Amino acid dipepetide frequency for Aerococcus christensenii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.109AlaAla: 5.109 ± 0.149
0.85AlaCys: 0.85 ± 0.046
3.67AlaAsp: 3.67 ± 0.113
4.026AlaGlu: 4.026 ± 0.101
3.366AlaPhe: 3.366 ± 0.102
4.675AlaGly: 4.675 ± 0.133
1.571AlaHis: 1.571 ± 0.059
5.86AlaIle: 5.86 ± 0.128
5.351AlaLys: 5.351 ± 0.155
8.248AlaLeu: 8.248 ± 0.149
2.186AlaMet: 2.186 ± 0.077
2.936AlaAsn: 2.936 ± 0.08
2.06AlaPro: 2.06 ± 0.09
3.286AlaGln: 3.286 ± 0.102
2.772AlaArg: 2.772 ± 0.074
4.345AlaSer: 4.345 ± 0.116
3.646AlaThr: 3.646 ± 0.114
4.824AlaVal: 4.824 ± 0.119
0.634AlaTrp: 0.634 ± 0.037
3.301AlaTyr: 3.301 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.483CysAla: 0.483 ± 0.037
0.114CysCys: 0.114 ± 0.017
0.485CysAsp: 0.485 ± 0.032
0.507CysGlu: 0.507 ± 0.037
0.401CysPhe: 0.401 ± 0.036
0.755CysGly: 0.755 ± 0.044
0.268CysHis: 0.268 ± 0.022
0.403CysIle: 0.403 ± 0.029
0.337CysLys: 0.337 ± 0.03
1.081CysLeu: 1.081 ± 0.055
0.186CysMet: 0.186 ± 0.019
0.255CysAsn: 0.255 ± 0.021
0.369CysPro: 0.369 ± 0.03
0.723CysGln: 0.723 ± 0.047
0.388CysArg: 0.388 ± 0.035
0.516CysSer: 0.516 ± 0.032
0.321CysThr: 0.321 ± 0.028
0.529CysVal: 0.529 ± 0.031
0.047CysTrp: 0.047 ± 0.01
0.358CysTyr: 0.358 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.355AspAla: 3.355 ± 0.112
0.444AspCys: 0.444 ± 0.035
2.583AspAsp: 2.583 ± 0.097
3.86AspGlu: 3.86 ± 0.104
2.816AspPhe: 2.816 ± 0.091
2.949AspGly: 2.949 ± 0.096
1.556AspHis: 1.556 ± 0.055
3.732AspIle: 3.732 ± 0.097
3.773AspLys: 3.773 ± 0.11
5.937AspLeu: 5.937 ± 0.097
1.355AspMet: 1.355 ± 0.055
1.948AspAsn: 1.948 ± 0.072
2.067AspPro: 2.067 ± 0.064
3.284AspGln: 3.284 ± 0.092
2.511AspArg: 2.511 ± 0.076
2.831AspSer: 2.831 ± 0.074
2.378AspThr: 2.378 ± 0.086
3.074AspVal: 3.074 ± 0.084
0.6AspTrp: 0.6 ± 0.038
2.8AspTyr: 2.8 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
6.108GluAla: 6.108 ± 0.151
0.403GluCys: 0.403 ± 0.032
4.654GluAsp: 4.654 ± 0.109
7.75GluGlu: 7.75 ± 0.171
2.112GluPhe: 2.112 ± 0.064
4.91GluGly: 4.91 ± 0.111
1.107GluHis: 1.107 ± 0.05
4.781GluIle: 4.781 ± 0.119
6.378GluLys: 6.378 ± 0.129
5.927GluLeu: 5.927 ± 0.127
2.076GluMet: 2.076 ± 0.07
3.597GluAsn: 3.597 ± 0.075
1.614GluPro: 1.614 ± 0.059
2.831GluGln: 2.831 ± 0.089
3.333GluArg: 3.333 ± 0.095
3.415GluSer: 3.415 ± 0.085
3.4GluThr: 3.4 ± 0.094
5.351GluVal: 5.351 ± 0.128
0.738GluTrp: 0.738 ± 0.041
2.026GluTyr: 2.026 ± 0.064
0.002GluXaa: 0.002 ± 0.002
Phe
2.563PheAla: 2.563 ± 0.07
0.434PheCys: 0.434 ± 0.03
2.526PheAsp: 2.526 ± 0.073
2.723PheGlu: 2.723 ± 0.085
1.946PhePhe: 1.946 ± 0.077
2.794PheGly: 2.794 ± 0.092
0.917PheHis: 0.917 ± 0.044
2.969PheIle: 2.969 ± 0.099
2.736PheLys: 2.736 ± 0.09
4.46PheLeu: 4.46 ± 0.118
0.967PheMet: 0.967 ± 0.043
1.942PheAsn: 1.942 ± 0.069
1.551PhePro: 1.551 ± 0.062
1.855PheGln: 1.855 ± 0.078
1.474PheArg: 1.474 ± 0.054
3.049PheSer: 3.049 ± 0.093
2.145PheThr: 2.145 ± 0.065
2.82PheVal: 2.82 ± 0.092
0.332PheTrp: 0.332 ± 0.026
1.819PheTyr: 1.819 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
4.326GlyAla: 4.326 ± 0.122
0.626GlyCys: 0.626 ± 0.038
3.202GlyAsp: 3.202 ± 0.093
4.388GlyGlu: 4.388 ± 0.101
2.872GlyPhe: 2.872 ± 0.075
4.28GlyGly: 4.28 ± 0.134
1.54GlyHis: 1.54 ± 0.058
5.299GlyIle: 5.299 ± 0.113
5.068GlyLys: 5.068 ± 0.111
6.693GlyLeu: 6.693 ± 0.146
1.92GlyMet: 1.92 ± 0.066
2.639GlyAsn: 2.639 ± 0.066
1.605GlyPro: 1.605 ± 0.062
3.197GlyGln: 3.197 ± 0.088
2.967GlyArg: 2.967 ± 0.07
3.735GlySer: 3.735 ± 0.1
3.607GlyThr: 3.607 ± 0.095
4.615GlyVal: 4.615 ± 0.106
0.587GlyTrp: 0.587 ± 0.037
2.798GlyTyr: 2.798 ± 0.088
0.002GlyXaa: 0.002 ± 0.002
His
1.381HisAla: 1.381 ± 0.056
0.239HisCys: 0.239 ± 0.023
0.887HisAsp: 0.887 ± 0.042
1.137HisGlu: 1.137 ± 0.051
1.301HisPhe: 1.301 ± 0.06
1.206HisGly: 1.206 ± 0.054
0.697HisHis: 0.697 ± 0.042
1.407HisIle: 1.407 ± 0.059
1.083HisLys: 1.083 ± 0.042
2.621HisLeu: 2.621 ± 0.09
0.58HisMet: 0.58 ± 0.034
0.706HisAsn: 0.706 ± 0.044
1.437HisPro: 1.437 ± 0.064
1.206HisGln: 1.206 ± 0.052
1.077HisArg: 1.077 ± 0.049
1.325HisSer: 1.325 ± 0.05
1.072HisThr: 1.072 ± 0.045
1.314HisVal: 1.314 ± 0.049
0.246HisTrp: 0.246 ± 0.023
1.191HisTyr: 1.191 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
5.42IleAla: 5.42 ± 0.129
0.77IleCys: 0.77 ± 0.047
4.231IleAsp: 4.231 ± 0.109
4.718IleGlu: 4.718 ± 0.119
2.973IlePhe: 2.973 ± 0.099
5.012IleGly: 5.012 ± 0.121
1.635IleHis: 1.635 ± 0.066
4.589IleIle: 4.589 ± 0.114
4.015IleLys: 4.015 ± 0.089
6.639IleLeu: 6.639 ± 0.172
1.581IleMet: 1.581 ± 0.065
2.893IleAsn: 2.893 ± 0.079
2.794IlePro: 2.794 ± 0.077
3.385IleGln: 3.385 ± 0.091
3.111IleArg: 3.111 ± 0.098
4.313IleSer: 4.313 ± 0.106
3.67IleThr: 3.67 ± 0.095
4.33IleVal: 4.33 ± 0.093
0.602IleTrp: 0.602 ± 0.04
2.529IleTyr: 2.529 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
5.724LysAla: 5.724 ± 0.15
0.341LysCys: 0.341 ± 0.027
4.302LysAsp: 4.302 ± 0.128
7.195LysGlu: 7.195 ± 0.138
1.916LysPhe: 1.916 ± 0.073
4.714LysGly: 4.714 ± 0.106
1.249LysHis: 1.249 ± 0.055
4.613LysIle: 4.613 ± 0.111
6.045LysLys: 6.045 ± 0.16
5.241LysLeu: 5.241 ± 0.11
1.944LysMet: 1.944 ± 0.068
3.478LysAsn: 3.478 ± 0.09
1.858LysPro: 1.858 ± 0.063
3.102LysGln: 3.102 ± 0.101
3.56LysArg: 3.56 ± 0.095
3.56LysSer: 3.56 ± 0.093
4.039LysThr: 4.039 ± 0.115
4.675LysVal: 4.675 ± 0.124
0.69LysTrp: 0.69 ± 0.043
2.164LysTyr: 2.164 ± 0.071
0.002LysXaa: 0.002 ± 0.002
Leu
8.147LeuAla: 8.147 ± 0.155
0.77LeuCys: 0.77 ± 0.04
5.256LeuAsp: 5.256 ± 0.113
7.018LeuGlu: 7.018 ± 0.14
4.244LeuPhe: 4.244 ± 0.119
6.682LeuGly: 6.682 ± 0.142
1.912LeuHis: 1.912 ± 0.064
6.455LeuIle: 6.455 ± 0.154
7.42LeuLys: 7.42 ± 0.13
10.104LeuLeu: 10.104 ± 0.226
2.757LeuMet: 2.757 ± 0.075
4.239LeuAsn: 4.239 ± 0.11
4.365LeuPro: 4.365 ± 0.102
4.151LeuGln: 4.151 ± 0.102
3.802LeuArg: 3.802 ± 0.098
7.251LeuSer: 7.251 ± 0.15
6.138LeuThr: 6.138 ± 0.111
6.6LeuVal: 6.6 ± 0.127
0.708LeuTrp: 0.708 ± 0.035
3.156LeuTyr: 3.156 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
2.157MetAla: 2.157 ± 0.076
0.173MetCys: 0.173 ± 0.019
1.532MetAsp: 1.532 ± 0.06
1.549MetGlu: 1.549 ± 0.065
0.723MetPhe: 0.723 ± 0.037
1.89MetGly: 1.89 ± 0.057
0.382MetHis: 0.382 ± 0.031
1.909MetIle: 1.909 ± 0.071
2.196MetLys: 2.196 ± 0.066
2.004MetLeu: 2.004 ± 0.063
0.753MetMet: 0.753 ± 0.039
1.353MetAsn: 1.353 ± 0.055
0.967MetPro: 0.967 ± 0.04
0.956MetGln: 0.956 ± 0.044
1.115MetArg: 1.115 ± 0.048
1.663MetSer: 1.663 ± 0.061
1.83MetThr: 1.83 ± 0.071
1.758MetVal: 1.758 ± 0.065
0.224MetTrp: 0.224 ± 0.023
0.593MetTyr: 0.593 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.755AsnAla: 2.755 ± 0.105
0.38AsnCys: 0.38 ± 0.029
1.983AsnAsp: 1.983 ± 0.072
2.714AsnGlu: 2.714 ± 0.083
1.782AsnPhe: 1.782 ± 0.057
2.921AsnGly: 2.921 ± 0.087
1.193AsnHis: 1.193 ± 0.048
2.93AsnIle: 2.93 ± 0.082
2.848AsnLys: 2.848 ± 0.089
4.116AsnLeu: 4.116 ± 0.09
0.98AsnMet: 0.98 ± 0.042
1.78AsnAsn: 1.78 ± 0.079
1.989AsnPro: 1.989 ± 0.079
2.412AsnGln: 2.412 ± 0.075
2.086AsnArg: 2.086 ± 0.069
2.123AsnSer: 2.123 ± 0.065
1.957AsnThr: 1.957 ± 0.081
2.492AsnVal: 2.492 ± 0.079
0.518AsnTrp: 0.518 ± 0.041
1.866AsnTyr: 1.866 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
2.188ProAla: 2.188 ± 0.087
0.25ProCys: 0.25 ± 0.026
1.983ProAsp: 1.983 ± 0.065
2.919ProGlu: 2.919 ± 0.08
1.793ProPhe: 1.793 ± 0.072
2.043ProGly: 2.043 ± 0.07
0.923ProHis: 0.923 ± 0.048
2.583ProIle: 2.583 ± 0.096
2.608ProLys: 2.608 ± 0.091
3.674ProLeu: 3.674 ± 0.093
0.759ProMet: 0.759 ± 0.042
1.644ProAsn: 1.644 ± 0.058
0.74ProPro: 0.74 ± 0.042
1.594ProGln: 1.594 ± 0.062
1.167ProArg: 1.167 ± 0.051
2.513ProSer: 2.513 ± 0.076
2.17ProThr: 2.17 ± 0.126
2.442ProVal: 2.442 ± 0.078
0.3ProTrp: 0.3 ± 0.025
1.482ProTyr: 1.482 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.757GlnAla: 4.757 ± 0.118
0.259GlnCys: 0.259 ± 0.02
1.983GlnAsp: 1.983 ± 0.065
4.181GlnGlu: 4.181 ± 0.108
1.687GlnPhe: 1.687 ± 0.076
2.703GlnGly: 2.703 ± 0.065
0.766GlnHis: 0.766 ± 0.038
2.962GlnIle: 2.962 ± 0.071
3.754GlnLys: 3.754 ± 0.102
4.986GlnLeu: 4.986 ± 0.12
1.172GlnMet: 1.172 ± 0.05
1.802GlnAsn: 1.802 ± 0.056
1.456GlnPro: 1.456 ± 0.068
1.832GlnGln: 1.832 ± 0.075
2.076GlnArg: 2.076 ± 0.068
2.82GlnSer: 2.82 ± 0.098
2.71GlnThr: 2.71 ± 0.096
3.804GlnVal: 3.804 ± 0.097
0.529GlnTrp: 0.529 ± 0.037
1.305GlnTyr: 1.305 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.52ArgAla: 2.52 ± 0.07
0.412ArgCys: 0.412 ± 0.034
1.985ArgAsp: 1.985 ± 0.067
3.195ArgGlu: 3.195 ± 0.074
1.95ArgPhe: 1.95 ± 0.075
2.46ArgGly: 2.46 ± 0.079
0.999ArgHis: 0.999 ± 0.049
3.074ArgIle: 3.074 ± 0.076
3.049ArgLys: 3.049 ± 0.086
4.977ArgLeu: 4.977 ± 0.122
1.169ArgMet: 1.169 ± 0.052
1.538ArgAsn: 1.538 ± 0.063
1.573ArgPro: 1.573 ± 0.058
2.649ArgGln: 2.649 ± 0.085
2.203ArgArg: 2.203 ± 0.09
2.304ArgSer: 2.304 ± 0.072
1.974ArgThr: 1.974 ± 0.063
2.803ArgVal: 2.803 ± 0.096
0.35ArgTrp: 0.35 ± 0.03
1.942ArgTyr: 1.942 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
3.754SerAla: 3.754 ± 0.082
0.472SerCys: 0.472 ± 0.034
3.107SerAsp: 3.107 ± 0.083
3.909SerGlu: 3.909 ± 0.097
2.822SerPhe: 2.822 ± 0.084
4.378SerGly: 4.378 ± 0.114
1.53SerHis: 1.53 ± 0.059
3.832SerIle: 3.832 ± 0.098
3.717SerLys: 3.717 ± 0.103
6.861SerLeu: 6.861 ± 0.159
1.297SerMet: 1.297 ± 0.052
2.403SerAsn: 2.403 ± 0.078
2.354SerPro: 2.354 ± 0.083
3.135SerGln: 3.135 ± 0.078
2.516SerArg: 2.516 ± 0.069
3.871SerSer: 3.871 ± 0.107
3.003SerThr: 3.003 ± 0.09
3.791SerVal: 3.791 ± 0.093
0.531SerTrp: 0.531 ± 0.033
2.511SerTyr: 2.511 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
3.86ThrAla: 3.86 ± 0.11
0.47ThrCys: 0.47 ± 0.036
2.824ThrAsp: 2.824 ± 0.094
3.09ThrGlu: 3.09 ± 0.077
2.457ThrPhe: 2.457 ± 0.069
3.948ThrGly: 3.948 ± 0.09
1.288ThrHis: 1.288 ± 0.054
3.929ThrIle: 3.929 ± 0.092
2.979ThrLys: 2.979 ± 0.092
5.776ThrLeu: 5.776 ± 0.12
1.141ThrMet: 1.141 ± 0.048
2.091ThrAsn: 2.091 ± 0.068
2.621ThrPro: 2.621 ± 0.128
2.198ThrGln: 2.198 ± 0.082
1.974ThrArg: 1.974 ± 0.075
3.251ThrSer: 3.251 ± 0.081
2.992ThrThr: 2.992 ± 0.103
3.78ThrVal: 3.78 ± 0.099
0.464ThrTrp: 0.464 ± 0.031
2.265ThrTyr: 2.265 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.977ValAla: 4.977 ± 0.121
0.662ValCys: 0.662 ± 0.038
4.039ValAsp: 4.039 ± 0.099
4.658ValGlu: 4.658 ± 0.105
2.516ValPhe: 2.516 ± 0.077
4.511ValGly: 4.511 ± 0.118
1.277ValHis: 1.277 ± 0.056
4.947ValIle: 4.947 ± 0.094
4.451ValLys: 4.451 ± 0.107
6.38ValLeu: 6.38 ± 0.125
1.799ValMet: 1.799 ± 0.062
2.869ValAsn: 2.869 ± 0.081
2.494ValPro: 2.494 ± 0.079
2.533ValGln: 2.533 ± 0.082
2.567ValArg: 2.567 ± 0.084
4.263ValSer: 4.263 ± 0.092
4.037ValThr: 4.037 ± 0.099
4.68ValVal: 4.68 ± 0.109
0.518ValTrp: 0.518 ± 0.034
2.449ValTyr: 2.449 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.57TrpAla: 0.57 ± 0.031
0.069TrpCys: 0.069 ± 0.012
0.41TrpAsp: 0.41 ± 0.033
0.563TrpGlu: 0.563 ± 0.037
0.35TrpPhe: 0.35 ± 0.033
0.511TrpGly: 0.511 ± 0.039
0.194TrpHis: 0.194 ± 0.021
0.721TrpIle: 0.721 ± 0.034
0.684TrpLys: 0.684 ± 0.045
1.176TrpLeu: 1.176 ± 0.062
0.311TrpMet: 0.311 ± 0.027
0.373TrpAsn: 0.373 ± 0.028
0.265TrpPro: 0.265 ± 0.025
0.591TrpGln: 0.591 ± 0.037
0.427TrpArg: 0.427 ± 0.029
0.466TrpSer: 0.466 ± 0.034
0.483TrpThr: 0.483 ± 0.036
0.561TrpVal: 0.561 ± 0.035
0.093TrpTrp: 0.093 ± 0.015
0.291TrpTyr: 0.291 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.561TyrAla: 2.561 ± 0.071
0.386TyrCys: 0.386 ± 0.03
2.214TyrAsp: 2.214 ± 0.07
2.41TyrGlu: 2.41 ± 0.077
1.994TyrPhe: 1.994 ± 0.072
2.621TyrGly: 2.621 ± 0.082
1.109TyrHis: 1.109 ± 0.05
2.216TyrIle: 2.216 ± 0.066
1.922TyrLys: 1.922 ± 0.08
4.274TyrLeu: 4.274 ± 0.108
0.794TyrMet: 0.794 ± 0.044
1.34TyrAsn: 1.34 ± 0.062
1.599TyrPro: 1.599 ± 0.06
2.621TyrGln: 2.621 ± 0.087
2.0TyrArg: 2.0 ± 0.077
2.175TyrSer: 2.175 ± 0.069
1.827TyrThr: 1.827 ± 0.063
2.386TyrVal: 2.386 ± 0.081
0.399TyrTrp: 0.399 ± 0.033
1.717TyrTyr: 1.717 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.004XaaSer: 0.004 ± 0.003
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1496 proteins (463502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski