283LysTrp: 0.283 ± 0.016	0.618LysTyr: 0.618 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	14.964LeuAla: 14.964 ± 0.175	1.165LeuCys: 1.165 ± 0.038	6.769LeuAsp: 6.769 ± 0.103	5.742LeuGlu: 5.742 ± 0.1	3.487LeuPhe: 3.487 ± 0.081	8.795LeuGly: 8.795 ± 0.125	2.451LeuHis: 2.451 ± 0.065	5.054LeuIle: 5.054 ± 0.081	3.186LeuLys: 3.186 ± 0.068	11.523LeuLeu: 11.523 ± 0.171	2.191LeuMet: 2.191 ± 0.06	2.292LeuAsn: 2.292 ± 0.05	6.444LeuPro: 6.444 ± 0.103	3.505LeuGln: 3.505 ± 0.076	9.931LeuArg: 9.931 ± 0.152	5.575LeuSer: 5.575 ± 0.087	5.373LeuThr: 5.373 ± 0.085	7.553LeuVal: 7.553 ± 0.098	1.477LeuTrp: 1.477 ± 0.049	2.447LeuTyr: 2.447 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.457MetAla: 2.457 ± 0.055	0.167MetCys: 0.167 ± 0.014	0.997MetAsp: 0.997 ± 0.039	0.856MetGlu: 0.856 ± 0.032	0.659MetPhe: 0.659 ± 0.028	1.427MetGly: 1.427 ± 0.048	0.505MetHis: 0.505 ± 0.021	0.978MetIle: 0.978 ± 0.036	0.822MetLys: 0.822 ± 0.033	2.307MetLeu: 2.307 ± 0.051	0.427MetMet: 0.427 ± 0.025	0.713MetAsn: 0.713 ± 0.033	1.27MetPro: 1.27 ± 0.04	0.809MetGln: 0.809 ± 0.027	1.853MetArg: 1.853 ± 0.045	1.295MetSer: 1.295 ± 0.042	1.311MetThr: 1.311 ± 0.04	1.227MetVal: 1.227 ± 0.039	0.156MetTrp: 0.156 ± 0.013	0.362MetTyr: 0.362 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.964AsnAla: 2.964 ± 0.064	0.245AsnCys: 0.245 ± 0.019	1.114AsnAsp: 1.114 ± 0.035	1.107AsnGlu: 1.107 ± 0.032	0.844AsnPhe: 0.844 ± 0.034	2.038AsnGly: 2.038 ± 0.055	0.455AsnHis: 0.455 ± 0.023	1.071AsnIle: 1.071 ± 0.036	0.583AsnLys: 0.583 ± 0.03	2.503AsnLeu: 2.503 ± 0.057	0.393AsnMet: 0.393 ± 0.023	0.58AsnAsn: 0.58 ± 0.029	1.803AsnPro: 1.803 ± 0.052	0.727AsnGln: 0.727 ± 0.029	1.735AsnArg: 1.735 ± 0.047	0.807AsnSer: 0.807 ± 0.033	1.308AsnThr: 1.308 ± 0.04	1.66AsnVal: 1.66 ± 0.047	0.381AsnTrp: 0.381 ± 0.022	0.618AsnTyr: 0.618 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.063ProAla: 7.063 ± 0.112	0.4ProCys: 0.4 ± 0.024	3.677ProAsp: 3.677 ± 0.061	3.564ProGlu: 3.564 ± 0.064	1.802ProPhe: 1.802 ± 0.049	4.885ProGly: 4.885 ± 0.076	1.301ProHis: 1.301 ± 0.04	2.116ProIle: 2.116 ± 0.052	1.289ProLys: 1.289 ± 0.043	5.636ProLeu: 5.636 ± 0.088	1.21ProMet: 1.21 ± 0.045	1.216ProAsn: 1.216 ± 0.037	3.525ProPro: 3.525 ± 0.093	2.475ProGln: 2.475 ± 0.064	3.8ProArg: 3.8 ± 0.063	2.465ProSer: 2.465 ± 0.056	2.476ProThr: 2.476 ± 0.061	4.572ProVal: 4.572 ± 0.081	0.813ProTrp: 0.813 ± 0.033	1.361ProTyr: 1.361 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	5.229GlnAla: 5.229 ± 0.091	0.293GlnCys: 0.293 ± 0.019	1.485GlnAsp: 1.485 ± 0.041	1.473GlnGlu: 1.473 ± 0.045	1.133GlnPhe: 1.133 ± 0.037	2.566GlnGly: 2.566 ± 0.052	0.863GlnHis: 0.863 ± 0.033	1.927GlnIle: 1.927 ± 0.047	0.962GlnLys: 0.962 ± 0.036	3.84GlnLeu: 3.84 ± 0.069	0.859GlnMet: 0.859 ± 0.031	0.754GlnAsn: 0.754 ± 0.029	2.136GlnPro: 2.136 ± 0.051	1.577GlnGln: 1.577 ± 0.055	3.645GlnArg: 3.645 ± 0.065	1.555GlnSer: 1.555 ± 0.042	2.099GlnThr: 2.099 ± 0.054	2.494GlnVal: 2.494 ± 0.057	0.576GlnTrp: 0.576 ± 0.028	0.819GlnTyr: 0.819 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	9.759ArgAla: 9.759 ± 0.128	0.818ArgCys: 0.818 ± 0.04	4.19ArgAsp: 4.19 ± 0.078	4.953ArgGlu: 4.953 ± 0.082	3.101ArgPhe: 3.101 ± 0.059	5.321ArgGly: 5.321 ± 0.084	2.221ArgHis: 2.221 ± 0.048	5.004ArgIle: 5.004 ± 0.082	2.124ArgLys: 2.124 ± 0.061	10.352ArgLeu: 10.352 ± 0.137	2.036ArgMet: 2.036 ± 0.053	1.845ArgAsn: 1.845 ± 0.053	3.931ArgPro: 3.931 ± 0.072	2.939ArgGln: 2.939 ± 0.064	7.213ArgArg: 7.213 ± 0.127	3.574ArgSer: 3.574 ± 0.069	3.69ArgThr: 3.69 ± 0.063	5.651ArgVal: 5.651 ± 0.074	1.48ArgTrp: 1.48 ± 0.039	2.703ArgTyr: 2.703 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.927SerAla: 5.927 ± 0.092	0.424SerCys: 0.424 ± 0.025	2.292SerAsp: 2.292 ± 0.05	2.284SerGlu: 2.284 ± 0.059	1.668SerPhe: 1.668 ± 0.048	4.886SerGly: 4.886 ± 0.088	0.888SerHis: 0.888 ± 0.032	2.132SerIle: 2.132 ± 0.05	1.111SerLys: 1.111 ± 0.036	4.636SerLeu: 4.636 ± 0.082	0.987SerMet: 0.987 ± 0.035	1.053SerAsn: 1.053 ± 0.042	2.618SerPro: 2.618 ± 0.046	1.332SerGln: 1.332 ± 0.04	3.275SerArg: 3.275 ± 0.066	2.199SerSer: 2.199 ± 0.066	2.254SerThr: 2.254 ± 0.054	3.403SerVal: 3.403 ± 0.065	0.645SerTrp: 0.645 ± 0.028	1.046SerTyr: 1.046 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.244ThrAla: 6.244 ± 0.094	0.47ThrCys: 0.47 ± 0.027	2.591ThrAsp: 2.591 ± 0.059	2.407ThrGlu: 2.407 ± 0.062	1.451ThrPhe: 1.451 ± 0.044	4.596ThrGly: 4.596 ± 0.074	1.254ThrHis: 1.254 ± 0.037	2.268ThrIle: 2.268 ± 0.059	0.908ThrLys: 0.908 ± 0.036	6.34ThrLeu: 6.34 ± 0.097	0.902ThrMet: 0.902 ± 0.034	0.992ThrAsn: 0.992 ± 0.036	3.616ThrPro: 3.616 ± 0.07	1.867ThrGln: 1.867 ± 0.042	3.809ThrArg: 3.809 ± 0.061	2.085ThrSer: 2.085 ± 0.055	2.613ThrThr: 2.613 ± 0.059	4.119ThrVal: 4.119 ± 0.086	0.64ThrTrp: 0.64 ± 0.03	1.116ThrTyr: 1.116 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.544ValAla: 8.544 ± 0.112	0.865ValCys: 0.865 ± 0.035	3.916ValAsp: 3.916 ± 0.07	4.382ValGlu: 4.382 ± 0.079	2.701ValPhe: 2.701 ± 0.058	5.369ValGly: 5.369 ± 0.078	1.78ValHis: 1.78 ± 0.045	3.749ValIle: 3.749 ± 0.066	1.954ValLys: 1.954 ± 0.06	8.537ValLeu: 8.537 ± 0.124	1.542ValMet: 1.542 ± 0.047	1.889ValAsn: 1.889 ± 0.048	4.161ValPro: 4.161 ± 0.086	2.537ValGln: 2.537 ± 0.056	6.083ValArg: 6.083 ± 0.096	3.52ValSer: 3.52 ± 0.061	3.789ValThr: 3.789 ± 0.079	5.701ValVal: 5.701 ± 0.084	0.94ValTrp: 0.94 ± 0.033	1.692ValTyr: 1.692 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.366TrpAla: 1.366 ± 0.045	0.179TrpCys: 0.179 ± 0.016	0.655TrpAsp: 0.655 ± 0.026	0.555TrpGlu: 0.555 ± 0.027	0.532TrpPhe: 0.532 ± 0.028	0.935TrpGly: 0.935 ± 0.042	0.356TrpHis: 0.356 ± 0.02	0.77TrpIle: 0.77 ± 0.031	0.352TrpLys: 0.352 ± 0.023	2.186TrpLeu: 2.186 ± 0.063	0.356TrpMet: 0.356 ± 0.019	0.414TrpAsn: 0.414 ± 0.026	0.775TrpPro: 0.775 ± 0.03	0.685TrpGln: 0.685 ± 0.032	1.385TrpArg: 1.385 ± 0.038	0.785TrpSer: 0.785 ± 0.028	0.787TrpThr: 0.787 ± 0.031	1.016TrpVal: 1.016 ± 0.034	0.289TrpTrp: 0.289 ± 0.018	0.337TrpTyr: 0.337 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.274TyrAla: 3.274 ± 0.06	0.262TyrCys: 0.262 ± 0.017	1.467TyrAsp: 1.467 ± 0.051	1.345TyrGlu: 1.345 ± 0.041	0.994TyrPhe: 0.994 ± 0.035	2.309TyrGly: 2.309 ± 0.048	0.57TyrHis: 0.57 ± 0.028	0.945TyrIle: 0.945 ± 0.035	0.625TyrLys: 0.625 ± 0.032	2.673TyrLeu: 2.673 ± 0.058	0.378TyrMet: 0.378 ± 0.023	0.614TyrAsn: 0.614 ± 0.031	1.303TyrPro: 1.303 ± 0.044	0.85TyrGln: 0.85 ± 0.032	2.409TyrArg: 2.409 ± 0.054	1.063TyrSer: 1.063 ± 0.037	1.329TyrThr: 1.329 ± 0.043	1.892TyrVal: 1.892 ± 0.05	0.386TyrTrp: 0.386 ± 0.024	0.697TyrTyr: 0.697 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2498 proteins (840331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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