Amino acid dipepetide frequency for Alkalimonas amylolytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.849AlaAla: 10.849 ± 0.114	1.135AlaCys: 1.135 ± 0.031	5.65AlaAsp: 5.65 ± 0.072	7.015AlaGlu: 7.015 ± 0.091	3.658AlaPhe: 3.658 ± 0.06	7.497AlaGly: 7.497 ± 0.093	1.834AlaHis: 1.834 ± 0.037	5.808AlaIle: 5.808 ± 0.073	3.89AlaLys: 3.89 ± 0.067	12.179AlaLeu: 12.179 ± 0.131	2.823AlaMet: 2.823 ± 0.053	3.252AlaAsn: 3.252 ± 0.053	3.304AlaPro: 3.304 ± 0.057	4.49AlaGln: 4.49 ± 0.06	5.111AlaArg: 5.111 ± 0.076	6.292AlaSer: 6.292 ± 0.073	4.59AlaThr: 4.59 ± 0.066	6.679AlaVal: 6.679 ± 0.086	1.187AlaTrp: 1.187 ± 0.034	2.468AlaTyr: 2.468 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.855CysAla: 0.855 ± 0.029	0.189CysCys: 0.189 ± 0.014	0.531CysAsp: 0.531 ± 0.016	0.496CysGlu: 0.496 ± 0.021	0.452CysPhe: 0.452 ± 0.019	0.802CysGly: 0.802 ± 0.027	0.324CysHis: 0.324 ± 0.017	0.529CysIle: 0.529 ± 0.022	0.337CysLys: 0.337 ± 0.017	1.129CysLeu: 1.129 ± 0.031	0.214CysMet: 0.214 ± 0.013	0.287CysAsn: 0.287 ± 0.016	0.486CysPro: 0.486 ± 0.02	0.733CysGln: 0.733 ± 0.027	0.583CysArg: 0.583 ± 0.023	0.76CysSer: 0.76 ± 0.028	0.466CysThr: 0.466 ± 0.019	0.534CysVal: 0.534 ± 0.02	0.203CysTrp: 0.203 ± 0.013	0.383CysTyr: 0.383 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.047AspAla: 5.047 ± 0.089	0.56AspCys: 0.56 ± 0.02	2.932AspAsp: 2.932 ± 0.06	3.301AspGlu: 3.301 ± 0.057	2.599AspPhe: 2.599 ± 0.053	3.855AspGly: 3.855 ± 0.062	1.131AspHis: 1.131 ± 0.033	3.144AspIle: 3.144 ± 0.056	2.116AspLys: 2.116 ± 0.045	5.046AspLeu: 5.046 ± 0.064	1.269AspMet: 1.269 ± 0.031	1.83AspAsn: 1.83 ± 0.045	2.25AspPro: 2.25 ± 0.046	2.339AspGln: 2.339 ± 0.046	2.426AspArg: 2.426 ± 0.052	3.01AspSer: 3.01 ± 0.054	2.479AspThr: 2.479 ± 0.046	3.413AspVal: 3.413 ± 0.059	1.069AspTrp: 1.069 ± 0.029	1.961AspTyr: 1.961 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.362GluAla: 5.362 ± 0.072	0.369GluCys: 0.369 ± 0.018	2.245GluAsp: 2.245 ± 0.048	2.432GluGlu: 2.432 ± 0.061	2.066GluPhe: 2.066 ± 0.044	2.897GluGly: 2.897 ± 0.047	1.722GluHis: 1.722 ± 0.039	2.542GluIle: 2.542 ± 0.051	2.176GluLys: 2.176 ± 0.053	8.208GluLeu: 8.208 ± 0.087	1.249GluMet: 1.249 ± 0.035	1.511GluAsn: 1.511 ± 0.038	2.633GluPro: 2.633 ± 0.05	5.79GluGln: 5.79 ± 0.095	3.847GluArg: 3.847 ± 0.062	2.616GluSer: 2.616 ± 0.046	2.403GluThr: 2.403 ± 0.04	3.849GluVal: 3.849 ± 0.05	0.614GluTrp: 0.614 ± 0.021	1.303GluTyr: 1.303 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.106PheAla: 4.106 ± 0.069	0.528PheCys: 0.528 ± 0.02	2.555PheAsp: 2.555 ± 0.05	2.201PheGlu: 2.201 ± 0.046	1.742PhePhe: 1.742 ± 0.044	3.106PheGly: 3.106 ± 0.047	0.907PheHis: 0.907 ± 0.027	2.281PheIle: 2.281 ± 0.047	1.362PheLys: 1.362 ± 0.035	3.433PheLeu: 3.433 ± 0.056	0.933PheMet: 0.933 ± 0.025	1.561PheAsn: 1.561 ± 0.04	1.446PhePro: 1.446 ± 0.041	1.695PheGln: 1.695 ± 0.044	1.97PheArg: 1.97 ± 0.043	3.275PheSer: 3.275 ± 0.05	2.094PheThr: 2.094 ± 0.048	2.695PheVal: 2.695 ± 0.051	0.655PheTrp: 0.655 ± 0.026	1.374PheTyr: 1.374 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.453GlyAla: 5.453 ± 0.076	0.881GlyCys: 0.881 ± 0.029	3.405GlyAsp: 3.405 ± 0.061	3.592GlyGlu: 3.592 ± 0.059	3.372GlyPhe: 3.372 ± 0.055	4.58GlyGly: 4.58 ± 0.088	1.68GlyHis: 1.68 ± 0.039	4.07GlyIle: 4.07 ± 0.06	3.087GlyLys: 3.087 ± 0.058	7.522GlyLeu: 7.522 ± 0.087	1.96GlyMet: 1.96 ± 0.042	2.284GlyAsn: 2.284 ± 0.043	2.018GlyPro: 2.018 ± 0.043	3.607GlyGln: 3.607 ± 0.058	3.809GlyArg: 3.809 ± 0.065	4.385GlySer: 4.385 ± 0.073	3.266GlyThr: 3.266 ± 0.065	4.837GlyVal: 4.837 ± 0.078	1.232GlyTrp: 1.232 ± 0.037	2.541GlyTyr: 2.541 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.966HisAla: 1.966 ± 0.042	0.386HisCys: 0.386 ± 0.019	1.105HisAsp: 1.105 ± 0.034	1.069HisGlu: 1.069 ± 0.035	1.178HisPhe: 1.178 ± 0.033	1.915HisGly: 1.915 ± 0.039	0.803HisHis: 0.803 ± 0.031	1.263HisIle: 1.263 ± 0.03	0.824HisLys: 0.824 ± 0.026	2.597HisLeu: 2.597 ± 0.05	0.436HisMet: 0.436 ± 0.021	0.806HisAsn: 0.806 ± 0.027	1.407HisPro: 1.407 ± 0.036	1.866HisGln: 1.866 ± 0.043	1.318HisArg: 1.318 ± 0.03	1.712HisSer: 1.712 ± 0.038	1.039HisThr: 1.039 ± 0.03	1.085HisVal: 1.085 ± 0.032	0.61HisTrp: 0.61 ± 0.024	1.091HisTyr: 1.091 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.899IleAla: 5.899 ± 0.084	0.575IleCys: 0.575 ± 0.02	3.119IleAsp: 3.119 ± 0.055	3.644IleGlu: 3.644 ± 0.061	1.711IlePhe: 1.711 ± 0.038	4.0IleGly: 4.0 ± 0.059	1.137IleHis: 1.137 ± 0.031	2.431IleIle: 2.431 ± 0.052	1.967IleLys: 1.967 ± 0.045	4.615IleLeu: 4.615 ± 0.076	0.902IleMet: 0.902 ± 0.028	2.004IleAsn: 2.004 ± 0.044	2.389IlePro: 2.389 ± 0.049	2.335IleGln: 2.335 ± 0.049	3.246IleArg: 3.246 ± 0.046	3.687IleSer: 3.687 ± 0.063	2.698IleThr: 2.698 ± 0.045	3.111IleVal: 3.111 ± 0.053	0.646IleTrp: 0.646 ± 0.026	1.378IleTyr: 1.378 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.356LysAla: 4.356 ± 0.076	0.195LysCys: 0.195 ± 0.012	1.911LysAsp: 1.911 ± 0.042	2.037LysGlu: 2.037 ± 0.052	0.968LysPhe: 0.968 ± 0.027	2.279LysGly: 2.279 ± 0.044	0.935LysHis: 0.935 ± 0.031	1.726LysIle: 1.726 ± 0.039	1.699LysLys: 1.699 ± 0.046	4.091LysLeu: 4.091 ± 0.067	0.843LysMet: 0.843 ± 0.027	1.187LysAsn: 1.187 ± 0.028	2.038LysPro: 2.038 ± 0.046	2.529LysGln: 2.529 ± 0.057	2.271LysArg: 2.271 ± 0.044	1.965LysSer: 1.965 ± 0.044	2.088LysThr: 2.088 ± 0.046	2.792LysVal: 2.792 ± 0.052	0.341LysTrp: 0.341 ± 0.016	0.807LysTyr: 0.807 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.211LeuAla: 13.211 ± 0.136	1.384LeuCys: 1.384 ± 0.037	5.999LeuAsp: 5.999 ± 0.074	6.035LeuGlu: 6.035 ± 0.072	4.366LeuPhe: 4.366 ± 0.07	7.432LeuGly: 7.432 ± 0.086	2.822LeuHis: 2.822 ± 0.054	5.573LeuIle: 5.573 ± 0.08	4.481LeuLys: 4.481 ± 0.063	15.345LeuLeu: 15.345 ± 0.207	2.816LeuMet: 2.816 ± 0.043	4.112LeuAsn: 4.112 ± 0.062	6.11LeuPro: 6.11 ± 0.092	7.826LeuGln: 7.826 ± 0.133	5.867LeuArg: 5.867 ± 0.072	8.218LeuSer: 8.218 ± 0.091	6.489LeuThr: 6.489 ± 0.081	7.62LeuVal: 7.62 ± 0.085	1.606LeuTrp: 1.606 ± 0.044	2.975LeuTyr: 2.975 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.717MetAla: 2.717 ± 0.048	0.127MetCys: 0.127 ± 0.011	1.069MetAsp: 1.069 ± 0.026	1.074MetGlu: 1.074 ± 0.029	0.642MetPhe: 0.642 ± 0.024	1.373MetGly: 1.373 ± 0.031	0.591MetHis: 0.591 ± 0.022	1.067MetIle: 1.067 ± 0.034	1.043MetLys: 1.043 ± 0.03	3.109MetLeu: 3.109 ± 0.055	0.615MetMet: 0.615 ± 0.025	0.815MetAsn: 0.815 ± 0.029	1.263MetPro: 1.263 ± 0.033	1.759MetGln: 1.759 ± 0.043	1.233MetArg: 1.233 ± 0.029	1.487MetSer: 1.487 ± 0.039	1.448MetThr: 1.448 ± 0.037	1.653MetVal: 1.653 ± 0.041	0.19MetTrp: 0.19 ± 0.013	0.462MetTyr: 0.462 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.928AsnAla: 2.928 ± 0.05	0.336AsnCys: 0.336 ± 0.018	1.641AsnAsp: 1.641 ± 0.045	1.758AsnGlu: 1.758 ± 0.042	1.33AsnPhe: 1.33 ± 0.031	2.192AsnGly: 2.192 ± 0.047	0.792AsnHis: 0.792 ± 0.026	1.707AsnIle: 1.707 ± 0.041	1.277AsnLys: 1.277 ± 0.032	3.34AsnLeu: 3.34 ± 0.057	0.756AsnMet: 0.756 ± 0.027	1.309AsnAsn: 1.309 ± 0.045	2.013AsnPro: 2.013 ± 0.041	2.108AsnGln: 2.108 ± 0.043	2.074AsnArg: 2.074 ± 0.039	2.013AsnSer: 2.013 ± 0.043	1.767AsnThr: 1.767 ± 0.041	1.815AsnVal: 1.815 ± 0.042	0.641AsnTrp: 0.641 ± 0.021	1.149AsnTyr: 1.149 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.069ProAla: 5.069 ± 0.074	0.376ProCys: 0.376 ± 0.02	2.961ProAsp: 2.961 ± 0.049	3.624ProGlu: 3.624 ± 0.062	1.786ProPhe: 1.786 ± 0.035	3.194ProGly: 3.194 ± 0.058	0.942ProHis: 0.942 ± 0.027	2.014ProIle: 2.014 ± 0.046	1.585ProLys: 1.585 ± 0.036	5.088ProLeu: 5.088 ± 0.077	1.095ProMet: 1.095 ± 0.026	1.41ProAsn: 1.41 ± 0.034	1.348ProPro: 1.348 ± 0.039	1.996ProGln: 1.996 ± 0.049	1.725ProArg: 1.725 ± 0.042	2.25ProSer: 2.25 ± 0.045	1.948ProThr: 1.948 ± 0.037	3.6ProVal: 3.6 ± 0.053	0.697ProTrp: 0.697 ± 0.025	1.318ProTyr: 1.318 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.642GlnAla: 6.642 ± 0.104	0.474GlnCys: 0.474 ± 0.02	2.529GlnAsp: 2.529 ± 0.049	2.434GlnGlu: 2.434 ± 0.057	2.107GlnPhe: 2.107 ± 0.042	3.911GlnGly: 3.911 ± 0.061	2.296GlnHis: 2.296 ± 0.054	2.436GlnIle: 2.436 ± 0.043	1.804GlnLys: 1.804 ± 0.04	10.059GlnLeu: 10.059 ± 0.165	1.235GlnMet: 1.235 ± 0.034	1.532GlnAsn: 1.532 ± 0.038	3.121GlnPro: 3.121 ± 0.057	8.658GlnGln: 8.658 ± 0.197	3.999GlnArg: 3.999 ± 0.06	3.622GlnSer: 3.622 ± 0.071	2.37GlnThr: 2.37 ± 0.05	3.867GlnVal: 3.867 ± 0.06	0.884GlnTrp: 0.884 ± 0.027	1.476GlnTyr: 1.476 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.409ArgAla: 4.409 ± 0.069	0.562ArgCys: 0.562 ± 0.024	2.693ArgAsp: 2.693 ± 0.048	2.966ArgGlu: 2.966 ± 0.051	2.825ArgPhe: 2.825 ± 0.054	3.011ArgGly: 3.011 ± 0.054	1.472ArgHis: 1.472 ± 0.035	3.286ArgIle: 3.286 ± 0.053	1.967ArgLys: 1.967 ± 0.045	7.191ArgLeu: 7.191 ± 0.075	1.397ArgMet: 1.397 ± 0.031	1.862ArgAsn: 1.862 ± 0.043	2.161ArgPro: 2.161 ± 0.043	4.144ArgGln: 4.144 ± 0.064	3.005ArgArg: 3.005 ± 0.048	3.214ArgSer: 3.214 ± 0.051	2.359ArgThr: 2.359 ± 0.047	3.441ArgVal: 3.441 ± 0.06	0.931ArgTrp: 0.931 ± 0.03	2.188ArgTyr: 2.188 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.865SerAla: 5.865 ± 0.075	0.681SerCys: 0.681 ± 0.024	3.252SerAsp: 3.252 ± 0.055	3.491SerGlu: 3.491 ± 0.05	2.703SerPhe: 2.703 ± 0.051	4.864SerGly: 4.864 ± 0.075	1.435SerHis: 1.435 ± 0.035	3.298SerIle: 3.298 ± 0.055	2.421SerLys: 2.421 ± 0.047	6.956SerLeu: 6.956 ± 0.09	1.667SerMet: 1.667 ± 0.04	2.151SerAsn: 2.151 ± 0.048	2.554SerPro: 2.554 ± 0.048	3.25SerGln: 3.25 ± 0.053	3.617SerArg: 3.617 ± 0.055	4.317SerSer: 4.317 ± 0.068	2.958SerThr: 2.958 ± 0.058	3.921SerVal: 3.921 ± 0.069	1.158SerTrp: 1.158 ± 0.036	2.11SerTyr: 2.11 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.167ThrAla: 5.167 ± 0.069	0.355ThrCys: 0.355 ± 0.018	2.751ThrAsp: 2.751 ± 0.054	3.465ThrGlu: 3.465 ± 0.063	1.681ThrPhe: 1.681 ± 0.042	3.894ThrGly: 3.894 ± 0.059	0.9ThrHis: 0.9 ± 0.03	2.638ThrIle: 2.638 ± 0.043	1.602ThrLys: 1.602 ± 0.043	5.882ThrLeu: 5.882 ± 0.072	1.024ThrMet: 1.024 ± 0.028	1.582ThrAsn: 1.582 ± 0.038	2.576ThrPro: 2.576 ± 0.047	2.096ThrGln: 2.096 ± 0.047	2.265ThrArg: 2.265 ± 0.05	2.914ThrSer: 2.914 ± 0.056	2.547ThrThr: 2.547 ± 0.055	3.388ThrVal: 3.388 ± 0.061	0.455ThrTrp: 0.455 ± 0.021	1.086ThrTyr: 1.086 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	6.549ValAla: 6.549 ± 0.074	0.661ValCys: 0.661 ± 0.024	3.431ValAsp: 3.431 ± 0.06	3.563ValGlu: 3.563 ± 0.054	2.701ValPhe: 2.701 ± 0.052	3.984ValGly: 3.984 ± 0.059	1.462ValHis: 1.462 ± 0.036	3.843ValIle: 3.843 ± 0.054	2.347ValLys: 2.347 ± 0.049	8.122ValLeu: 8.122 ± 0.096	1.7ValMet: 1.7 ± 0.04	2.241ValAsn: 2.241 ± 0.045	2.805ValPro: 2.805 ± 0.048	3.444ValGln: 3.444 ± 0.058	3.618ValArg: 3.618 ± 0.059	4.259ValSer: 4.259 ± 0.069	3.497ValThr: 3.497 ± 0.059	4.829ValVal: 4.829 ± 0.066	0.794ValTrp: 0.794 ± 0.026	1.656ValTyr: 1.656 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.918TrpAla: 0.918 ± 0.031	0.168TrpCys: 0.168 ± 0.012	0.574TrpAsp: 0.574 ± 0.024	0.405TrpGlu: 0.405 ± 0.019	0.726TrpPhe: 0.726 ± 0.026	0.739TrpGly: 0.739 ± 0.026	0.487TrpHis: 0.487 ± 0.02	0.566TrpIle: 0.566 ± 0.023	0.257TrpLys: 0.257 ± 0.014	2.684TrpLeu: 2.684 ± 0.066	0.315TrpMet: 0.315 ± 0.015	0.352TrpAsn: 0.352 ± 0.019	0.678TrpPro: 0.678 ± 0.023	2.014TrpGln: 2.014 ± 0.052	0.972TrpArg: 0.972 ± 0.027	0.786TrpSer: 0.786 ± 0.028	0.495TrpThr: 0.495 ± 0.024	0.839TrpVal: 0.839 ± 0.025	0.282TrpTrp: 0.282 ± 0.016	0.461TrpTyr: 0.461 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.344TyrAla: 2.344 ± 0.044	0.351TyrCys: 0.351 ± 0.016	1.425TyrAsp: 1.425 ± 0.04	1.23TyrGlu: 1.23 ± 0.034	1.305TyrPhe: 1.305 ± 0.035	2.055TyrGly: 2.055 ± 0.049	0.805TyrHis: 0.805 ± 0.027	1.271TyrIle: 1.271 ± 0.036	0.815TyrLys: 0.815 ± 0.026	3.69TyrLeu: 3.69 ± 0.058	0.487TyrMet: 0.487 ± 0.019	0.855TyrAsn: 0.855 ± 0.027	1.429TyrPro: 1.429 ± 0.036	2.778TyrGln: 2.778 ± 0.052	2.131TyrArg: 2.131 ± 0.047	1.887TyrSer: 1.887 ± 0.037	1.266TyrThr: 1.266 ± 0.033	1.537TyrVal: 1.537 ± 0.038	0.525TyrTrp: 0.525 ± 0.02	0.975TyrTyr: 0.975 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3615 proteins (1228723 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---