Amino acid dipepetide frequency for Breoghania sp. L-A4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.448AlaAla: 17.448 ± 0.181	1.237AlaCys: 1.237 ± 0.035	7.379AlaAsp: 7.379 ± 0.077	7.483AlaGlu: 7.483 ± 0.081	4.611AlaPhe: 4.611 ± 0.058	10.931AlaGly: 10.931 ± 0.128	2.447AlaHis: 2.447 ± 0.047	6.422AlaIle: 6.422 ± 0.079	3.669AlaLys: 3.669 ± 0.068	13.69AlaLeu: 13.69 ± 0.121	3.664AlaMet: 3.664 ± 0.054	3.017AlaAsn: 3.017 ± 0.051	5.639AlaPro: 5.639 ± 0.089	3.893AlaGln: 3.893 ± 0.066	9.483AlaArg: 9.483 ± 0.095	6.674AlaSer: 6.674 ± 0.072	6.079AlaThr: 6.079 ± 0.09	8.868AlaVal: 8.868 ± 0.093	1.453AlaTrp: 1.453 ± 0.036	2.609AlaTyr: 2.609 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.084CysAla: 1.084 ± 0.032	0.145CysCys: 0.145 ± 0.012	0.603CysAsp: 0.603 ± 0.023	0.489CysGlu: 0.489 ± 0.019	0.33CysPhe: 0.33 ± 0.015	1.035CysGly: 1.035 ± 0.032	0.277CysHis: 0.277 ± 0.017	0.402CysIle: 0.402 ± 0.021	0.219CysLys: 0.219 ± 0.013	0.808CysLeu: 0.808 ± 0.024	0.214CysMet: 0.214 ± 0.014	0.216CysAsn: 0.216 ± 0.013	0.489CysPro: 0.489 ± 0.022	0.229CysGln: 0.229 ± 0.014	0.683CysArg: 0.683 ± 0.024	0.492CysSer: 0.492 ± 0.021	0.47CysThr: 0.47 ± 0.02	0.694CysVal: 0.694 ± 0.022	0.116CysTrp: 0.116 ± 0.009	0.222CysTyr: 0.222 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.954AspAla: 7.954 ± 0.096	0.552AspCys: 0.552 ± 0.024	3.599AspAsp: 3.599 ± 0.061	3.521AspGlu: 3.521 ± 0.059	2.299AspPhe: 2.299 ± 0.045	5.499AspGly: 5.499 ± 0.077	1.278AspHis: 1.278 ± 0.032	3.309AspIle: 3.309 ± 0.051	1.7AspLys: 1.7 ± 0.039	6.022AspLeu: 6.022 ± 0.075	1.483AspMet: 1.483 ± 0.036	1.351AspAsn: 1.351 ± 0.033	3.642AspPro: 3.642 ± 0.065	1.567AspGln: 1.567 ± 0.039	4.123AspArg: 4.123 ± 0.06	2.329AspSer: 2.329 ± 0.04	3.118AspThr: 3.118 ± 0.059	4.456AspVal: 4.456 ± 0.065	1.023AspTrp: 1.023 ± 0.031	1.514AspTyr: 1.514 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.804GluAla: 7.804 ± 0.106	0.387GluCys: 0.387 ± 0.019	3.035GluAsp: 3.035 ± 0.051	3.272GluGlu: 3.272 ± 0.06	1.708GluPhe: 1.708 ± 0.036	4.152GluGly: 4.152 ± 0.066	1.257GluHis: 1.257 ± 0.034	3.739GluIle: 3.739 ± 0.058	2.176GluLys: 2.176 ± 0.049	5.259GluLeu: 5.259 ± 0.065	1.613GluMet: 1.613 ± 0.04	1.601GluAsn: 1.601 ± 0.034	2.835GluPro: 2.835 ± 0.056	1.96GluGln: 1.96 ± 0.038	4.799GluArg: 4.799 ± 0.072	2.463GluSer: 2.463 ± 0.047	4.079GluThr: 4.079 ± 0.068	3.549GluVal: 3.549 ± 0.059	0.645GluTrp: 0.645 ± 0.026	0.98GluTyr: 0.98 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.531PheAla: 4.531 ± 0.066	0.416PheCys: 0.416 ± 0.017	2.659PheAsp: 2.659 ± 0.05	2.299PheGlu: 2.299 ± 0.046	1.468PhePhe: 1.468 ± 0.034	3.65PheGly: 3.65 ± 0.067	0.747PheHis: 0.747 ± 0.025	1.758PheIle: 1.758 ± 0.041	1.051PheLys: 1.051 ± 0.029	3.344PheLeu: 3.344 ± 0.063	0.808PheMet: 0.808 ± 0.025	1.049PheAsn: 1.049 ± 0.034	1.588PhePro: 1.588 ± 0.037	0.973PheGln: 0.973 ± 0.028	2.159PheArg: 2.159 ± 0.042	2.366PheSer: 2.366 ± 0.041	2.005PheThr: 2.005 ± 0.044	2.907PheVal: 2.907 ± 0.051	0.584PheTrp: 0.584 ± 0.022	0.897PheTyr: 0.897 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.955GlyAla: 9.955 ± 0.105	0.925GlyCys: 0.925 ± 0.032	4.81GlyAsp: 4.81 ± 0.064	4.898GlyGlu: 4.898 ± 0.067	3.666GlyPhe: 3.666 ± 0.053	7.51GlyGly: 7.51 ± 0.114	1.961GlyHis: 1.961 ± 0.038	4.678GlyIle: 4.678 ± 0.064	3.004GlyLys: 3.004 ± 0.051	8.767GlyLeu: 8.767 ± 0.083	2.543GlyMet: 2.543 ± 0.053	2.121GlyAsn: 2.121 ± 0.043	3.528GlyPro: 3.528 ± 0.06	2.602GlyGln: 2.602 ± 0.049	5.937GlyArg: 5.937 ± 0.074	4.627GlySer: 4.627 ± 0.077	4.743GlyThr: 4.743 ± 0.094	6.333GlyVal: 6.333 ± 0.076	1.302GlyTrp: 1.302 ± 0.034	2.331GlyTyr: 2.331 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.497HisAla: 2.497 ± 0.045	0.229HisCys: 0.229 ± 0.014	1.278HisAsp: 1.278 ± 0.035	1.081HisGlu: 1.081 ± 0.033	0.874HisPhe: 0.874 ± 0.025	1.941HisGly: 1.941 ± 0.043	0.537HisHis: 0.537 ± 0.024	0.98HisIle: 0.98 ± 0.031	0.506HisLys: 0.506 ± 0.021	1.984HisLeu: 1.984 ± 0.041	0.523HisMet: 0.523 ± 0.024	0.472HisAsn: 0.472 ± 0.02	1.306HisPro: 1.306 ± 0.033	0.565HisGln: 0.565 ± 0.023	1.393HisArg: 1.393 ± 0.038	0.957HisSer: 0.957 ± 0.032	0.95HisThr: 0.95 ± 0.027	1.572HisVal: 1.572 ± 0.035	0.314HisTrp: 0.314 ± 0.016	0.529HisTyr: 0.529 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.557IleAla: 7.557 ± 0.087	0.527IleCys: 0.527 ± 0.021	3.804IleAsp: 3.804 ± 0.059	3.568IleGlu: 3.568 ± 0.061	1.83IlePhe: 1.83 ± 0.043	5.294IleGly: 5.294 ± 0.071	0.898IleHis: 0.898 ± 0.025	2.376IleIle: 2.376 ± 0.05	1.398IleLys: 1.398 ± 0.033	4.619IleLeu: 4.619 ± 0.063	1.004IleMet: 1.004 ± 0.029	1.42IleAsn: 1.42 ± 0.032	2.331IlePro: 2.331 ± 0.048	1.175IleGln: 1.175 ± 0.028	3.291IleArg: 3.291 ± 0.053	3.118IleSer: 3.118 ± 0.054	2.816IleThr: 2.816 ± 0.055	4.302IleVal: 4.302 ± 0.069	0.594IleTrp: 0.594 ± 0.022	1.103IleTyr: 1.103 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.156LysAla: 4.156 ± 0.068	0.176LysCys: 0.176 ± 0.012	1.7LysAsp: 1.7 ± 0.043	1.383LysGlu: 1.383 ± 0.041	0.84LysPhe: 0.84 ± 0.024	2.438LysGly: 2.438 ± 0.042	0.624LysHis: 0.624 ± 0.025	1.768LysIle: 1.768 ± 0.042	1.167LysLys: 1.167 ± 0.042	3.058LysLeu: 3.058 ± 0.06	0.795LysMet: 0.795 ± 0.027	0.794LysAsn: 0.794 ± 0.024	1.973LysPro: 1.973 ± 0.041	0.974LysGln: 0.974 ± 0.027	2.393LysArg: 2.393 ± 0.049	1.781LysSer: 1.781 ± 0.041	2.082LysThr: 2.082 ± 0.041	2.168LysVal: 2.168 ± 0.046	0.35LysTrp: 0.35 ± 0.018	0.612LysTyr: 0.612 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.187LeuAla: 13.187 ± 0.13	0.926LeuCys: 0.926 ± 0.03	6.401LeuAsp: 6.401 ± 0.077	5.787LeuGlu: 5.787 ± 0.073	3.576LeuPhe: 3.576 ± 0.074	8.203LeuGly: 8.203 ± 0.09	1.766LeuHis: 1.766 ± 0.037	5.042LeuIle: 5.042 ± 0.071	3.631LeuLys: 3.631 ± 0.064	8.97LeuLeu: 8.97 ± 0.134	2.366LeuMet: 2.366 ± 0.044	2.579LeuAsn: 2.579 ± 0.047	5.098LeuPro: 5.098 ± 0.067	2.42LeuGln: 2.42 ± 0.051	6.712LeuArg: 6.712 ± 0.083	6.352LeuSer: 6.352 ± 0.089	5.545LeuThr: 5.545 ± 0.067	7.301LeuVal: 7.301 ± 0.085	1.06LeuTrp: 1.06 ± 0.028	2.044LeuTyr: 2.044 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.214MetAla: 3.214 ± 0.058	0.173MetCys: 0.173 ± 0.013	1.295MetAsp: 1.295 ± 0.035	1.221MetGlu: 1.221 ± 0.033	0.756MetPhe: 0.756 ± 0.025	1.863MetGly: 1.863 ± 0.039	0.492MetHis: 0.492 ± 0.019	1.472MetIle: 1.472 ± 0.042	0.95MetLys: 0.95 ± 0.032	2.513MetLeu: 2.513 ± 0.046	0.736MetMet: 0.736 ± 0.039	0.734MetAsn: 0.734 ± 0.022	1.572MetPro: 1.572 ± 0.035	0.839MetGln: 0.839 ± 0.035	1.976MetArg: 1.976 ± 0.044	1.73MetSer: 1.73 ± 0.039	1.933MetThr: 1.933 ± 0.038	1.75MetVal: 1.75 ± 0.036	0.198MetTrp: 0.198 ± 0.013	0.319MetTyr: 0.319 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.294AsnAla: 3.294 ± 0.053	0.242AsnCys: 0.242 ± 0.016	1.444AsnAsp: 1.444 ± 0.036	1.317AsnGlu: 1.317 ± 0.039	0.907AsnPhe: 0.907 ± 0.029	2.33AsnGly: 2.33 ± 0.052	0.474AsnHis: 0.474 ± 0.021	1.259AsnIle: 1.259 ± 0.036	0.688AsnLys: 0.688 ± 0.026	2.477AsnLeu: 2.477 ± 0.039	0.592AsnMet: 0.592 ± 0.022	0.671AsnAsn: 0.671 ± 0.023	1.768AsnPro: 1.768 ± 0.039	0.699AsnGln: 0.699 ± 0.024	1.828AsnArg: 1.828 ± 0.038	1.169AsnSer: 1.169 ± 0.036	1.342AsnThr: 1.342 ± 0.039	1.952AsnVal: 1.952 ± 0.039	0.389AsnTrp: 0.389 ± 0.02	0.597AsnTyr: 0.597 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.129ProAla: 6.129 ± 0.087	0.392ProCys: 0.392 ± 0.019	3.801ProAsp: 3.801 ± 0.063	3.576ProGlu: 3.576 ± 0.056	1.939ProPhe: 1.939 ± 0.039	4.626ProGly: 4.626 ± 0.059	1.082ProHis: 1.082 ± 0.03	2.269ProIle: 2.269 ± 0.044	1.587ProLys: 1.587 ± 0.036	4.727ProLeu: 4.727 ± 0.069	1.213ProMet: 1.213 ± 0.029	1.217ProAsn: 1.217 ± 0.031	2.362ProPro: 2.362 ± 0.049	1.619ProGln: 1.619 ± 0.038	3.05ProArg: 3.05 ± 0.053	2.606ProSer: 2.606 ± 0.049	2.238ProThr: 2.238 ± 0.046	4.342ProVal: 4.342 ± 0.063	0.696ProTrp: 0.696 ± 0.023	1.097ProTyr: 1.097 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.056GlnAla: 4.056 ± 0.051	0.238GlnCys: 0.238 ± 0.015	1.445GlnAsp: 1.445 ± 0.031	1.379GlnGlu: 1.379 ± 0.032	1.001GlnPhe: 1.001 ± 0.026	2.253GlnGly: 2.253 ± 0.041	0.598GlnHis: 0.598 ± 0.023	1.746GlnIle: 1.746 ± 0.039	0.964GlnLys: 0.964 ± 0.033	2.545GlnLeu: 2.545 ± 0.05	0.861GlnMet: 0.861 ± 0.027	0.749GlnAsn: 0.749 ± 0.028	1.636GlnPro: 1.636 ± 0.035	1.006GlnGln: 1.006 ± 0.033	2.233GlnArg: 2.233 ± 0.047	1.658GlnSer: 1.658 ± 0.036	1.762GlnThr: 1.762 ± 0.043	1.998GlnVal: 1.998 ± 0.049	0.37GlnTrp: 0.37 ± 0.018	0.537GlnTyr: 0.537 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.497ArgAla: 8.497 ± 0.083	0.594ArgCys: 0.594 ± 0.022	4.339ArgAsp: 4.339 ± 0.063	4.098ArgGlu: 4.098 ± 0.063	2.911ArgPhe: 2.911 ± 0.05	4.953ArgGly: 4.953 ± 0.07	1.717ArgHis: 1.717 ± 0.044	4.158ArgIle: 4.158 ± 0.069	2.277ArgLys: 2.277 ± 0.047	7.646ArgLeu: 7.646 ± 0.087	1.904ArgMet: 1.904 ± 0.034	1.851ArgAsn: 1.851 ± 0.04	3.455ArgPro: 3.455 ± 0.053	2.327ArgGln: 2.327 ± 0.04	5.708ArgArg: 5.708 ± 0.087	3.568ArgSer: 3.568 ± 0.056	3.515ArgThr: 3.515 ± 0.047	4.682ArgVal: 4.682 ± 0.063	0.948ArgTrp: 0.948 ± 0.031	1.599ArgTyr: 1.599 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.373SerAla: 6.373 ± 0.076	0.492SerCys: 0.492 ± 0.024	3.332SerAsp: 3.332 ± 0.055	2.969SerGlu: 2.969 ± 0.059	2.161SerPhe: 2.161 ± 0.041	5.901SerGly: 5.901 ± 0.08	1.067SerHis: 1.067 ± 0.028	2.865SerIle: 2.865 ± 0.051	1.592SerLys: 1.592 ± 0.041	5.192SerLeu: 5.192 ± 0.07	1.371SerMet: 1.371 ± 0.032	1.35SerAsn: 1.35 ± 0.037	2.547SerPro: 2.547 ± 0.048	1.628SerGln: 1.628 ± 0.04	3.683SerArg: 3.683 ± 0.065	2.984SerSer: 2.984 ± 0.061	2.685SerThr: 2.685 ± 0.045	4.206SerVal: 4.206 ± 0.06	0.706SerTrp: 0.706 ± 0.025	1.311SerTyr: 1.311 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.293ThrAla: 6.293 ± 0.086	0.459ThrCys: 0.459 ± 0.022	2.961ThrAsp: 2.961 ± 0.052	2.741ThrGlu: 2.741 ± 0.048	2.083ThrPhe: 2.083 ± 0.038	5.433ThrGly: 5.433 ± 0.088	1.073ThrHis: 1.073 ± 0.03	3.114ThrIle: 3.114 ± 0.045	1.439ThrLys: 1.439 ± 0.036	5.994ThrLeu: 5.994 ± 0.075	1.224ThrMet: 1.224 ± 0.03	1.316ThrAsn: 1.316 ± 0.031	3.284ThrPro: 3.284 ± 0.045	1.454ThrGln: 1.454 ± 0.038	3.614ThrArg: 3.614 ± 0.056	2.872ThrSer: 2.872 ± 0.057	2.895ThrThr: 2.895 ± 0.06	4.633ThrVal: 4.633 ± 0.064	0.636ThrTrp: 0.636 ± 0.023	1.176ThrTyr: 1.176 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.043ValAla: 9.043 ± 0.1	0.677ValCys: 0.677 ± 0.023	4.305ValAsp: 4.305 ± 0.059	4.454ValGlu: 4.454 ± 0.068	2.837ValPhe: 2.837 ± 0.049	5.378ValGly: 5.378 ± 0.079	1.42ValHis: 1.42 ± 0.035	4.103ValIle: 4.103 ± 0.067	2.162ValLys: 2.162 ± 0.043	7.564ValLeu: 7.564 ± 0.096	1.995ValMet: 1.995 ± 0.045	1.94ValAsn: 1.94 ± 0.042	3.763ValPro: 3.763 ± 0.055	1.966ValGln: 1.966 ± 0.037	4.819ValArg: 4.819 ± 0.07	4.67ValSer: 4.67 ± 0.067	4.555ValThr: 4.555 ± 0.073	5.793ValVal: 5.793 ± 0.09	0.919ValTrp: 0.919 ± 0.03	1.534ValTyr: 1.534 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.182TrpAla: 1.182 ± 0.034	0.143TrpCys: 0.143 ± 0.012	0.642TrpAsp: 0.642 ± 0.023	0.537TrpGlu: 0.537 ± 0.021	0.53TrpPhe: 0.53 ± 0.021	0.866TrpGly: 0.866 ± 0.028	0.312TrpHis: 0.312 ± 0.017	0.683TrpIle: 0.683 ± 0.023	0.446TrpLys: 0.446 ± 0.02	1.542TrpLeu: 1.542 ± 0.039	0.365TrpMet: 0.365 ± 0.017	0.413TrpAsn: 0.413 ± 0.019	0.721TrpPro: 0.721 ± 0.023	0.49TrpGln: 0.49 ± 0.019	1.112TrpArg: 1.112 ± 0.031	0.828TrpSer: 0.828 ± 0.028	0.743TrpThr: 0.743 ± 0.024	0.797TrpVal: 0.797 ± 0.025	0.207TrpTrp: 0.207 ± 0.012	0.28TrpTyr: 0.28 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.041	0.284TyrCys: 0.284 ± 0.016	1.505TyrAsp: 1.505 ± 0.036	1.239TyrGlu: 1.239 ± 0.032	0.932TyrPhe: 0.932 ± 0.033	1.988TyrGly: 1.988 ± 0.042	0.461TyrHis: 0.461 ± 0.018	0.884TyrIle: 0.884 ± 0.029	0.606TyrLys: 0.606 ± 0.026	2.248TyrLeu: 2.248 ± 0.049	0.463TyrMet: 0.463 ± 0.019	0.576TyrAsn: 0.576 ± 0.022	1.028TyrPro: 1.028 ± 0.029	0.648TyrGln: 0.648 ± 0.023	1.752TyrArg: 1.752 ± 0.041	1.171TyrSer: 1.171 ± 0.03	1.139TyrThr: 1.139 ± 0.029	1.596TyrVal: 1.596 ± 0.036	0.327TyrTrp: 0.327 ± 0.016	0.561TyrTyr: 0.561 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4084 proteins (1258513 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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