Amino acid dipepetide frequency for Diplodia seriata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.234AlaAla: 12.234 ± 0.097	1.102AlaCys: 1.102 ± 0.018	5.17AlaAsp: 5.17 ± 0.039	5.819AlaGlu: 5.819 ± 0.047	3.449AlaPhe: 3.449 ± 0.034	7.035AlaGly: 7.035 ± 0.057	2.009AlaHis: 2.009 ± 0.025	4.043AlaIle: 4.043 ± 0.036	4.425AlaLys: 4.425 ± 0.039	8.499AlaLeu: 8.499 ± 0.057	2.048AlaMet: 2.048 ± 0.023	3.144AlaAsn: 3.144 ± 0.031	5.528AlaPro: 5.528 ± 0.053	3.706AlaGln: 3.706 ± 0.033	5.667AlaArg: 5.667 ± 0.038	7.704AlaSer: 7.704 ± 0.057	5.661AlaThr: 5.661 ± 0.042	6.191AlaVal: 6.191 ± 0.045	1.322AlaTrp: 1.322 ± 0.022	2.435AlaTyr: 2.435 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.002CysAla: 1.002 ± 0.015	0.222CysCys: 0.222 ± 0.007	0.604CysAsp: 0.604 ± 0.014	0.573CysGlu: 0.573 ± 0.013	0.51CysPhe: 0.51 ± 0.012	0.957CysGly: 0.957 ± 0.018	0.283CysHis: 0.283 ± 0.009	0.612CysIle: 0.612 ± 0.014	0.458CysLys: 0.458 ± 0.011	1.119CysLeu: 1.119 ± 0.019	0.266CysMet: 0.266 ± 0.008	0.38CysAsn: 0.38 ± 0.01	0.6CysPro: 0.6 ± 0.014	0.372CysGln: 0.372 ± 0.01	0.701CysArg: 0.701 ± 0.015	0.774CysSer: 0.774 ± 0.015	0.635CysThr: 0.635 ± 0.014	0.806CysVal: 0.806 ± 0.016	0.196CysTrp: 0.196 ± 0.007	0.339CysTyr: 0.339 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.718AspAla: 5.718 ± 0.042	0.583AspCys: 0.583 ± 0.012	4.819AspAsp: 4.819 ± 0.053	4.806AspGlu: 4.806 ± 0.041	2.296AspPhe: 2.296 ± 0.027	4.591AspGly: 4.591 ± 0.036	1.169AspHis: 1.169 ± 0.018	2.675AspIle: 2.675 ± 0.03	2.335AspLys: 2.335 ± 0.03	4.864AspLeu: 4.864 ± 0.037	1.222AspMet: 1.222 ± 0.018	1.737AspAsn: 1.737 ± 0.022	3.393AspPro: 3.393 ± 0.028	1.754AspGln: 1.754 ± 0.024	3.1AspArg: 3.1 ± 0.034	3.786AspSer: 3.786 ± 0.034	2.806AspThr: 2.806 ± 0.03	4.104AspVal: 4.104 ± 0.033	0.917AspTrp: 0.917 ± 0.016	1.604AspTyr: 1.604 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.875GluAla: 5.875 ± 0.048	0.565GluCys: 0.565 ± 0.012	4.311GluAsp: 4.311 ± 0.043	5.866GluGlu: 5.866 ± 0.059	1.841GluPhe: 1.841 ± 0.021	4.347GluGly: 4.347 ± 0.04	1.404GluHis: 1.404 ± 0.02	2.691GluIle: 2.691 ± 0.029	3.866GluLys: 3.866 ± 0.038	5.178GluLeu: 5.178 ± 0.045	1.476GluMet: 1.476 ± 0.02	2.094GluAsn: 2.094 ± 0.025	2.709GluPro: 2.709 ± 0.034	2.547GluGln: 2.547 ± 0.031	4.359GluArg: 4.359 ± 0.04	3.859GluSer: 3.859 ± 0.04	3.184GluThr: 3.184 ± 0.031	3.703GluVal: 3.703 ± 0.033	0.929GluTrp: 0.929 ± 0.016	1.634GluTyr: 1.634 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.446PheAla: 3.446 ± 0.037	0.547PheCys: 0.547 ± 0.013	2.341PheAsp: 2.341 ± 0.028	2.146PheGlu: 2.146 ± 0.026	1.712PhePhe: 1.712 ± 0.024	3.003PheGly: 3.003 ± 0.031	0.856PheHis: 0.856 ± 0.015	1.585PheIle: 1.585 ± 0.023	1.46PheLys: 1.46 ± 0.024	3.358PheLeu: 3.358 ± 0.034	0.758PheMet: 0.758 ± 0.014	1.385PheAsn: 1.385 ± 0.019	1.926PhePro: 1.926 ± 0.022	1.238PheGln: 1.238 ± 0.018	1.901PheArg: 1.901 ± 0.02	2.776PheSer: 2.776 ± 0.028	2.053PheThr: 2.053 ± 0.025	2.564PheVal: 2.564 ± 0.031	0.666PheTrp: 0.666 ± 0.015	1.092PheTyr: 1.092 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	6.667GlyAla: 6.667 ± 0.054	0.87GlyCys: 0.87 ± 0.016	4.027GlyAsp: 4.027 ± 0.038	4.27GlyGlu: 4.27 ± 0.04	2.945GlyPhe: 2.945 ± 0.031	7.645GlyGly: 7.645 ± 0.095	1.685GlyHis: 1.685 ± 0.024	3.326GlyIle: 3.326 ± 0.032	3.585GlyLys: 3.585 ± 0.032	6.134GlyLeu: 6.134 ± 0.049	1.729GlyMet: 1.729 ± 0.027	2.493GlyAsn: 2.493 ± 0.029	3.41GlyPro: 3.41 ± 0.035	2.496GlyGln: 2.496 ± 0.029	4.495GlyArg: 4.495 ± 0.041	5.857GlySer: 5.857 ± 0.054	4.102GlyThr: 4.102 ± 0.038	4.947GlyVal: 4.947 ± 0.044	1.319GlyTrp: 1.319 ± 0.02	2.141GlyTyr: 2.141 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.145HisAla: 2.145 ± 0.022	0.314HisCys: 0.314 ± 0.009	1.301HisAsp: 1.301 ± 0.02	1.317HisGlu: 1.317 ± 0.018	0.915HisPhe: 0.915 ± 0.016	1.732HisGly: 1.732 ± 0.022	0.947HisHis: 0.947 ± 0.019	1.018HisIle: 1.018 ± 0.016	0.871HisLys: 0.871 ± 0.016	2.126HisLeu: 2.126 ± 0.03	0.472HisMet: 0.472 ± 0.01	0.779HisAsn: 0.779 ± 0.013	1.653HisPro: 1.653 ± 0.022	0.974HisGln: 0.974 ± 0.017	1.512HisArg: 1.512 ± 0.022	1.689HisSer: 1.689 ± 0.023	1.212HisThr: 1.212 ± 0.017	1.498HisVal: 1.498 ± 0.02	0.327HisTrp: 0.327 ± 0.01	0.688HisTyr: 0.688 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.064IleAla: 4.064 ± 0.035	0.633IleCys: 0.633 ± 0.013	2.603IleAsp: 2.603 ± 0.028	2.529IleGlu: 2.529 ± 0.029	1.761IlePhe: 1.761 ± 0.023	2.96IleGly: 2.96 ± 0.034	1.044IleHis: 1.044 ± 0.015	2.063IleIle: 2.063 ± 0.025	1.994IleLys: 1.994 ± 0.023	3.892IleLeu: 3.892 ± 0.036	0.912IleMet: 0.912 ± 0.015	1.648IleAsn: 1.648 ± 0.02	2.66IlePro: 2.66 ± 0.026	1.584IleGln: 1.584 ± 0.021	2.508IleArg: 2.508 ± 0.027	3.171IleSer: 3.171 ± 0.033	2.558IleThr: 2.558 ± 0.029	3.024IleVal: 3.024 ± 0.033	0.649IleTrp: 0.649 ± 0.014	1.25IleTyr: 1.25 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.453LysAla: 4.453 ± 0.043	0.44LysCys: 0.44 ± 0.011	2.787LysAsp: 2.787 ± 0.031	3.458LysGlu: 3.458 ± 0.038	1.397LysPhe: 1.397 ± 0.019	3.126LysGly: 3.126 ± 0.032	1.105LysHis: 1.105 ± 0.019	1.994LysIle: 1.994 ± 0.024	3.527LysLys: 3.527 ± 0.049	3.888LysLeu: 3.888 ± 0.036	0.962LysMet: 0.962 ± 0.016	1.671LysAsn: 1.671 ± 0.022	2.723LysPro: 2.723 ± 0.034	1.833LysGln: 1.833 ± 0.023	3.457LysArg: 3.457 ± 0.037	3.151LysSer: 3.151 ± 0.034	2.662LysThr: 2.662 ± 0.027	2.824LysVal: 2.824 ± 0.028	0.647LysTrp: 0.647 ± 0.015	1.292LysTyr: 1.292 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.345LeuAla: 8.345 ± 0.061	1.113LeuCys: 1.113 ± 0.019	5.126LeuAsp: 5.126 ± 0.041	5.21LeuGlu: 5.21 ± 0.043	3.323LeuPhe: 3.323 ± 0.04	6.046LeuGly: 6.046 ± 0.049	2.196LeuHis: 2.196 ± 0.026	3.494LeuIle: 3.494 ± 0.032	3.996LeuLys: 3.996 ± 0.041	8.179LeuLeu: 8.179 ± 0.07	1.732LeuMet: 1.732 ± 0.022	2.978LeuAsn: 2.978 ± 0.032	5.36LeuPro: 5.36 ± 0.035	3.534LeuGln: 3.534 ± 0.035	5.801LeuArg: 5.801 ± 0.044	6.66LeuSer: 6.66 ± 0.045	4.672LeuThr: 4.672 ± 0.038	5.423LeuVal: 5.423 ± 0.04	1.198LeuTrp: 1.198 ± 0.019	2.274LeuTyr: 2.274 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.246MetAla: 2.246 ± 0.026	0.241MetCys: 0.241 ± 0.007	1.271MetAsp: 1.271 ± 0.019	1.229MetGlu: 1.229 ± 0.021	0.732MetPhe: 0.732 ± 0.014	1.536MetGly: 1.536 ± 0.022	0.483MetHis: 0.483 ± 0.012	0.887MetIle: 0.887 ± 0.016	0.96MetLys: 0.96 ± 0.016	1.897MetLeu: 1.897 ± 0.022	0.551MetMet: 0.551 ± 0.013	0.746MetAsn: 0.746 ± 0.014	1.28MetPro: 1.28 ± 0.019	0.85MetGln: 0.85 ± 0.015	1.352MetArg: 1.352 ± 0.019	1.69MetSer: 1.69 ± 0.024	1.205MetThr: 1.205 ± 0.018	1.325MetVal: 1.325 ± 0.018	0.289MetTrp: 0.289 ± 0.008	0.518MetTyr: 0.518 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.301AsnAla: 3.301 ± 0.029	0.389AsnCys: 0.389 ± 0.011	1.896AsnAsp: 1.896 ± 0.021	1.866AsnGlu: 1.866 ± 0.021	1.321AsnPhe: 1.321 ± 0.02	3.024AsnGly: 3.024 ± 0.034	0.782AsnHis: 0.782 ± 0.014	1.772AsnIle: 1.772 ± 0.023	1.509AsnLys: 1.509 ± 0.021	2.955AsnLeu: 2.955 ± 0.026	0.797AsnMet: 0.797 ± 0.016	1.486AsnAsn: 1.486 ± 0.026	2.295AsnPro: 2.295 ± 0.028	1.181AsnGln: 1.181 ± 0.018	1.801AsnArg: 1.801 ± 0.023	2.46AsnSer: 2.46 ± 0.031	2.04AsnThr: 2.04 ± 0.022	2.338AsnVal: 2.338 ± 0.026	0.525AsnTrp: 0.525 ± 0.013	0.999AsnTyr: 0.999 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.155ProAla: 6.155 ± 0.059	0.44ProCys: 0.44 ± 0.013	3.302ProAsp: 3.302 ± 0.032	3.718ProGlu: 3.718 ± 0.035	2.033ProPhe: 2.033 ± 0.025	4.101ProGly: 4.101 ± 0.036	1.416ProHis: 1.416 ± 0.019	2.204ProIle: 2.204 ± 0.023	2.547ProLys: 2.547 ± 0.034	4.697ProLeu: 4.697 ± 0.036	1.073ProMet: 1.073 ± 0.02	2.065ProAsn: 2.065 ± 0.025	5.723ProPro: 5.723 ± 0.084	2.518ProGln: 2.518 ± 0.038	3.515ProArg: 3.515 ± 0.04	5.774ProSer: 5.774 ± 0.061	3.911ProThr: 3.911 ± 0.037	3.581ProVal: 3.581 ± 0.035	0.726ProTrp: 0.726 ± 0.015	1.507ProTyr: 1.507 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.554GlnAla: 3.554 ± 0.041	0.395GlnCys: 0.395 ± 0.01	1.955GlnAsp: 1.955 ± 0.026	2.285GlnGlu: 2.285 ± 0.027	1.194GlnPhe: 1.194 ± 0.019	2.308GlnGly: 2.308 ± 0.029	1.116GlnHis: 1.116 ± 0.019	1.64GlnIle: 1.64 ± 0.018	1.905GlnLys: 1.905 ± 0.024	3.329GlnLeu: 3.329 ± 0.03	0.882GlnMet: 0.882 ± 0.016	1.399GlnAsn: 1.399 ± 0.024	2.593GlnPro: 2.593 ± 0.038	2.847GlnGln: 2.847 ± 0.077	2.671GlnArg: 2.671 ± 0.027	2.747GlnSer: 2.747 ± 0.031	2.133GlnThr: 2.133 ± 0.026	2.007GlnVal: 2.007 ± 0.023	0.558GlnTrp: 0.558 ± 0.012	1.112GlnTyr: 1.112 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.44ArgAla: 5.44 ± 0.045	0.695ArgCys: 0.695 ± 0.015	3.459ArgAsp: 3.459 ± 0.038	4.104ArgGlu: 4.104 ± 0.046	2.148ArgPhe: 2.148 ± 0.027	4.118ArgGly: 4.118 ± 0.05	1.522ArgHis: 1.522 ± 0.019	2.703ArgIle: 2.703 ± 0.029	3.519ArgLys: 3.519 ± 0.035	5.41ArgLeu: 5.41 ± 0.04	1.352ArgMet: 1.352 ± 0.02	2.202ArgAsn: 2.202 ± 0.023	3.565ArgPro: 3.565 ± 0.031	2.527ArgGln: 2.527 ± 0.029	5.448ArgArg: 5.448 ± 0.057	4.617ArgSer: 4.617 ± 0.055	3.324ArgThr: 3.324 ± 0.033	3.614ArgVal: 3.614 ± 0.029	1.011ArgTrp: 1.011 ± 0.016	1.625ArgTyr: 1.625 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.224SerAla: 7.224 ± 0.056	0.75SerCys: 0.75 ± 0.016	3.999SerAsp: 3.999 ± 0.035	3.765SerGlu: 3.765 ± 0.039	2.845SerPhe: 2.845 ± 0.03	5.608SerGly: 5.608 ± 0.043	1.716SerHis: 1.716 ± 0.021	3.408SerIle: 3.408 ± 0.035	3.336SerLys: 3.336 ± 0.032	6.45SerLeu: 6.45 ± 0.042	1.595SerMet: 1.595 ± 0.023	2.736SerAsn: 2.736 ± 0.032	5.437SerPro: 5.437 ± 0.074	2.822SerGln: 2.822 ± 0.032	4.644SerArg: 4.644 ± 0.051	8.509SerSer: 8.509 ± 0.106	5.194SerThr: 5.194 ± 0.045	4.397SerVal: 4.397 ± 0.036	1.063SerTrp: 1.063 ± 0.019	1.946SerTyr: 1.946 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.721ThrAla: 5.721 ± 0.038	0.668ThrCys: 0.668 ± 0.015	2.796ThrAsp: 2.796 ± 0.029	2.885ThrGlu: 2.885 ± 0.03	2.176ThrPhe: 2.176 ± 0.023	4.214ThrGly: 4.214 ± 0.038	1.28ThrHis: 1.28 ± 0.018	2.727ThrIle: 2.727 ± 0.028	2.407ThrLys: 2.407 ± 0.026	4.998ThrLeu: 4.998 ± 0.037	1.125ThrMet: 1.125 ± 0.017	2.026ThrAsn: 2.026 ± 0.025	4.39ThrPro: 4.39 ± 0.051	1.931ThrGln: 1.931 ± 0.021	2.991ThrArg: 2.991 ± 0.029	4.836ThrSer: 4.836 ± 0.048	4.338ThrThr: 4.338 ± 0.053	3.702ThrVal: 3.702 ± 0.03	0.832ThrTrp: 0.832 ± 0.015	1.545ThrTyr: 1.545 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.985ValAla: 5.985 ± 0.047	0.844ValCys: 0.844 ± 0.017	3.916ValAsp: 3.916 ± 0.033	4.205ValGlu: 4.205 ± 0.032	2.507ValPhe: 2.507 ± 0.028	4.627ValGly: 4.627 ± 0.044	1.405ValHis: 1.405 ± 0.019	2.666ValIle: 2.666 ± 0.029	2.894ValLys: 2.894 ± 0.035	5.728ValLeu: 5.728 ± 0.047	1.36ValMet: 1.36 ± 0.02	2.143ValAsn: 2.143 ± 0.027	3.701ValPro: 3.701 ± 0.032	2.331ValGln: 2.331 ± 0.028	3.855ValArg: 3.855 ± 0.033	4.453ValSer: 4.453 ± 0.037	3.372ValThr: 3.372 ± 0.034	4.873ValVal: 4.873 ± 0.047	0.957ValTrp: 0.957 ± 0.018	1.745ValTyr: 1.745 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.254TrpAla: 1.254 ± 0.021	0.208TrpCys: 0.208 ± 0.007	0.917TrpAsp: 0.917 ± 0.015	0.866TrpGlu: 0.866 ± 0.016	0.563TrpPhe: 0.563 ± 0.014	0.999TrpGly: 0.999 ± 0.019	0.371TrpHis: 0.371 ± 0.01	0.723TrpIle: 0.723 ± 0.013	0.749TrpLys: 0.749 ± 0.014	1.384TrpLeu: 1.384 ± 0.022	0.373TrpMet: 0.373 ± 0.01	0.581TrpAsn: 0.581 ± 0.013	0.615TrpPro: 0.615 ± 0.013	0.571TrpGln: 0.571 ± 0.012	1.054TrpArg: 1.054 ± 0.019	1.032TrpSer: 1.032 ± 0.018	0.932TrpThr: 0.932 ± 0.016	0.943TrpVal: 0.943 ± 0.017	0.311TrpTrp: 0.311 ± 0.01	0.442TrpTyr: 0.442 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.027	0.39TyrCys: 0.39 ± 0.01	1.676TyrAsp: 1.676 ± 0.023	1.519TyrGlu: 1.519 ± 0.022	1.145TyrPhe: 1.145 ± 0.02	2.165TyrGly: 2.165 ± 0.028	0.702TyrHis: 0.702 ± 0.013	1.276TyrIle: 1.276 ± 0.019	1.055TyrLys: 1.055 ± 0.018	2.574TyrLeu: 2.574 ± 0.026	0.604TyrMet: 0.604 ± 0.012	1.046TyrAsn: 1.046 ± 0.018	1.443TyrPro: 1.443 ± 0.02	1.015TyrGln: 1.015 ± 0.017	1.572TyrArg: 1.572 ± 0.022	1.899TyrSer: 1.899 ± 0.024	1.594TyrThr: 1.594 ± 0.026	1.703TyrVal: 1.703 ± 0.02	0.446TyrTrp: 0.446 ± 0.013	0.935TyrTyr: 0.935 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8038 proteins (4002348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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