Amino acid dipepetide frequency for endosymbiont of Escarpia spicata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.323AlaAla: 9.323 ± 0.109	1.015AlaCys: 1.015 ± 0.039	5.546AlaAsp: 5.546 ± 0.072	6.402AlaGlu: 6.402 ± 0.082	3.333AlaPhe: 3.333 ± 0.056	7.733AlaGly: 7.733 ± 0.1	1.755AlaHis: 1.755 ± 0.038	5.113AlaIle: 5.113 ± 0.076	3.762AlaLys: 3.762 ± 0.08	9.874AlaLeu: 9.874 ± 0.111	2.513AlaMet: 2.513 ± 0.048	2.85AlaAsn: 2.85 ± 0.055	3.291AlaPro: 3.291 ± 0.072	3.226AlaGln: 3.226 ± 0.06	5.157AlaArg: 5.157 ± 0.077	4.992AlaSer: 4.992 ± 0.075	4.406AlaThr: 4.406 ± 0.071	6.474AlaVal: 6.474 ± 0.074	1.203AlaTrp: 1.203 ± 0.038	2.203AlaTyr: 2.203 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.769CysAla: 0.769 ± 0.032	0.15CysCys: 0.15 ± 0.012	0.547CysAsp: 0.547 ± 0.021	0.544CysGlu: 0.544 ± 0.023	0.336CysPhe: 0.336 ± 0.017	0.974CysGly: 0.974 ± 0.034	0.546CysHis: 0.546 ± 0.039	0.482CysIle: 0.482 ± 0.021	0.344CysLys: 0.344 ± 0.018	0.944CysLeu: 0.944 ± 0.028	0.2CysMet: 0.2 ± 0.014	0.332CysAsn: 0.332 ± 0.018	0.608CysPro: 0.608 ± 0.023	0.323CysGln: 0.323 ± 0.016	0.694CysArg: 0.694 ± 0.027	0.607CysSer: 0.607 ± 0.022	0.453CysThr: 0.453 ± 0.018	0.579CysVal: 0.579 ± 0.025	0.124CysTrp: 0.124 ± 0.009	0.238CysTyr: 0.238 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.215AspAla: 5.215 ± 0.082	0.585AspCys: 0.585 ± 0.021	3.463AspAsp: 3.463 ± 0.067	4.347AspGlu: 4.347 ± 0.073	2.492AspPhe: 2.492 ± 0.051	4.782AspGly: 4.782 ± 0.111	1.259AspHis: 1.259 ± 0.035	3.468AspIle: 3.468 ± 0.058	2.265AspLys: 2.265 ± 0.048	6.269AspLeu: 6.269 ± 0.073	1.33AspMet: 1.33 ± 0.037	2.036AspAsn: 2.036 ± 0.058	3.16AspPro: 3.16 ± 0.063	2.342AspGln: 2.342 ± 0.042	3.506AspArg: 3.506 ± 0.058	3.285AspSer: 3.285 ± 0.058	2.788AspThr: 2.788 ± 0.054	3.694AspVal: 3.694 ± 0.06	0.943AspTrp: 0.943 ± 0.031	1.952AspTyr: 1.952 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.361GluAla: 6.361 ± 0.094	0.484GluCys: 0.484 ± 0.022	3.168GluAsp: 3.168 ± 0.061	4.254GluGlu: 4.254 ± 0.087	2.099GluPhe: 2.099 ± 0.044	4.461GluGly: 4.461 ± 0.065	1.418GluHis: 1.418 ± 0.038	4.339GluIle: 4.339 ± 0.078	3.466GluLys: 3.466 ± 0.067	6.758GluLeu: 6.758 ± 0.084	1.985GluMet: 1.985 ± 0.046	2.368GluAsn: 2.368 ± 0.045	2.415GluPro: 2.415 ± 0.045	3.737GluGln: 3.737 ± 0.077	4.461GluArg: 4.461 ± 0.075	4.162GluSer: 4.162 ± 0.064	3.896GluThr: 3.896 ± 0.065	4.529GluVal: 4.529 ± 0.066	0.887GluTrp: 0.887 ± 0.027	1.624GluTyr: 1.624 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.053PheAla: 3.053 ± 0.058	0.431PheCys: 0.431 ± 0.021	2.669PheAsp: 2.669 ± 0.054	2.336PheGlu: 2.336 ± 0.052	1.662PhePhe: 1.662 ± 0.051	3.098PheGly: 3.098 ± 0.065	0.891PheHis: 0.891 ± 0.03	2.056PheIle: 2.056 ± 0.046	1.427PheLys: 1.427 ± 0.036	3.726PheLeu: 3.726 ± 0.069	0.85PheMet: 0.85 ± 0.029	1.436PheAsn: 1.436 ± 0.037	1.586PhePro: 1.586 ± 0.036	1.32PheGln: 1.32 ± 0.033	2.097PheArg: 2.097 ± 0.041	3.033PheSer: 3.033 ± 0.054	2.157PheThr: 2.157 ± 0.048	2.357PheVal: 2.357 ± 0.049	0.502PheTrp: 0.502 ± 0.024	1.14PheTyr: 1.14 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.904GlyAla: 5.904 ± 0.092	0.963GlyCys: 0.963 ± 0.032	4.492GlyAsp: 4.492 ± 0.065	5.333GlyGlu: 5.333 ± 0.083	3.323GlyPhe: 3.323 ± 0.054	5.901GlyGly: 5.901 ± 0.095	1.744GlyHis: 1.744 ± 0.041	4.906GlyIle: 4.906 ± 0.077	3.829GlyLys: 3.829 ± 0.066	8.033GlyLeu: 8.033 ± 0.078	2.325GlyMet: 2.325 ± 0.044	2.68GlyAsn: 2.68 ± 0.072	2.306GlyPro: 2.306 ± 0.053	2.841GlyGln: 2.841 ± 0.052	4.657GlyArg: 4.657 ± 0.068	4.666GlySer: 4.666 ± 0.08	4.031GlyThr: 4.031 ± 0.088	5.436GlyVal: 5.436 ± 0.073	1.127GlyTrp: 1.127 ± 0.03	2.445GlyTyr: 2.445 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.933HisAla: 1.933 ± 0.044	0.277HisCys: 0.277 ± 0.016	1.209HisAsp: 1.209 ± 0.036	1.344HisGlu: 1.344 ± 0.034	0.982HisPhe: 0.982 ± 0.03	1.673HisGly: 1.673 ± 0.04	0.693HisHis: 0.693 ± 0.026	1.266HisIle: 1.266 ± 0.033	0.848HisLys: 0.848 ± 0.024	2.533HisLeu: 2.533 ± 0.059	0.533HisMet: 0.533 ± 0.021	0.762HisAsn: 0.762 ± 0.025	1.329HisPro: 1.329 ± 0.033	0.99HisGln: 0.99 ± 0.031	1.501HisArg: 1.501 ± 0.039	1.291HisSer: 1.291 ± 0.037	1.096HisThr: 1.096 ± 0.034	1.23HisVal: 1.23 ± 0.031	0.381HisTrp: 0.381 ± 0.016	0.772HisTyr: 0.772 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.315IleAla: 5.315 ± 0.074	0.584IleCys: 0.584 ± 0.024	3.932IleAsp: 3.932 ± 0.059	4.146IleGlu: 4.146 ± 0.07	2.012IlePhe: 2.012 ± 0.046	4.612IleGly: 4.612 ± 0.073	1.291IleHis: 1.291 ± 0.035	2.996IleIle: 2.996 ± 0.059	2.452IleLys: 2.452 ± 0.051	5.465IleLeu: 5.465 ± 0.092	1.109IleMet: 1.109 ± 0.033	2.298IleAsn: 2.298 ± 0.054	2.851IlePro: 2.851 ± 0.052	2.0IleGln: 2.0 ± 0.041	3.546IleArg: 3.546 ± 0.062	3.921IleSer: 3.921 ± 0.06	3.376IleThr: 3.376 ± 0.056	3.437IleVal: 3.437 ± 0.062	0.628IleTrp: 0.628 ± 0.025	1.492IleTyr: 1.492 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.951LysAla: 3.951 ± 0.075	0.304LysCys: 0.304 ± 0.017	2.118LysAsp: 2.118 ± 0.045	2.724LysGlu: 2.724 ± 0.064	1.09LysPhe: 1.09 ± 0.031	3.127LysGly: 3.127 ± 0.056	1.001LysHis: 1.001 ± 0.033	2.429LysIle: 2.429 ± 0.06	2.566LysLys: 2.566 ± 0.094	4.239LysLeu: 4.239 ± 0.066	1.126LysMet: 1.126 ± 0.031	1.518LysAsn: 1.518 ± 0.046	2.212LysPro: 2.212 ± 0.05	2.036LysGln: 2.036 ± 0.048	2.995LysArg: 2.995 ± 0.059	2.554LysSer: 2.554 ± 0.049	2.486LysThr: 2.486 ± 0.048	2.957LysVal: 2.957 ± 0.057	0.442LysTrp: 0.442 ± 0.016	0.966LysTyr: 0.966 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.216LeuAla: 10.216 ± 0.105	0.939LeuCys: 0.939 ± 0.03	6.517LeuAsp: 6.517 ± 0.09	7.177LeuGlu: 7.177 ± 0.095	4.413LeuPhe: 4.413 ± 0.07	7.627LeuGly: 7.627 ± 0.091	2.279LeuHis: 2.279 ± 0.049	5.869LeuIle: 5.869 ± 0.078	4.721LeuLys: 4.721 ± 0.073	12.49LeuLeu: 12.49 ± 0.157	2.557LeuMet: 2.557 ± 0.058	3.743LeuAsn: 3.743 ± 0.062	5.345LeuPro: 5.345 ± 0.082	4.527LeuGln: 4.527 ± 0.074	6.339LeuArg: 6.339 ± 0.093	7.246LeuSer: 7.246 ± 0.091	5.533LeuThr: 5.533 ± 0.081	7.013LeuVal: 7.013 ± 0.098	1.191LeuTrp: 1.191 ± 0.037	2.421LeuTyr: 2.421 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.535MetAla: 2.535 ± 0.052	0.153MetCys: 0.153 ± 0.011	1.515MetAsp: 1.515 ± 0.04	1.649MetGlu: 1.649 ± 0.041	0.734MetPhe: 0.734 ± 0.025	1.896MetGly: 1.896 ± 0.046	0.492MetHis: 0.492 ± 0.02	1.292MetIle: 1.292 ± 0.035	1.285MetLys: 1.285 ± 0.036	2.701MetLeu: 2.701 ± 0.048	0.748MetMet: 0.748 ± 0.026	0.94MetAsn: 0.94 ± 0.028	1.42MetPro: 1.42 ± 0.038	1.072MetGln: 1.072 ± 0.032	1.505MetArg: 1.505 ± 0.036	1.678MetSer: 1.678 ± 0.036	1.38MetThr: 1.38 ± 0.036	1.691MetVal: 1.691 ± 0.041	0.149MetTrp: 0.149 ± 0.013	0.385MetTyr: 0.385 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.055AsnAla: 3.055 ± 0.053	0.377AsnCys: 0.377 ± 0.019	1.95AsnAsp: 1.95 ± 0.054	1.967AsnGlu: 1.967 ± 0.042	1.156AsnPhe: 1.156 ± 0.037	2.697AsnGly: 2.697 ± 0.067	0.819AsnHis: 0.819 ± 0.031	2.068AsnIle: 2.068 ± 0.047	1.385AsnLys: 1.385 ± 0.035	3.776AsnLeu: 3.776 ± 0.068	0.812AsnMet: 0.812 ± 0.027	1.342AsnAsn: 1.342 ± 0.041	2.244AsnPro: 2.244 ± 0.051	1.413AsnGln: 1.413 ± 0.038	2.456AsnArg: 2.456 ± 0.051	1.993AsnSer: 1.993 ± 0.05	1.628AsnThr: 1.628 ± 0.042	1.916AsnVal: 1.916 ± 0.05	0.489AsnTrp: 0.489 ± 0.022	0.941AsnTyr: 0.941 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.133ProAla: 4.133 ± 0.067	0.369ProCys: 0.369 ± 0.024	3.364ProAsp: 3.364 ± 0.06	3.774ProGlu: 3.774 ± 0.063	1.744ProPhe: 1.744 ± 0.037	3.786ProGly: 3.786 ± 0.059	0.922ProHis: 0.922 ± 0.032	2.264ProIle: 2.264 ± 0.041	1.813ProLys: 1.813 ± 0.048	4.681ProLeu: 4.681 ± 0.068	1.145ProMet: 1.145 ± 0.032	1.421ProAsn: 1.421 ± 0.039	2.003ProPro: 2.003 ± 0.054	1.577ProGln: 1.577 ± 0.039	2.002ProArg: 2.002 ± 0.043	2.418ProSer: 2.418 ± 0.041	2.139ProThr: 2.139 ± 0.045	3.998ProVal: 3.998 ± 0.059	0.618ProTrp: 0.618 ± 0.028	1.197ProTyr: 1.197 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.297GlnAla: 4.297 ± 0.068	0.309GlnCys: 0.309 ± 0.018	1.896GlnAsp: 1.896 ± 0.042	2.525GlnGlu: 2.525 ± 0.056	1.314GlnPhe: 1.314 ± 0.03	2.94GlnGly: 2.94 ± 0.046	0.938GlnHis: 0.938 ± 0.03	2.38GlnIle: 2.38 ± 0.045	1.644GlnLys: 1.644 ± 0.045	4.403GlnLeu: 4.403 ± 0.066	1.032GlnMet: 1.032 ± 0.028	1.214GlnAsn: 1.214 ± 0.034	1.886GlnPro: 1.886 ± 0.047	2.451GlnGln: 2.451 ± 0.059	2.855GlnArg: 2.855 ± 0.058	2.404GlnSer: 2.404 ± 0.051	2.171GlnThr: 2.171 ± 0.044	2.976GlnVal: 2.976 ± 0.056	0.504GlnTrp: 0.504 ± 0.022	0.843GlnTyr: 0.843 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.421ArgAla: 4.421 ± 0.07	0.59ArgCys: 0.59 ± 0.025	3.365ArgAsp: 3.365 ± 0.065	4.245ArgGlu: 4.245 ± 0.079	2.883ArgPhe: 2.883 ± 0.057	3.596ArgGly: 3.596 ± 0.061	1.586ArgHis: 1.586 ± 0.038	4.057ArgIle: 4.057 ± 0.061	2.797ArgLys: 2.797 ± 0.058	7.517ArgLeu: 7.517 ± 0.107	1.658ArgMet: 1.658 ± 0.04	2.206ArgAsn: 2.206 ± 0.042	2.397ArgPro: 2.397 ± 0.052	2.865ArgGln: 2.865 ± 0.059	4.221ArgArg: 4.221 ± 0.072	3.368ArgSer: 3.368 ± 0.058	2.815ArgThr: 2.815 ± 0.053	4.106ArgVal: 4.106 ± 0.058	0.917ArgTrp: 0.917 ± 0.034	2.03ArgTyr: 2.03 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.449SerAla: 5.449 ± 0.081	0.632SerCys: 0.632 ± 0.032	3.626SerAsp: 3.626 ± 0.065	3.871SerGlu: 3.871 ± 0.065	2.268SerPhe: 2.268 ± 0.051	5.754SerGly: 5.754 ± 0.079	1.541SerHis: 1.541 ± 0.035	3.406SerIle: 3.406 ± 0.053	2.277SerLys: 2.277 ± 0.053	6.753SerLeu: 6.753 ± 0.071	1.572SerMet: 1.572 ± 0.039	2.086SerAsn: 2.086 ± 0.044	2.609SerPro: 2.609 ± 0.048	2.267SerGln: 2.267 ± 0.051	3.909SerArg: 3.909 ± 0.073	3.761SerSer: 3.761 ± 0.076	2.961SerThr: 2.961 ± 0.062	4.096SerVal: 4.096 ± 0.073	0.793SerTrp: 0.793 ± 0.028	1.608SerTyr: 1.608 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.932ThrAla: 4.932 ± 0.083	0.473ThrCys: 0.473 ± 0.019	3.076ThrAsp: 3.076 ± 0.068	3.117ThrGlu: 3.117 ± 0.063	1.821ThrPhe: 1.821 ± 0.041	4.661ThrGly: 4.661 ± 0.067	1.227ThrHis: 1.227 ± 0.034	2.951ThrIle: 2.951 ± 0.062	1.709ThrLys: 1.709 ± 0.04	6.459ThrLeu: 6.459 ± 0.094	1.044ThrMet: 1.044 ± 0.032	1.57ThrAsn: 1.57 ± 0.04	3.003ThrPro: 3.003 ± 0.053	1.91ThrGln: 1.91 ± 0.043	2.887ThrArg: 2.887 ± 0.049	2.956ThrSer: 2.956 ± 0.054	2.85ThrThr: 2.85 ± 0.06	3.637ThrVal: 3.637 ± 0.096	0.553ThrTrp: 0.553 ± 0.022	1.268ThrTyr: 1.268 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.285ValAla: 6.285 ± 0.083	0.694ValCys: 0.694 ± 0.027	4.443ValAsp: 4.443 ± 0.068	4.888ValGlu: 4.888 ± 0.07	2.5ValPhe: 2.5 ± 0.062	4.743ValGly: 4.743 ± 0.083	1.268ValHis: 1.268 ± 0.031	4.111ValIle: 4.111 ± 0.069	2.719ValLys: 2.719 ± 0.052	6.786ValLeu: 6.786 ± 0.084	1.798ValMet: 1.798 ± 0.048	2.338ValAsn: 2.338 ± 0.053	2.852ValPro: 2.852 ± 0.049	2.248ValGln: 2.248 ± 0.045	3.874ValArg: 3.874 ± 0.055	4.52ValSer: 4.52 ± 0.065	4.066ValThr: 4.066 ± 0.088	5.296ValVal: 5.296 ± 0.085	0.789ValTrp: 0.789 ± 0.03	1.653ValTyr: 1.653 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.844TrpAla: 0.844 ± 0.033	0.167TrpCys: 0.167 ± 0.011	0.71TrpAsp: 0.71 ± 0.026	0.723TrpGlu: 0.723 ± 0.022	0.554TrpPhe: 0.554 ± 0.021	0.874TrpGly: 0.874 ± 0.029	0.323TrpHis: 0.323 ± 0.018	0.734TrpIle: 0.734 ± 0.028	0.568TrpLys: 0.568 ± 0.024	1.65TrpLeu: 1.65 ± 0.049	0.349TrpMet: 0.349 ± 0.018	0.457TrpAsn: 0.457 ± 0.019	0.525TrpPro: 0.525 ± 0.022	0.656TrpGln: 0.656 ± 0.021	0.948TrpArg: 0.948 ± 0.034	0.776TrpSer: 0.776 ± 0.032	0.528TrpThr: 0.528 ± 0.022	0.885TrpVal: 0.885 ± 0.025	0.227TrpTrp: 0.227 ± 0.014	0.354TrpTyr: 0.354 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.177TyrAla: 2.177 ± 0.047	0.298TyrCys: 0.298 ± 0.017	1.576TyrAsp: 1.576 ± 0.059	1.505TyrGlu: 1.505 ± 0.044	1.11TyrPhe: 1.11 ± 0.034	2.006TyrGly: 2.006 ± 0.042	0.647TyrHis: 0.647 ± 0.02	1.276TyrIle: 1.276 ± 0.034	0.965TyrLys: 0.965 ± 0.028	3.106TyrLeu: 3.106 ± 0.052	0.532TyrMet: 0.532 ± 0.023	0.889TyrAsn: 0.889 ± 0.034	1.33TyrPro: 1.33 ± 0.035	1.18TyrGln: 1.18 ± 0.033	2.032TyrArg: 2.032 ± 0.043	1.609TyrSer: 1.609 ± 0.039	1.345TyrThr: 1.345 ± 0.047	1.562TyrVal: 1.562 ± 0.039	0.386TyrTrp: 0.386 ± 0.018	0.815TyrTyr: 0.815 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3499 proteins (1169978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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