Amino acid dipepetide frequency for Streptococcus satellite phage Javan600

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.468AlaCys: 0.468 ± 0.349
4.212AlaAsp: 4.212 ± 1.485
4.212AlaGlu: 4.212 ± 1.513
3.744AlaPhe: 3.744 ± 1.647
4.212AlaGly: 4.212 ± 1.356
0.0AlaHis: 0.0 ± 0.0
5.615AlaIle: 5.615 ± 1.164
6.551AlaLys: 6.551 ± 1.71
4.212AlaLeu: 4.212 ± 1.306
0.936AlaMet: 0.936 ± 0.656
5.147AlaAsn: 5.147 ± 1.375
1.872AlaPro: 1.872 ± 1.606
3.276AlaGln: 3.276 ± 1.173
3.744AlaArg: 3.744 ± 0.896
2.34AlaSer: 2.34 ± 0.944
3.744AlaThr: 3.744 ± 1.124
2.34AlaVal: 2.34 ± 0.758
0.468AlaTrp: 0.468 ± 0.38
3.276AlaTyr: 3.276 ± 0.714
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.404CysAsp: 1.404 ± 0.774
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.936CysGly: 0.936 ± 0.566
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.468CysLys: 0.468 ± 0.349
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.468CysAsn: 0.468 ± 0.349
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.468CysArg: 0.468 ± 0.38
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.468CysTyr: 0.468 ± 0.426
0.0CysXaa: 0.0 ± 0.0
Asp
0.468AspAla: 0.468 ± 0.426
0.468AspCys: 0.468 ± 0.426
1.404AspAsp: 1.404 ± 0.775
6.551AspGlu: 6.551 ± 2.0
3.276AspPhe: 3.276 ± 1.043
4.212AspGly: 4.212 ± 1.86
0.468AspHis: 0.468 ± 0.484
4.212AspIle: 4.212 ± 1.457
6.551AspLys: 6.551 ± 1.566
5.147AspLeu: 5.147 ± 1.771
3.276AspMet: 3.276 ± 0.875
4.679AspAsn: 4.679 ± 1.638
0.936AspPro: 0.936 ± 0.428
0.468AspGln: 0.468 ± 0.38
1.872AspArg: 1.872 ± 0.878
3.276AspSer: 3.276 ± 0.848
3.276AspThr: 3.276 ± 0.977
3.276AspVal: 3.276 ± 0.885
0.936AspTrp: 0.936 ± 0.697
2.34AspTyr: 2.34 ± 1.199
0.0AspXaa: 0.0 ± 0.0
Glu
6.551GluAla: 6.551 ± 1.22
0.468GluCys: 0.468 ± 0.568
2.808GluAsp: 2.808 ± 0.921
4.212GluGlu: 4.212 ± 1.354
3.744GluPhe: 3.744 ± 1.001
2.808GluGly: 2.808 ± 1.025
1.404GluHis: 1.404 ± 0.723
4.212GluIle: 4.212 ± 1.248
7.487GluLys: 7.487 ± 2.148
11.231GluLeu: 11.231 ± 1.915
1.404GluMet: 1.404 ± 1.222
3.744GluAsn: 3.744 ± 0.913
2.34GluPro: 2.34 ± 1.386
5.615GluGln: 5.615 ± 4.196
1.872GluArg: 1.872 ± 1.339
2.34GluSer: 2.34 ± 0.858
7.019GluThr: 7.019 ± 2.134
0.936GluVal: 0.936 ± 0.61
0.468GluTrp: 0.468 ± 0.55
2.808GluTyr: 2.808 ± 1.48
0.0GluXaa: 0.0 ± 0.0
Phe
0.468PheAla: 0.468 ± 0.349
0.0PheCys: 0.0 ± 0.0
3.276PheAsp: 3.276 ± 0.838
3.276PheGlu: 3.276 ± 1.425
0.468PhePhe: 0.468 ± 0.504
1.404PheGly: 1.404 ± 0.654
0.468PheHis: 0.468 ± 0.38
1.872PheIle: 1.872 ± 0.751
2.808PheLys: 2.808 ± 1.131
4.679PheLeu: 4.679 ± 0.779
0.468PheMet: 0.468 ± 0.466
5.147PheAsn: 5.147 ± 1.817
0.468PhePro: 0.468 ± 0.441
0.468PheGln: 0.468 ± 0.349
1.404PheArg: 1.404 ± 0.734
2.34PheSer: 2.34 ± 0.735
2.808PheThr: 2.808 ± 1.185
1.404PheVal: 1.404 ± 0.795
0.468PheTrp: 0.468 ± 0.349
2.808PheTyr: 2.808 ± 0.936
0.0PheXaa: 0.0 ± 0.0
Gly
1.872GlyAla: 1.872 ± 0.638
0.936GlyCys: 0.936 ± 0.557
4.212GlyAsp: 4.212 ± 1.621
3.744GlyGlu: 3.744 ± 1.068
2.34GlyPhe: 2.34 ± 1.011
1.872GlyGly: 1.872 ± 0.82
0.468GlyHis: 0.468 ± 0.38
5.147GlyIle: 5.147 ± 2.229
5.147GlyLys: 5.147 ± 1.074
4.679GlyLeu: 4.679 ± 2.197
0.0GlyMet: 0.0 ± 0.0
2.808GlyAsn: 2.808 ± 1.283
0.0GlyPro: 0.0 ± 0.0
1.404GlyGln: 1.404 ± 0.592
2.808GlyArg: 2.808 ± 0.96
1.872GlySer: 1.872 ± 0.803
1.872GlyThr: 1.872 ± 0.927
4.212GlyVal: 4.212 ± 1.392
0.936GlyTrp: 0.936 ± 0.697
7.019GlyTyr: 7.019 ± 2.486
0.0GlyXaa: 0.0 ± 0.0
His
2.34HisAla: 2.34 ± 1.208
0.0HisCys: 0.0 ± 0.0
0.468HisAsp: 0.468 ± 0.55
1.404HisGlu: 1.404 ± 0.703
1.404HisPhe: 1.404 ± 0.74
1.404HisGly: 1.404 ± 0.916
0.468HisHis: 0.468 ± 0.568
0.936HisIle: 0.936 ± 0.605
0.468HisLys: 0.468 ± 0.55
0.468HisLeu: 0.468 ± 0.38
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.468HisGln: 0.468 ± 0.487
0.468HisArg: 0.468 ± 0.38
1.404HisSer: 1.404 ± 0.718
3.276HisThr: 3.276 ± 0.992
1.404HisVal: 1.404 ± 0.798
0.0HisTrp: 0.0 ± 0.0
0.936HisTyr: 0.936 ± 0.545
0.0HisXaa: 0.0 ± 0.0
Ile
3.744IleAla: 3.744 ± 1.553
0.0IleCys: 0.0 ± 0.0
3.744IleAsp: 3.744 ± 1.247
4.679IleGlu: 4.679 ± 1.226
1.872IlePhe: 1.872 ± 0.696
2.808IleGly: 2.808 ± 0.637
1.404IleHis: 1.404 ± 0.562
2.34IleIle: 2.34 ± 0.866
6.083IleLys: 6.083 ± 1.357
5.147IleLeu: 5.147 ± 1.143
1.872IleMet: 1.872 ± 0.648
5.147IleAsn: 5.147 ± 1.493
3.744IlePro: 3.744 ± 1.458
1.872IleGln: 1.872 ± 0.729
0.936IleArg: 0.936 ± 0.632
5.147IleSer: 5.147 ± 1.742
6.083IleThr: 6.083 ± 0.97
3.276IleVal: 3.276 ± 1.186
0.0IleTrp: 0.0 ± 0.0
2.34IleTyr: 2.34 ± 0.722
0.0IleXaa: 0.0 ± 0.0
Lys
8.423LysAla: 8.423 ± 2.576
0.0LysCys: 0.0 ± 0.0
4.679LysAsp: 4.679 ± 1.228
8.891LysGlu: 8.891 ± 1.461
3.744LysPhe: 3.744 ± 1.028
4.679LysGly: 4.679 ± 1.285
2.808LysHis: 2.808 ± 1.088
6.083LysIle: 6.083 ± 0.653
8.423LysLys: 8.423 ± 1.963
8.891LysLeu: 8.891 ± 1.988
1.872LysMet: 1.872 ± 0.773
7.487LysAsn: 7.487 ± 1.718
5.147LysPro: 5.147 ± 1.631
2.34LysGln: 2.34 ± 0.709
5.615LysArg: 5.615 ± 1.698
6.083LysSer: 6.083 ± 1.454
5.615LysThr: 5.615 ± 0.926
5.147LysVal: 5.147 ± 1.56
0.936LysTrp: 0.936 ± 0.641
2.34LysTyr: 2.34 ± 0.744
0.0LysXaa: 0.0 ± 0.0
Leu
7.955LeuAla: 7.955 ± 1.688
0.468LeuCys: 0.468 ± 0.349
9.359LeuAsp: 9.359 ± 2.144
7.019LeuGlu: 7.019 ± 2.801
2.808LeuPhe: 2.808 ± 0.855
7.019LeuGly: 7.019 ± 2.225
1.404LeuHis: 1.404 ± 0.916
3.276LeuIle: 3.276 ± 0.967
9.359LeuLys: 9.359 ± 1.289
8.891LeuLeu: 8.891 ± 1.62
2.34LeuMet: 2.34 ± 1.015
4.212LeuAsn: 4.212 ± 1.761
3.744LeuPro: 3.744 ± 1.086
3.276LeuGln: 3.276 ± 1.003
4.212LeuArg: 4.212 ± 1.49
4.679LeuSer: 4.679 ± 1.18
3.276LeuThr: 3.276 ± 1.124
5.615LeuVal: 5.615 ± 1.279
0.468LeuTrp: 0.468 ± 0.349
1.872LeuTyr: 1.872 ± 1.006
0.0LeuXaa: 0.0 ± 0.0
Met
1.872MetAla: 1.872 ± 1.333
0.0MetCys: 0.0 ± 0.0
2.34MetAsp: 2.34 ± 0.949
0.936MetGlu: 0.936 ± 0.553
0.0MetPhe: 0.0 ± 0.0
1.404MetGly: 1.404 ± 0.718
0.0MetHis: 0.0 ± 0.0
1.404MetIle: 1.404 ± 0.76
4.212MetLys: 4.212 ± 1.156
0.936MetLeu: 0.936 ± 0.803
0.936MetMet: 0.936 ± 0.436
0.936MetAsn: 0.936 ± 0.501
0.0MetPro: 0.0 ± 0.0
0.468MetGln: 0.468 ± 0.487
0.936MetArg: 0.936 ± 0.641
1.404MetSer: 1.404 ± 0.665
2.808MetThr: 2.808 ± 0.716
1.404MetVal: 1.404 ± 0.677
0.468MetTrp: 0.468 ± 0.426
0.468MetTyr: 0.468 ± 0.349
0.0MetXaa: 0.0 ± 0.0
Asn
5.147AsnAla: 5.147 ± 1.592
0.468AsnCys: 0.468 ± 0.38
3.276AsnAsp: 3.276 ± 1.219
5.147AsnGlu: 5.147 ± 0.846
1.872AsnPhe: 1.872 ± 0.707
4.679AsnGly: 4.679 ± 1.354
0.936AsnHis: 0.936 ± 0.605
4.212AsnIle: 4.212 ± 0.845
4.212AsnLys: 4.212 ± 0.908
4.679AsnLeu: 4.679 ± 1.818
1.404AsnMet: 1.404 ± 0.834
5.615AsnAsn: 5.615 ± 1.435
4.212AsnPro: 4.212 ± 1.011
1.404AsnGln: 1.404 ± 0.592
2.34AsnArg: 2.34 ± 0.776
4.212AsnSer: 4.212 ± 1.67
5.615AsnThr: 5.615 ± 1.645
4.679AsnVal: 4.679 ± 1.467
0.0AsnTrp: 0.0 ± 0.0
3.744AsnTyr: 3.744 ± 0.909
0.0AsnXaa: 0.0 ± 0.0
Pro
1.872ProAla: 1.872 ± 0.513
0.0ProCys: 0.0 ± 0.0
1.404ProAsp: 1.404 ± 0.63
0.936ProGlu: 0.936 ± 0.794
1.872ProPhe: 1.872 ± 0.942
0.468ProGly: 0.468 ± 0.55
0.468ProHis: 0.468 ± 0.441
0.936ProIle: 0.936 ± 0.503
4.212ProLys: 4.212 ± 2.276
2.808ProLeu: 2.808 ± 0.705
0.0ProMet: 0.0 ± 0.0
4.212ProAsn: 4.212 ± 2.244
2.808ProPro: 2.808 ± 1.108
0.936ProGln: 0.936 ± 0.606
1.872ProArg: 1.872 ± 1.33
3.276ProSer: 3.276 ± 2.622
2.808ProThr: 2.808 ± 1.638
3.744ProVal: 3.744 ± 1.265
0.468ProTrp: 0.468 ± 0.349
0.936ProTyr: 0.936 ± 0.605
0.0ProXaa: 0.0 ± 0.0
Gln
5.147GlnAla: 5.147 ± 2.611
0.0GlnCys: 0.0 ± 0.0
0.936GlnAsp: 0.936 ± 0.606
4.679GlnGlu: 4.679 ± 1.96
1.404GlnPhe: 1.404 ± 0.74
1.404GlnGly: 1.404 ± 0.794
0.468GlnHis: 0.468 ± 0.38
3.276GlnIle: 3.276 ± 1.482
2.808GlnLys: 2.808 ± 0.794
0.936GlnLeu: 0.936 ± 0.645
0.0GlnMet: 0.0 ± 0.0
0.468GlnAsn: 0.468 ± 0.349
1.872GlnPro: 1.872 ± 1.279
1.872GlnGln: 1.872 ± 0.924
2.34GlnArg: 2.34 ± 0.713
2.808GlnSer: 2.808 ± 1.333
3.744GlnThr: 3.744 ± 2.177
2.34GlnVal: 2.34 ± 1.126
0.0GlnTrp: 0.0 ± 0.0
0.936GlnTyr: 0.936 ± 0.61
0.0GlnXaa: 0.0 ± 0.0
Arg
2.808ArgAla: 2.808 ± 0.976
0.0ArgCys: 0.0 ± 0.0
2.808ArgAsp: 2.808 ± 1.634
3.276ArgGlu: 3.276 ± 1.677
0.0ArgPhe: 0.0 ± 0.0
1.404ArgGly: 1.404 ± 1.004
1.872ArgHis: 1.872 ± 0.9
2.808ArgIle: 2.808 ± 1.184
4.212ArgLys: 4.212 ± 0.905
4.679ArgLeu: 4.679 ± 1.316
0.468ArgMet: 0.468 ± 0.529
3.744ArgAsn: 3.744 ± 0.952
0.936ArgPro: 0.936 ± 0.601
0.936ArgGln: 0.936 ± 0.58
0.936ArgArg: 0.936 ± 0.581
1.404ArgSer: 1.404 ± 0.498
1.872ArgThr: 1.872 ± 0.724
3.276ArgVal: 3.276 ± 1.383
1.404ArgTrp: 1.404 ± 0.84
2.808ArgTyr: 2.808 ± 0.946
0.0ArgXaa: 0.0 ± 0.0
Ser
1.872SerAla: 1.872 ± 0.878
0.0SerCys: 0.0 ± 0.0
4.212SerAsp: 4.212 ± 1.445
4.679SerGlu: 4.679 ± 2.524
1.404SerPhe: 1.404 ± 0.659
2.34SerGly: 2.34 ± 0.722
1.872SerHis: 1.872 ± 0.876
3.276SerIle: 3.276 ± 1.157
7.019SerLys: 7.019 ± 1.577
6.083SerLeu: 6.083 ± 1.87
1.404SerMet: 1.404 ± 0.487
3.276SerAsn: 3.276 ± 1.027
1.404SerPro: 1.404 ± 1.098
2.808SerGln: 2.808 ± 1.691
2.808SerArg: 2.808 ± 1.231
2.808SerSer: 2.808 ± 1.71
5.147SerThr: 5.147 ± 2.029
3.276SerVal: 3.276 ± 1.328
1.404SerTrp: 1.404 ± 0.875
1.404SerTyr: 1.404 ± 0.782
0.0SerXaa: 0.0 ± 0.0
Thr
5.147ThrAla: 5.147 ± 1.649
0.0ThrCys: 0.0 ± 0.0
2.808ThrAsp: 2.808 ± 0.948
1.872ThrGlu: 1.872 ± 0.939
3.744ThrPhe: 3.744 ± 1.959
3.276ThrGly: 3.276 ± 1.431
0.936ThrHis: 0.936 ± 0.436
4.679ThrIle: 4.679 ± 2.263
7.487ThrLys: 7.487 ± 1.084
7.019ThrLeu: 7.019 ± 1.31
2.808ThrMet: 2.808 ± 1.016
2.808ThrAsn: 2.808 ± 0.905
2.808ThrPro: 2.808 ± 0.949
5.615ThrGln: 5.615 ± 3.755
2.808ThrArg: 2.808 ± 1.138
4.679ThrSer: 4.679 ± 1.958
3.744ThrThr: 3.744 ± 1.28
4.679ThrVal: 4.679 ± 1.005
0.468ThrTrp: 0.468 ± 0.441
2.808ThrTyr: 2.808 ± 1.253
0.0ThrXaa: 0.0 ± 0.0
Val
3.744ValAla: 3.744 ± 1.44
0.936ValCys: 0.936 ± 0.566
1.872ValAsp: 1.872 ± 0.929
2.808ValGlu: 2.808 ± 1.459
2.808ValPhe: 2.808 ± 0.911
2.808ValGly: 2.808 ± 1.006
0.468ValHis: 0.468 ± 0.38
5.147ValIle: 5.147 ± 1.04
5.147ValLys: 5.147 ± 0.802
6.083ValLeu: 6.083 ± 1.64
0.936ValMet: 0.936 ± 0.638
5.147ValAsn: 5.147 ± 1.434
1.872ValPro: 1.872 ± 1.061
1.404ValGln: 1.404 ± 0.677
0.468ValArg: 0.468 ± 0.349
4.212ValSer: 4.212 ± 1.632
6.083ValThr: 6.083 ± 1.496
3.744ValVal: 3.744 ± 0.978
0.0ValTrp: 0.0 ± 0.0
1.872ValTyr: 1.872 ± 1.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.468TrpAsp: 0.468 ± 0.38
0.936TrpGlu: 0.936 ± 0.639
0.0TrpPhe: 0.0 ± 0.0
0.468TrpGly: 0.468 ± 0.55
0.936TrpHis: 0.936 ± 0.58
0.468TrpIle: 0.468 ± 0.349
1.404TrpLys: 1.404 ± 0.586
0.468TrpLeu: 0.468 ± 0.349
0.468TrpMet: 0.468 ± 0.426
0.468TrpAsn: 0.468 ± 0.55
0.0TrpPro: 0.0 ± 0.0
0.468TrpGln: 0.468 ± 0.349
0.468TrpArg: 0.468 ± 0.349
0.936TrpSer: 0.936 ± 0.545
0.0TrpThr: 0.0 ± 0.0
0.468TrpVal: 0.468 ± 0.441
0.468TrpTrp: 0.468 ± 0.38
0.468TrpTyr: 0.468 ± 0.349
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.936TyrAla: 0.936 ± 0.515
0.0TyrCys: 0.0 ± 0.0
1.404TyrAsp: 1.404 ± 0.458
4.212TyrGlu: 4.212 ± 1.379
0.0TyrPhe: 0.0 ± 0.0
3.744TyrGly: 3.744 ± 1.107
0.468TyrHis: 0.468 ± 0.441
2.34TyrIle: 2.34 ± 0.665
5.147TyrLys: 5.147 ± 2.004
4.212TyrLeu: 4.212 ± 1.02
1.872TyrMet: 1.872 ± 0.668
2.808TyrAsn: 2.808 ± 1.425
1.872TyrPro: 1.872 ± 0.997
2.34TyrGln: 2.34 ± 1.11
3.276TyrArg: 3.276 ± 1.155
3.276TyrSer: 3.276 ± 1.457
1.404TyrThr: 1.404 ± 0.775
2.34TyrVal: 2.34 ± 1.081
0.0TyrTrp: 0.0 ± 0.0
1.872TyrTyr: 1.872 ± 0.743
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (2138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski