Amino acid dipepetide frequency for Elstera litoralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.95AlaAla: 17.95 ± 0.223	1.095AlaCys: 1.095 ± 0.039	7.024AlaAsp: 7.024 ± 0.109	7.66AlaGlu: 7.66 ± 0.121	4.423AlaPhe: 4.423 ± 0.093	10.338AlaGly: 10.338 ± 0.116	2.063AlaHis: 2.063 ± 0.051	5.908AlaIle: 5.908 ± 0.082	4.105AlaLys: 4.105 ± 0.084	15.859AlaLeu: 15.859 ± 0.192	3.257AlaMet: 3.257 ± 0.079	2.724AlaAsn: 2.724 ± 0.055	5.9AlaPro: 5.9 ± 0.111	4.839AlaGln: 4.839 ± 0.086	8.571AlaArg: 8.571 ± 0.125	5.777AlaSer: 5.777 ± 0.097	6.337AlaThr: 6.337 ± 0.089	9.098AlaVal: 9.098 ± 0.122	1.652AlaTrp: 1.652 ± 0.045	2.774AlaTyr: 2.774 ± 0.063	0.001AlaXaa: 0.001 ± 0.001
Cys	0.928CysAla: 0.928 ± 0.035	0.102CysCys: 0.102 ± 0.012	0.516CysAsp: 0.516 ± 0.027	0.293CysGlu: 0.293 ± 0.022	0.343CysPhe: 0.343 ± 0.021	0.883CysGly: 0.883 ± 0.033	0.231CysHis: 0.231 ± 0.017	0.374CysIle: 0.374 ± 0.021	0.153CysLys: 0.153 ± 0.014	0.96CysLeu: 0.96 ± 0.036	0.121CysMet: 0.121 ± 0.013	0.143CysAsn: 0.143 ± 0.014	0.48CysPro: 0.48 ± 0.03	0.249CysGln: 0.249 ± 0.017	0.574CysArg: 0.574 ± 0.029	0.349CysSer: 0.349 ± 0.024	0.493CysThr: 0.493 ± 0.026	0.554CysVal: 0.554 ± 0.028	0.128CysTrp: 0.128 ± 0.015	0.168CysTyr: 0.168 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.765AspAla: 6.765 ± 0.086	0.439AspCys: 0.439 ± 0.024	2.651AspAsp: 2.651 ± 0.066	2.838AspGlu: 2.838 ± 0.063	2.139AspPhe: 2.139 ± 0.056	4.928AspGly: 4.928 ± 0.082	1.153AspHis: 1.153 ± 0.041	2.933AspIle: 2.933 ± 0.057	1.766AspLys: 1.766 ± 0.052	6.595AspLeu: 6.595 ± 0.094	1.129AspMet: 1.129 ± 0.034	1.064AspAsn: 1.064 ± 0.039	3.501AspPro: 3.501 ± 0.068	1.849AspGln: 1.849 ± 0.053	4.019AspArg: 4.019 ± 0.068	2.233AspSer: 2.233 ± 0.051	2.578AspThr: 2.578 ± 0.069	3.45AspVal: 3.45 ± 0.079	0.988AspTrp: 0.988 ± 0.035	1.453AspTyr: 1.453 ± 0.043	0.001AspXaa: 0.001 ± 0.001
Glu	7.878GluAla: 7.878 ± 0.115	0.287GluCys: 0.287 ± 0.019	2.344GluAsp: 2.344 ± 0.062	2.701GluGlu: 2.701 ± 0.065	1.664GluPhe: 1.664 ± 0.048	3.927GluGly: 3.927 ± 0.069	0.952GluHis: 0.952 ± 0.032	3.329GluIle: 3.329 ± 0.076	2.218GluLys: 2.218 ± 0.055	4.574GluLeu: 4.574 ± 0.085	1.337GluMet: 1.337 ± 0.039	1.459GluAsn: 1.459 ± 0.044	2.479GluPro: 2.479 ± 0.06	2.025GluGln: 2.025 ± 0.06	3.922GluArg: 3.922 ± 0.085	2.205GluSer: 2.205 ± 0.054	3.747GluThr: 3.747 ± 0.066	3.503GluVal: 3.503 ± 0.07	0.559GluTrp: 0.559 ± 0.027	0.944GluTyr: 0.944 ± 0.034	0.001GluXaa: 0.001 ± 0.0
Phe	4.4PheAla: 4.4 ± 0.066	0.449PheCys: 0.449 ± 0.021	2.542PheAsp: 2.542 ± 0.055	1.911PheGlu: 1.911 ± 0.053	1.602PhePhe: 1.602 ± 0.048	3.812PheGly: 3.812 ± 0.079	0.743PheHis: 0.743 ± 0.032	1.918PheIle: 1.918 ± 0.05	1.084PheLys: 1.084 ± 0.046	3.802PheLeu: 3.802 ± 0.067	0.762PheMet: 0.762 ± 0.036	1.045PheAsn: 1.045 ± 0.044	1.678PhePro: 1.678 ± 0.046	1.113PheGln: 1.113 ± 0.034	2.17PheArg: 2.17 ± 0.047	2.227PheSer: 2.227 ± 0.059	2.264PheThr: 2.264 ± 0.056	2.51PheVal: 2.51 ± 0.057	0.614PheTrp: 0.614 ± 0.03	1.02PheTyr: 1.02 ± 0.038	0.001PheXaa: 0.001 ± 0.001
Gly	9.304GlyAla: 9.304 ± 0.139	0.825GlyCys: 0.825 ± 0.037	4.296GlyAsp: 4.296 ± 0.092	4.249GlyGlu: 4.249 ± 0.077	3.736GlyPhe: 3.736 ± 0.068	7.396GlyGly: 7.396 ± 0.15	1.562GlyHis: 1.562 ± 0.045	4.506GlyIle: 4.506 ± 0.081	3.317GlyLys: 3.317 ± 0.072	10.101GlyLeu: 10.101 ± 0.119	2.205GlyMet: 2.205 ± 0.053	2.022GlyAsn: 2.022 ± 0.073	3.575GlyPro: 3.575 ± 0.077	3.216GlyGln: 3.216 ± 0.064	5.666GlyArg: 5.666 ± 0.088	4.262GlySer: 4.262 ± 0.083	4.875GlyThr: 4.875 ± 0.097	6.214GlyVal: 6.214 ± 0.09	1.31GlyTrp: 1.31 ± 0.039	2.102GlyTyr: 2.102 ± 0.061	0.002GlyXaa: 0.002 ± 0.002
His	2.054HisAla: 2.054 ± 0.061	0.197HisCys: 0.197 ± 0.016	0.896HisAsp: 0.896 ± 0.035	0.841HisGlu: 0.841 ± 0.036	0.822HisPhe: 0.822 ± 0.031	1.668HisGly: 1.668 ± 0.043	0.586HisHis: 0.586 ± 0.03	0.954HisIle: 0.954 ± 0.037	0.484HisLys: 0.484 ± 0.027	2.207HisLeu: 2.207 ± 0.056	0.383HisMet: 0.383 ± 0.023	0.452HisAsn: 0.452 ± 0.026	1.325HisPro: 1.325 ± 0.044	0.637HisGln: 0.637 ± 0.029	1.464HisArg: 1.464 ± 0.049	0.876HisSer: 0.876 ± 0.034	0.83HisThr: 0.83 ± 0.035	1.124HisVal: 1.124 ± 0.035	0.313HisTrp: 0.313 ± 0.018	0.536HisTyr: 0.536 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.307IleAla: 7.307 ± 0.109	0.442IleCys: 0.442 ± 0.023	3.72IleAsp: 3.72 ± 0.077	3.222IleGlu: 3.222 ± 0.068	1.82IlePhe: 1.82 ± 0.056	5.248IleGly: 5.248 ± 0.099	0.912IleHis: 0.912 ± 0.035	2.536IleIle: 2.536 ± 0.07	1.327IleLys: 1.327 ± 0.043	5.512IleLeu: 5.512 ± 0.096	0.887IleMet: 0.887 ± 0.036	1.304IleAsn: 1.304 ± 0.045	2.456IlePro: 2.456 ± 0.062	1.431IleGln: 1.431 ± 0.044	3.032IleArg: 3.032 ± 0.065	2.815IleSer: 2.815 ± 0.058	3.041IleThr: 3.041 ± 0.073	4.028IleVal: 4.028 ± 0.068	0.457IleTrp: 0.457 ± 0.024	1.108IleTyr: 1.108 ± 0.037	0.002IleXaa: 0.002 ± 0.001
Lys	4.275LysAla: 4.275 ± 0.081	0.119LysCys: 0.119 ± 0.012	1.69LysAsp: 1.69 ± 0.049	1.521LysGlu: 1.521 ± 0.045	1.003LysPhe: 1.003 ± 0.04	2.512LysGly: 2.512 ± 0.057	0.545LysHis: 0.545 ± 0.028	2.017LysIle: 2.017 ± 0.058	1.249LysLys: 1.249 ± 0.044	3.747LysLeu: 3.747 ± 0.067	0.723LysMet: 0.723 ± 0.033	0.993LysAsn: 0.993 ± 0.042	2.058LysPro: 2.058 ± 0.058	1.064LysGln: 1.064 ± 0.039	2.335LysArg: 2.335 ± 0.056	1.825LysSer: 1.825 ± 0.052	2.026LysThr: 2.026 ± 0.049	2.147LysVal: 2.147 ± 0.063	0.288LysTrp: 0.288 ± 0.017	0.646LysTyr: 0.646 ± 0.029	0.002LysXaa: 0.002 ± 0.002
Leu	15.441LeuAla: 15.441 ± 0.185	0.933LeuCys: 0.933 ± 0.034	6.146LeuAsp: 6.146 ± 0.095	5.29LeuGlu: 5.29 ± 0.087	3.979LeuPhe: 3.979 ± 0.07	9.222LeuGly: 9.222 ± 0.131	2.087LeuHis: 2.087 ± 0.063	5.743LeuIle: 5.743 ± 0.093	3.876LeuLys: 3.876 ± 0.067	11.939LeuLeu: 11.939 ± 0.17	2.547LeuMet: 2.547 ± 0.055	2.822LeuAsn: 2.822 ± 0.066	6.906LeuPro: 6.906 ± 0.105	2.899LeuGln: 2.899 ± 0.072	7.481LeuArg: 7.481 ± 0.113	6.922LeuSer: 6.922 ± 0.106	7.312LeuThr: 7.312 ± 0.101	7.733LeuVal: 7.733 ± 0.115	1.412LeuTrp: 1.412 ± 0.046	2.383LeuTyr: 2.383 ± 0.059	0.002LeuXaa: 0.002 ± 0.002
Met	2.923MetAla: 2.923 ± 0.058	0.12MetCys: 0.12 ± 0.013	1.068MetAsp: 1.068 ± 0.035	0.933MetGlu: 0.933 ± 0.037	0.606MetPhe: 0.606 ± 0.029	1.781MetGly: 1.781 ± 0.051	0.347MetHis: 0.347 ± 0.018	1.466MetIle: 1.466 ± 0.04	0.816MetLys: 0.816 ± 0.032	2.505MetLeu: 2.505 ± 0.059	0.627MetMet: 0.627 ± 0.027	0.63MetAsn: 0.63 ± 0.026	1.341MetPro: 1.341 ± 0.043	0.79MetGln: 0.79 ± 0.031	1.585MetArg: 1.585 ± 0.047	1.512MetSer: 1.512 ± 0.042	1.69MetThr: 1.69 ± 0.047	1.729MetVal: 1.729 ± 0.047	0.128MetTrp: 0.128 ± 0.012	0.288MetTyr: 0.288 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.75AsnAla: 2.75 ± 0.062	0.249AsnCys: 0.249 ± 0.022	1.377AsnAsp: 1.377 ± 0.05	1.055AsnGlu: 1.055 ± 0.037	1.091AsnPhe: 1.091 ± 0.038	2.318AsnGly: 2.318 ± 0.064	0.465AsnHis: 0.465 ± 0.022	1.38AsnIle: 1.38 ± 0.042	0.707AsnLys: 0.707 ± 0.027	2.838AsnLeu: 2.838 ± 0.055	0.526AsnMet: 0.526 ± 0.026	0.74AsnAsn: 0.74 ± 0.039	1.892AsnPro: 1.892 ± 0.052	0.811AsnGln: 0.811 ± 0.035	1.866AsnArg: 1.866 ± 0.045	1.267AsnSer: 1.267 ± 0.044	1.094AsnThr: 1.094 ± 0.045	1.572AsnVal: 1.572 ± 0.042	0.357AsnTrp: 0.357 ± 0.019	0.65AsnTyr: 0.65 ± 0.031	0.001AsnXaa: 0.001 ± 0.001
Pro	6.288ProAla: 6.288 ± 0.107	0.323ProCys: 0.323 ± 0.021	3.584ProAsp: 3.584 ± 0.079	3.601ProGlu: 3.601 ± 0.07	1.978ProPhe: 1.978 ± 0.05	4.468ProGly: 4.468 ± 0.077	1.062ProHis: 1.062 ± 0.035	2.583ProIle: 2.583 ± 0.058	1.769ProLys: 1.769 ± 0.045	5.755ProLeu: 5.755 ± 0.103	1.335ProMet: 1.335 ± 0.041	1.458ProAsn: 1.458 ± 0.044	2.992ProPro: 2.992 ± 0.081	1.805ProGln: 1.805 ± 0.049	2.966ProArg: 2.966 ± 0.059	2.866ProSer: 2.866 ± 0.054	2.979ProThr: 2.979 ± 0.058	4.308ProVal: 4.308 ± 0.074	0.735ProTrp: 0.735 ± 0.032	1.169ProTyr: 1.169 ± 0.043	0.001ProXaa: 0.001 ± 0.001
Gln	4.779GlnAla: 4.779 ± 0.087	0.193GlnCys: 0.193 ± 0.014	1.548GlnAsp: 1.548 ± 0.044	1.679GlnGlu: 1.679 ± 0.051	1.204GlnPhe: 1.204 ± 0.034	2.621GlnGly: 2.621 ± 0.056	0.627GlnHis: 0.627 ± 0.031	2.109GlnIle: 2.109 ± 0.057	1.275GlnLys: 1.275 ± 0.04	2.92GlnLeu: 2.92 ± 0.067	0.883GlnMet: 0.883 ± 0.033	0.99GlnAsn: 0.99 ± 0.034	1.774GlnPro: 1.774 ± 0.047	1.447GlnGln: 1.447 ± 0.053	2.708GlnArg: 2.708 ± 0.066	1.855GlnSer: 1.855 ± 0.053	2.146GlnThr: 2.146 ± 0.053	2.516GlnVal: 2.516 ± 0.051	0.379GlnTrp: 0.379 ± 0.022	0.555GlnTyr: 0.555 ± 0.027	0.001GlnXaa: 0.001 ± 0.001
Arg	8.223ArgAla: 8.223 ± 0.117	0.524ArgCys: 0.524 ± 0.028	3.751ArgAsp: 3.751 ± 0.067	3.258ArgGlu: 3.258 ± 0.071	3.006ArgPhe: 3.006 ± 0.066	4.612ArgGly: 4.612 ± 0.074	1.437ArgHis: 1.437 ± 0.049	3.529ArgIle: 3.529 ± 0.071	1.995ArgLys: 1.995 ± 0.053	8.789ArgLeu: 8.789 ± 0.13	1.543ArgMet: 1.543 ± 0.043	1.665ArgAsn: 1.665 ± 0.053	3.496ArgPro: 3.496 ± 0.067	2.669ArgGln: 2.669 ± 0.068	5.314ArgArg: 5.314 ± 0.092	3.264ArgSer: 3.264 ± 0.076	3.165ArgThr: 3.165 ± 0.067	4.819ArgVal: 4.819 ± 0.083	1.076ArgTrp: 1.076 ± 0.041	1.655ArgTyr: 1.655 ± 0.042	0.002ArgXaa: 0.002 ± 0.002
Ser	6.186SerAla: 6.186 ± 0.089	0.383SerCys: 0.383 ± 0.026	2.701SerAsp: 2.701 ± 0.062	2.437SerGlu: 2.437 ± 0.064	2.444SerPhe: 2.444 ± 0.058	5.093SerGly: 5.093 ± 0.085	0.878SerHis: 0.878 ± 0.035	2.627SerIle: 2.627 ± 0.06	1.438SerLys: 1.438 ± 0.041	6.323SerLeu: 6.323 ± 0.085	1.176SerMet: 1.176 ± 0.035	1.271SerAsn: 1.271 ± 0.038	2.753SerPro: 2.753 ± 0.069	1.599SerGln: 1.599 ± 0.043	3.137SerArg: 3.137 ± 0.068	2.55SerSer: 2.55 ± 0.067	2.626SerThr: 2.626 ± 0.048	4.104SerVal: 4.104 ± 0.066	0.636SerTrp: 0.636 ± 0.028	1.22SerTyr: 1.22 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.938ThrAla: 6.938 ± 0.094	0.435ThrCys: 0.435 ± 0.024	2.961ThrAsp: 2.961 ± 0.061	2.969ThrGlu: 2.969 ± 0.066	1.756ThrPhe: 1.756 ± 0.058	5.294ThrGly: 5.294 ± 0.106	1.024ThrHis: 1.024 ± 0.037	3.024ThrIle: 3.024 ± 0.07	1.604ThrLys: 1.604 ± 0.048	7.045ThrLeu: 7.045 ± 0.112	0.992ThrMet: 0.992 ± 0.033	1.426ThrAsn: 1.426 ± 0.042	3.566ThrPro: 3.566 ± 0.066	1.946ThrGln: 1.946 ± 0.051	3.413ThrArg: 3.413 ± 0.06	2.711ThrSer: 2.711 ± 0.062	2.699ThrThr: 2.699 ± 0.07	4.624ThrVal: 4.624 ± 0.096	0.649ThrTrp: 0.649 ± 0.032	1.316ThrTyr: 1.316 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.98ValAla: 8.98 ± 0.114	0.579ValCys: 0.579 ± 0.027	3.801ValAsp: 3.801 ± 0.07	3.945ValGlu: 3.945 ± 0.08	2.61ValPhe: 2.61 ± 0.055	5.506ValGly: 5.506 ± 0.102	1.166ValHis: 1.166 ± 0.042	3.975ValIle: 3.975 ± 0.074	2.523ValLys: 2.523 ± 0.067	7.533ValLeu: 7.533 ± 0.097	1.79ValMet: 1.79 ± 0.045	1.817ValAsn: 1.817 ± 0.051	4.073ValPro: 4.073 ± 0.079	2.395ValGln: 2.395 ± 0.053	4.587ValArg: 4.587 ± 0.074	4.182ValSer: 4.182 ± 0.07	4.568ValThr: 4.568 ± 0.093	4.738ValVal: 4.738 ± 0.09	0.851ValTrp: 0.851 ± 0.03	1.464ValTyr: 1.464 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.406TrpAla: 1.406 ± 0.049	0.131TrpCys: 0.131 ± 0.012	0.593TrpAsp: 0.593 ± 0.028	0.543TrpGlu: 0.543 ± 0.026	0.51TrpPhe: 0.51 ± 0.026	1.008TrpGly: 1.008 ± 0.039	0.288TrpHis: 0.288 ± 0.017	0.691TrpIle: 0.691 ± 0.03	0.385TrpLys: 0.385 ± 0.022	1.638TrpLeu: 1.638 ± 0.051	0.302TrpMet: 0.302 ± 0.021	0.372TrpAsn: 0.372 ± 0.023	0.679TrpPro: 0.679 ± 0.029	0.602TrpGln: 0.602 ± 0.027	1.133TrpArg: 1.133 ± 0.036	0.705TrpSer: 0.705 ± 0.029	0.718TrpThr: 0.718 ± 0.029	0.921TrpVal: 0.921 ± 0.04	0.206TrpTrp: 0.206 ± 0.015	0.301TrpTyr: 0.301 ± 0.02	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.578TyrAla: 2.578 ± 0.057	0.221TyrCys: 0.221 ± 0.016	1.265TyrAsp: 1.265 ± 0.041	1.109TyrGlu: 1.109 ± 0.034	0.931TyrPhe: 0.931 ± 0.034	2.104TyrGly: 2.104 ± 0.062	0.519TyrHis: 0.519 ± 0.027	1.003TyrIle: 1.003 ± 0.037	0.69TyrLys: 0.69 ± 0.034	2.43TyrLeu: 2.43 ± 0.056	0.356TyrMet: 0.356 ± 0.021	0.61TyrAsn: 0.61 ± 0.028	1.099TyrPro: 1.099 ± 0.033	0.823TyrGln: 0.823 ± 0.033	1.847TyrArg: 1.847 ± 0.055	1.179TyrSer: 1.179 ± 0.041	1.204TyrThr: 1.204 ± 0.04	1.395TyrVal: 1.395 ± 0.044	0.393TyrTrp: 0.393 ± 0.021	0.665TyrTyr: 0.665 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.004XaaLys: 0.004 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.002	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3298 proteins (801678 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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