Amino acid dipepetide frequency for Microviridae sp. ctnrr37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.615AlaAla: 9.615 ± 6.018
0.874AlaCys: 0.874 ± 1.126
7.867AlaAsp: 7.867 ± 1.506
7.867AlaGlu: 7.867 ± 3.457
3.497AlaPhe: 3.497 ± 0.989
6.993AlaGly: 6.993 ± 4.063
1.748AlaHis: 1.748 ± 0.952
4.371AlaIle: 4.371 ± 2.581
4.371AlaLys: 4.371 ± 2.948
7.867AlaLeu: 7.867 ± 4.099
2.622AlaMet: 2.622 ± 2.118
3.497AlaAsn: 3.497 ± 2.907
6.119AlaPro: 6.119 ± 2.957
5.245AlaGln: 5.245 ± 2.033
6.993AlaArg: 6.993 ± 2.602
7.867AlaSer: 7.867 ± 3.576
8.741AlaThr: 8.741 ± 1.989
6.119AlaVal: 6.119 ± 1.159
0.0AlaTrp: 0.0 ± 0.0
2.622AlaTyr: 2.622 ± 1.629
0.0AlaXaa: 0.0 ± 0.0
Cys
1.748CysAla: 1.748 ± 1.086
0.874CysCys: 0.874 ± 1.126
1.748CysAsp: 1.748 ± 1.457
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.874CysLys: 0.874 ± 1.094
0.874CysLeu: 0.874 ± 0.543
0.874CysMet: 0.874 ± 1.201
0.0CysAsn: 0.0 ± 0.0
0.874CysPro: 0.874 ± 1.126
1.748CysGln: 1.748 ± 1.091
0.874CysArg: 0.874 ± 1.126
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
7.867AspAla: 7.867 ± 2.523
0.874AspCys: 0.874 ± 1.094
2.622AspAsp: 2.622 ± 2.226
2.622AspGlu: 2.622 ± 1.098
6.119AspPhe: 6.119 ± 2.455
0.874AspGly: 0.874 ± 0.543
0.874AspHis: 0.874 ± 0.543
0.0AspIle: 0.0 ± 0.0
0.874AspLys: 0.874 ± 1.201
6.119AspLeu: 6.119 ± 0.903
3.497AspMet: 3.497 ± 1.604
1.748AspAsn: 1.748 ± 1.086
1.748AspPro: 1.748 ± 1.088
0.874AspGln: 0.874 ± 0.918
0.874AspArg: 0.874 ± 0.543
4.371AspSer: 4.371 ± 1.842
4.371AspThr: 4.371 ± 2.715
5.245AspVal: 5.245 ± 0.999
0.874AspTrp: 0.874 ± 1.126
3.497AspTyr: 3.497 ± 2.172
0.0AspXaa: 0.0 ± 0.0
Glu
5.245GluAla: 5.245 ± 2.695
0.874GluCys: 0.874 ± 1.126
2.622GluAsp: 2.622 ± 1.305
0.0GluGlu: 0.0 ± 0.0
2.622GluPhe: 2.622 ± 1.978
2.622GluGly: 2.622 ± 1.098
0.874GluHis: 0.874 ± 0.543
0.874GluIle: 0.874 ± 0.543
2.622GluLys: 2.622 ± 1.636
3.497GluLeu: 3.497 ± 1.37
1.748GluMet: 1.748 ± 1.088
0.874GluAsn: 0.874 ± 0.543
0.0GluPro: 0.0 ± 0.0
2.622GluGln: 2.622 ± 1.094
4.371GluArg: 4.371 ± 2.412
0.874GluSer: 0.874 ± 0.543
0.874GluThr: 0.874 ± 1.094
2.622GluVal: 2.622 ± 1.098
0.874GluTrp: 0.874 ± 0.543
3.497GluTyr: 3.497 ± 1.419
0.0GluXaa: 0.0 ± 0.0
Phe
6.119PheAla: 6.119 ± 2.979
0.874PheCys: 0.874 ± 0.543
2.622PheAsp: 2.622 ± 1.231
0.874PheGlu: 0.874 ± 1.201
3.497PhePhe: 3.497 ± 1.448
7.867PheGly: 7.867 ± 2.359
0.0PheHis: 0.0 ± 0.0
2.622PheIle: 2.622 ± 1.152
3.497PheLys: 3.497 ± 2.886
1.748PheLeu: 1.748 ± 0.952
3.497PheMet: 3.497 ± 2.062
4.371PheAsn: 4.371 ± 2.027
0.874PhePro: 0.874 ± 0.543
3.497PheGln: 3.497 ± 2.529
4.371PheArg: 4.371 ± 1.511
4.371PheSer: 4.371 ± 1.987
4.371PheThr: 4.371 ± 1.306
2.622PheVal: 2.622 ± 1.143
0.874PheTrp: 0.874 ± 0.918
0.874PheTyr: 0.874 ± 0.543
0.0PheXaa: 0.0 ± 0.0
Gly
12.238GlyAla: 12.238 ± 8.987
0.0GlyCys: 0.0 ± 0.0
3.497GlyAsp: 3.497 ± 1.069
3.497GlyGlu: 3.497 ± 2.526
2.622GlyPhe: 2.622 ± 1.636
9.615GlyGly: 9.615 ± 3.753
0.0GlyHis: 0.0 ± 0.0
2.622GlyIle: 2.622 ± 1.629
3.497GlyLys: 3.497 ± 1.242
10.49GlyLeu: 10.49 ± 1.608
0.874GlyMet: 0.874 ± 0.918
2.622GlyAsn: 2.622 ± 1.016
4.371GlyPro: 4.371 ± 1.987
1.748GlyGln: 1.748 ± 0.952
1.748GlyArg: 1.748 ± 1.773
9.615GlySer: 9.615 ± 1.988
6.993GlyThr: 6.993 ± 3.473
4.371GlyVal: 4.371 ± 1.749
0.0GlyTrp: 0.0 ± 0.0
3.497GlyTyr: 3.497 ± 1.448
0.0GlyXaa: 0.0 ± 0.0
His
1.748HisAla: 1.748 ± 1.086
0.874HisCys: 0.874 ± 0.543
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
3.497HisPhe: 3.497 ± 1.531
1.748HisGly: 1.748 ± 1.086
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.748HisLys: 1.748 ± 1.69
1.748HisLeu: 1.748 ± 1.086
0.0HisMet: 0.0 ± 0.0
1.748HisAsn: 1.748 ± 2.312
0.874HisPro: 0.874 ± 1.201
0.874HisGln: 0.874 ± 1.094
0.0HisArg: 0.0 ± 0.0
0.874HisSer: 0.874 ± 1.156
1.748HisThr: 1.748 ± 1.091
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.748IleAla: 1.748 ± 0.802
0.0IleCys: 0.0 ± 0.0
2.622IleAsp: 2.622 ± 1.231
0.0IleGlu: 0.0 ± 0.0
1.748IlePhe: 1.748 ± 1.69
3.497IleGly: 3.497 ± 2.172
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
2.622IleLys: 2.622 ± 1.191
5.245IleLeu: 5.245 ± 3.361
0.874IleMet: 0.874 ± 0.543
5.245IleAsn: 5.245 ± 2.268
2.622IlePro: 2.622 ± 1.629
2.622IleGln: 2.622 ± 1.775
1.748IleArg: 1.748 ± 1.435
3.497IleSer: 3.497 ± 2.081
0.874IleThr: 0.874 ± 0.543
1.748IleVal: 1.748 ± 1.086
0.874IleTrp: 0.874 ± 0.543
1.748IleTyr: 1.748 ± 1.088
0.0IleXaa: 0.0 ± 0.0
Lys
4.371LysAla: 4.371 ± 1.94
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
2.622LysGlu: 2.622 ± 2.287
4.371LysPhe: 4.371 ± 2.069
3.497LysGly: 3.497 ± 2.109
1.748LysHis: 1.748 ± 1.69
2.622LysIle: 2.622 ± 1.066
2.622LysLys: 2.622 ± 2.363
1.748LysLeu: 1.748 ± 1.69
1.748LysMet: 1.748 ± 1.019
0.874LysAsn: 0.874 ± 1.201
2.622LysPro: 2.622 ± 1.48
2.622LysGln: 2.622 ± 1.152
3.497LysArg: 3.497 ± 2.075
1.748LysSer: 1.748 ± 1.091
4.371LysThr: 4.371 ± 2.512
2.622LysVal: 2.622 ± 2.03
0.874LysTrp: 0.874 ± 0.918
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
7.867LeuAla: 7.867 ± 1.711
1.748LeuCys: 1.748 ± 1.569
3.497LeuAsp: 3.497 ± 1.179
0.0LeuGlu: 0.0 ± 0.0
6.993LeuPhe: 6.993 ± 2.812
6.119LeuGly: 6.119 ± 1.782
1.748LeuHis: 1.748 ± 1.088
6.993LeuIle: 6.993 ± 3.062
3.497LeuLys: 3.497 ± 1.523
4.371LeuLeu: 4.371 ± 1.983
0.874LeuMet: 0.874 ± 0.918
6.119LeuAsn: 6.119 ± 1.984
5.245LeuPro: 5.245 ± 1.585
5.245LeuGln: 5.245 ± 2.033
5.245LeuArg: 5.245 ± 3.808
2.622LeuSer: 2.622 ± 2.132
3.497LeuThr: 3.497 ± 1.419
2.622LeuVal: 2.622 ± 1.48
0.874LeuTrp: 0.874 ± 1.156
2.622LeuTyr: 2.622 ± 1.586
0.0LeuXaa: 0.0 ± 0.0
Met
4.371MetAla: 4.371 ± 1.923
1.748MetCys: 1.748 ± 2.252
2.622MetAsp: 2.622 ± 1.094
1.748MetGlu: 1.748 ± 0.802
0.0MetPhe: 0.0 ± 0.0
3.497MetGly: 3.497 ± 1.7
0.874MetHis: 0.874 ± 0.543
1.748MetIle: 1.748 ± 1.086
1.748MetLys: 1.748 ± 1.373
4.371MetLeu: 4.371 ± 2.476
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.748MetPro: 1.748 ± 1.088
0.874MetGln: 0.874 ± 0.918
1.748MetArg: 1.748 ± 0.952
2.622MetSer: 2.622 ± 1.636
0.874MetThr: 0.874 ± 1.126
0.874MetVal: 0.874 ± 0.918
0.874MetTrp: 0.874 ± 0.543
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.371AsnAla: 4.371 ± 1.983
0.0AsnCys: 0.0 ± 0.0
1.748AsnAsp: 1.748 ± 0.952
2.622AsnGlu: 2.622 ± 1.305
2.622AsnPhe: 2.622 ± 1.143
2.622AsnGly: 2.622 ± 1.629
0.874AsnHis: 0.874 ± 1.156
2.622AsnIle: 2.622 ± 1.432
0.874AsnLys: 0.874 ± 1.201
5.245AsnLeu: 5.245 ± 3.436
0.0AsnMet: 0.0 ± 0.0
2.622AsnAsn: 2.622 ± 2.745
2.622AsnPro: 2.622 ± 1.152
3.497AsnGln: 3.497 ± 1.065
5.245AsnArg: 5.245 ± 2.271
0.0AsnSer: 0.0 ± 0.0
1.748AsnThr: 1.748 ± 0.802
0.874AsnVal: 0.874 ± 0.543
0.874AsnTrp: 0.874 ± 0.543
2.622AsnTyr: 2.622 ± 1.066
0.0AsnXaa: 0.0 ± 0.0
Pro
4.371ProAla: 4.371 ± 3.11
0.0ProCys: 0.0 ± 0.0
4.371ProAsp: 4.371 ± 1.891
4.371ProGlu: 4.371 ± 1.236
0.874ProPhe: 0.874 ± 1.126
5.245ProGly: 5.245 ± 2.003
0.0ProHis: 0.0 ± 0.0
3.497ProIle: 3.497 ± 1.069
0.874ProLys: 0.874 ± 1.094
2.622ProLeu: 2.622 ± 1.143
2.622ProMet: 2.622 ± 1.305
2.622ProAsn: 2.622 ± 1.629
1.748ProPro: 1.748 ± 2.401
3.497ProGln: 3.497 ± 1.562
0.874ProArg: 0.874 ± 0.543
4.371ProSer: 4.371 ± 2.401
2.622ProThr: 2.622 ± 1.629
6.119ProVal: 6.119 ± 3.106
0.874ProTrp: 0.874 ± 0.543
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
5.245GlnAla: 5.245 ± 2.033
0.0GlnCys: 0.0 ± 0.0
3.497GlnAsp: 3.497 ± 3.051
4.371GlnGlu: 4.371 ± 1.034
0.874GlnPhe: 0.874 ± 1.126
2.622GlnGly: 2.622 ± 1.636
0.874GlnHis: 0.874 ± 0.543
1.748GlnIle: 1.748 ± 1.836
3.497GlnLys: 3.497 ± 1.065
3.497GlnLeu: 3.497 ± 1.675
1.748GlnMet: 1.748 ± 1.836
1.748GlnAsn: 1.748 ± 1.741
0.874GlnPro: 0.874 ± 0.918
3.497GlnGln: 3.497 ± 2.529
4.371GlnArg: 4.371 ± 1.657
2.622GlnSer: 2.622 ± 1.016
5.245GlnThr: 5.245 ± 2.041
3.497GlnVal: 3.497 ± 1.675
0.0GlnTrp: 0.0 ± 0.0
0.874GlnTyr: 0.874 ± 0.918
0.0GlnXaa: 0.0 ± 0.0
Arg
6.993ArgAla: 6.993 ± 2.174
0.0ArgCys: 0.0 ± 0.0
3.497ArgAsp: 3.497 ± 2.442
1.748ArgGlu: 1.748 ± 1.836
2.622ArgPhe: 2.622 ± 2.318
3.497ArgGly: 3.497 ± 1.562
2.622ArgHis: 2.622 ± 2.132
3.497ArgIle: 3.497 ± 2.081
0.0ArgLys: 0.0 ± 0.0
4.371ArgLeu: 4.371 ± 1.485
3.497ArgMet: 3.497 ± 2.34
2.622ArgAsn: 2.622 ± 2.481
2.622ArgPro: 2.622 ± 1.305
3.497ArgGln: 3.497 ± 1.79
4.371ArgArg: 4.371 ± 3.426
7.867ArgSer: 7.867 ± 2.169
1.748ArgThr: 1.748 ± 0.952
2.622ArgVal: 2.622 ± 2.101
0.0ArgTrp: 0.0 ± 0.0
2.622ArgTyr: 2.622 ± 1.629
0.0ArgXaa: 0.0 ± 0.0
Ser
8.741SerAla: 8.741 ± 1.63
0.874SerCys: 0.874 ± 0.543
0.874SerAsp: 0.874 ± 1.201
1.748SerGlu: 1.748 ± 1.088
5.245SerPhe: 5.245 ± 1.369
7.867SerGly: 7.867 ± 1.949
2.622SerHis: 2.622 ± 1.191
1.748SerIle: 1.748 ± 1.69
5.245SerLys: 5.245 ± 2.826
4.371SerLeu: 4.371 ± 1.964
2.622SerMet: 2.622 ± 1.737
3.497SerAsn: 3.497 ± 1.604
3.497SerPro: 3.497 ± 1.548
2.622SerGln: 2.622 ± 1.016
4.371SerArg: 4.371 ± 2.17
10.49SerSer: 10.49 ± 2.918
3.497SerThr: 3.497 ± 1.419
2.622SerVal: 2.622 ± 1.629
0.874SerTrp: 0.874 ± 0.543
1.748SerTyr: 1.748 ± 1.091
0.0SerXaa: 0.0 ± 0.0
Thr
4.371ThrAla: 4.371 ± 1.983
0.0ThrCys: 0.0 ± 0.0
6.119ThrAsp: 6.119 ± 2.914
2.622ThrGlu: 2.622 ± 1.629
3.497ThrPhe: 3.497 ± 2.172
8.741ThrGly: 8.741 ± 2.141
0.874ThrHis: 0.874 ± 1.126
0.874ThrIle: 0.874 ± 0.543
3.497ThrLys: 3.497 ± 1.616
3.497ThrLeu: 3.497 ± 1.394
1.748ThrMet: 1.748 ± 1.086
0.874ThrAsn: 0.874 ± 0.543
6.119ThrPro: 6.119 ± 0.903
1.748ThrGln: 1.748 ± 1.091
2.622ThrArg: 2.622 ± 1.098
2.622ThrSer: 2.622 ± 1.629
2.622ThrThr: 2.622 ± 1.016
2.622ThrVal: 2.622 ± 1.231
2.622ThrTrp: 2.622 ± 2.226
1.748ThrTyr: 1.748 ± 0.802
0.0ThrXaa: 0.0 ± 0.0
Val
2.622ValAla: 2.622 ± 1.191
0.874ValCys: 0.874 ± 0.543
0.874ValAsp: 0.874 ± 0.543
1.748ValGlu: 1.748 ± 1.04
5.245ValPhe: 5.245 ± 2.041
4.371ValGly: 4.371 ± 3.436
0.0ValHis: 0.0 ± 0.0
1.748ValIle: 1.748 ± 1.086
1.748ValLys: 1.748 ± 1.088
4.371ValLeu: 4.371 ± 1.893
0.874ValMet: 0.874 ± 0.543
0.874ValAsn: 0.874 ± 0.543
5.245ValPro: 5.245 ± 2.197
1.748ValGln: 1.748 ± 0.952
5.245ValArg: 5.245 ± 2.399
6.993ValSer: 6.993 ± 1.169
2.622ValThr: 2.622 ± 1.305
0.874ValVal: 0.874 ± 0.543
0.0ValTrp: 0.0 ± 0.0
1.748ValTyr: 1.748 ± 0.802
0.0ValXaa: 0.0 ± 0.0
Trp
0.874TrpAla: 0.874 ± 0.918
0.0TrpCys: 0.0 ± 0.0
1.748TrpAsp: 1.748 ± 1.088
0.874TrpGlu: 0.874 ± 0.543
0.874TrpPhe: 0.874 ± 0.543
0.0TrpGly: 0.0 ± 0.0
0.874TrpHis: 0.874 ± 0.543
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.874TrpLeu: 0.874 ± 1.156
0.874TrpMet: 0.874 ± 1.201
0.874TrpAsn: 0.874 ± 0.543
1.748TrpPro: 1.748 ± 1.086
0.0TrpGln: 0.0 ± 0.0
0.874TrpArg: 0.874 ± 1.126
0.874TrpSer: 0.874 ± 0.918
0.874TrpThr: 0.874 ± 0.543
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.371TyrAla: 4.371 ± 1.236
0.0TyrCys: 0.0 ± 0.0
3.497TyrAsp: 3.497 ± 1.069
0.874TyrGlu: 0.874 ± 0.543
2.622TyrPhe: 2.622 ± 1.016
2.622TyrGly: 2.622 ± 1.586
0.874TyrHis: 0.874 ± 0.543
1.748TyrIle: 1.748 ± 1.04
0.874TyrLys: 0.874 ± 0.543
0.874TyrLeu: 0.874 ± 0.543
0.874TyrMet: 0.874 ± 0.543
0.874TyrAsn: 0.874 ± 0.543
0.0TyrPro: 0.0 ± 0.0
2.622TyrGln: 2.622 ± 1.016
1.748TyrArg: 1.748 ± 0.802
0.874TyrSer: 0.874 ± 0.543
1.748TyrThr: 1.748 ± 1.086
1.748TyrVal: 1.748 ± 1.091
0.874TyrTrp: 0.874 ± 0.543
0.874TyrTyr: 0.874 ± 0.543
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1145 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski