Amino acid dipepetide frequency for Draconibacterium orientale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.363AlaAla: 5.363 ± 0.081	0.71AlaCys: 0.71 ± 0.026	4.101AlaAsp: 4.101 ± 0.059	5.074AlaGlu: 5.074 ± 0.06	3.482AlaPhe: 3.482 ± 0.057	5.248AlaGly: 5.248 ± 0.067	1.188AlaHis: 1.188 ± 0.034	5.13AlaIle: 5.13 ± 0.066	4.396AlaLys: 4.396 ± 0.057	6.275AlaLeu: 6.275 ± 0.097	1.682AlaMet: 1.682 ± 0.035	3.442AlaAsn: 3.442 ± 0.056	2.061AlaPro: 2.061 ± 0.042	2.615AlaGln: 2.615 ± 0.042	2.533AlaArg: 2.533 ± 0.042	3.944AlaSer: 3.944 ± 0.059	3.66AlaThr: 3.66 ± 0.069	4.576AlaVal: 4.576 ± 0.063	0.83AlaTrp: 0.83 ± 0.028	2.601AlaTyr: 2.601 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.516CysAla: 0.516 ± 0.021	0.117CysCys: 0.117 ± 0.009	0.485CysAsp: 0.485 ± 0.022	0.482CysGlu: 0.482 ± 0.022	0.407CysPhe: 0.407 ± 0.017	0.727CysGly: 0.727 ± 0.029	0.249CysHis: 0.249 ± 0.021	0.544CysIle: 0.544 ± 0.02	0.536CysLys: 0.536 ± 0.02	0.649CysLeu: 0.649 ± 0.022	0.197CysMet: 0.197 ± 0.013	0.473CysAsn: 0.473 ± 0.018	0.395CysPro: 0.395 ± 0.024	0.268CysGln: 0.268 ± 0.014	0.347CysArg: 0.347 ± 0.013	0.568CysSer: 0.568 ± 0.023	0.498CysThr: 0.498 ± 0.021	0.529CysVal: 0.529 ± 0.033	0.109CysTrp: 0.109 ± 0.009	0.342CysTyr: 0.342 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.759AspAla: 3.759 ± 0.064	0.484AspCys: 0.484 ± 0.024	3.099AspAsp: 3.099 ± 0.052	4.397AspGlu: 4.397 ± 0.061	3.413AspPhe: 3.413 ± 0.057	4.111AspGly: 4.111 ± 0.071	0.936AspHis: 0.936 ± 0.031	4.044AspIle: 4.044 ± 0.061	3.86AspLys: 3.86 ± 0.056	4.986AspLeu: 4.986 ± 0.055	1.367AspMet: 1.367 ± 0.035	2.957AspAsn: 2.957 ± 0.051	2.13AspPro: 2.13 ± 0.046	1.652AspGln: 1.652 ± 0.034	2.016AspArg: 2.016 ± 0.04	2.903AspSer: 2.903 ± 0.054	2.391AspThr: 2.391 ± 0.045	3.639AspVal: 3.639 ± 0.061	0.892AspTrp: 0.892 ± 0.026	2.817AspTyr: 2.817 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.875GluAla: 4.875 ± 0.071	0.436GluCys: 0.436 ± 0.021	3.438GluAsp: 3.438 ± 0.057	5.269GluGlu: 5.269 ± 0.077	3.056GluPhe: 3.056 ± 0.051	3.953GluGly: 3.953 ± 0.058	1.167GluHis: 1.167 ± 0.031	5.538GluIle: 5.538 ± 0.062	6.075GluLys: 6.075 ± 0.076	6.918GluLeu: 6.918 ± 0.076	2.02GluMet: 2.02 ± 0.04	4.755GluAsn: 4.755 ± 0.063	1.986GluPro: 1.986 ± 0.039	2.694GluGln: 2.694 ± 0.049	2.741GluArg: 2.741 ± 0.047	3.558GluSer: 3.558 ± 0.05	3.795GluThr: 3.795 ± 0.064	4.613GluVal: 4.613 ± 0.067	0.883GluTrp: 0.883 ± 0.027	2.601GluTyr: 2.601 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.409PheAla: 3.409 ± 0.053	0.475PheCys: 0.475 ± 0.019	3.18PheAsp: 3.18 ± 0.044	3.35PheGlu: 3.35 ± 0.058	2.566PhePhe: 2.566 ± 0.06	3.466PheGly: 3.466 ± 0.059	0.886PheHis: 0.886 ± 0.025	3.544PheIle: 3.544 ± 0.056	2.972PheLys: 2.972 ± 0.051	4.379PheLeu: 4.379 ± 0.069	1.256PheMet: 1.256 ± 0.029	2.962PheAsn: 2.962 ± 0.047	1.814PhePro: 1.814 ± 0.043	1.561PheGln: 1.561 ± 0.036	2.005PheArg: 2.005 ± 0.039	3.861PheSer: 3.861 ± 0.054	2.888PheThr: 2.888 ± 0.042	3.357PheVal: 3.357 ± 0.052	0.647PheTrp: 0.647 ± 0.024	2.066PheTyr: 2.066 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.451GlyAla: 4.451 ± 0.069	0.649GlyCys: 0.649 ± 0.024	3.548GlyAsp: 3.548 ± 0.052	4.446GlyGlu: 4.446 ± 0.064	3.655GlyPhe: 3.655 ± 0.047	4.85GlyGly: 4.85 ± 0.079	1.206GlyHis: 1.206 ± 0.03	5.537GlyIle: 5.537 ± 0.071	5.013GlyLys: 5.013 ± 0.067	6.006GlyLeu: 6.006 ± 0.072	1.858GlyMet: 1.858 ± 0.045	3.672GlyAsn: 3.672 ± 0.06	1.546GlyPro: 1.546 ± 0.033	2.041GlyGln: 2.041 ± 0.04	2.439GlyArg: 2.439 ± 0.039	3.953GlySer: 3.953 ± 0.051	4.098GlyThr: 4.098 ± 0.066	4.694GlyVal: 4.694 ± 0.083	0.989GlyTrp: 0.989 ± 0.031	2.933GlyTyr: 2.933 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.031HisAla: 1.031 ± 0.029	0.206HisCys: 0.206 ± 0.012	0.897HisAsp: 0.897 ± 0.023	1.056HisGlu: 1.056 ± 0.031	1.184HisPhe: 1.184 ± 0.03	1.2HisGly: 1.2 ± 0.031	0.429HisHis: 0.429 ± 0.02	1.29HisIle: 1.29 ± 0.033	1.126HisLys: 1.126 ± 0.033	1.755HisLeu: 1.755 ± 0.042	0.38HisMet: 0.38 ± 0.017	0.99HisAsn: 0.99 ± 0.028	0.941HisPro: 0.941 ± 0.028	0.663HisGln: 0.663 ± 0.021	0.767HisArg: 0.767 ± 0.021	1.145HisSer: 1.145 ± 0.027	0.921HisThr: 0.921 ± 0.027	0.991HisVal: 0.991 ± 0.029	0.271HisTrp: 0.271 ± 0.014	0.82HisTyr: 0.82 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.301IleAla: 5.301 ± 0.068	0.629IleCys: 0.629 ± 0.023	4.675IleAsp: 4.675 ± 0.059	5.211IleGlu: 5.211 ± 0.064	3.281IlePhe: 3.281 ± 0.058	4.857IleGly: 4.857 ± 0.074	1.35IleHis: 1.35 ± 0.028	5.123IleIle: 5.123 ± 0.072	4.782IleLys: 4.782 ± 0.07	6.344IleLeu: 6.344 ± 0.07	1.363IleMet: 1.363 ± 0.03	3.983IleAsn: 3.983 ± 0.052	3.16IlePro: 3.16 ± 0.049	2.37IleGln: 2.37 ± 0.05	2.947IleArg: 2.947 ± 0.047	5.12IleSer: 5.12 ± 0.062	4.241IleThr: 4.241 ± 0.067	4.5IleVal: 4.5 ± 0.057	0.771IleTrp: 0.771 ± 0.025	2.746IleTyr: 2.746 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.781LysAla: 4.781 ± 0.067	0.413LysCys: 0.413 ± 0.02	3.651LysAsp: 3.651 ± 0.053	5.311LysGlu: 5.311 ± 0.071	2.572LysPhe: 2.572 ± 0.044	4.2LysGly: 4.2 ± 0.062	1.3LysHis: 1.3 ± 0.031	5.261LysIle: 5.261 ± 0.072	5.5LysLys: 5.5 ± 0.082	6.32LysLeu: 6.32 ± 0.078	2.038LysMet: 2.038 ± 0.041	4.337LysAsn: 4.337 ± 0.063	2.407LysPro: 2.407 ± 0.044	2.815LysGln: 2.815 ± 0.053	2.981LysArg: 2.981 ± 0.047	3.941LysSer: 3.941 ± 0.062	4.172LysThr: 4.172 ± 0.049	4.55LysVal: 4.55 ± 0.057	0.838LysTrp: 0.838 ± 0.028	2.965LysTyr: 2.965 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.521LeuAla: 6.521 ± 0.088	0.693LeuCys: 0.693 ± 0.022	4.668LeuAsp: 4.668 ± 0.065	5.791LeuGlu: 5.791 ± 0.077	4.908LeuPhe: 4.908 ± 0.08	5.571LeuGly: 5.571 ± 0.08	1.627LeuHis: 1.627 ± 0.039	6.402LeuIle: 6.402 ± 0.077	7.18LeuLys: 7.18 ± 0.075	8.908LeuLeu: 8.908 ± 0.122	2.113LeuMet: 2.113 ± 0.039	5.44LeuAsn: 5.44 ± 0.068	3.776LeuPro: 3.776 ± 0.056	3.239LeuGln: 3.239 ± 0.054	3.425LeuArg: 3.425 ± 0.055	6.214LeuSer: 6.214 ± 0.081	4.932LeuThr: 4.932 ± 0.06	5.749LeuVal: 5.749 ± 0.068	0.985LeuTrp: 0.985 ± 0.028	3.205LeuTyr: 3.205 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.948MetAla: 1.948 ± 0.04	0.149MetCys: 0.149 ± 0.01	1.291MetAsp: 1.291 ± 0.031	1.695MetGlu: 1.695 ± 0.035	0.965MetPhe: 0.965 ± 0.026	1.671MetGly: 1.671 ± 0.035	0.43MetHis: 0.43 ± 0.019	1.544MetIle: 1.544 ± 0.032	2.173MetLys: 2.173 ± 0.039	2.204MetLeu: 2.204 ± 0.037	0.648MetMet: 0.648 ± 0.022	1.436MetAsn: 1.436 ± 0.032	1.005MetPro: 1.005 ± 0.027	0.967MetGln: 0.967 ± 0.026	0.996MetArg: 0.996 ± 0.028	1.299MetSer: 1.299 ± 0.031	1.107MetThr: 1.107 ± 0.032	1.64MetVal: 1.64 ± 0.039	0.215MetTrp: 0.215 ± 0.013	0.726MetTyr: 0.726 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.573AsnAla: 3.573 ± 0.051	0.523AsnCys: 0.523 ± 0.026	3.183AsnAsp: 3.183 ± 0.054	3.855AsnGlu: 3.855 ± 0.058	2.773AsnPhe: 2.773 ± 0.047	4.042AsnGly: 4.042 ± 0.056	1.016AsnHis: 1.016 ± 0.026	4.222AsnIle: 4.222 ± 0.058	3.719AsnLys: 3.719 ± 0.057	5.012AsnLeu: 5.012 ± 0.064	1.306AsnMet: 1.306 ± 0.03	3.363AsnAsn: 3.363 ± 0.059	2.756AsnPro: 2.756 ± 0.04	2.027AsnGln: 2.027 ± 0.039	2.415AsnArg: 2.415 ± 0.041	3.428AsnSer: 3.428 ± 0.058	3.048AsnThr: 3.048 ± 0.05	3.207AsnVal: 3.207 ± 0.058	0.89AsnTrp: 0.89 ± 0.026	2.665AsnTyr: 2.665 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.572ProAla: 2.572 ± 0.048	0.236ProCys: 0.236 ± 0.013	2.587ProAsp: 2.587 ± 0.047	3.679ProGlu: 3.679 ± 0.053	1.882ProPhe: 1.882 ± 0.043	2.756ProGly: 2.756 ± 0.045	0.668ProHis: 0.668 ± 0.023	2.243ProIle: 2.243 ± 0.04	2.084ProLys: 2.084 ± 0.052	3.067ProLeu: 3.067 ± 0.054	0.769ProMet: 0.769 ± 0.025	1.905ProAsn: 1.905 ± 0.041	0.982ProPro: 0.982 ± 0.028	1.225ProGln: 1.225 ± 0.033	1.134ProArg: 1.134 ± 0.029	1.923ProSer: 1.923 ± 0.034	1.856ProThr: 1.856 ± 0.042	3.137ProVal: 3.137 ± 0.056	0.448ProTrp: 0.448 ± 0.019	1.468ProTyr: 1.468 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.258GlnAla: 2.258 ± 0.046	0.215GlnCys: 0.215 ± 0.012	1.533GlnAsp: 1.533 ± 0.031	2.366GlnGlu: 2.366 ± 0.054	1.631GlnPhe: 1.631 ± 0.035	1.853GlnGly: 1.853 ± 0.037	0.698GlnHis: 0.698 ± 0.022	2.554GlnIle: 2.554 ± 0.044	2.799GlnLys: 2.799 ± 0.054	3.73GlnLeu: 3.73 ± 0.06	0.902GlnMet: 0.902 ± 0.022	2.263GlnAsn: 2.263 ± 0.049	1.276GlnPro: 1.276 ± 0.033	1.718GlnGln: 1.718 ± 0.044	1.431GlnArg: 1.431 ± 0.033	1.991GlnSer: 1.991 ± 0.042	1.873GlnThr: 1.873 ± 0.038	2.206GlnVal: 2.206 ± 0.039	0.423GlnTrp: 0.423 ± 0.021	1.316GlnTyr: 1.316 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.324ArgAla: 2.324 ± 0.039	0.283ArgCys: 0.283 ± 0.014	1.928ArgAsp: 1.928 ± 0.039	2.745ArgGlu: 2.745 ± 0.046	2.225ArgPhe: 2.225 ± 0.034	2.246ArgGly: 2.246 ± 0.042	0.711ArgHis: 0.711 ± 0.024	3.18ArgIle: 3.18 ± 0.043	3.134ArgLys: 3.134 ± 0.051	3.658ArgLeu: 3.658 ± 0.049	1.011ArgMet: 1.011 ± 0.028	2.28ArgAsn: 2.28 ± 0.042	1.267ArgPro: 1.267 ± 0.028	1.352ArgGln: 1.352 ± 0.032	1.6ArgArg: 1.6 ± 0.041	2.128ArgSer: 2.128 ± 0.043	2.006ArgThr: 2.006 ± 0.037	2.362ArgVal: 2.362 ± 0.04	0.551ArgTrp: 0.551 ± 0.024	1.729ArgTyr: 1.729 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.179SerAla: 4.179 ± 0.059	0.661SerCys: 0.661 ± 0.024	3.45SerAsp: 3.45 ± 0.053	4.126SerGlu: 4.126 ± 0.059	3.386SerPhe: 3.386 ± 0.052	4.926SerGly: 4.926 ± 0.07	1.098SerHis: 1.098 ± 0.033	4.354SerIle: 4.354 ± 0.063	3.761SerLys: 3.761 ± 0.055	5.363SerLeu: 5.363 ± 0.067	1.386SerMet: 1.386 ± 0.031	3.103SerAsn: 3.103 ± 0.057	2.182SerPro: 2.182 ± 0.042	1.892SerGln: 1.892 ± 0.035	2.333SerArg: 2.333 ± 0.04	3.766SerSer: 3.766 ± 0.07	3.168SerThr: 3.168 ± 0.053	4.271SerVal: 4.271 ± 0.061	0.857SerTrp: 0.857 ± 0.024	2.645SerTyr: 2.645 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.966ThrAla: 3.966 ± 0.061	0.467ThrCys: 0.467 ± 0.034	3.275ThrAsp: 3.275 ± 0.062	3.658ThrGlu: 3.658 ± 0.051	2.702ThrPhe: 2.702 ± 0.045	4.274ThrGly: 4.274 ± 0.064	0.948ThrHis: 0.948 ± 0.026	4.21ThrIle: 4.21 ± 0.061	3.217ThrLys: 3.217 ± 0.053	4.82ThrLeu: 4.82 ± 0.065	1.099ThrMet: 1.099 ± 0.027	2.816ThrAsn: 2.816 ± 0.047	2.388ThrPro: 2.388 ± 0.044	1.748ThrGln: 1.748 ± 0.033	1.906ThrArg: 1.906 ± 0.036	3.245ThrSer: 3.245 ± 0.06	3.185ThrThr: 3.185 ± 0.063	3.749ThrVal: 3.749 ± 0.077	0.599ThrTrp: 0.599 ± 0.022	2.112ThrTyr: 2.112 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.698ValAla: 4.698 ± 0.067	0.588ValCys: 0.588 ± 0.019	3.808ValAsp: 3.808 ± 0.066	4.503ValGlu: 4.503 ± 0.068	3.525ValPhe: 3.525 ± 0.057	3.985ValGly: 3.985 ± 0.067	1.082ValHis: 1.082 ± 0.03	4.597ValIle: 4.597 ± 0.067	4.497ValLys: 4.497 ± 0.069	6.136ValLeu: 6.136 ± 0.074	1.459ValMet: 1.459 ± 0.036	3.533ValAsn: 3.533 ± 0.044	2.54ValPro: 2.54 ± 0.047	2.098ValGln: 2.098 ± 0.036	2.331ValArg: 2.331 ± 0.04	4.377ValSer: 4.377 ± 0.058	3.624ValThr: 3.624 ± 0.078	4.745ValVal: 4.745 ± 0.066	0.744ValTrp: 0.744 ± 0.024	2.565ValTyr: 2.565 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.813TrpAla: 0.813 ± 0.025	0.124TrpCys: 0.124 ± 0.01	0.752TrpAsp: 0.752 ± 0.026	0.919TrpGlu: 0.919 ± 0.03	0.621TrpPhe: 0.621 ± 0.021	0.966TrpGly: 0.966 ± 0.026	0.264TrpHis: 0.264 ± 0.014	0.882TrpIle: 0.882 ± 0.03	0.856TrpLys: 0.856 ± 0.025	1.139TrpLeu: 1.139 ± 0.03	0.389TrpMet: 0.389 ± 0.019	0.744TrpAsn: 0.744 ± 0.023	0.337TrpPro: 0.337 ± 0.018	0.56TrpGln: 0.56 ± 0.021	0.512TrpArg: 0.512 ± 0.02	0.752TrpSer: 0.752 ± 0.026	0.661TrpThr: 0.661 ± 0.03	0.742TrpVal: 0.742 ± 0.023	0.202TrpTrp: 0.202 ± 0.013	0.476TrpTyr: 0.476 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.04	0.381TyrCys: 0.381 ± 0.018	2.302TyrAsp: 2.302 ± 0.04	2.438TyrGlu: 2.438 ± 0.049	2.41TyrPhe: 2.41 ± 0.045	2.682TyrGly: 2.682 ± 0.048	0.809TyrHis: 0.809 ± 0.026	2.552TyrIle: 2.552 ± 0.044	2.674TyrLys: 2.674 ± 0.041	3.678TyrLeu: 3.678 ± 0.052	0.864TyrMet: 0.864 ± 0.024	2.569TyrAsn: 2.569 ± 0.055	1.677TyrPro: 1.677 ± 0.04	1.531TyrGln: 1.531 ± 0.032	1.86TyrArg: 1.86 ± 0.037	2.792TyrSer: 2.792 ± 0.051	2.26TyrThr: 2.26 ± 0.044	2.179TyrVal: 2.179 ± 0.04	0.568TyrTrp: 0.568 ± 0.019	1.946TyrTyr: 1.946 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3940 proteins (1407688 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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