Amino acid dipepetide frequency for Alsobacter soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.627AlaAla: 20.627 ± 0.2	1.286AlaCys: 1.286 ± 0.036	6.8AlaAsp: 6.8 ± 0.078	8.158AlaGlu: 8.158 ± 0.091	4.907AlaPhe: 4.907 ± 0.067	12.038AlaGly: 12.038 ± 0.11	2.303AlaHis: 2.303 ± 0.044	6.152AlaIle: 6.152 ± 0.072	4.139AlaLys: 4.139 ± 0.073	15.313AlaLeu: 15.313 ± 0.148	3.75AlaMet: 3.75 ± 0.053	2.626AlaAsn: 2.626 ± 0.048	7.323AlaPro: 7.323 ± 0.105	4.448AlaGln: 4.448 ± 0.067	10.29AlaArg: 10.29 ± 0.116	7.023AlaSer: 7.023 ± 0.08	6.098AlaThr: 6.098 ± 0.067	10.173AlaVal: 10.173 ± 0.089	1.762AlaTrp: 1.762 ± 0.037	2.656AlaTyr: 2.656 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	1.106CysAla: 1.106 ± 0.028	0.117CysCys: 0.117 ± 0.008	0.492CysAsp: 0.492 ± 0.019	0.43CysGlu: 0.43 ± 0.019	0.308CysPhe: 0.308 ± 0.015	0.949CysGly: 0.949 ± 0.031	0.225CysHis: 0.225 ± 0.013	0.362CysIle: 0.362 ± 0.016	0.18CysLys: 0.18 ± 0.011	0.755CysLeu: 0.755 ± 0.022	0.162CysMet: 0.162 ± 0.01	0.173CysAsn: 0.173 ± 0.011	0.499CysPro: 0.499 ± 0.022	0.209CysGln: 0.209 ± 0.013	0.643CysArg: 0.643 ± 0.022	0.47CysSer: 0.47 ± 0.019	0.325CysThr: 0.325 ± 0.015	0.682CysVal: 0.682 ± 0.02	0.123CysTrp: 0.123 ± 0.008	0.181CysTyr: 0.181 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.005AspAla: 7.005 ± 0.073	0.44AspCys: 0.44 ± 0.022	2.727AspAsp: 2.727 ± 0.048	3.357AspGlu: 3.357 ± 0.052	1.903AspPhe: 1.903 ± 0.034	4.807AspGly: 4.807 ± 0.079	1.086AspHis: 1.086 ± 0.026	2.449AspIle: 2.449 ± 0.046	1.629AspLys: 1.629 ± 0.037	5.929AspLeu: 5.929 ± 0.074	1.185AspMet: 1.185 ± 0.028	0.985AspAsn: 0.985 ± 0.028	3.752AspPro: 3.752 ± 0.052	1.657AspGln: 1.657 ± 0.037	4.38AspArg: 4.38 ± 0.063	1.874AspSer: 1.874 ± 0.041	2.142AspThr: 2.142 ± 0.052	4.372AspVal: 4.372 ± 0.059	0.879AspTrp: 0.879 ± 0.025	1.314AspTyr: 1.314 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	8.433GluAla: 8.433 ± 0.099	0.307GluCys: 0.307 ± 0.014	2.67GluAsp: 2.67 ± 0.042	3.064GluGlu: 3.064 ± 0.057	1.611GluPhe: 1.611 ± 0.037	4.549GluGly: 4.549 ± 0.055	1.162GluHis: 1.162 ± 0.03	2.943GluIle: 2.943 ± 0.043	1.977GluLys: 1.977 ± 0.038	5.094GluLeu: 5.094 ± 0.066	1.329GluMet: 1.329 ± 0.033	1.364GluAsn: 1.364 ± 0.033	3.309GluPro: 3.309 ± 0.061	2.065GluGln: 2.065 ± 0.036	5.43GluArg: 5.43 ± 0.068	2.27GluSer: 2.27 ± 0.042	3.106GluThr: 3.106 ± 0.05	3.881GluVal: 3.881 ± 0.056	0.613GluTrp: 0.613 ± 0.02	0.817GluTyr: 0.817 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.734PheAla: 4.734 ± 0.058	0.375PheCys: 0.375 ± 0.017	2.345PheAsp: 2.345 ± 0.038	1.995PheGlu: 1.995 ± 0.037	1.334PhePhe: 1.334 ± 0.035	3.71PheGly: 3.71 ± 0.058	0.662PheHis: 0.662 ± 0.024	1.363PheIle: 1.363 ± 0.033	0.918PheLys: 0.918 ± 0.029	3.225PheLeu: 3.225 ± 0.056	0.817PheMet: 0.817 ± 0.022	0.843PheAsn: 0.843 ± 0.024	1.653PhePro: 1.653 ± 0.033	0.994PheGln: 0.994 ± 0.026	2.464PheArg: 2.464 ± 0.043	1.936PheSer: 1.936 ± 0.038	1.893PheThr: 1.893 ± 0.035	2.955PheVal: 2.955 ± 0.053	0.556PheTrp: 0.556 ± 0.023	0.818PheTyr: 0.818 ± 0.026	0.001PheXaa: 0.001 ± 0.001
Gly	11.496GlyAla: 11.496 ± 0.131	0.876GlyCys: 0.876 ± 0.029	4.346GlyAsp: 4.346 ± 0.07	4.937GlyGlu: 4.937 ± 0.064	3.63GlyPhe: 3.63 ± 0.046	7.865GlyGly: 7.865 ± 0.121	1.762GlyHis: 1.762 ± 0.04	3.49GlyIle: 3.49 ± 0.058	3.06GlyLys: 3.06 ± 0.051	9.768GlyLeu: 9.768 ± 0.088	2.307GlyMet: 2.307 ± 0.049	1.646GlyAsn: 1.646 ± 0.049	4.334GlyPro: 4.334 ± 0.056	3.029GlyGln: 3.029 ± 0.05	7.207GlyArg: 7.207 ± 0.079	4.775GlySer: 4.775 ± 0.061	3.624GlyThr: 3.624 ± 0.058	7.476GlyVal: 7.476 ± 0.076	1.463GlyTrp: 1.463 ± 0.034	2.223GlyTyr: 2.223 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.433HisAla: 2.433 ± 0.043	0.207HisCys: 0.207 ± 0.012	1.104HisAsp: 1.104 ± 0.03	1.012HisGlu: 1.012 ± 0.026	0.678HisPhe: 0.678 ± 0.021	1.977HisGly: 1.977 ± 0.045	0.523HisHis: 0.523 ± 0.024	0.68HisIle: 0.68 ± 0.024	0.435HisLys: 0.435 ± 0.017	1.84HisLeu: 1.84 ± 0.039	0.451HisMet: 0.451 ± 0.017	0.393HisAsn: 0.393 ± 0.017	1.353HisPro: 1.353 ± 0.03	0.495HisGln: 0.495 ± 0.019	1.357HisArg: 1.357 ± 0.031	0.759HisSer: 0.759 ± 0.026	0.757HisThr: 0.757 ± 0.023	1.591HisVal: 1.591 ± 0.034	0.329HisTrp: 0.329 ± 0.016	0.463HisTyr: 0.463 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.42IleAla: 6.42 ± 0.07	0.391IleCys: 0.391 ± 0.017	2.708IleAsp: 2.708 ± 0.047	2.839IleGlu: 2.839 ± 0.044	1.37IlePhe: 1.37 ± 0.033	4.45IleGly: 4.45 ± 0.06	0.83IleHis: 0.83 ± 0.025	1.65IleIle: 1.65 ± 0.042	1.168IleLys: 1.168 ± 0.033	4.153IleLeu: 4.153 ± 0.061	0.829IleMet: 0.829 ± 0.022	1.059IleAsn: 1.059 ± 0.029	2.253IlePro: 2.253 ± 0.04	1.188IleGln: 1.188 ± 0.028	3.114IleArg: 3.114 ± 0.048	2.232IleSer: 2.232 ± 0.037	2.244IleThr: 2.244 ± 0.04	3.905IleVal: 3.905 ± 0.059	0.489IleTrp: 0.489 ± 0.018	0.92IleTyr: 0.92 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.438LysAla: 4.438 ± 0.061	0.129LysCys: 0.129 ± 0.009	1.7LysAsp: 1.7 ± 0.037	1.425LysGlu: 1.425 ± 0.04	0.746LysPhe: 0.746 ± 0.024	2.74LysGly: 2.74 ± 0.046	0.552LysHis: 0.552 ± 0.017	1.361LysIle: 1.361 ± 0.037	1.062LysLys: 1.062 ± 0.036	3.138LysLeu: 3.138 ± 0.06	0.619LysMet: 0.619 ± 0.023	0.7LysAsn: 0.7 ± 0.022	2.115LysPro: 2.115 ± 0.036	0.941LysGln: 0.941 ± 0.026	2.261LysArg: 2.261 ± 0.041	1.6LysSer: 1.6 ± 0.036	1.717LysThr: 1.717 ± 0.037	2.358LysVal: 2.358 ± 0.049	0.312LysTrp: 0.312 ± 0.014	0.505LysTyr: 0.505 ± 0.02	0.001LysXaa: 0.001 ± 0.001
Leu	15.906LeuAla: 15.906 ± 0.13	0.892LeuCys: 0.892 ± 0.029	6.069LeuAsp: 6.069 ± 0.08	5.307LeuGlu: 5.307 ± 0.08	3.565LeuPhe: 3.565 ± 0.053	9.107LeuGly: 9.107 ± 0.082	1.746LeuHis: 1.746 ± 0.04	4.103LeuIle: 4.103 ± 0.066	3.325LeuLys: 3.325 ± 0.056	9.6LeuLeu: 9.6 ± 0.109	2.181LeuMet: 2.181 ± 0.041	2.304LeuAsn: 2.304 ± 0.04	5.533LeuPro: 5.533 ± 0.057	2.822LeuGln: 2.822 ± 0.042	7.339LeuArg: 7.339 ± 0.079	6.001LeuSer: 6.001 ± 0.075	5.117LeuThr: 5.117 ± 0.059	8.34LeuVal: 8.34 ± 0.084	1.215LeuTrp: 1.215 ± 0.031	1.987LeuTyr: 1.987 ± 0.04	0.002LeuXaa: 0.002 ± 0.001
Met	3.288MetAla: 3.288 ± 0.048	0.138MetCys: 0.138 ± 0.008	1.12MetAsp: 1.12 ± 0.029	1.041MetGlu: 1.041 ± 0.029	0.633MetPhe: 0.633 ± 0.02	1.946MetGly: 1.946 ± 0.038	0.379MetHis: 0.379 ± 0.016	1.104MetIle: 1.104 ± 0.028	0.865MetLys: 0.865 ± 0.026	2.426MetLeu: 2.426 ± 0.047	0.563MetMet: 0.563 ± 0.023	0.645MetAsn: 0.645 ± 0.023	1.359MetPro: 1.359 ± 0.029	0.749MetGln: 0.749 ± 0.022	1.918MetArg: 1.918 ± 0.037	1.577MetSer: 1.577 ± 0.027	1.706MetThr: 1.706 ± 0.039	1.62MetVal: 1.62 ± 0.029	0.181MetTrp: 0.181 ± 0.013	0.276MetTyr: 0.276 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.911AsnAla: 2.911 ± 0.044	0.216AsnCys: 0.216 ± 0.011	1.156AsnAsp: 1.156 ± 0.04	1.096AsnGlu: 1.096 ± 0.029	0.761AsnPhe: 0.761 ± 0.024	2.079AsnGly: 2.079 ± 0.039	0.416AsnHis: 0.416 ± 0.018	1.001AsnIle: 1.001 ± 0.032	0.596AsnLys: 0.596 ± 0.019	2.327AsnLeu: 2.327 ± 0.047	0.502AsnMet: 0.502 ± 0.017	0.538AsnAsn: 0.538 ± 0.018	1.712AsnPro: 1.712 ± 0.034	0.645AsnGln: 0.645 ± 0.023	1.641AsnArg: 1.641 ± 0.036	0.919AsnSer: 0.919 ± 0.022	1.047AsnThr: 1.047 ± 0.029	1.769AsnVal: 1.769 ± 0.036	0.37AsnTrp: 0.37 ± 0.015	0.509AsnTyr: 0.509 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.692ProAla: 7.692 ± 0.104	0.376ProCys: 0.376 ± 0.016	3.724ProAsp: 3.724 ± 0.045	3.969ProGlu: 3.969 ± 0.052	2.06ProPhe: 2.06 ± 0.038	5.349ProGly: 5.349 ± 0.062	1.135ProHis: 1.135 ± 0.031	2.207ProIle: 2.207 ± 0.038	1.71ProLys: 1.71 ± 0.032	4.982ProLeu: 4.982 ± 0.059	1.296ProMet: 1.296 ± 0.028	1.443ProAsn: 1.443 ± 0.033	3.092ProPro: 3.092 ± 0.059	1.679ProGln: 1.679 ± 0.034	3.531ProArg: 3.531 ± 0.056	3.0ProSer: 3.0 ± 0.048	2.604ProThr: 2.604 ± 0.049	4.561ProVal: 4.561 ± 0.057	0.762ProTrp: 0.762 ± 0.023	1.176ProTyr: 1.176 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.725GlnAla: 4.725 ± 0.074	0.204GlnCys: 0.204 ± 0.012	1.594GlnAsp: 1.594 ± 0.035	1.471GlnGlu: 1.471 ± 0.032	0.958GlnPhe: 0.958 ± 0.025	2.567GlnGly: 2.567 ± 0.041	0.587GlnHis: 0.587 ± 0.021	1.503GlnIle: 1.503 ± 0.03	0.947GlnLys: 0.947 ± 0.027	2.711GlnLeu: 2.711 ± 0.047	0.731GlnMet: 0.731 ± 0.023	0.773GlnAsn: 0.773 ± 0.027	1.936GlnPro: 1.936 ± 0.044	1.176GlnGln: 1.176 ± 0.034	2.438GlnArg: 2.438 ± 0.046	1.601GlnSer: 1.601 ± 0.033	1.602GlnThr: 1.602 ± 0.035	2.259GlnVal: 2.259 ± 0.044	0.375GlnTrp: 0.375 ± 0.018	0.512GlnTyr: 0.512 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.258ArgAla: 9.258 ± 0.096	0.594ArgCys: 0.594 ± 0.023	4.14ArgAsp: 4.14 ± 0.052	4.564ArgGlu: 4.564 ± 0.059	3.07ArgPhe: 3.07 ± 0.048	5.491ArgGly: 5.491 ± 0.065	1.575ArgHis: 1.575 ± 0.035	3.93ArgIle: 3.93 ± 0.048	2.289ArgLys: 2.289 ± 0.038	8.609ArgLeu: 8.609 ± 0.099	1.948ArgMet: 1.948 ± 0.038	1.71ArgAsn: 1.71 ± 0.031	4.288ArgPro: 4.288 ± 0.055	2.549ArgGln: 2.549 ± 0.045	6.892ArgArg: 6.892 ± 0.081	3.997ArgSer: 3.997 ± 0.056	3.563ArgThr: 3.563 ± 0.051	5.453ArgVal: 5.453 ± 0.061	1.103ArgTrp: 1.103 ± 0.029	1.664ArgTyr: 1.664 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	6.505SerAla: 6.505 ± 0.083	0.425SerCys: 0.425 ± 0.017	2.496SerAsp: 2.496 ± 0.045	2.506SerGlu: 2.506 ± 0.041	2.152SerPhe: 2.152 ± 0.043	5.333SerGly: 5.333 ± 0.059	0.952SerHis: 0.952 ± 0.024	2.326SerIle: 2.326 ± 0.041	1.433SerLys: 1.433 ± 0.032	5.394SerLeu: 5.394 ± 0.06	1.239SerMet: 1.239 ± 0.032	1.149SerAsn: 1.149 ± 0.028	3.088SerPro: 3.088 ± 0.054	1.536SerGln: 1.536 ± 0.037	3.896SerArg: 3.896 ± 0.061	2.806SerSer: 2.806 ± 0.053	2.524SerThr: 2.524 ± 0.047	3.894SerVal: 3.894 ± 0.06	0.731SerTrp: 0.731 ± 0.022	1.157SerTyr: 1.157 ± 0.025	0.001SerXaa: 0.001 ± 0.001
Thr	6.073ThrAla: 6.073 ± 0.065	0.403ThrCys: 0.403 ± 0.017	2.367ThrAsp: 2.367 ± 0.042	2.361ThrGlu: 2.361 ± 0.038	1.775ThrPhe: 1.775 ± 0.033	4.815ThrGly: 4.815 ± 0.065	0.878ThrHis: 0.878 ± 0.024	2.354ThrIle: 2.354 ± 0.042	1.247ThrLys: 1.247 ± 0.033	5.557ThrLeu: 5.557 ± 0.063	1.043ThrMet: 1.043 ± 0.032	1.061ThrAsn: 1.061 ± 0.029	3.328ThrPro: 3.328 ± 0.051	1.314ThrGln: 1.314 ± 0.032	3.258ThrArg: 3.258 ± 0.041	2.515ThrSer: 2.515 ± 0.041	2.557ThrThr: 2.557 ± 0.051	4.343ThrVal: 4.343 ± 0.057	0.635ThrTrp: 0.635 ± 0.02	1.095ThrTyr: 1.095 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.699ValAla: 10.699 ± 0.106	0.682ValCys: 0.682 ± 0.019	4.35ValAsp: 4.35 ± 0.065	4.748ValGlu: 4.748 ± 0.058	2.864ValPhe: 2.864 ± 0.046	6.354ValGly: 6.354 ± 0.078	1.433ValHis: 1.433 ± 0.033	3.853ValIle: 3.853 ± 0.056	2.412ValLys: 2.412 ± 0.046	8.005ValLeu: 8.005 ± 0.084	1.854ValMet: 1.854 ± 0.036	1.922ValAsn: 1.922 ± 0.041	3.602ValPro: 3.602 ± 0.055	2.218ValGln: 2.218 ± 0.039	5.632ValArg: 5.632 ± 0.067	4.413ValSer: 4.413 ± 0.058	4.551ValThr: 4.551 ± 0.062	6.866ValVal: 6.866 ± 0.078	0.939ValTrp: 0.939 ± 0.027	1.569ValTyr: 1.569 ± 0.034	0.003ValXaa: 0.003 ± 0.002
Trp	1.475TrpAla: 1.475 ± 0.034	0.126TrpCys: 0.126 ± 0.009	0.668TrpAsp: 0.668 ± 0.02	0.559TrpGlu: 0.559 ± 0.021	0.497TrpPhe: 0.497 ± 0.018	1.027TrpGly: 1.027 ± 0.028	0.236TrpHis: 0.236 ± 0.015	0.648TrpIle: 0.648 ± 0.023	0.443TrpLys: 0.443 ± 0.02	1.581TrpLeu: 1.581 ± 0.033	0.331TrpMet: 0.331 ± 0.016	0.387TrpAsn: 0.387 ± 0.013	0.757TrpPro: 0.757 ± 0.022	0.384TrpGln: 0.384 ± 0.018	1.379TrpArg: 1.379 ± 0.033	0.827TrpSer: 0.827 ± 0.02	0.833TrpThr: 0.833 ± 0.026	0.778TrpVal: 0.778 ± 0.025	0.229TrpTrp: 0.229 ± 0.01	0.264TrpTyr: 0.264 ± 0.014	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.646TyrAla: 2.646 ± 0.041	0.208TyrCys: 0.208 ± 0.012	1.294TyrAsp: 1.294 ± 0.032	1.155TyrGlu: 1.155 ± 0.031	0.766TyrPhe: 0.766 ± 0.021	2.16TyrGly: 2.16 ± 0.051	0.396TyrHis: 0.396 ± 0.016	0.73TyrIle: 0.73 ± 0.024	0.583TyrLys: 0.583 ± 0.02	2.052TyrLeu: 2.052 ± 0.04	0.398TyrMet: 0.398 ± 0.018	0.492TyrAsn: 0.492 ± 0.019	1.059TyrPro: 1.059 ± 0.029	0.57TyrGln: 0.57 ± 0.021	1.621TyrArg: 1.621 ± 0.035	0.951TyrSer: 0.951 ± 0.026	0.966TyrThr: 0.966 ± 0.026	1.691TyrVal: 1.691 ± 0.032	0.364TyrTrp: 0.364 ± 0.016	0.543TyrTyr: 0.543 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4752 proteins (1490446 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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