Amino acid dipepetide frequency for Nocardioides luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.009AlaAla: 19.009 ± 0.162
0.834AlaCys: 0.834 ± 0.022
8.196AlaAsp: 8.196 ± 0.068
8.676AlaGlu: 8.676 ± 0.091
3.545AlaPhe: 3.545 ± 0.054
12.292AlaGly: 12.292 ± 0.094
2.42AlaHis: 2.42 ± 0.042
4.969AlaIle: 4.969 ± 0.064
3.174AlaLys: 3.174 ± 0.051
13.049AlaLeu: 13.049 ± 0.119
2.753AlaMet: 2.753 ± 0.044
2.172AlaAsn: 2.172 ± 0.036
5.867AlaPro: 5.867 ± 0.072
3.307AlaGln: 3.307 ± 0.048
8.389AlaArg: 8.389 ± 0.084
6.325AlaSer: 6.325 ± 0.062
7.757AlaThr: 7.757 ± 0.075
11.075AlaVal: 11.075 ± 0.108
1.936AlaTrp: 1.936 ± 0.038
3.042AlaTyr: 3.042 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.779CysAla: 0.779 ± 0.025
0.086CysCys: 0.086 ± 0.007
0.397CysAsp: 0.397 ± 0.014
0.325CysGlu: 0.325 ± 0.015
0.207CysPhe: 0.207 ± 0.011
0.802CysGly: 0.802 ± 0.026
0.157CysHis: 0.157 ± 0.009
0.2CysIle: 0.2 ± 0.011
0.09CysLys: 0.09 ± 0.007
0.631CysLeu: 0.631 ± 0.02
0.122CysMet: 0.122 ± 0.009
0.14CysAsn: 0.14 ± 0.009
0.397CysPro: 0.397 ± 0.016
0.157CysGln: 0.157 ± 0.009
0.435CysArg: 0.435 ± 0.015
0.361CysSer: 0.361 ± 0.017
0.396CysThr: 0.396 ± 0.016
0.577CysVal: 0.577 ± 0.018
0.101CysTrp: 0.101 ± 0.008
0.142CysTyr: 0.142 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.468AspAla: 7.468 ± 0.072
0.339AspCys: 0.339 ± 0.014
4.019AspAsp: 4.019 ± 0.061
4.386AspGlu: 4.386 ± 0.056
1.691AspPhe: 1.691 ± 0.033
6.226AspGly: 6.226 ± 0.069
1.48AspHis: 1.48 ± 0.027
2.258AspIle: 2.258 ± 0.034
1.36AspLys: 1.36 ± 0.032
7.213AspLeu: 7.213 ± 0.077
0.885AspMet: 0.885 ± 0.023
1.083AspAsn: 1.083 ± 0.026
4.46AspPro: 4.46 ± 0.06
1.847AspGln: 1.847 ± 0.035
4.539AspArg: 4.539 ± 0.06
2.665AspSer: 2.665 ± 0.046
2.961AspThr: 2.961 ± 0.045
5.544AspVal: 5.544 ± 0.062
0.983AspTrp: 0.983 ± 0.025
1.391AspTyr: 1.391 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.76GluAla: 7.76 ± 0.087
0.345GluCys: 0.345 ± 0.014
3.286GluAsp: 3.286 ± 0.046
3.888GluGlu: 3.888 ± 0.056
1.599GluPhe: 1.599 ± 0.032
4.453GluGly: 4.453 ± 0.05
1.577GluHis: 1.577 ± 0.031
3.087GluIle: 3.087 ± 0.042
1.827GluLys: 1.827 ± 0.039
6.404GluLeu: 6.404 ± 0.074
1.163GluMet: 1.163 ± 0.025
1.139GluAsn: 1.139 ± 0.027
3.368GluPro: 3.368 ± 0.055
2.26GluGln: 2.26 ± 0.038
4.948GluArg: 4.948 ± 0.062
2.958GluSer: 2.958 ± 0.047
3.567GluThr: 3.567 ± 0.053
5.338GluVal: 5.338 ± 0.066
0.95GluTrp: 0.95 ± 0.024
0.975GluTyr: 0.975 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
3.745PheAla: 3.745 ± 0.056
0.23PheCys: 0.23 ± 0.011
2.16PheAsp: 2.16 ± 0.043
1.754PheGlu: 1.754 ± 0.035
0.959PhePhe: 0.959 ± 0.027
3.243PheGly: 3.243 ± 0.054
0.613PheHis: 0.613 ± 0.019
0.952PheIle: 0.952 ± 0.029
0.594PheLys: 0.594 ± 0.019
2.69PheLeu: 2.69 ± 0.051
0.466PheMet: 0.466 ± 0.018
0.608PheAsn: 0.608 ± 0.018
1.375PhePro: 1.375 ± 0.029
0.709PheGln: 0.709 ± 0.018
1.67PheArg: 1.67 ± 0.034
1.568PheSer: 1.568 ± 0.033
1.927PheThr: 1.927 ± 0.036
2.603PheVal: 2.603 ± 0.043
0.499PheTrp: 0.499 ± 0.016
0.692PheTyr: 0.692 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
10.123GlyAla: 10.123 ± 0.079
0.734GlyCys: 0.734 ± 0.024
5.258GlyAsp: 5.258 ± 0.062
5.272GlyGlu: 5.272 ± 0.062
3.206GlyPhe: 3.206 ± 0.047
7.965GlyGly: 7.965 ± 0.086
2.062GlyHis: 2.062 ± 0.03
4.24GlyIle: 4.24 ± 0.053
2.513GlyLys: 2.513 ± 0.042
9.478GlyLeu: 9.478 ± 0.091
1.999GlyMet: 1.999 ± 0.038
1.814GlyAsn: 1.814 ± 0.039
4.3GlyPro: 4.3 ± 0.05
2.476GlyGln: 2.476 ± 0.048
6.434GlyArg: 6.434 ± 0.075
5.557GlySer: 5.557 ± 0.064
5.665GlyThr: 5.665 ± 0.066
7.907GlyVal: 7.907 ± 0.078
1.831GlyTrp: 1.831 ± 0.037
2.345GlyTyr: 2.345 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.355HisAla: 2.355 ± 0.039
0.159HisCys: 0.159 ± 0.01
1.378HisAsp: 1.378 ± 0.024
1.255HisGlu: 1.255 ± 0.03
0.625HisPhe: 0.625 ± 0.02
2.151HisGly: 2.151 ± 0.038
0.672HisHis: 0.672 ± 0.022
0.71HisIle: 0.71 ± 0.021
0.374HisLys: 0.374 ± 0.016
2.384HisLeu: 2.384 ± 0.04
0.312HisMet: 0.312 ± 0.013
0.41HisAsn: 0.41 ± 0.016
1.527HisPro: 1.527 ± 0.031
0.637HisGln: 0.637 ± 0.02
1.706HisArg: 1.706 ± 0.034
0.933HisSer: 0.933 ± 0.024
1.099HisThr: 1.099 ± 0.029
1.804HisVal: 1.804 ± 0.035
0.334HisTrp: 0.334 ± 0.015
0.488HisTyr: 0.488 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.836IleAla: 5.836 ± 0.066
0.294IleCys: 0.294 ± 0.014
3.139IleAsp: 3.139 ± 0.038
2.805IleGlu: 2.805 ± 0.045
1.043IlePhe: 1.043 ± 0.028
4.349IleGly: 4.349 ± 0.059
0.76IleHis: 0.76 ± 0.022
1.352IleIle: 1.352 ± 0.033
0.978IleLys: 0.978 ± 0.025
3.188IleLeu: 3.188 ± 0.042
0.567IleMet: 0.567 ± 0.019
0.935IleAsn: 0.935 ± 0.024
2.111IlePro: 2.111 ± 0.036
0.871IleGln: 0.871 ± 0.021
2.454IleArg: 2.454 ± 0.034
2.285IleSer: 2.285 ± 0.034
2.657IleThr: 2.657 ± 0.045
3.786IleVal: 3.786 ± 0.059
0.506IleTrp: 0.506 ± 0.017
0.746IleTyr: 0.746 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.165LysAla: 3.165 ± 0.055
0.099LysCys: 0.099 ± 0.008
1.413LysAsp: 1.413 ± 0.036
1.357LysGlu: 1.357 ± 0.035
0.54LysPhe: 0.54 ± 0.019
1.866LysGly: 1.866 ± 0.043
0.503LysHis: 0.503 ± 0.017
1.079LysIle: 1.079 ± 0.028
0.941LysLys: 0.941 ± 0.031
2.146LysLeu: 2.146 ± 0.042
0.451LysMet: 0.451 ± 0.018
0.496LysAsn: 0.496 ± 0.016
1.445LysPro: 1.445 ± 0.034
0.804LysGln: 0.804 ± 0.022
1.529LysArg: 1.529 ± 0.034
1.23LysSer: 1.23 ± 0.028
1.489LysThr: 1.489 ± 0.034
2.357LysVal: 2.357 ± 0.047
0.276LysTrp: 0.276 ± 0.014
0.47LysTyr: 0.47 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.532LeuAla: 14.532 ± 0.121
0.655LeuCys: 0.655 ± 0.022
6.793LeuAsp: 6.793 ± 0.071
5.623LeuGlu: 5.623 ± 0.061
2.638LeuPhe: 2.638 ± 0.044
9.59LeuGly: 9.59 ± 0.086
1.977LeuHis: 1.977 ± 0.03
3.776LeuIle: 3.776 ± 0.053
2.063LeuLys: 2.063 ± 0.043
10.289LeuLeu: 10.289 ± 0.127
1.753LeuMet: 1.753 ± 0.034
1.744LeuAsn: 1.744 ± 0.031
5.621LeuPro: 5.621 ± 0.056
2.277LeuGln: 2.277 ± 0.041
7.223LeuArg: 7.223 ± 0.071
5.417LeuSer: 5.417 ± 0.059
6.555LeuThr: 6.555 ± 0.059
9.81LeuVal: 9.81 ± 0.11
1.254LeuTrp: 1.254 ± 0.029
1.677LeuTyr: 1.677 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.308MetAla: 2.308 ± 0.04
0.135MetCys: 0.135 ± 0.009
0.864MetAsp: 0.864 ± 0.024
0.8MetGlu: 0.8 ± 0.024
0.525MetPhe: 0.525 ± 0.018
1.352MetGly: 1.352 ± 0.03
0.348MetHis: 0.348 ± 0.015
0.855MetIle: 0.855 ± 0.026
0.502MetLys: 0.502 ± 0.018
1.983MetLeu: 1.983 ± 0.037
0.398MetMet: 0.398 ± 0.015
0.444MetAsn: 0.444 ± 0.016
1.155MetPro: 1.155 ± 0.028
0.466MetGln: 0.466 ± 0.018
1.43MetArg: 1.43 ± 0.031
1.519MetSer: 1.519 ± 0.033
1.816MetThr: 1.816 ± 0.03
1.582MetVal: 1.582 ± 0.031
0.243MetTrp: 0.243 ± 0.012
0.293MetTyr: 0.293 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.289AsnAla: 2.289 ± 0.037
0.132AsnCys: 0.132 ± 0.009
1.19AsnAsp: 1.19 ± 0.03
0.936AsnGlu: 0.936 ± 0.024
0.498AsnPhe: 0.498 ± 0.018
1.973AsnGly: 1.973 ± 0.038
0.439AsnHis: 0.439 ± 0.019
0.809AsnIle: 0.809 ± 0.022
0.459AsnLys: 0.459 ± 0.018
1.954AsnLeu: 1.954 ± 0.029
0.326AsnMet: 0.326 ± 0.015
0.484AsnAsn: 0.484 ± 0.019
1.498AsnPro: 1.498 ± 0.033
0.602AsnGln: 0.602 ± 0.02
1.244AsnArg: 1.244 ± 0.029
0.911AsnSer: 0.911 ± 0.026
1.118AsnThr: 1.118 ± 0.029
1.567AsnVal: 1.567 ± 0.03
0.288AsnTrp: 0.288 ± 0.013
0.436AsnTyr: 0.436 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.144ProAla: 7.144 ± 0.083
0.251ProCys: 0.251 ± 0.013
4.151ProAsp: 4.151 ± 0.049
4.347ProGlu: 4.347 ± 0.051
1.554ProPhe: 1.554 ± 0.03
5.474ProGly: 5.474 ± 0.06
1.137ProHis: 1.137 ± 0.028
1.883ProIle: 1.883 ± 0.037
1.288ProLys: 1.288 ± 0.03
4.762ProLeu: 4.762 ± 0.055
1.007ProMet: 1.007 ± 0.026
1.001ProAsn: 1.001 ± 0.02
2.579ProPro: 2.579 ± 0.056
1.405ProGln: 1.405 ± 0.033
3.244ProArg: 3.244 ± 0.045
3.05ProSer: 3.05 ± 0.046
3.472ProThr: 3.472 ± 0.053
4.995ProVal: 4.995 ± 0.055
0.915ProTrp: 0.915 ± 0.028
1.198ProTyr: 1.198 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
3.413GlnAla: 3.413 ± 0.044
0.135GlnCys: 0.135 ± 0.008
1.297GlnAsp: 1.297 ± 0.029
1.429GlnGlu: 1.429 ± 0.025
0.682GlnPhe: 0.682 ± 0.022
2.045GlnGly: 2.045 ± 0.037
0.644GlnHis: 0.644 ± 0.017
1.378GlnIle: 1.378 ± 0.031
0.702GlnLys: 0.702 ± 0.018
2.91GlnLeu: 2.91 ± 0.043
0.595GlnMet: 0.595 ± 0.02
0.492GlnAsn: 0.492 ± 0.018
1.572GlnPro: 1.572 ± 0.036
1.082GlnGln: 1.082 ± 0.026
2.213GlnArg: 2.213 ± 0.037
1.261GlnSer: 1.261 ± 0.032
1.49GlnThr: 1.49 ± 0.029
2.596GlnVal: 2.596 ± 0.038
0.425GlnTrp: 0.425 ± 0.017
0.461GlnTyr: 0.461 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
7.898ArgAla: 7.898 ± 0.083
0.406ArgCys: 0.406 ± 0.015
4.191ArgAsp: 4.191 ± 0.049
4.331ArgGlu: 4.331 ± 0.053
2.23ArgPhe: 2.23 ± 0.042
5.027ArgGly: 5.027 ± 0.057
1.69ArgHis: 1.69 ± 0.035
3.39ArgIle: 3.39 ± 0.048
1.542ArgLys: 1.542 ± 0.033
7.601ArgLeu: 7.601 ± 0.082
1.643ArgMet: 1.643 ± 0.033
1.361ArgAsn: 1.361 ± 0.029
3.829ArgPro: 3.829 ± 0.052
1.981ArgGln: 1.981 ± 0.037
6.403ArgArg: 6.403 ± 0.086
3.963ArgSer: 3.963 ± 0.06
4.482ArgThr: 4.482 ± 0.058
5.495ArgVal: 5.495 ± 0.059
1.258ArgTrp: 1.258 ± 0.028
1.595ArgTyr: 1.595 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.64SerAla: 6.64 ± 0.073
0.338SerCys: 0.338 ± 0.017
2.991SerAsp: 2.991 ± 0.045
2.836SerGlu: 2.836 ± 0.045
1.768SerPhe: 1.768 ± 0.034
5.672SerGly: 5.672 ± 0.066
1.097SerHis: 1.097 ± 0.026
2.076SerIle: 2.076 ± 0.037
1.186SerLys: 1.186 ± 0.03
5.328SerLeu: 5.328 ± 0.055
1.268SerMet: 1.268 ± 0.03
1.02SerAsn: 1.02 ± 0.025
3.074SerPro: 3.074 ± 0.04
1.36SerGln: 1.36 ± 0.027
3.517SerArg: 3.517 ± 0.042
3.22SerSer: 3.22 ± 0.052
3.519SerThr: 3.519 ± 0.051
4.619SerVal: 4.619 ± 0.051
1.007SerTrp: 1.007 ± 0.027
1.334SerTyr: 1.334 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
7.559ThrAla: 7.559 ± 0.081
0.41ThrCys: 0.41 ± 0.016
3.813ThrAsp: 3.813 ± 0.055
3.381ThrGlu: 3.381 ± 0.053
1.989ThrPhe: 1.989 ± 0.035
6.054ThrGly: 6.054 ± 0.067
1.2ThrHis: 1.2 ± 0.026
2.635ThrIle: 2.635 ± 0.037
1.394ThrLys: 1.394 ± 0.033
5.919ThrLeu: 5.919 ± 0.069
1.112ThrMet: 1.112 ± 0.026
1.257ThrAsn: 1.257 ± 0.032
3.985ThrPro: 3.985 ± 0.059
1.505ThrGln: 1.505 ± 0.032
3.792ThrArg: 3.792 ± 0.049
3.716ThrSer: 3.716 ± 0.048
4.301ThrThr: 4.301 ± 0.062
5.765ThrVal: 5.765 ± 0.066
1.052ThrTrp: 1.052 ± 0.027
1.766ThrTyr: 1.766 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
12.05ValAla: 12.05 ± 0.11
0.627ValCys: 0.627 ± 0.019
5.636ValAsp: 5.636 ± 0.056
5.558ValGlu: 5.558 ± 0.067
2.469ValPhe: 2.469 ± 0.042
7.425ValGly: 7.425 ± 0.085
1.799ValHis: 1.799 ± 0.033
3.816ValIle: 3.816 ± 0.049
1.885ValLys: 1.885 ± 0.041
9.318ValLeu: 9.318 ± 0.1
1.595ValMet: 1.595 ± 0.036
1.74ValAsn: 1.74 ± 0.035
4.88ValPro: 4.88 ± 0.057
1.93ValGln: 1.93 ± 0.037
6.336ValArg: 6.336 ± 0.063
4.872ValSer: 4.872 ± 0.049
6.107ValThr: 6.107 ± 0.073
9.347ValVal: 9.347 ± 0.084
1.127ValTrp: 1.127 ± 0.025
1.57ValTyr: 1.57 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.717TrpAla: 1.717 ± 0.033
0.128TrpCys: 0.128 ± 0.009
0.861TrpAsp: 0.861 ± 0.026
0.732TrpGlu: 0.732 ± 0.022
0.572TrpPhe: 0.572 ± 0.016
1.126TrpGly: 1.126 ± 0.027
0.365TrpHis: 0.365 ± 0.015
0.644TrpIle: 0.644 ± 0.021
0.381TrpLys: 0.381 ± 0.015
1.836TrpLeu: 1.836 ± 0.038
0.352TrpMet: 0.352 ± 0.016
0.38TrpAsn: 0.38 ± 0.015
0.76TrpPro: 0.76 ± 0.022
0.546TrpGln: 0.546 ± 0.022
1.256TrpArg: 1.256 ± 0.033
1.019TrpSer: 1.019 ± 0.026
1.072TrpThr: 1.072 ± 0.031
1.231TrpVal: 1.231 ± 0.025
0.374TrpTrp: 0.374 ± 0.018
0.34TrpTyr: 0.34 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.995TyrAla: 2.995 ± 0.042
0.163TyrCys: 0.163 ± 0.009
1.763TyrAsp: 1.763 ± 0.04
1.201TyrGlu: 1.201 ± 0.028
0.717TyrPhe: 0.717 ± 0.021
2.097TyrGly: 2.097 ± 0.041
0.375TyrHis: 0.375 ± 0.013
0.552TyrIle: 0.552 ± 0.017
0.406TyrLys: 0.406 ± 0.016
2.186TyrLeu: 2.186 ± 0.04
0.25TyrMet: 0.25 ± 0.011
0.436TyrAsn: 0.436 ± 0.016
1.051TyrPro: 1.051 ± 0.028
0.6TyrGln: 0.6 ± 0.019
1.552TyrArg: 1.552 ± 0.035
1.043TyrSer: 1.043 ± 0.027
1.154TyrThr: 1.154 ± 0.027
2.089TyrVal: 2.089 ± 0.03
0.334TyrTrp: 0.334 ± 0.012
0.504TyrTyr: 0.504 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5357 proteins (1728418 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski