Amino acid dipepetide frequency for Klebsiella virus 2019KP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.648AlaAla: 14.648 ± 1.117
1.406AlaCys: 1.406 ± 0.312
5.623AlaAsp: 5.623 ± 0.767
4.513AlaGlu: 4.513 ± 0.69
3.255AlaPhe: 3.255 ± 0.525
7.324AlaGly: 7.324 ± 1.306
1.332AlaHis: 1.332 ± 0.403
4.291AlaIle: 4.291 ± 0.75
6.14AlaLys: 6.14 ± 1.209
9.396AlaLeu: 9.396 ± 0.835
2.145AlaMet: 2.145 ± 0.331
2.737AlaAsn: 2.737 ± 0.447
3.847AlaPro: 3.847 ± 0.729
4.809AlaGln: 4.809 ± 0.964
5.992AlaArg: 5.992 ± 0.837
5.992AlaSer: 5.992 ± 0.729
5.697AlaThr: 5.697 ± 0.741
5.918AlaVal: 5.918 ± 0.652
1.036AlaTrp: 1.036 ± 0.259
3.403AlaTyr: 3.403 ± 0.55
0.0AlaXaa: 0.0 ± 0.0
Cys
1.184CysAla: 1.184 ± 0.444
0.222CysCys: 0.222 ± 0.112
0.518CysAsp: 0.518 ± 0.164
0.592CysGlu: 0.592 ± 0.209
0.592CysPhe: 0.592 ± 0.24
1.258CysGly: 1.258 ± 0.444
0.518CysHis: 0.518 ± 0.218
0.962CysIle: 0.962 ± 0.312
0.222CysLys: 0.222 ± 0.132
1.184CysLeu: 1.184 ± 0.32
0.222CysMet: 0.222 ± 0.138
0.518CysAsn: 0.518 ± 0.231
0.74CysPro: 0.74 ± 0.298
0.37CysGln: 0.37 ± 0.193
1.48CysArg: 1.48 ± 0.414
1.406CysSer: 1.406 ± 0.394
1.702CysThr: 1.702 ± 0.4
1.332CysVal: 1.332 ± 0.306
0.592CysTrp: 0.592 ± 0.259
0.592CysTyr: 0.592 ± 0.21
0.0CysXaa: 0.0 ± 0.0
Asp
5.771AspAla: 5.771 ± 0.803
0.888AspCys: 0.888 ± 0.409
2.589AspAsp: 2.589 ± 0.392
3.477AspGlu: 3.477 ± 0.549
2.145AspPhe: 2.145 ± 0.469
3.551AspGly: 3.551 ± 0.542
0.37AspHis: 0.37 ± 0.277
2.515AspIle: 2.515 ± 0.474
2.737AspLys: 2.737 ± 0.544
4.217AspLeu: 4.217 ± 0.634
1.997AspMet: 1.997 ± 0.295
2.441AspAsn: 2.441 ± 0.443
2.145AspPro: 2.145 ± 0.373
1.184AspGln: 1.184 ± 0.272
2.589AspArg: 2.589 ± 0.58
4.809AspSer: 4.809 ± 0.777
3.403AspThr: 3.403 ± 0.516
3.403AspVal: 3.403 ± 0.533
0.814AspTrp: 0.814 ± 0.202
2.589AspTyr: 2.589 ± 0.615
0.0AspXaa: 0.0 ± 0.0
Glu
4.809GluAla: 4.809 ± 0.682
0.444GluCys: 0.444 ± 0.252
2.959GluAsp: 2.959 ± 0.419
3.847GluGlu: 3.847 ± 0.67
2.367GluPhe: 2.367 ± 0.494
3.107GluGly: 3.107 ± 0.57
2.071GluHis: 2.071 ± 0.4
1.997GluIle: 1.997 ± 0.446
1.406GluLys: 1.406 ± 0.404
4.217GluLeu: 4.217 ± 0.574
2.293GluMet: 2.293 ± 0.417
1.406GluAsn: 1.406 ± 0.335
1.554GluPro: 1.554 ± 0.412
2.959GluGln: 2.959 ± 0.612
3.181GluArg: 3.181 ± 0.469
2.441GluSer: 2.441 ± 0.498
2.811GluThr: 2.811 ± 0.549
3.921GluVal: 3.921 ± 0.63
0.666GluTrp: 0.666 ± 0.199
2.367GluTyr: 2.367 ± 0.474
0.0GluXaa: 0.0 ± 0.0
Phe
2.145PheAla: 2.145 ± 0.411
0.37PheCys: 0.37 ± 0.209
1.85PheAsp: 1.85 ± 0.337
2.145PheGlu: 2.145 ± 0.43
1.406PhePhe: 1.406 ± 0.366
1.997PheGly: 1.997 ± 0.403
0.518PheHis: 0.518 ± 0.189
1.258PheIle: 1.258 ± 0.371
2.515PheLys: 2.515 ± 0.495
1.628PheLeu: 1.628 ± 0.309
0.888PheMet: 0.888 ± 0.254
2.071PheAsn: 2.071 ± 0.494
1.258PhePro: 1.258 ± 0.227
1.11PheGln: 1.11 ± 0.336
1.997PheArg: 1.997 ± 0.415
1.776PheSer: 1.776 ± 0.326
2.293PheThr: 2.293 ± 0.527
1.332PheVal: 1.332 ± 0.399
0.444PheTrp: 0.444 ± 0.192
1.406PheTyr: 1.406 ± 0.355
0.0PheXaa: 0.0 ± 0.0
Gly
4.587GlyAla: 4.587 ± 0.55
1.702GlyCys: 1.702 ± 0.465
4.217GlyAsp: 4.217 ± 0.559
3.625GlyGlu: 3.625 ± 0.475
3.699GlyPhe: 3.699 ± 0.708
4.143GlyGly: 4.143 ± 0.702
1.776GlyHis: 1.776 ± 0.402
4.143GlyIle: 4.143 ± 0.63
4.143GlyLys: 4.143 ± 0.776
7.398GlyLeu: 7.398 ± 0.834
2.293GlyMet: 2.293 ± 0.473
3.033GlyAsn: 3.033 ± 0.476
1.48GlyPro: 1.48 ± 0.377
2.293GlyGln: 2.293 ± 0.465
5.401GlyArg: 5.401 ± 0.712
3.921GlySer: 3.921 ± 0.432
5.771GlyThr: 5.771 ± 0.791
4.439GlyVal: 4.439 ± 0.692
0.518GlyTrp: 0.518 ± 0.182
3.625GlyTyr: 3.625 ± 0.607
0.0GlyXaa: 0.0 ± 0.0
His
1.924HisAla: 1.924 ± 0.507
0.666HisCys: 0.666 ± 0.214
0.888HisAsp: 0.888 ± 0.278
0.814HisGlu: 0.814 ± 0.341
0.222HisPhe: 0.222 ± 0.093
2.071HisGly: 2.071 ± 0.528
0.444HisHis: 0.444 ± 0.169
0.518HisIle: 0.518 ± 0.167
0.962HisLys: 0.962 ± 0.362
2.293HisLeu: 2.293 ± 0.584
0.666HisMet: 0.666 ± 0.23
0.666HisAsn: 0.666 ± 0.238
1.11HisPro: 1.11 ± 0.516
0.444HisGln: 0.444 ± 0.23
1.258HisArg: 1.258 ± 0.352
0.888HisSer: 0.888 ± 0.305
0.74HisThr: 0.74 ± 0.283
1.036HisVal: 1.036 ± 0.305
0.296HisTrp: 0.296 ± 0.188
0.962HisTyr: 0.962 ± 0.277
0.0HisXaa: 0.0 ± 0.0
Ile
3.181IleAla: 3.181 ± 0.653
0.444IleCys: 0.444 ± 0.177
1.554IleAsp: 1.554 ± 0.402
2.071IleGlu: 2.071 ± 0.481
0.592IlePhe: 0.592 ± 0.172
2.811IleGly: 2.811 ± 0.453
0.74IleHis: 0.74 ± 0.208
1.85IleIle: 1.85 ± 0.406
3.699IleLys: 3.699 ± 0.755
4.513IleLeu: 4.513 ± 0.712
1.332IleMet: 1.332 ± 0.359
1.85IleAsn: 1.85 ± 0.47
2.145IlePro: 2.145 ± 0.484
1.997IleGln: 1.997 ± 0.325
2.811IleArg: 2.811 ± 0.402
3.107IleSer: 3.107 ± 0.466
2.811IleThr: 2.811 ± 0.438
2.811IleVal: 2.811 ± 0.491
0.518IleTrp: 0.518 ± 0.235
1.11IleTyr: 1.11 ± 0.284
0.0IleXaa: 0.0 ± 0.0
Lys
5.327LysAla: 5.327 ± 0.874
0.962LysCys: 0.962 ± 0.335
2.589LysAsp: 2.589 ± 0.553
3.403LysGlu: 3.403 ± 0.56
1.184LysPhe: 1.184 ± 0.329
2.219LysGly: 2.219 ± 0.626
0.888LysHis: 0.888 ± 0.302
1.702LysIle: 1.702 ± 0.427
1.776LysLys: 1.776 ± 0.362
4.809LysLeu: 4.809 ± 0.585
1.258LysMet: 1.258 ± 0.327
1.406LysAsn: 1.406 ± 0.373
2.219LysPro: 2.219 ± 0.609
3.403LysGln: 3.403 ± 0.581
4.143LysArg: 4.143 ± 0.577
3.773LysSer: 3.773 ± 0.594
2.737LysThr: 2.737 ± 0.556
3.255LysVal: 3.255 ± 0.598
1.036LysTrp: 1.036 ± 0.291
0.962LysTyr: 0.962 ± 0.292
0.0LysXaa: 0.0 ± 0.0
Leu
7.694LeuAla: 7.694 ± 0.744
1.85LeuCys: 1.85 ± 0.643
6.362LeuAsp: 6.362 ± 0.804
4.069LeuGlu: 4.069 ± 0.722
1.85LeuPhe: 1.85 ± 0.406
7.102LeuGly: 7.102 ± 0.712
1.776LeuHis: 1.776 ± 0.397
4.069LeuIle: 4.069 ± 0.746
2.589LeuLys: 2.589 ± 0.524
8.212LeuLeu: 8.212 ± 1.165
2.219LeuMet: 2.219 ± 0.5
2.811LeuAsn: 2.811 ± 0.475
3.773LeuPro: 3.773 ± 0.553
4.069LeuGln: 4.069 ± 0.569
7.62LeuArg: 7.62 ± 0.687
7.324LeuSer: 7.324 ± 0.813
6.584LeuThr: 6.584 ± 0.95
6.806LeuVal: 6.806 ± 0.707
1.184LeuTrp: 1.184 ± 0.282
3.181LeuTyr: 3.181 ± 0.599
0.0LeuXaa: 0.0 ± 0.0
Met
3.625MetAla: 3.625 ± 0.485
0.222MetCys: 0.222 ± 0.112
1.924MetAsp: 1.924 ± 0.496
1.036MetGlu: 1.036 ± 0.254
1.036MetPhe: 1.036 ± 0.253
1.406MetGly: 1.406 ± 0.334
0.74MetHis: 0.74 ± 0.264
0.37MetIle: 0.37 ± 0.143
1.11MetLys: 1.11 ± 0.329
3.773MetLeu: 3.773 ± 0.523
0.444MetMet: 0.444 ± 0.188
0.592MetAsn: 0.592 ± 0.295
1.258MetPro: 1.258 ± 0.391
2.441MetGln: 2.441 ± 0.462
1.997MetArg: 1.997 ± 0.413
2.959MetSer: 2.959 ± 0.519
1.258MetThr: 1.258 ± 0.301
2.367MetVal: 2.367 ± 0.561
0.296MetTrp: 0.296 ± 0.155
0.444MetTyr: 0.444 ± 0.188
0.0MetXaa: 0.0 ± 0.0
Asn
2.589AsnAla: 2.589 ± 0.586
0.296AsnCys: 0.296 ± 0.158
1.554AsnAsp: 1.554 ± 0.364
1.11AsnGlu: 1.11 ± 0.351
0.888AsnPhe: 0.888 ± 0.234
3.181AsnGly: 3.181 ± 0.538
0.296AsnHis: 0.296 ± 0.219
2.367AsnIle: 2.367 ± 0.443
2.145AsnLys: 2.145 ± 0.495
3.107AsnLeu: 3.107 ± 0.57
1.11AsnMet: 1.11 ± 0.268
1.184AsnAsn: 1.184 ± 0.399
1.997AsnPro: 1.997 ± 0.391
1.184AsnGln: 1.184 ± 0.314
1.702AsnArg: 1.702 ± 0.324
2.515AsnSer: 2.515 ± 0.517
2.811AsnThr: 2.811 ± 0.584
2.811AsnVal: 2.811 ± 0.518
0.666AsnTrp: 0.666 ± 0.26
1.85AsnTyr: 1.85 ± 0.398
0.0AsnXaa: 0.0 ± 0.0
Pro
3.477ProAla: 3.477 ± 0.887
0.222ProCys: 0.222 ± 0.117
2.515ProAsp: 2.515 ± 0.467
2.441ProGlu: 2.441 ± 0.517
1.184ProPhe: 1.184 ± 0.282
2.441ProGly: 2.441 ± 0.47
0.74ProHis: 0.74 ± 0.299
1.11ProIle: 1.11 ± 0.251
1.85ProLys: 1.85 ± 0.486
3.921ProLeu: 3.921 ± 0.489
1.406ProMet: 1.406 ± 0.441
1.332ProAsn: 1.332 ± 0.336
0.814ProPro: 0.814 ± 0.215
1.332ProGln: 1.332 ± 0.516
2.441ProArg: 2.441 ± 0.43
3.551ProSer: 3.551 ± 0.71
3.033ProThr: 3.033 ± 0.432
2.959ProVal: 2.959 ± 0.564
0.37ProTrp: 0.37 ± 0.185
1.554ProTyr: 1.554 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
3.773GlnAla: 3.773 ± 0.713
0.222GlnCys: 0.222 ± 0.129
2.589GlnAsp: 2.589 ± 0.532
2.885GlnGlu: 2.885 ± 0.53
1.332GlnPhe: 1.332 ± 0.311
3.181GlnGly: 3.181 ± 0.459
1.036GlnHis: 1.036 ± 0.325
0.814GlnIle: 0.814 ± 0.294
2.663GlnLys: 2.663 ± 0.599
4.587GlnLeu: 4.587 ± 0.873
1.258GlnMet: 1.258 ± 0.259
2.071GlnAsn: 2.071 ± 0.425
1.554GlnPro: 1.554 ± 0.424
2.515GlnGln: 2.515 ± 0.673
2.515GlnArg: 2.515 ± 0.412
2.441GlnSer: 2.441 ± 0.388
1.628GlnThr: 1.628 ± 0.49
3.033GlnVal: 3.033 ± 0.569
0.592GlnTrp: 0.592 ± 0.218
1.332GlnTyr: 1.332 ± 0.41
0.0GlnXaa: 0.0 ± 0.0
Arg
7.472ArgAla: 7.472 ± 1.123
1.258ArgCys: 1.258 ± 0.297
2.071ArgAsp: 2.071 ± 0.482
3.255ArgGlu: 3.255 ± 0.472
2.515ArgPhe: 2.515 ± 0.454
5.771ArgGly: 5.771 ± 0.979
0.888ArgHis: 0.888 ± 0.298
3.107ArgIle: 3.107 ± 0.68
3.995ArgLys: 3.995 ± 0.652
6.806ArgLeu: 6.806 ± 0.813
2.293ArgMet: 2.293 ± 0.389
2.293ArgAsn: 2.293 ± 0.386
2.367ArgPro: 2.367 ± 0.365
2.071ArgGln: 2.071 ± 0.518
5.401ArgArg: 5.401 ± 0.743
4.439ArgSer: 4.439 ± 0.496
5.327ArgThr: 5.327 ± 0.713
3.921ArgVal: 3.921 ± 0.738
0.888ArgTrp: 0.888 ± 0.304
2.071ArgTyr: 2.071 ± 0.386
0.0ArgXaa: 0.0 ± 0.0
Ser
11.023SerAla: 11.023 ± 1.241
1.554SerCys: 1.554 ± 0.368
3.625SerAsp: 3.625 ± 0.397
2.885SerGlu: 2.885 ± 0.452
1.85SerPhe: 1.85 ± 0.327
4.809SerGly: 4.809 ± 0.721
0.74SerHis: 0.74 ± 0.282
3.107SerIle: 3.107 ± 0.514
4.291SerLys: 4.291 ± 0.499
4.439SerLeu: 4.439 ± 0.538
3.255SerMet: 3.255 ± 0.482
2.441SerAsn: 2.441 ± 0.501
3.033SerPro: 3.033 ± 0.577
1.48SerGln: 1.48 ± 0.483
4.587SerArg: 4.587 ± 0.688
6.732SerSer: 6.732 ± 0.84
5.623SerThr: 5.623 ± 0.922
5.475SerVal: 5.475 ± 0.65
1.48SerTrp: 1.48 ± 0.337
1.48SerTyr: 1.48 ± 0.357
0.0SerXaa: 0.0 ± 0.0
Thr
6.658ThrAla: 6.658 ± 0.761
1.554ThrCys: 1.554 ± 0.396
2.811ThrAsp: 2.811 ± 0.48
2.441ThrGlu: 2.441 ± 0.618
1.776ThrPhe: 1.776 ± 0.409
6.066ThrGly: 6.066 ± 0.784
1.48ThrHis: 1.48 ± 0.47
2.515ThrIle: 2.515 ± 0.428
2.367ThrLys: 2.367 ± 0.39
6.066ThrLeu: 6.066 ± 0.884
1.406ThrMet: 1.406 ± 0.491
2.071ThrAsn: 2.071 ± 0.492
2.663ThrPro: 2.663 ± 0.411
3.181ThrGln: 3.181 ± 0.611
4.661ThrArg: 4.661 ± 0.597
6.066ThrSer: 6.066 ± 1.039
4.957ThrThr: 4.957 ± 0.844
5.475ThrVal: 5.475 ± 0.874
1.184ThrTrp: 1.184 ± 0.288
2.515ThrTyr: 2.515 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
5.844ValAla: 5.844 ± 0.719
0.74ValCys: 0.74 ± 0.269
4.143ValAsp: 4.143 ± 0.703
3.699ValGlu: 3.699 ± 0.664
1.036ValPhe: 1.036 ± 0.235
5.844ValGly: 5.844 ± 0.911
1.554ValHis: 1.554 ± 0.44
3.255ValIle: 3.255 ± 0.569
2.293ValLys: 2.293 ± 0.49
5.253ValLeu: 5.253 ± 0.761
1.776ValMet: 1.776 ± 0.321
2.663ValAsn: 2.663 ± 0.76
3.255ValPro: 3.255 ± 0.689
3.107ValGln: 3.107 ± 0.401
4.735ValArg: 4.735 ± 0.635
5.623ValSer: 5.623 ± 0.711
4.661ValThr: 4.661 ± 0.746
6.14ValVal: 6.14 ± 0.578
0.74ValTrp: 0.74 ± 0.265
2.959ValTyr: 2.959 ± 0.539
0.0ValXaa: 0.0 ± 0.0
Trp
1.11TrpAla: 1.11 ± 0.317
0.592TrpCys: 0.592 ± 0.207
0.888TrpAsp: 0.888 ± 0.242
0.74TrpGlu: 0.74 ± 0.197
0.592TrpPhe: 0.592 ± 0.193
1.036TrpGly: 1.036 ± 0.317
0.222TrpHis: 0.222 ± 0.1
0.444TrpIle: 0.444 ± 0.155
0.518TrpLys: 0.518 ± 0.178
1.48TrpLeu: 1.48 ± 0.373
0.148TrpMet: 0.148 ± 0.108
0.814TrpAsn: 0.814 ± 0.265
0.37TrpPro: 0.37 ± 0.184
0.444TrpGln: 0.444 ± 0.173
1.258TrpArg: 1.258 ± 0.377
0.814TrpSer: 0.814 ± 0.268
1.258TrpThr: 1.258 ± 0.36
1.258TrpVal: 1.258 ± 0.261
0.37TrpTrp: 0.37 ± 0.226
0.666TrpTyr: 0.666 ± 0.249
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.663TyrAla: 2.663 ± 0.543
0.592TyrCys: 0.592 ± 0.24
2.367TyrAsp: 2.367 ± 0.532
1.776TyrGlu: 1.776 ± 0.411
0.888TyrPhe: 0.888 ± 0.244
2.885TyrGly: 2.885 ± 0.605
0.74TyrHis: 0.74 ± 0.259
1.554TyrIle: 1.554 ± 0.457
1.628TyrLys: 1.628 ± 0.403
3.847TyrLeu: 3.847 ± 0.48
0.814TyrMet: 0.814 ± 0.22
0.962TyrAsn: 0.962 ± 0.284
1.11TyrPro: 1.11 ± 0.269
1.628TyrGln: 1.628 ± 0.343
2.515TyrArg: 2.515 ± 0.505
3.329TyrSer: 3.329 ± 0.615
2.811TyrThr: 2.811 ± 0.491
1.628TyrVal: 1.628 ± 0.361
1.332TyrTrp: 1.332 ± 0.29
1.406TyrTyr: 1.406 ± 0.282
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (13518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski