Amino acid dipepetide frequency for Streptococcus virus C1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.479AlaAla: 2.479 ± 0.966
0.0AlaCys: 0.0 ± 0.0
4.958AlaAsp: 4.958 ± 1.531
3.718AlaGlu: 3.718 ± 1.108
1.239AlaPhe: 1.239 ± 0.432
2.892AlaGly: 2.892 ± 1.041
0.826AlaHis: 0.826 ± 0.49
4.958AlaIle: 4.958 ± 0.902
3.099AlaLys: 3.099 ± 0.658
6.197AlaLeu: 6.197 ± 0.763
1.239AlaMet: 1.239 ± 0.511
4.545AlaAsn: 4.545 ± 1.018
1.859AlaPro: 1.859 ± 0.776
2.892AlaGln: 2.892 ± 0.899
1.239AlaArg: 1.239 ± 0.462
2.892AlaSer: 2.892 ± 0.77
4.131AlaThr: 4.131 ± 0.791
2.685AlaVal: 2.685 ± 0.7
0.826AlaTrp: 0.826 ± 0.464
1.859AlaTyr: 1.859 ± 0.439
0.0AlaXaa: 0.0 ± 0.0
Cys
0.207CysAla: 0.207 ± 0.201
0.0CysCys: 0.0 ± 0.0
0.826CysAsp: 0.826 ± 0.337
0.413CysGlu: 0.413 ± 0.235
0.207CysPhe: 0.207 ± 0.193
0.62CysGly: 0.62 ± 0.364
0.413CysHis: 0.413 ± 0.279
0.207CysIle: 0.207 ± 0.176
0.207CysLys: 0.207 ± 0.169
0.62CysLeu: 0.62 ± 0.308
0.0CysMet: 0.0 ± 0.0
0.62CysAsn: 0.62 ± 0.445
0.0CysPro: 0.0 ± 0.0
0.207CysGln: 0.207 ± 0.193
0.0CysArg: 0.0 ± 0.0
0.413CysSer: 0.413 ± 0.263
0.207CysThr: 0.207 ± 0.169
0.207CysVal: 0.207 ± 0.201
0.0CysTrp: 0.0 ± 0.0
0.62CysTyr: 0.62 ± 0.41
0.0CysXaa: 0.0 ± 0.0
Asp
2.479AspAla: 2.479 ± 0.765
0.207AspCys: 0.207 ± 0.169
2.479AspAsp: 2.479 ± 0.746
5.577AspGlu: 5.577 ± 1.246
3.718AspPhe: 3.718 ± 0.883
4.958AspGly: 4.958 ± 0.996
1.239AspHis: 1.239 ± 0.459
4.958AspIle: 4.958 ± 1.107
4.958AspLys: 4.958 ± 0.711
6.197AspLeu: 6.197 ± 1.187
1.859AspMet: 1.859 ± 0.497
4.338AspAsn: 4.338 ± 0.974
1.446AspPro: 1.446 ± 0.652
1.239AspGln: 1.239 ± 0.337
1.653AspArg: 1.653 ± 0.533
3.099AspSer: 3.099 ± 0.818
3.099AspThr: 3.099 ± 0.703
4.751AspVal: 4.751 ± 0.707
1.239AspTrp: 1.239 ± 0.512
4.545AspTyr: 4.545 ± 0.947
0.0AspXaa: 0.0 ± 0.0
Glu
2.685GluAla: 2.685 ± 0.743
0.826GluCys: 0.826 ± 0.425
3.925GluAsp: 3.925 ± 1.119
5.371GluGlu: 5.371 ± 1.305
3.512GluPhe: 3.512 ± 0.53
2.892GluGly: 2.892 ± 0.735
1.446GluHis: 1.446 ± 0.477
4.338GluIle: 4.338 ± 0.959
2.892GluLys: 2.892 ± 0.573
6.404GluLeu: 6.404 ± 1.164
2.479GluMet: 2.479 ± 0.721
3.925GluAsn: 3.925 ± 1.04
1.033GluPro: 1.033 ± 0.553
4.338GluGln: 4.338 ± 0.879
1.446GluArg: 1.446 ± 0.435
4.338GluSer: 4.338 ± 0.645
4.751GluThr: 4.751 ± 1.148
3.305GluVal: 3.305 ± 0.883
1.033GluTrp: 1.033 ± 0.546
4.751GluTyr: 4.751 ± 0.75
0.0GluXaa: 0.0 ± 0.0
Phe
0.62PheAla: 0.62 ± 0.409
0.0PheCys: 0.0 ± 0.0
3.099PheAsp: 3.099 ± 0.497
3.305PheGlu: 3.305 ± 0.796
1.239PhePhe: 1.239 ± 0.513
3.099PheGly: 3.099 ± 0.456
1.033PheHis: 1.033 ± 0.445
4.338PheIle: 4.338 ± 0.989
3.925PheLys: 3.925 ± 0.799
2.479PheLeu: 2.479 ± 0.807
0.826PheMet: 0.826 ± 0.324
6.404PheAsn: 6.404 ± 1.218
1.033PhePro: 1.033 ± 0.306
1.033PheGln: 1.033 ± 0.449
1.446PheArg: 1.446 ± 0.742
2.479PheSer: 2.479 ± 0.647
3.305PheThr: 3.305 ± 0.535
1.446PheVal: 1.446 ± 0.491
0.413PheTrp: 0.413 ± 0.272
3.099PheTyr: 3.099 ± 0.669
0.0PheXaa: 0.0 ± 0.0
Gly
4.338GlyAla: 4.338 ± 1.204
0.0GlyCys: 0.0 ± 0.0
4.131GlyAsp: 4.131 ± 1.026
2.479GlyGlu: 2.479 ± 0.485
2.272GlyPhe: 2.272 ± 0.816
3.099GlyGly: 3.099 ± 0.607
1.446GlyHis: 1.446 ± 0.409
4.338GlyIle: 4.338 ± 0.763
4.751GlyLys: 4.751 ± 0.879
4.131GlyLeu: 4.131 ± 1.0
0.826GlyMet: 0.826 ± 0.352
3.925GlyAsn: 3.925 ± 1.043
0.0GlyPro: 0.0 ± 0.0
2.685GlyGln: 2.685 ± 0.863
1.859GlyArg: 1.859 ± 0.401
3.305GlySer: 3.305 ± 1.053
3.305GlyThr: 3.305 ± 1.23
5.577GlyVal: 5.577 ± 1.068
0.826GlyTrp: 0.826 ± 0.41
3.718GlyTyr: 3.718 ± 0.848
0.0GlyXaa: 0.0 ± 0.0
His
1.033HisAla: 1.033 ± 0.333
0.0HisCys: 0.0 ± 0.0
1.239HisAsp: 1.239 ± 0.574
1.653HisGlu: 1.653 ± 0.478
1.033HisPhe: 1.033 ± 0.493
0.413HisGly: 0.413 ± 0.248
0.826HisHis: 0.826 ± 0.407
1.446HisIle: 1.446 ± 0.607
1.239HisLys: 1.239 ± 0.333
1.653HisLeu: 1.653 ± 0.549
0.62HisMet: 0.62 ± 0.393
1.446HisAsn: 1.446 ± 0.473
0.207HisPro: 0.207 ± 0.236
0.62HisGln: 0.62 ± 0.277
0.413HisArg: 0.413 ± 0.337
1.033HisSer: 1.033 ± 0.672
1.033HisThr: 1.033 ± 0.517
1.653HisVal: 1.653 ± 0.574
0.826HisTrp: 0.826 ± 0.38
2.272HisTyr: 2.272 ± 0.569
0.0HisXaa: 0.0 ± 0.0
Ile
3.099IleAla: 3.099 ± 0.818
0.413IleCys: 0.413 ± 0.299
5.164IleAsp: 5.164 ± 0.911
5.99IleGlu: 5.99 ± 1.258
2.066IlePhe: 2.066 ± 0.736
3.099IleGly: 3.099 ± 0.485
1.859IleHis: 1.859 ± 0.6
4.131IleIle: 4.131 ± 0.863
7.436IleLys: 7.436 ± 1.501
5.371IleLeu: 5.371 ± 1.229
0.826IleMet: 0.826 ± 0.462
4.751IleAsn: 4.751 ± 1.081
2.272IlePro: 2.272 ± 0.513
2.685IleGln: 2.685 ± 0.613
3.099IleArg: 3.099 ± 0.613
5.577IleSer: 5.577 ± 0.921
4.751IleThr: 4.751 ± 0.826
3.099IleVal: 3.099 ± 0.629
0.62IleTrp: 0.62 ± 0.291
3.512IleTyr: 3.512 ± 0.744
0.0IleXaa: 0.0 ± 0.0
Lys
3.925LysAla: 3.925 ± 0.91
0.413LysCys: 0.413 ± 0.262
3.512LysAsp: 3.512 ± 0.647
5.164LysGlu: 5.164 ± 0.914
2.272LysPhe: 2.272 ± 0.597
3.099LysGly: 3.099 ± 0.59
2.066LysHis: 2.066 ± 0.535
4.338LysIle: 4.338 ± 0.846
6.197LysLys: 6.197 ± 1.285
8.263LysLeu: 8.263 ± 1.784
2.479LysMet: 2.479 ± 0.535
4.751LysAsn: 4.751 ± 0.866
2.272LysPro: 2.272 ± 0.379
4.958LysGln: 4.958 ± 1.317
2.479LysArg: 2.479 ± 0.846
5.784LysSer: 5.784 ± 1.281
3.718LysThr: 3.718 ± 1.105
3.512LysVal: 3.512 ± 0.912
0.62LysTrp: 0.62 ± 0.315
4.751LysTyr: 4.751 ± 1.378
0.0LysXaa: 0.0 ± 0.0
Leu
4.545LeuAla: 4.545 ± 0.864
0.826LeuCys: 0.826 ± 0.309
6.404LeuAsp: 6.404 ± 1.373
4.958LeuGlu: 4.958 ± 0.953
4.958LeuPhe: 4.958 ± 1.177
5.784LeuGly: 5.784 ± 0.936
1.446LeuHis: 1.446 ± 0.348
4.338LeuIle: 4.338 ± 0.78
8.056LeuLys: 8.056 ± 1.317
6.61LeuLeu: 6.61 ± 1.308
2.272LeuMet: 2.272 ± 0.458
8.056LeuAsn: 8.056 ± 1.509
3.718LeuPro: 3.718 ± 0.829
3.305LeuGln: 3.305 ± 0.988
3.099LeuArg: 3.099 ± 0.961
5.784LeuSer: 5.784 ± 1.543
5.164LeuThr: 5.164 ± 0.855
2.892LeuVal: 2.892 ± 0.513
0.207LeuTrp: 0.207 ± 0.193
3.925LeuTyr: 3.925 ± 1.234
0.0LeuXaa: 0.0 ± 0.0
Met
2.066MetAla: 2.066 ± 0.594
0.0MetCys: 0.0 ± 0.0
1.446MetAsp: 1.446 ± 0.421
2.066MetGlu: 2.066 ± 0.807
0.826MetPhe: 0.826 ± 0.378
1.653MetGly: 1.653 ± 0.515
0.0MetHis: 0.0 ± 0.0
1.653MetIle: 1.653 ± 0.42
3.099MetLys: 3.099 ± 0.702
2.685MetLeu: 2.685 ± 0.591
0.62MetMet: 0.62 ± 0.335
2.066MetAsn: 2.066 ± 0.666
0.413MetPro: 0.413 ± 0.302
0.826MetGln: 0.826 ± 0.364
1.033MetArg: 1.033 ± 0.297
2.272MetSer: 2.272 ± 0.577
1.446MetThr: 1.446 ± 0.628
1.859MetVal: 1.859 ± 0.952
0.207MetTrp: 0.207 ± 0.169
1.653MetTyr: 1.653 ± 0.505
0.0MetXaa: 0.0 ± 0.0
Asn
5.99AsnAla: 5.99 ± 1.574
0.207AsnCys: 0.207 ± 0.169
5.164AsnAsp: 5.164 ± 1.192
5.784AsnGlu: 5.784 ± 1.503
2.685AsnPhe: 2.685 ± 0.93
5.164AsnGly: 5.164 ± 0.907
1.239AsnHis: 1.239 ± 0.692
5.371AsnIle: 5.371 ± 1.093
3.305AsnLys: 3.305 ± 0.976
5.99AsnLeu: 5.99 ± 0.813
2.685AsnMet: 2.685 ± 0.691
8.263AsnAsn: 8.263 ± 1.691
2.479AsnPro: 2.479 ± 0.843
2.272AsnGln: 2.272 ± 0.536
1.859AsnArg: 1.859 ± 0.835
4.751AsnSer: 4.751 ± 0.935
5.577AsnThr: 5.577 ± 1.211
5.371AsnVal: 5.371 ± 1.695
0.826AsnTrp: 0.826 ± 0.364
4.958AsnTyr: 4.958 ± 0.898
0.0AsnXaa: 0.0 ± 0.0
Pro
2.479ProAla: 2.479 ± 0.726
0.0ProCys: 0.0 ± 0.0
1.033ProAsp: 1.033 ± 0.319
1.653ProGlu: 1.653 ± 0.714
2.066ProPhe: 2.066 ± 0.606
0.413ProGly: 0.413 ± 0.403
0.207ProHis: 0.207 ± 0.212
1.239ProIle: 1.239 ± 0.544
3.099ProLys: 3.099 ± 0.611
2.479ProLeu: 2.479 ± 0.675
0.207ProMet: 0.207 ± 0.201
1.033ProAsn: 1.033 ± 0.584
0.207ProPro: 0.207 ± 0.201
0.413ProGln: 0.413 ± 0.262
0.0ProArg: 0.0 ± 0.0
2.479ProSer: 2.479 ± 0.607
0.826ProThr: 0.826 ± 0.515
2.685ProVal: 2.685 ± 0.824
0.207ProTrp: 0.207 ± 0.193
1.239ProTyr: 1.239 ± 0.405
0.0ProXaa: 0.0 ± 0.0
Gln
2.066GlnAla: 2.066 ± 0.692
0.207GlnCys: 0.207 ± 0.201
1.653GlnAsp: 1.653 ± 0.541
2.272GlnGlu: 2.272 ± 0.717
1.653GlnPhe: 1.653 ± 0.585
3.099GlnGly: 3.099 ± 0.619
0.826GlnHis: 0.826 ± 0.344
3.305GlnIle: 3.305 ± 1.054
2.685GlnLys: 2.685 ± 0.631
3.099GlnLeu: 3.099 ± 0.552
1.446GlnMet: 1.446 ± 0.455
2.272GlnAsn: 2.272 ± 0.559
0.826GlnPro: 0.826 ± 0.422
3.718GlnGln: 3.718 ± 1.023
0.826GlnArg: 0.826 ± 0.363
2.272GlnSer: 2.272 ± 0.578
2.479GlnThr: 2.479 ± 0.842
3.099GlnVal: 3.099 ± 0.931
0.62GlnTrp: 0.62 ± 0.353
2.066GlnTyr: 2.066 ± 0.639
0.0GlnXaa: 0.0 ± 0.0
Arg
2.272ArgAla: 2.272 ± 0.548
0.207ArgCys: 0.207 ± 0.169
2.892ArgAsp: 2.892 ± 0.853
2.479ArgGlu: 2.479 ± 0.474
1.033ArgPhe: 1.033 ± 0.471
1.446ArgGly: 1.446 ± 0.593
0.413ArgHis: 0.413 ± 0.228
1.033ArgIle: 1.033 ± 0.459
2.272ArgLys: 2.272 ± 0.612
4.131ArgLeu: 4.131 ± 0.861
0.62ArgMet: 0.62 ± 0.277
2.892ArgAsn: 2.892 ± 0.791
0.826ArgPro: 0.826 ± 0.39
0.826ArgGln: 0.826 ± 0.412
0.62ArgArg: 0.62 ± 0.361
1.653ArgSer: 1.653 ± 0.473
1.033ArgThr: 1.033 ± 0.46
2.066ArgVal: 2.066 ± 0.775
0.0ArgTrp: 0.0 ± 0.0
1.653ArgTyr: 1.653 ± 0.946
0.0ArgXaa: 0.0 ± 0.0
Ser
3.099SerAla: 3.099 ± 0.555
0.207SerCys: 0.207 ± 0.193
3.305SerAsp: 3.305 ± 0.745
4.131SerGlu: 4.131 ± 1.091
3.305SerPhe: 3.305 ± 0.858
3.925SerGly: 3.925 ± 1.052
1.033SerHis: 1.033 ± 0.443
4.751SerIle: 4.751 ± 0.789
6.404SerLys: 6.404 ± 1.113
4.958SerLeu: 4.958 ± 1.038
1.446SerMet: 1.446 ± 0.359
4.958SerAsn: 4.958 ± 0.953
1.653SerPro: 1.653 ± 0.656
2.066SerGln: 2.066 ± 0.576
2.892SerArg: 2.892 ± 0.694
4.131SerSer: 4.131 ± 1.02
5.164SerThr: 5.164 ± 1.216
2.892SerVal: 2.892 ± 0.699
0.62SerTrp: 0.62 ± 0.309
3.099SerTyr: 3.099 ± 0.815
0.0SerXaa: 0.0 ± 0.0
Thr
3.512ThrAla: 3.512 ± 0.658
0.413ThrCys: 0.413 ± 0.228
4.958ThrAsp: 4.958 ± 0.969
2.272ThrGlu: 2.272 ± 0.708
4.131ThrPhe: 4.131 ± 0.934
4.545ThrGly: 4.545 ± 1.701
1.239ThrHis: 1.239 ± 0.41
6.404ThrIle: 6.404 ± 1.42
2.685ThrLys: 2.685 ± 0.86
5.371ThrLeu: 5.371 ± 1.23
3.099ThrMet: 3.099 ± 0.63
6.197ThrAsn: 6.197 ± 1.233
1.239ThrPro: 1.239 ± 0.534
2.685ThrGln: 2.685 ± 0.677
1.033ThrArg: 1.033 ± 0.438
3.099ThrSer: 3.099 ± 0.683
2.892ThrThr: 2.892 ± 1.078
3.925ThrVal: 3.925 ± 1.12
0.62ThrTrp: 0.62 ± 0.26
3.099ThrTyr: 3.099 ± 0.65
0.0ThrXaa: 0.0 ± 0.0
Val
4.338ValAla: 4.338 ± 1.416
0.413ValCys: 0.413 ± 0.271
3.305ValAsp: 3.305 ± 0.647
2.685ValGlu: 2.685 ± 1.188
2.272ValPhe: 2.272 ± 0.806
3.099ValGly: 3.099 ± 1.112
1.446ValHis: 1.446 ± 0.935
3.512ValIle: 3.512 ± 0.987
4.958ValLys: 4.958 ± 1.085
3.305ValLeu: 3.305 ± 0.759
2.066ValMet: 2.066 ± 0.568
5.164ValAsn: 5.164 ± 1.122
0.826ValPro: 0.826 ± 0.408
2.272ValGln: 2.272 ± 0.748
2.892ValArg: 2.892 ± 0.893
4.131ValSer: 4.131 ± 1.13
5.99ValThr: 5.99 ± 1.05
3.718ValVal: 3.718 ± 0.82
0.62ValTrp: 0.62 ± 0.41
2.272ValTyr: 2.272 ± 0.752
0.0ValXaa: 0.0 ± 0.0
Trp
0.413TrpAla: 0.413 ± 0.284
0.413TrpCys: 0.413 ± 0.282
0.62TrpAsp: 0.62 ± 0.315
0.207TrpGlu: 0.207 ± 0.201
0.413TrpPhe: 0.413 ± 0.271
0.207TrpGly: 0.207 ± 0.201
0.62TrpHis: 0.62 ± 0.229
1.653TrpIle: 1.653 ± 0.435
0.207TrpLys: 0.207 ± 0.194
1.859TrpLeu: 1.859 ± 0.53
0.0TrpMet: 0.0 ± 0.0
0.413TrpAsn: 0.413 ± 0.237
0.207TrpPro: 0.207 ± 0.194
0.0TrpGln: 0.0 ± 0.0
0.207TrpArg: 0.207 ± 0.169
0.826TrpSer: 0.826 ± 0.605
0.62TrpThr: 0.62 ± 0.317
1.239TrpVal: 1.239 ± 0.563
0.207TrpTrp: 0.207 ± 0.201
0.826TrpTyr: 0.826 ± 0.435
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.892TyrAla: 2.892 ± 0.689
1.239TyrCys: 1.239 ± 0.337
3.925TyrAsp: 3.925 ± 1.397
3.512TyrGlu: 3.512 ± 0.88
3.718TyrPhe: 3.718 ± 1.036
3.512TyrGly: 3.512 ± 0.921
1.033TyrHis: 1.033 ± 0.404
3.512TyrIle: 3.512 ± 0.698
3.305TyrLys: 3.305 ± 0.866
4.545TyrLeu: 4.545 ± 0.803
2.066TyrMet: 2.066 ± 0.566
3.925TyrAsn: 3.925 ± 0.557
1.446TyrPro: 1.446 ± 0.37
1.446TyrGln: 1.446 ± 0.482
2.272TyrArg: 2.272 ± 0.565
3.718TyrSer: 3.718 ± 0.723
3.925TyrThr: 3.925 ± 0.989
3.305TyrVal: 3.305 ± 0.869
0.62TyrTrp: 0.62 ± 0.299
2.272TyrTyr: 2.272 ± 0.788
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (4842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski