Amino acid dipepetide frequency for Arthrobacter sp. U41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.646AlaAla: 21.646 ± 0.241
0.823AlaCys: 0.823 ± 0.031
7.068AlaAsp: 7.068 ± 0.083
8.316AlaGlu: 8.316 ± 0.12
3.69AlaPhe: 3.69 ± 0.053
13.752AlaGly: 13.752 ± 0.135
2.26AlaHis: 2.26 ± 0.043
4.802AlaIle: 4.802 ± 0.071
3.73AlaLys: 3.73 ± 0.064
13.021AlaLeu: 13.021 ± 0.139
2.744AlaMet: 2.744 ± 0.048
2.611AlaAsn: 2.611 ± 0.044
6.424AlaPro: 6.424 ± 0.101
3.776AlaGln: 3.776 ± 0.06
8.212AlaArg: 8.212 ± 0.095
6.969AlaSer: 6.969 ± 0.078
6.68AlaThr: 6.68 ± 0.089
11.401AlaVal: 11.401 ± 0.119
1.684AlaTrp: 1.684 ± 0.045
2.23AlaTyr: 2.23 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.715CysAla: 0.715 ± 0.023
0.073CysCys: 0.073 ± 0.007
0.34CysAsp: 0.34 ± 0.018
0.317CysGlu: 0.317 ± 0.016
0.212CysPhe: 0.212 ± 0.013
0.743CysGly: 0.743 ± 0.028
0.134CysHis: 0.134 ± 0.01
0.26CysIle: 0.26 ± 0.013
0.11CysLys: 0.11 ± 0.009
0.599CysLeu: 0.599 ± 0.023
0.108CysMet: 0.108 ± 0.009
0.15CysAsn: 0.15 ± 0.012
0.382CysPro: 0.382 ± 0.02
0.18CysGln: 0.18 ± 0.012
0.471CysArg: 0.471 ± 0.019
0.402CysSer: 0.402 ± 0.018
0.418CysThr: 0.418 ± 0.019
0.431CysVal: 0.431 ± 0.019
0.118CysTrp: 0.118 ± 0.011
0.178CysTyr: 0.178 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.257AspAla: 7.257 ± 0.08
0.343AspCys: 0.343 ± 0.017
2.91AspAsp: 2.91 ± 0.059
3.38AspGlu: 3.38 ± 0.059
1.907AspPhe: 1.907 ± 0.035
5.555AspGly: 5.555 ± 0.077
1.189AspHis: 1.189 ± 0.03
2.397AspIle: 2.397 ± 0.042
1.452AspLys: 1.452 ± 0.036
5.507AspLeu: 5.507 ± 0.067
0.946AspMet: 0.946 ± 0.029
1.093AspAsn: 1.093 ± 0.03
3.766AspPro: 3.766 ± 0.059
1.599AspGln: 1.599 ± 0.035
3.604AspArg: 3.604 ± 0.059
2.889AspSer: 2.889 ± 0.052
2.778AspThr: 2.778 ± 0.052
4.709AspVal: 4.709 ± 0.065
0.88AspTrp: 0.88 ± 0.024
1.304AspTyr: 1.304 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.13GluAla: 7.13 ± 0.086
0.312GluCys: 0.312 ± 0.015
3.084GluAsp: 3.084 ± 0.055
3.354GluGlu: 3.354 ± 0.063
1.787GluPhe: 1.787 ± 0.038
4.038GluGly: 4.038 ± 0.056
1.518GluHis: 1.518 ± 0.032
2.683GluIle: 2.683 ± 0.052
1.809GluLys: 1.809 ± 0.049
7.178GluLeu: 7.178 ± 0.092
1.025GluMet: 1.025 ± 0.032
1.49GluAsn: 1.49 ± 0.04
2.928GluPro: 2.928 ± 0.053
2.319GluGln: 2.319 ± 0.052
4.162GluArg: 4.162 ± 0.061
3.079GluSer: 3.079 ± 0.05
3.132GluThr: 3.132 ± 0.051
4.256GluVal: 4.256 ± 0.06
0.774GluTrp: 0.774 ± 0.025
1.152GluTyr: 1.152 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.0PheAla: 4.0 ± 0.058
0.248PheCys: 0.248 ± 0.012
2.157PheAsp: 2.157 ± 0.044
1.765PheGlu: 1.765 ± 0.044
1.121PhePhe: 1.121 ± 0.033
3.368PheGly: 3.368 ± 0.058
0.682PheHis: 0.682 ± 0.023
1.356PheIle: 1.356 ± 0.036
0.813PheLys: 0.813 ± 0.028
3.042PheLeu: 3.042 ± 0.058
0.555PheMet: 0.555 ± 0.021
0.874PheAsn: 0.874 ± 0.027
1.522PhePro: 1.522 ± 0.039
0.85PheGln: 0.85 ± 0.024
1.903PheArg: 1.903 ± 0.042
2.008PheSer: 2.008 ± 0.039
2.131PheThr: 2.131 ± 0.043
2.487PheVal: 2.487 ± 0.047
0.43PheTrp: 0.43 ± 0.021
0.702PheTyr: 0.702 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
10.324GlyAla: 10.324 ± 0.115
0.662GlyCys: 0.662 ± 0.024
4.266GlyAsp: 4.266 ± 0.064
4.631GlyGlu: 4.631 ± 0.064
3.29GlyPhe: 3.29 ± 0.054
7.857GlyGly: 7.857 ± 0.107
2.019GlyHis: 2.019 ± 0.041
4.703GlyIle: 4.703 ± 0.063
3.109GlyLys: 3.109 ± 0.061
9.283GlyLeu: 9.283 ± 0.092
2.163GlyMet: 2.163 ± 0.045
2.223GlyAsn: 2.223 ± 0.042
4.441GlyPro: 4.441 ± 0.059
3.084GlyGln: 3.084 ± 0.05
6.118GlyArg: 6.118 ± 0.072
5.89GlySer: 5.89 ± 0.075
6.108GlyThr: 6.108 ± 0.073
7.161GlyVal: 7.161 ± 0.08
1.565GlyTrp: 1.565 ± 0.037
2.403GlyTyr: 2.403 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.287HisAla: 2.287 ± 0.048
0.188HisCys: 0.188 ± 0.012
1.156HisAsp: 1.156 ± 0.031
1.234HisGlu: 1.234 ± 0.033
0.705HisPhe: 0.705 ± 0.022
2.083HisGly: 2.083 ± 0.047
0.671HisHis: 0.671 ± 0.022
0.826HisIle: 0.826 ± 0.029
0.459HisLys: 0.459 ± 0.019
2.096HisLeu: 2.096 ± 0.042
0.355HisMet: 0.355 ± 0.018
0.492HisAsn: 0.492 ± 0.02
1.532HisPro: 1.532 ± 0.039
0.655HisGln: 0.655 ± 0.021
1.595HisArg: 1.595 ± 0.037
1.201HisSer: 1.201 ± 0.032
1.101HisThr: 1.101 ± 0.032
1.622HisVal: 1.622 ± 0.038
0.326HisTrp: 0.326 ± 0.017
0.458HisTyr: 0.458 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.667IleAla: 5.667 ± 0.074
0.34IleCys: 0.34 ± 0.016
2.723IleAsp: 2.723 ± 0.051
2.422IleGlu: 2.422 ± 0.046
1.358IlePhe: 1.358 ± 0.04
4.117IleGly: 4.117 ± 0.065
0.874IleHis: 0.874 ± 0.029
1.901IleIle: 1.901 ± 0.049
1.16IleLys: 1.16 ± 0.036
3.883IleLeu: 3.883 ± 0.064
0.792IleMet: 0.792 ± 0.028
1.207IleAsn: 1.207 ± 0.034
2.368IlePro: 2.368 ± 0.047
1.212IleGln: 1.212 ± 0.032
2.867IleArg: 2.867 ± 0.048
2.765IleSer: 2.765 ± 0.047
2.824IleThr: 2.824 ± 0.048
3.586IleVal: 3.586 ± 0.06
0.526IleTrp: 0.526 ± 0.02
0.861IleTyr: 0.861 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.7LysAla: 3.7 ± 0.07
0.116LysCys: 0.116 ± 0.01
1.794LysAsp: 1.794 ± 0.044
1.483LysGlu: 1.483 ± 0.038
0.789LysPhe: 0.789 ± 0.028
2.056LysGly: 2.056 ± 0.041
0.638LysHis: 0.638 ± 0.022
1.323LysIle: 1.323 ± 0.036
1.032LysLys: 1.032 ± 0.038
2.803LysLeu: 2.803 ± 0.05
0.619LysMet: 0.619 ± 0.021
0.834LysAsn: 0.834 ± 0.026
1.69LysPro: 1.69 ± 0.045
0.849LysGln: 0.849 ± 0.024
1.736LysArg: 1.736 ± 0.043
1.676LysSer: 1.676 ± 0.041
1.762LysThr: 1.762 ± 0.041
2.375LysVal: 2.375 ± 0.054
0.328LysTrp: 0.328 ± 0.017
0.683LysTyr: 0.683 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.465LeuAla: 14.465 ± 0.141
0.625LeuCys: 0.625 ± 0.024
6.199LeuAsp: 6.199 ± 0.08
5.593LeuGlu: 5.593 ± 0.079
2.958LeuPhe: 2.958 ± 0.059
9.168LeuGly: 9.168 ± 0.107
2.072LeuHis: 2.072 ± 0.042
4.415LeuIle: 4.415 ± 0.075
2.868LeuLys: 2.868 ± 0.057
10.603LeuLeu: 10.603 ± 0.138
1.97LeuMet: 1.97 ± 0.043
2.5LeuAsn: 2.5 ± 0.047
5.79LeuPro: 5.79 ± 0.07
3.047LeuGln: 3.047 ± 0.051
7.036LeuArg: 7.036 ± 0.08
6.127LeuSer: 6.127 ± 0.081
6.024LeuThr: 6.024 ± 0.068
8.302LeuVal: 8.302 ± 0.097
1.223LeuTrp: 1.223 ± 0.033
1.732LeuTyr: 1.732 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.635MetAla: 2.635 ± 0.046
0.122MetCys: 0.122 ± 0.009
1.066MetAsp: 1.066 ± 0.028
0.951MetGlu: 0.951 ± 0.029
0.622MetPhe: 0.622 ± 0.023
1.628MetGly: 1.628 ± 0.04
0.37MetHis: 0.37 ± 0.019
0.932MetIle: 0.932 ± 0.03
0.646MetLys: 0.646 ± 0.023
1.981MetLeu: 1.981 ± 0.037
0.406MetMet: 0.406 ± 0.02
0.549MetAsn: 0.549 ± 0.022
1.133MetPro: 1.133 ± 0.029
0.581MetGln: 0.581 ± 0.022
1.201MetArg: 1.201 ± 0.03
1.485MetSer: 1.485 ± 0.037
1.629MetThr: 1.629 ± 0.035
1.546MetVal: 1.546 ± 0.037
0.228MetTrp: 0.228 ± 0.013
0.326MetTyr: 0.326 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.799AsnAla: 2.799 ± 0.05
0.169AsnCys: 0.169 ± 0.011
1.269AsnAsp: 1.269 ± 0.033
1.159AsnGlu: 1.159 ± 0.03
0.791AsnPhe: 0.791 ± 0.025
2.201AsnGly: 2.201 ± 0.045
0.524AsnHis: 0.524 ± 0.023
1.089AsnIle: 1.089 ± 0.036
0.683AsnLys: 0.683 ± 0.025
2.253AsnLeu: 2.253 ± 0.05
0.499AsnMet: 0.499 ± 0.021
0.693AsnAsn: 0.693 ± 0.024
1.856AsnPro: 1.856 ± 0.038
0.711AsnGln: 0.711 ± 0.027
1.598AsnArg: 1.598 ± 0.037
1.321AsnSer: 1.321 ± 0.032
1.352AsnThr: 1.352 ± 0.04
1.906AsnVal: 1.906 ± 0.035
0.367AsnTrp: 0.367 ± 0.016
0.611AsnTyr: 0.611 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
8.595ProAla: 8.595 ± 0.111
0.238ProCys: 0.238 ± 0.015
3.645ProAsp: 3.645 ± 0.058
4.257ProGlu: 4.257 ± 0.06
1.647ProPhe: 1.647 ± 0.038
5.959ProGly: 5.959 ± 0.071
1.081ProHis: 1.081 ± 0.031
1.631ProIle: 1.631 ± 0.04
1.376ProLys: 1.376 ± 0.034
4.928ProLeu: 4.928 ± 0.069
1.015ProMet: 1.015 ± 0.028
1.098ProAsn: 1.098 ± 0.031
2.401ProPro: 2.401 ± 0.056
1.632ProGln: 1.632 ± 0.037
3.081ProArg: 3.081 ± 0.054
3.139ProSer: 3.139 ± 0.054
2.655ProThr: 2.655 ± 0.049
4.891ProVal: 4.891 ± 0.066
0.821ProTrp: 0.821 ± 0.029
1.028ProTyr: 1.028 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.941GlnAla: 3.941 ± 0.061
0.153GlnCys: 0.153 ± 0.011
1.639GlnAsp: 1.639 ± 0.035
1.722GlnGlu: 1.722 ± 0.034
0.903GlnPhe: 0.903 ± 0.025
2.367GlnGly: 2.367 ± 0.043
0.729GlnHis: 0.729 ± 0.027
1.44GlnIle: 1.44 ± 0.033
0.883GlnLys: 0.883 ± 0.027
3.921GlnLeu: 3.921 ± 0.059
0.599GlnMet: 0.599 ± 0.022
0.748GlnAsn: 0.748 ± 0.025
1.753GlnPro: 1.753 ± 0.043
1.384GlnGln: 1.384 ± 0.037
2.352GlnArg: 2.352 ± 0.046
1.637GlnSer: 1.637 ± 0.035
1.493GlnThr: 1.493 ± 0.032
2.269GlnVal: 2.269 ± 0.042
0.478GlnTrp: 0.478 ± 0.021
0.665GlnTyr: 0.665 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.21ArgAla: 7.21 ± 0.082
0.406ArgCys: 0.406 ± 0.018
3.504ArgAsp: 3.504 ± 0.052
3.999ArgGlu: 3.999 ± 0.071
2.246ArgPhe: 2.246 ± 0.038
4.956ArgGly: 4.956 ± 0.068
1.722ArgHis: 1.722 ± 0.036
3.49ArgIle: 3.49 ± 0.057
2.012ArgLys: 2.012 ± 0.043
6.937ArgLeu: 6.937 ± 0.093
1.552ArgMet: 1.552 ± 0.035
1.764ArgAsn: 1.764 ± 0.036
3.571ArgPro: 3.571 ± 0.053
2.394ArgGln: 2.394 ± 0.045
5.636ArgArg: 5.636 ± 0.078
3.976ArgSer: 3.976 ± 0.064
4.141ArgThr: 4.141 ± 0.055
4.651ArgVal: 4.651 ± 0.065
1.095ArgTrp: 1.095 ± 0.032
1.557ArgTyr: 1.557 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.406SerAla: 7.406 ± 0.09
0.398SerCys: 0.398 ± 0.016
2.76SerAsp: 2.76 ± 0.044
2.917SerGlu: 2.917 ± 0.045
2.046SerPhe: 2.046 ± 0.039
6.144SerGly: 6.144 ± 0.064
1.143SerHis: 1.143 ± 0.026
2.429SerIle: 2.429 ± 0.045
1.585SerLys: 1.585 ± 0.041
5.822SerLeu: 5.822 ± 0.067
1.34SerMet: 1.34 ± 0.031
1.359SerAsn: 1.359 ± 0.031
3.326SerPro: 3.326 ± 0.053
1.674SerGln: 1.674 ± 0.036
3.885SerArg: 3.885 ± 0.06
3.555SerSer: 3.555 ± 0.056
3.47SerThr: 3.47 ± 0.05
4.695SerVal: 4.695 ± 0.068
0.957SerTrp: 0.957 ± 0.03
1.468SerTyr: 1.468 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
8.226ThrAla: 8.226 ± 0.09
0.291ThrCys: 0.291 ± 0.018
3.176ThrAsp: 3.176 ± 0.054
3.167ThrGlu: 3.167 ± 0.054
1.832ThrPhe: 1.832 ± 0.04
6.189ThrGly: 6.189 ± 0.076
1.074ThrHis: 1.074 ± 0.031
2.45ThrIle: 2.45 ± 0.039
1.447ThrLys: 1.447 ± 0.037
5.571ThrLeu: 5.571 ± 0.071
1.03ThrMet: 1.03 ± 0.027
1.193ThrAsn: 1.193 ± 0.031
3.701ThrPro: 3.701 ± 0.056
1.483ThrGln: 1.483 ± 0.033
3.342ThrArg: 3.342 ± 0.047
3.32ThrSer: 3.32 ± 0.051
3.499ThrThr: 3.499 ± 0.063
5.543ThrVal: 5.543 ± 0.078
0.702ThrTrp: 0.702 ± 0.027
1.11ThrTyr: 1.11 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
9.974ValAla: 9.974 ± 0.108
0.544ValCys: 0.544 ± 0.021
4.737ValAsp: 4.737 ± 0.068
4.764ValGlu: 4.764 ± 0.069
2.721ValPhe: 2.721 ± 0.05
6.117ValGly: 6.117 ± 0.074
1.651ValHis: 1.651 ± 0.037
3.89ValIle: 3.89 ± 0.062
2.153ValLys: 2.153 ± 0.05
9.25ValLeu: 9.25 ± 0.114
1.66ValMet: 1.66 ± 0.033
2.013ValAsn: 2.013 ± 0.044
4.766ValPro: 4.766 ± 0.067
2.365ValGln: 2.365 ± 0.041
5.37ValArg: 5.37 ± 0.061
4.823ValSer: 4.823 ± 0.055
5.136ValThr: 5.136 ± 0.068
7.37ValVal: 7.37 ± 0.092
1.017ValTrp: 1.017 ± 0.031
1.491ValTyr: 1.491 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.513TrpAla: 1.513 ± 0.036
0.117TrpCys: 0.117 ± 0.009
0.753TrpAsp: 0.753 ± 0.026
0.65TrpGlu: 0.65 ± 0.025
0.553TrpPhe: 0.553 ± 0.018
0.967TrpGly: 0.967 ± 0.031
0.324TrpHis: 0.324 ± 0.016
0.666TrpIle: 0.666 ± 0.025
0.426TrpLys: 0.426 ± 0.017
1.76TrpLeu: 1.76 ± 0.052
0.349TrpMet: 0.349 ± 0.018
0.441TrpAsn: 0.441 ± 0.016
0.696TrpPro: 0.696 ± 0.025
0.575TrpGln: 0.575 ± 0.022
1.022TrpArg: 1.022 ± 0.034
0.85TrpSer: 0.85 ± 0.028
0.875TrpThr: 0.875 ± 0.025
1.028TrpVal: 1.028 ± 0.031
0.305TrpTrp: 0.305 ± 0.019
0.285TrpTyr: 0.285 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.349TyrAla: 2.349 ± 0.038
0.174TyrCys: 0.174 ± 0.01
1.217TyrAsp: 1.217 ± 0.033
1.131TyrGlu: 1.131 ± 0.035
0.835TyrPhe: 0.835 ± 0.03
2.037TyrGly: 2.037 ± 0.044
0.366TyrHis: 0.366 ± 0.018
0.77TyrIle: 0.77 ± 0.028
0.533TyrLys: 0.533 ± 0.023
2.28TyrLeu: 2.28 ± 0.036
0.308TyrMet: 0.308 ± 0.015
0.516TyrAsn: 0.516 ± 0.019
1.072TyrPro: 1.072 ± 0.031
0.708TyrGln: 0.708 ± 0.033
1.627TyrArg: 1.627 ± 0.042
1.269TyrSer: 1.269 ± 0.033
1.138TyrThr: 1.138 ± 0.033
1.584TyrVal: 1.584 ± 0.035
0.331TyrTrp: 0.331 ± 0.013
0.5TyrTyr: 0.5 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4060 proteins (1290115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski