Amino acid dipepetide frequency for Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.674AlaAla: 4.674 ± 0.053	1.239AlaCys: 1.239 ± 0.019	2.99AlaAsp: 2.99 ± 0.026	3.919AlaGlu: 3.919 ± 0.043	2.653AlaPhe: 2.653 ± 0.029	2.867AlaGly: 2.867 ± 0.035	1.383AlaHis: 1.383 ± 0.018	3.845AlaIle: 3.845 ± 0.03	3.602AlaLys: 3.602 ± 0.03	5.973AlaLeu: 5.973 ± 0.045	1.437AlaMet: 1.437 ± 0.02	2.821AlaAsn: 2.821 ± 0.028	2.257AlaPro: 2.257 ± 0.029	2.333AlaGln: 2.333 ± 0.03	3.041AlaArg: 3.041 ± 0.032	4.869AlaSer: 4.869 ± 0.039	3.321AlaThr: 3.321 ± 0.029	4.645AlaVal: 4.645 ± 0.033	0.567AlaTrp: 0.567 ± 0.013	1.823AlaTyr: 1.823 ± 0.024	0.001AlaXaa: 0.001 ± 0.0
Cys	1.343CysAla: 1.343 ± 0.021	0.681CysCys: 0.681 ± 0.018	1.358CysAsp: 1.358 ± 0.029	1.39CysGlu: 1.39 ± 0.024	1.069CysPhe: 1.069 ± 0.018	1.371CysGly: 1.371 ± 0.023	0.594CysHis: 0.594 ± 0.015	1.515CysIle: 1.515 ± 0.027	1.356CysLys: 1.356 ± 0.024	2.065CysLeu: 2.065 ± 0.026	0.522CysMet: 0.522 ± 0.011	1.156CysAsn: 1.156 ± 0.019	1.073CysPro: 1.073 ± 0.03	0.877CysGln: 0.877 ± 0.017	1.312CysArg: 1.312 ± 0.022	2.143CysSer: 2.143 ± 0.029	1.211CysThr: 1.211 ± 0.017	1.337CysVal: 1.337 ± 0.022	0.263CysTrp: 0.263 ± 0.008	0.771CysTyr: 0.771 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.09AspAla: 3.09 ± 0.029	1.182AspCys: 1.182 ± 0.022	3.736AspAsp: 3.736 ± 0.044	4.361AspGlu: 4.361 ± 0.04	2.477AspPhe: 2.477 ± 0.022	3.144AspGly: 3.144 ± 0.043	1.175AspHis: 1.175 ± 0.017	3.492AspIle: 3.492 ± 0.03	2.888AspLys: 2.888 ± 0.026	4.897AspLeu: 4.897 ± 0.04	1.219AspMet: 1.219 ± 0.02	2.448AspAsn: 2.448 ± 0.026	1.978AspPro: 1.978 ± 0.021	1.898AspGln: 1.898 ± 0.021	2.685AspArg: 2.685 ± 0.029	4.232AspSer: 4.232 ± 0.035	2.29AspThr: 2.29 ± 0.023	3.48AspVal: 3.48 ± 0.031	0.652AspTrp: 0.652 ± 0.014	1.841AspTyr: 1.841 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	3.784GluAla: 3.784 ± 0.043	1.371GluCys: 1.371 ± 0.025	3.313GluAsp: 3.313 ± 0.03	5.263GluGlu: 5.263 ± 0.06	2.307GluPhe: 2.307 ± 0.022	2.669GluGly: 2.669 ± 0.026	1.456GluHis: 1.456 ± 0.019	4.351GluIle: 4.351 ± 0.035	5.272GluLys: 5.272 ± 0.052	5.854GluLeu: 5.854 ± 0.054	1.861GluMet: 1.861 ± 0.02	3.898GluAsn: 3.898 ± 0.035	1.964GluPro: 1.964 ± 0.023	2.95GluGln: 2.95 ± 0.034	3.852GluArg: 3.852 ± 0.039	4.641GluSer: 4.641 ± 0.04	3.337GluThr: 3.337 ± 0.029	3.676GluVal: 3.676 ± 0.034	0.736GluTrp: 0.736 ± 0.016	2.005GluTyr: 2.005 ± 0.024	0.001GluXaa: 0.001 ± 0.0
Phe	2.767PheAla: 2.767 ± 0.026	1.199PheCys: 1.199 ± 0.017	2.549PheAsp: 2.549 ± 0.021	2.594PheGlu: 2.594 ± 0.024	2.108PhePhe: 2.108 ± 0.029	2.681PheGly: 2.681 ± 0.031	1.17PheHis: 1.17 ± 0.018	2.997PheIle: 2.997 ± 0.031	2.121PheLys: 2.121 ± 0.023	4.311PheLeu: 4.311 ± 0.042	1.076PheMet: 1.076 ± 0.015	1.903PheAsn: 1.903 ± 0.022	1.778PhePro: 1.778 ± 0.025	1.62PheGln: 1.62 ± 0.021	2.327PheArg: 2.327 ± 0.027	3.714PheSer: 3.714 ± 0.032	2.419PheThr: 2.419 ± 0.021	2.909PheVal: 2.909 ± 0.031	0.57PheTrp: 0.57 ± 0.012	1.633PheTyr: 1.633 ± 0.019	0.001PheXaa: 0.001 ± 0.0
Gly	2.788GlyAla: 2.788 ± 0.035	1.097GlyCys: 1.097 ± 0.02	2.593GlyAsp: 2.593 ± 0.028	2.837GlyGlu: 2.837 ± 0.032	2.306GlyPhe: 2.306 ± 0.026	2.897GlyGly: 2.897 ± 0.047	1.227GlyHis: 1.227 ± 0.019	3.44GlyIle: 3.44 ± 0.032	3.168GlyLys: 3.168 ± 0.03	4.078GlyLeu: 4.078 ± 0.045	1.195GlyMet: 1.195 ± 0.021	2.567GlyAsn: 2.567 ± 0.024	1.782GlyPro: 1.782 ± 0.035	1.854GlyGln: 1.854 ± 0.025	2.923GlyArg: 2.923 ± 0.034	4.159GlySer: 4.159 ± 0.036	2.851GlyThr: 2.851 ± 0.028	2.893GlyVal: 2.893 ± 0.031	0.605GlyTrp: 0.605 ± 0.014	1.798GlyTyr: 1.798 ± 0.028	0.001GlyXaa: 0.001 ± 0.0
His	1.345HisAla: 1.345 ± 0.017	0.705HisCys: 0.705 ± 0.013	1.157HisAsp: 1.157 ± 0.015	1.454HisGlu: 1.454 ± 0.021	1.316HisPhe: 1.316 ± 0.018	1.221HisGly: 1.221 ± 0.017	0.758HisHis: 0.758 ± 0.017	1.626HisIle: 1.626 ± 0.022	1.245HisLys: 1.245 ± 0.02	2.539HisLeu: 2.539 ± 0.028	0.568HisMet: 0.568 ± 0.012	1.105HisAsn: 1.105 ± 0.017	1.13HisPro: 1.13 ± 0.016	1.056HisGln: 1.056 ± 0.019	1.456HisArg: 1.456 ± 0.019	2.119HisSer: 2.119 ± 0.025	1.153HisThr: 1.153 ± 0.018	1.445HisVal: 1.445 ± 0.02	0.321HisTrp: 0.321 ± 0.008	0.956HisTyr: 0.956 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.256IleAla: 4.256 ± 0.031	1.709IleCys: 1.709 ± 0.026	3.674IleAsp: 3.674 ± 0.031	3.972IleGlu: 3.972 ± 0.036	3.096IlePhe: 3.096 ± 0.032	3.241IleGly: 3.241 ± 0.03	1.592IleHis: 1.592 ± 0.02	4.243IleIle: 4.243 ± 0.039	3.54IleLys: 3.54 ± 0.032	5.822IleLeu: 5.822 ± 0.042	1.41IleMet: 1.41 ± 0.019	3.172IleAsn: 3.172 ± 0.026	2.981IlePro: 2.981 ± 0.028	2.338IleGln: 2.338 ± 0.026	3.571IleArg: 3.571 ± 0.03	5.803IleSer: 5.803 ± 0.041	3.663IleThr: 3.663 ± 0.036	3.964IleVal: 3.964 ± 0.033	0.745IleTrp: 0.745 ± 0.015	2.145IleTyr: 2.145 ± 0.025	0.001IleXaa: 0.001 ± 0.0
Lys	3.417LysAla: 3.417 ± 0.034	1.475LysCys: 1.475 ± 0.025	2.959LysAsp: 2.959 ± 0.032	4.318LysGlu: 4.318 ± 0.048	2.523LysPhe: 2.523 ± 0.025	2.541LysGly: 2.541 ± 0.033	1.531LysHis: 1.531 ± 0.021	4.179LysIle: 4.179 ± 0.034	5.243LysLys: 5.243 ± 0.054	6.047LysLeu: 6.047 ± 0.048	1.689LysMet: 1.689 ± 0.021	3.575LysAsn: 3.575 ± 0.037	2.317LysPro: 2.317 ± 0.026	2.766LysGln: 2.766 ± 0.029	3.916LysArg: 3.916 ± 0.033	4.608LysSer: 4.608 ± 0.043	3.212LysThr: 3.212 ± 0.03	3.543LysVal: 3.543 ± 0.03	0.748LysTrp: 0.748 ± 0.013	2.186LysTyr: 2.186 ± 0.025	0.001LysXaa: 0.001 ± 0.0
Leu	5.713LeuAla: 5.713 ± 0.047	2.211LeuCys: 2.211 ± 0.028	4.659LeuAsp: 4.659 ± 0.036	5.792LeuGlu: 5.792 ± 0.05	4.197LeuPhe: 4.197 ± 0.04	3.806LeuGly: 3.806 ± 0.032	2.63LeuHis: 2.63 ± 0.029	5.978LeuIle: 5.978 ± 0.041	6.231LeuLys: 6.231 ± 0.044	9.989LeuLeu: 9.989 ± 0.074	2.308LeuMet: 2.308 ± 0.022	4.734LeuAsn: 4.734 ± 0.038	4.621LeuPro: 4.621 ± 0.04	4.348LeuGln: 4.348 ± 0.036	5.6LeuArg: 5.6 ± 0.041	8.08LeuSer: 8.08 ± 0.055	4.912LeuThr: 4.912 ± 0.042	5.041LeuVal: 5.041 ± 0.036	1.001LeuTrp: 1.001 ± 0.014	2.951LeuTyr: 2.951 ± 0.026	0.001LeuXaa: 0.001 ± 0.0
Met	1.512MetAla: 1.512 ± 0.018	0.49MetCys: 0.49 ± 0.011	1.343MetAsp: 1.343 ± 0.022	1.681MetGlu: 1.681 ± 0.022	0.938MetPhe: 0.938 ± 0.017	1.022MetGly: 1.022 ± 0.015	0.635MetHis: 0.635 ± 0.012	1.512MetIle: 1.512 ± 0.019	1.792MetLys: 1.792 ± 0.02	2.335MetLeu: 2.335 ± 0.023	0.641MetMet: 0.641 ± 0.014	1.324MetAsn: 1.324 ± 0.018	0.998MetPro: 0.998 ± 0.018	1.196MetGln: 1.196 ± 0.017	1.331MetArg: 1.331 ± 0.017	1.81MetSer: 1.81 ± 0.021	1.271MetThr: 1.271 ± 0.016	1.374MetVal: 1.374 ± 0.019	0.245MetTrp: 0.245 ± 0.008	0.681MetTyr: 0.681 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.083AsnAla: 3.083 ± 0.031	1.216AsnCys: 1.216 ± 0.021	3.092AsnAsp: 3.092 ± 0.029	3.723AsnGlu: 3.723 ± 0.034	2.432AsnPhe: 2.432 ± 0.023	2.946AsnGly: 2.946 ± 0.035	1.152AsnHis: 1.152 ± 0.016	3.487AsnIle: 3.487 ± 0.029	2.786AsnLys: 2.786 ± 0.025	4.566AsnLeu: 4.566 ± 0.04	1.207AsnMet: 1.207 ± 0.017	2.76AsnAsn: 2.76 ± 0.036	1.932AsnPro: 1.932 ± 0.024	1.852AsnGln: 1.852 ± 0.025	2.574AsnArg: 2.574 ± 0.024	4.279AsnSer: 4.279 ± 0.043	2.514AsnThr: 2.514 ± 0.028	3.196AsnVal: 3.196 ± 0.027	0.572AsnTrp: 0.572 ± 0.011	1.822AsnTyr: 1.822 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	2.219ProAla: 2.219 ± 0.026	0.819ProCys: 0.819 ± 0.02	2.019ProAsp: 2.019 ± 0.027	2.595ProGlu: 2.595 ± 0.027	1.903ProPhe: 1.903 ± 0.021	2.194ProGly: 2.194 ± 0.081	0.947ProHis: 0.947 ± 0.013	2.4ProIle: 2.4 ± 0.023	2.357ProLys: 2.357 ± 0.025	3.841ProLeu: 3.841 ± 0.03	0.805ProMet: 0.805 ± 0.014	2.038ProAsn: 2.038 ± 0.021	2.819ProPro: 2.819 ± 0.058	1.663ProGln: 1.663 ± 0.026	1.959ProArg: 1.959 ± 0.024	4.015ProSer: 4.015 ± 0.043	2.323ProThr: 2.323 ± 0.023	2.836ProVal: 2.836 ± 0.028	0.416ProTrp: 0.416 ± 0.01	1.437ProTyr: 1.437 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.244GlnAla: 2.244 ± 0.027	1.004GlnCys: 1.004 ± 0.022	1.469GlnAsp: 1.469 ± 0.021	2.38GlnGlu: 2.38 ± 0.029	1.747GlnPhe: 1.747 ± 0.019	1.474GlnGly: 1.474 ± 0.021	1.096GlnHis: 1.096 ± 0.021	2.855GlnIle: 2.855 ± 0.028	2.981GlnLys: 2.981 ± 0.035	4.241GlnLeu: 4.241 ± 0.036	1.191GlnMet: 1.191 ± 0.017	2.27GlnAsn: 2.27 ± 0.025	1.657GlnPro: 1.657 ± 0.024	2.755GlnGln: 2.755 ± 0.066	2.41GlnArg: 2.41 ± 0.023	3.066GlnSer: 3.066 ± 0.025	2.076GlnThr: 2.076 ± 0.023	2.213GlnVal: 2.213 ± 0.023	0.509GlnTrp: 0.509 ± 0.01	1.355GlnTyr: 1.355 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	2.89ArgAla: 2.89 ± 0.028	1.354ArgCys: 1.354 ± 0.026	2.661ArgAsp: 2.661 ± 0.031	3.405ArgGlu: 3.405 ± 0.033	2.49ArgPhe: 2.49 ± 0.027	2.48ArgGly: 2.48 ± 0.034	1.439ArgHis: 1.439 ± 0.018	3.764ArgIle: 3.764 ± 0.031	4.118ArgLys: 4.118 ± 0.04	5.318ArgLeu: 5.318 ± 0.04	1.367ArgMet: 1.367 ± 0.016	3.147ArgAsn: 3.147 ± 0.023	2.069ArgPro: 2.069 ± 0.023	2.345ArgGln: 2.345 ± 0.026	4.119ArgArg: 4.119 ± 0.045	4.508ArgSer: 4.508 ± 0.043	2.856ArgThr: 2.856 ± 0.028	2.893ArgVal: 2.893 ± 0.029	0.649ArgTrp: 0.649 ± 0.014	1.888ArgTyr: 1.888 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	5.139SerAla: 5.139 ± 0.038	1.86SerCys: 1.86 ± 0.026	4.7SerAsp: 4.7 ± 0.036	5.055SerGlu: 5.055 ± 0.045	3.641SerPhe: 3.641 ± 0.033	4.399SerGly: 4.399 ± 0.042	1.931SerHis: 1.931 ± 0.023	4.882SerIle: 4.882 ± 0.036	4.889SerLys: 4.889 ± 0.041	7.806SerLeu: 7.806 ± 0.057	1.809SerMet: 1.809 ± 0.021	4.409SerAsn: 4.409 ± 0.043	3.363SerPro: 3.363 ± 0.039	3.158SerGln: 3.158 ± 0.033	4.373SerArg: 4.373 ± 0.042	9.449SerSer: 9.449 ± 0.086	5.16SerThr: 5.16 ± 0.043	5.569SerVal: 5.569 ± 0.034	0.847SerTrp: 0.847 ± 0.013	2.421SerTyr: 2.421 ± 0.025	0.001SerXaa: 0.001 ± 0.0
Thr	3.611ThrAla: 3.611 ± 0.034	1.207ThrCys: 1.207 ± 0.025	2.888ThrAsp: 2.888 ± 0.029	3.238ThrGlu: 3.238 ± 0.036	2.417ThrPhe: 2.417 ± 0.022	2.766ThrGly: 2.766 ± 0.03	1.156ThrHis: 1.156 ± 0.016	3.322ThrIle: 3.322 ± 0.029	3.034ThrLys: 3.034 ± 0.032	4.945ThrLeu: 4.945 ± 0.034	1.183ThrMet: 1.183 ± 0.015	2.649ThrAsn: 2.649 ± 0.028	2.346ThrPro: 2.346 ± 0.024	1.784ThrGln: 1.784 ± 0.021	2.42ThrArg: 2.42 ± 0.025	5.037ThrSer: 5.037 ± 0.048	3.471ThrThr: 3.471 ± 0.039	3.948ThrVal: 3.948 ± 0.031	0.531ThrTrp: 0.531 ± 0.012	1.626ThrTyr: 1.626 ± 0.02	0.001ThrXaa: 0.001 ± 0.0
Val	3.927ValAla: 3.927 ± 0.032	1.437ValCys: 1.437 ± 0.024	3.561ValAsp: 3.561 ± 0.033	4.029ValGlu: 4.029 ± 0.038	2.603ValPhe: 2.603 ± 0.024	2.947ValGly: 2.947 ± 0.031	1.57ValHis: 1.57 ± 0.019	4.227ValIle: 4.227 ± 0.038	3.619ValLys: 3.619 ± 0.032	5.817ValLeu: 5.817 ± 0.043	1.493ValMet: 1.493 ± 0.02	2.996ValAsn: 2.996 ± 0.026	2.761ValPro: 2.761 ± 0.031	2.42ValGln: 2.42 ± 0.024	3.239ValArg: 3.239 ± 0.029	4.863ValSer: 4.863 ± 0.038	3.4ValThr: 3.4 ± 0.029	4.114ValVal: 4.114 ± 0.048	0.639ValTrp: 0.639 ± 0.013	1.887ValTyr: 1.887 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.559TrpAla: 0.559 ± 0.011	0.243TrpCys: 0.243 ± 0.008	0.565TrpAsp: 0.565 ± 0.012	0.582TrpGlu: 0.582 ± 0.012	0.512TrpPhe: 0.512 ± 0.01	0.418TrpGly: 0.418 ± 0.011	0.299TrpHis: 0.299 ± 0.01	0.805TrpIle: 0.805 ± 0.016	0.845TrpLys: 0.845 ± 0.015	1.154TrpLeu: 1.154 ± 0.018	0.343TrpMet: 0.343 ± 0.01	0.706TrpAsn: 0.706 ± 0.014	0.448TrpPro: 0.448 ± 0.012	0.485TrpGln: 0.485 ± 0.012	0.675TrpArg: 0.675 ± 0.012	0.889TrpSer: 0.889 ± 0.017	0.62TrpThr: 0.62 ± 0.011	0.507TrpVal: 0.507 ± 0.01	0.163TrpTrp: 0.163 ± 0.007	0.391TrpTyr: 0.391 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.896TyrAla: 1.896 ± 0.023	0.908TyrCys: 0.908 ± 0.016	1.881TyrAsp: 1.881 ± 0.023	1.972TyrGlu: 1.972 ± 0.024	1.709TyrPhe: 1.709 ± 0.02	1.976TyrGly: 1.976 ± 0.026	0.934TyrHis: 0.934 ± 0.017	2.021TyrIle: 2.021 ± 0.025	1.708TyrLys: 1.708 ± 0.023	3.205TyrLeu: 3.205 ± 0.032	0.807TyrMet: 0.807 ± 0.014	1.511TyrAsn: 1.511 ± 0.022	1.33TyrPro: 1.33 ± 0.021	1.296TyrGln: 1.296 ± 0.018	1.978TyrArg: 1.978 ± 0.022	2.574TyrSer: 2.574 ± 0.029	1.517TyrThr: 1.517 ± 0.019	1.965TyrVal: 1.965 ± 0.022	0.429TyrTrp: 0.429 ± 0.012	1.321TyrTyr: 1.321 ± 0.019	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.057XaaXaa: 0.057 ± 0.012

Statistics based on 10885 proteins (4428208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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