Amino acid dipepetide frequency for Sphingobacterium daejeonense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.565AlaAla: 4.565 ± 0.059	0.553AlaCys: 0.553 ± 0.023	3.557AlaAsp: 3.557 ± 0.053	4.239AlaGlu: 4.239 ± 0.058	3.106AlaPhe: 3.106 ± 0.052	4.53AlaGly: 4.53 ± 0.064	1.07AlaHis: 1.07 ± 0.026	5.236AlaIle: 5.236 ± 0.063	4.668AlaLys: 4.668 ± 0.07	5.953AlaLeu: 5.953 ± 0.073	1.629AlaMet: 1.629 ± 0.035	3.6AlaAsn: 3.6 ± 0.058	1.864AlaPro: 1.864 ± 0.038	2.439AlaGln: 2.439 ± 0.043	2.209AlaArg: 2.209 ± 0.041	4.104AlaSer: 4.104 ± 0.064	3.338AlaThr: 3.338 ± 0.058	4.243AlaVal: 4.243 ± 0.065	0.723AlaTrp: 0.723 ± 0.024	2.524AlaTyr: 2.524 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.425CysAla: 0.425 ± 0.019	0.164CysCys: 0.164 ± 0.013	0.341CysAsp: 0.341 ± 0.017	0.364CysGlu: 0.364 ± 0.019	0.393CysPhe: 0.393 ± 0.017	0.539CysGly: 0.539 ± 0.02	0.21CysHis: 0.21 ± 0.013	0.591CysIle: 0.591 ± 0.025	0.468CysLys: 0.468 ± 0.022	0.795CysLeu: 0.795 ± 0.024	0.235CysMet: 0.235 ± 0.013	0.405CysAsn: 0.405 ± 0.017	0.334CysPro: 0.334 ± 0.018	0.295CysGln: 0.295 ± 0.016	0.324CysArg: 0.324 ± 0.016	0.564CysSer: 0.564 ± 0.023	0.402CysThr: 0.402 ± 0.016	0.384CysVal: 0.384 ± 0.022	0.096CysTrp: 0.096 ± 0.009	0.335CysTyr: 0.335 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.465AspAla: 3.465 ± 0.056	0.358AspCys: 0.358 ± 0.015	2.643AspAsp: 2.643 ± 0.053	3.632AspGlu: 3.632 ± 0.054	3.352AspPhe: 3.352 ± 0.048	3.796AspGly: 3.796 ± 0.063	1.105AspHis: 1.105 ± 0.032	4.228AspIle: 4.228 ± 0.061	4.137AspLys: 4.137 ± 0.054	5.598AspLeu: 5.598 ± 0.061	1.213AspMet: 1.213 ± 0.034	2.956AspAsn: 2.956 ± 0.046	2.191AspPro: 2.191 ± 0.039	2.209AspGln: 2.209 ± 0.044	2.37AspArg: 2.37 ± 0.046	3.352AspSer: 3.352 ± 0.061	2.233AspThr: 2.233 ± 0.042	3.34AspVal: 3.34 ± 0.057	0.826AspTrp: 0.826 ± 0.024	2.643AspTyr: 2.643 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.112GluAla: 4.112 ± 0.066	0.344GluCys: 0.344 ± 0.016	3.416GluAsp: 3.416 ± 0.058	4.821GluGlu: 4.821 ± 0.075	3.036GluPhe: 3.036 ± 0.051	3.791GluGly: 3.791 ± 0.056	1.153GluHis: 1.153 ± 0.027	5.434GluIle: 5.434 ± 0.074	5.582GluLys: 5.582 ± 0.071	6.471GluLeu: 6.471 ± 0.08	1.599GluMet: 1.599 ± 0.033	4.394GluAsn: 4.394 ± 0.055	1.683GluPro: 1.683 ± 0.035	2.434GluGln: 2.434 ± 0.045	2.677GluArg: 2.677 ± 0.047	3.472GluSer: 3.472 ± 0.057	3.137GluThr: 3.137 ± 0.053	4.215GluVal: 4.215 ± 0.062	0.733GluTrp: 0.733 ± 0.022	2.381GluTyr: 2.381 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.052PheAla: 3.052 ± 0.049	0.46PheCys: 0.46 ± 0.018	3.09PheAsp: 3.09 ± 0.045	3.118PheGlu: 3.118 ± 0.051	2.613PhePhe: 2.613 ± 0.053	3.563PheGly: 3.563 ± 0.053	0.9PheHis: 0.9 ± 0.031	3.796PheIle: 3.796 ± 0.06	3.388PheLys: 3.388 ± 0.052	4.567PheLeu: 4.567 ± 0.072	1.277PheMet: 1.277 ± 0.031	3.123PheAsn: 3.123 ± 0.056	1.831PhePro: 1.831 ± 0.034	1.758PheGln: 1.758 ± 0.037	2.009PheArg: 2.009 ± 0.04	3.846PheSer: 3.846 ± 0.059	2.661PheThr: 2.661 ± 0.046	2.934PheVal: 2.934 ± 0.046	0.635PheTrp: 0.635 ± 0.023	2.092PheTyr: 2.092 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.116GlyAla: 4.116 ± 0.067	0.557GlyCys: 0.557 ± 0.023	3.289GlyAsp: 3.289 ± 0.053	3.568GlyGlu: 3.568 ± 0.053	3.643GlyPhe: 3.643 ± 0.057	4.377GlyGly: 4.377 ± 0.074	1.173GlyHis: 1.173 ± 0.034	5.264GlyIle: 5.264 ± 0.069	5.349GlyLys: 5.349 ± 0.063	6.083GlyLeu: 6.083 ± 0.064	1.772GlyMet: 1.772 ± 0.038	3.783GlyAsn: 3.783 ± 0.054	1.53GlyPro: 1.53 ± 0.035	2.276GlyGln: 2.276 ± 0.037	2.607GlyArg: 2.607 ± 0.047	4.335GlySer: 4.335 ± 0.072	3.729GlyThr: 3.729 ± 0.069	4.175GlyVal: 4.175 ± 0.07	0.886GlyTrp: 0.886 ± 0.029	3.111GlyTyr: 3.111 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.071HisAla: 1.071 ± 0.029	0.204HisCys: 0.204 ± 0.012	0.907HisAsp: 0.907 ± 0.028	1.021HisGlu: 1.021 ± 0.026	1.078HisPhe: 1.078 ± 0.029	1.134HisGly: 1.134 ± 0.033	0.47HisHis: 0.47 ± 0.022	1.45HisIle: 1.45 ± 0.04	1.012HisLys: 1.012 ± 0.027	1.79HisLeu: 1.79 ± 0.038	0.384HisMet: 0.384 ± 0.019	1.002HisAsn: 1.002 ± 0.027	0.938HisPro: 0.938 ± 0.029	0.73HisGln: 0.73 ± 0.025	0.802HisArg: 0.802 ± 0.025	1.16HisSer: 1.16 ± 0.028	0.849HisThr: 0.849 ± 0.027	0.972HisVal: 0.972 ± 0.03	0.235HisTrp: 0.235 ± 0.013	0.878HisTyr: 0.878 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.383IleAla: 5.383 ± 0.07	0.708IleCys: 0.708 ± 0.026	4.73IleAsp: 4.73 ± 0.07	4.952IleGlu: 4.952 ± 0.059	3.518IlePhe: 3.518 ± 0.054	5.204IleGly: 5.204 ± 0.081	1.418IleHis: 1.418 ± 0.036	5.578IleIle: 5.578 ± 0.073	5.457IleLys: 5.457 ± 0.066	7.099IleLeu: 7.099 ± 0.082	1.604IleMet: 1.604 ± 0.037	4.591IleAsn: 4.591 ± 0.072	3.293IlePro: 3.293 ± 0.047	2.91IleGln: 2.91 ± 0.044	2.974IleArg: 2.974 ± 0.052	5.618IleSer: 5.618 ± 0.064	3.865IleThr: 3.865 ± 0.059	4.459IleVal: 4.459 ± 0.063	0.804IleTrp: 0.804 ± 0.026	2.784IleTyr: 2.784 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.711LysAla: 4.711 ± 0.062	0.336LysCys: 0.336 ± 0.016	4.68LysAsp: 4.68 ± 0.06	5.688LysGlu: 5.688 ± 0.077	3.033LysPhe: 3.033 ± 0.049	4.576LysGly: 4.576 ± 0.059	1.332LysHis: 1.332 ± 0.034	5.771LysIle: 5.771 ± 0.066	5.724LysLys: 5.724 ± 0.077	6.479LysLeu: 6.479 ± 0.077	1.996LysMet: 1.996 ± 0.036	4.805LysAsn: 4.805 ± 0.061	2.67LysPro: 2.67 ± 0.046	2.526LysGln: 2.526 ± 0.046	2.921LysArg: 2.921 ± 0.047	4.63LysSer: 4.63 ± 0.052	4.037LysThr: 4.037 ± 0.057	4.619LysVal: 4.619 ± 0.059	0.848LysTrp: 0.848 ± 0.027	3.072LysTyr: 3.072 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.126LeuAla: 6.126 ± 0.073	0.772LeuCys: 0.772 ± 0.025	5.209LeuAsp: 5.209 ± 0.075	5.892LeuGlu: 5.892 ± 0.068	4.767LeuPhe: 4.767 ± 0.07	6.008LeuGly: 6.008 ± 0.07	1.587LeuHis: 1.587 ± 0.033	7.015LeuIle: 7.015 ± 0.087	7.469LeuLys: 7.469 ± 0.078	8.639LeuLeu: 8.639 ± 0.098	2.434LeuMet: 2.434 ± 0.047	5.817LeuAsn: 5.817 ± 0.077	3.79LeuPro: 3.79 ± 0.055	3.286LeuGln: 3.286 ± 0.055	3.566LeuArg: 3.566 ± 0.048	6.816LeuSer: 6.816 ± 0.068	5.036LeuThr: 5.036 ± 0.061	5.211LeuVal: 5.211 ± 0.077	0.877LeuTrp: 0.877 ± 0.026	3.284LeuTyr: 3.284 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.807MetAla: 1.807 ± 0.036	0.151MetCys: 0.151 ± 0.011	1.487MetAsp: 1.487 ± 0.036	1.749MetGlu: 1.749 ± 0.039	0.984MetPhe: 0.984 ± 0.028	1.623MetGly: 1.623 ± 0.041	0.419MetHis: 0.419 ± 0.018	1.569MetIle: 1.569 ± 0.036	2.132MetLys: 2.132 ± 0.045	2.189MetLeu: 2.189 ± 0.039	0.679MetMet: 0.679 ± 0.025	1.485MetAsn: 1.485 ± 0.035	1.0MetPro: 1.0 ± 0.026	0.888MetGln: 0.888 ± 0.026	1.021MetArg: 1.021 ± 0.026	1.507MetSer: 1.507 ± 0.032	1.248MetThr: 1.248 ± 0.031	1.602MetVal: 1.602 ± 0.038	0.229MetTrp: 0.229 ± 0.013	0.742MetTyr: 0.742 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.634AsnAla: 3.634 ± 0.054	0.374AsnCys: 0.374 ± 0.02	2.888AsnAsp: 2.888 ± 0.045	3.505AsnGlu: 3.505 ± 0.049	3.024AsnPhe: 3.024 ± 0.05	3.963AsnGly: 3.963 ± 0.062	1.101AsnHis: 1.101 ± 0.034	4.754AsnIle: 4.754 ± 0.057	4.434AsnLys: 4.434 ± 0.055	5.687AsnLeu: 5.687 ± 0.076	1.388AsnMet: 1.388 ± 0.036	3.831AsnAsn: 3.831 ± 0.066	2.952AsnPro: 2.952 ± 0.057	2.474AsnGln: 2.474 ± 0.042	2.543AsnArg: 2.543 ± 0.047	4.092AsnSer: 4.092 ± 0.067	3.032AsnThr: 3.032 ± 0.053	3.192AsnVal: 3.192 ± 0.05	0.831AsnTrp: 0.831 ± 0.028	2.673AsnTyr: 2.673 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.199ProAla: 2.199 ± 0.039	0.215ProCys: 0.215 ± 0.014	2.181ProAsp: 2.181 ± 0.04	3.037ProGlu: 3.037 ± 0.049	1.89ProPhe: 1.89 ± 0.038	2.189ProGly: 2.189 ± 0.038	0.629ProHis: 0.629 ± 0.024	2.897ProIle: 2.897 ± 0.047	2.511ProLys: 2.511 ± 0.048	3.121ProLeu: 3.121 ± 0.049	0.831ProMet: 0.831 ± 0.029	2.365ProAsn: 2.365 ± 0.043	0.782ProPro: 0.782 ± 0.027	1.27ProGln: 1.27 ± 0.031	1.167ProArg: 1.167 ± 0.029	2.305ProSer: 2.305 ± 0.044	2.028ProThr: 2.028 ± 0.043	2.416ProVal: 2.416 ± 0.041	0.451ProTrp: 0.451 ± 0.02	1.491ProTyr: 1.491 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	2.389GlnAla: 2.389 ± 0.038	0.188GlnCys: 0.188 ± 0.011	1.959GlnAsp: 1.959 ± 0.04	2.647GlnGlu: 2.647 ± 0.045	1.707GlnPhe: 1.707 ± 0.032	2.162GlnGly: 2.162 ± 0.044	0.704GlnHis: 0.704 ± 0.021	2.859GlnIle: 2.859 ± 0.048	2.79GlnLys: 2.79 ± 0.05	3.453GlnLeu: 3.453 ± 0.052	0.946GlnMet: 0.946 ± 0.026	2.253GlnAsn: 2.253 ± 0.046	1.157GlnPro: 1.157 ± 0.033	1.768GlnGln: 1.768 ± 0.039	1.42GlnArg: 1.42 ± 0.035	2.113GlnSer: 2.113 ± 0.039	1.899GlnThr: 1.899 ± 0.038	2.289GlnVal: 2.289 ± 0.043	0.438GlnTrp: 0.438 ± 0.018	1.516GlnTyr: 1.516 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.307ArgAla: 2.307 ± 0.044	0.292ArgCys: 0.292 ± 0.018	2.03ArgAsp: 2.03 ± 0.042	2.543ArgGlu: 2.543 ± 0.04	2.149ArgPhe: 2.149 ± 0.038	2.196ArgGly: 2.196 ± 0.046	0.641ArgHis: 0.641 ± 0.023	3.218ArgIle: 3.218 ± 0.045	3.051ArgLys: 3.051 ± 0.047	3.628ArgLeu: 3.628 ± 0.054	1.151ArgMet: 1.151 ± 0.03	2.408ArgAsn: 2.408 ± 0.045	1.308ArgPro: 1.308 ± 0.033	1.316ArgGln: 1.316 ± 0.032	1.642ArgArg: 1.642 ± 0.04	2.48ArgSer: 2.48 ± 0.052	2.069ArgThr: 2.069 ± 0.042	2.342ArgVal: 2.342 ± 0.041	0.52ArgTrp: 0.52 ± 0.023	1.807ArgTyr: 1.807 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.067SerAla: 4.067 ± 0.056	0.676SerCys: 0.676 ± 0.025	3.472SerAsp: 3.472 ± 0.046	3.945SerGlu: 3.945 ± 0.051	3.7SerPhe: 3.7 ± 0.053	4.552SerGly: 4.552 ± 0.066	1.133SerHis: 1.133 ± 0.034	5.358SerIle: 5.358 ± 0.051	4.907SerLys: 4.907 ± 0.067	6.297SerLeu: 6.297 ± 0.069	1.567SerMet: 1.567 ± 0.035	3.911SerAsn: 3.911 ± 0.06	2.264SerPro: 2.264 ± 0.047	2.149SerGln: 2.149 ± 0.041	2.526SerArg: 2.526 ± 0.046	4.639SerSer: 4.639 ± 0.071	3.64SerThr: 3.64 ± 0.056	3.88SerVal: 3.88 ± 0.053	0.822SerTrp: 0.822 ± 0.026	2.836SerTyr: 2.836 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.605ThrAla: 3.605 ± 0.063	0.319ThrCys: 0.319 ± 0.016	3.03ThrAsp: 3.03 ± 0.05	3.179ThrGlu: 3.179 ± 0.05	2.698ThrPhe: 2.698 ± 0.049	3.847ThrGly: 3.847 ± 0.065	0.918ThrHis: 0.918 ± 0.027	4.061ThrIle: 4.061 ± 0.056	3.401ThrLys: 3.401 ± 0.056	4.864ThrLeu: 4.864 ± 0.068	1.124ThrMet: 1.124 ± 0.027	2.82ThrAsn: 2.82 ± 0.058	2.145ThrPro: 2.145 ± 0.036	1.6ThrGln: 1.6 ± 0.031	1.691ThrArg: 1.691 ± 0.034	3.412ThrSer: 3.412 ± 0.055	2.702ThrThr: 2.702 ± 0.055	3.482ThrVal: 3.482 ± 0.061	0.603ThrTrp: 0.603 ± 0.027	2.181ThrTyr: 2.181 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	3.865ValAla: 3.865 ± 0.058	0.511ValCys: 0.511 ± 0.021	3.683ValAsp: 3.683 ± 0.057	3.925ValGlu: 3.925 ± 0.057	3.031ValPhe: 3.031 ± 0.046	3.94ValGly: 3.94 ± 0.062	1.031ValHis: 1.031 ± 0.03	4.417ValIle: 4.417 ± 0.067	4.273ValLys: 4.273 ± 0.056	5.814ValLeu: 5.814 ± 0.074	1.404ValMet: 1.404 ± 0.032	3.549ValAsn: 3.549 ± 0.055	2.297ValPro: 2.297 ± 0.041	2.154ValGln: 2.154 ± 0.04	2.305ValArg: 2.305 ± 0.045	4.28ValSer: 4.28 ± 0.053	3.041ValThr: 3.041 ± 0.054	3.939ValVal: 3.939 ± 0.066	0.646ValTrp: 0.646 ± 0.022	2.364ValTyr: 2.364 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.707TrpAla: 0.707 ± 0.025	0.119TrpCys: 0.119 ± 0.01	0.646TrpAsp: 0.646 ± 0.023	0.779TrpGlu: 0.779 ± 0.022	0.57TrpPhe: 0.57 ± 0.021	0.819TrpGly: 0.819 ± 0.027	0.228TrpHis: 0.228 ± 0.013	0.823TrpIle: 0.823 ± 0.028	0.931TrpLys: 0.931 ± 0.029	1.102TrpLeu: 1.102 ± 0.029	0.398TrpMet: 0.398 ± 0.019	0.793TrpAsn: 0.793 ± 0.025	0.311TrpPro: 0.311 ± 0.015	0.481TrpGln: 0.481 ± 0.02	0.514TrpArg: 0.514 ± 0.019	0.697TrpSer: 0.697 ± 0.027	0.654TrpThr: 0.654 ± 0.024	0.679TrpVal: 0.679 ± 0.023	0.174TrpTrp: 0.174 ± 0.012	0.497TrpTyr: 0.497 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.543TyrAla: 2.543 ± 0.045	0.363TyrCys: 0.363 ± 0.016	2.411TyrAsp: 2.411 ± 0.042	2.281TyrGlu: 2.281 ± 0.041	2.42TyrPhe: 2.42 ± 0.042	2.814TyrGly: 2.814 ± 0.044	0.865TyrHis: 0.865 ± 0.026	2.63TyrIle: 2.63 ± 0.045	2.77TyrLys: 2.77 ± 0.049	3.971TyrLeu: 3.971 ± 0.061	0.879TyrMet: 0.879 ± 0.026	2.481TyrAsn: 2.481 ± 0.047	1.631TyrPro: 1.631 ± 0.036	1.696TyrGln: 1.696 ± 0.037	1.815TyrArg: 1.815 ± 0.036	2.918TyrSer: 2.918 ± 0.051	2.084TyrThr: 2.084 ± 0.039	2.096TyrVal: 2.096 ± 0.033	0.544TyrTrp: 0.544 ± 0.022	1.989TyrTyr: 1.989 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5549 proteins (1347359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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