Amino acid dipepetide frequency for Sporomusa termitida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.712AlaAla: 13.712 ± 0.186
1.289AlaCys: 1.289 ± 0.037
5.11AlaAsp: 5.11 ± 0.058
6.197AlaGlu: 6.197 ± 0.076
3.232AlaPhe: 3.232 ± 0.056
10.446AlaGly: 10.446 ± 0.174
1.485AlaHis: 1.485 ± 0.037
6.844AlaIle: 6.844 ± 0.14
5.052AlaLys: 5.052 ± 0.065
9.4AlaLeu: 9.4 ± 0.108
2.652AlaMet: 2.652 ± 0.046
3.338AlaAsn: 3.338 ± 0.059
3.07AlaPro: 3.07 ± 0.055
3.514AlaGln: 3.514 ± 0.07
4.773AlaArg: 4.773 ± 0.069
4.378AlaSer: 4.378 ± 0.084
5.29AlaThr: 5.29 ± 0.63
8.781AlaVal: 8.781 ± 0.112
0.93AlaTrp: 0.93 ± 0.026
2.848AlaTyr: 2.848 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.934CysAla: 0.934 ± 0.028
0.251CysCys: 0.251 ± 0.014
0.537CysAsp: 0.537 ± 0.018
0.6CysGlu: 0.6 ± 0.021
0.47CysPhe: 0.47 ± 0.019
1.335CysGly: 1.335 ± 0.035
0.284CysHis: 0.284 ± 0.013
0.728CysIle: 0.728 ± 0.025
0.53CysLys: 0.53 ± 0.018
1.19CysLeu: 1.19 ± 0.031
0.307CysMet: 0.307 ± 0.016
0.408CysAsn: 0.408 ± 0.016
0.705CysPro: 0.705 ± 0.029
0.517CysGln: 0.517 ± 0.022
0.805CysArg: 0.805 ± 0.027
0.728CysSer: 0.728 ± 0.023
0.601CysThr: 0.601 ± 0.024
0.773CysVal: 0.773 ± 0.027
0.135CysTrp: 0.135 ± 0.009
0.391CysTyr: 0.391 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.756AspAla: 3.756 ± 0.056
0.641AspCys: 0.641 ± 0.022
1.996AspAsp: 1.996 ± 0.045
2.948AspGlu: 2.948 ± 0.051
2.087AspPhe: 2.087 ± 0.042
3.398AspGly: 3.398 ± 0.057
0.812AspHis: 0.812 ± 0.023
4.196AspIle: 4.196 ± 0.057
3.119AspLys: 3.119 ± 0.054
4.46AspLeu: 4.46 ± 0.073
1.299AspMet: 1.299 ± 0.029
2.004AspAsn: 2.004 ± 0.058
1.876AspPro: 1.876 ± 0.043
1.568AspGln: 1.568 ± 0.035
2.573AspArg: 2.573 ± 0.045
2.502AspSer: 2.502 ± 0.048
2.55AspThr: 2.55 ± 0.051
3.273AspVal: 3.273 ± 0.057
0.631AspTrp: 0.631 ± 0.024
1.929AspTyr: 1.929 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.534GluAla: 5.534 ± 0.072
0.541GluCys: 0.541 ± 0.019
2.391GluAsp: 2.391 ± 0.049
3.676GluGlu: 3.676 ± 0.06
2.215GluPhe: 2.215 ± 0.039
3.111GluGly: 3.111 ± 0.05
1.174GluHis: 1.174 ± 0.03
4.57GluIle: 4.57 ± 0.06
3.83GluLys: 3.83 ± 0.061
6.649GluLeu: 6.649 ± 0.09
1.664GluMet: 1.664 ± 0.038
2.357GluAsn: 2.357 ± 0.041
1.964GluPro: 1.964 ± 0.037
3.314GluGln: 3.314 ± 0.061
3.199GluArg: 3.199 ± 0.063
2.348GluSer: 2.348 ± 0.044
3.45GluThr: 3.45 ± 0.481
4.024GluVal: 4.024 ± 0.057
0.56GluTrp: 0.56 ± 0.023
2.065GluTyr: 2.065 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.624PheAla: 3.624 ± 0.062
0.531PheCys: 0.531 ± 0.022
2.026PheAsp: 2.026 ± 0.042
1.765PheGlu: 1.765 ± 0.036
1.598PhePhe: 1.598 ± 0.041
3.142PheGly: 3.142 ± 0.06
0.652PheHis: 0.652 ± 0.023
2.81PheIle: 2.81 ± 0.051
1.758PheLys: 1.758 ± 0.034
3.499PheLeu: 3.499 ± 0.065
0.981PheMet: 0.981 ± 0.031
1.536PheAsn: 1.536 ± 0.038
1.419PhePro: 1.419 ± 0.032
1.123PheGln: 1.123 ± 0.028
1.666PheArg: 1.666 ± 0.033
2.556PheSer: 2.556 ± 0.045
2.433PheThr: 2.433 ± 0.041
2.578PheVal: 2.578 ± 0.049
0.463PheTrp: 0.463 ± 0.022
1.241PheTyr: 1.241 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.551GlyAla: 7.551 ± 0.801
1.215GlyCys: 1.215 ± 0.03
3.412GlyAsp: 3.412 ± 0.057
4.564GlyGlu: 4.564 ± 0.512
3.136GlyPhe: 3.136 ± 0.052
6.046GlyGly: 6.046 ± 0.127
1.477GlyHis: 1.477 ± 0.036
6.329GlyIle: 6.329 ± 0.136
4.657GlyLys: 4.657 ± 0.056
8.158GlyLeu: 8.158 ± 0.114
2.169GlyMet: 2.169 ± 0.046
2.852GlyAsn: 2.852 ± 0.075
2.311GlyPro: 2.311 ± 0.041
3.353GlyGln: 3.353 ± 0.09
4.127GlyArg: 4.127 ± 0.061
4.371GlySer: 4.371 ± 0.07
4.502GlyThr: 4.502 ± 0.073
5.777GlyVal: 5.777 ± 0.165
0.881GlyTrp: 0.881 ± 0.028
3.051GlyTyr: 3.051 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.373HisAla: 1.373 ± 0.028
0.312HisCys: 0.312 ± 0.016
0.855HisAsp: 0.855 ± 0.03
0.924HisGlu: 0.924 ± 0.023
0.76HisPhe: 0.76 ± 0.024
1.329HisGly: 1.329 ± 0.033
0.454HisHis: 0.454 ± 0.018
1.385HisIle: 1.385 ± 0.036
0.909HisLys: 0.909 ± 0.023
1.734HisLeu: 1.734 ± 0.038
0.431HisMet: 0.431 ± 0.017
0.825HisAsn: 0.825 ± 0.025
0.924HisPro: 0.924 ± 0.025
0.673HisGln: 0.673 ± 0.02
0.996HisArg: 0.996 ± 0.028
1.042HisSer: 1.042 ± 0.03
1.002HisThr: 1.002 ± 0.027
1.138HisVal: 1.138 ± 0.032
0.245HisTrp: 0.245 ± 0.013
0.735HisTyr: 0.735 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.339IleAla: 7.339 ± 0.091
0.843IleCys: 0.843 ± 0.025
3.843IleAsp: 3.843 ± 0.06
4.08IleGlu: 4.08 ± 0.067
2.468IlePhe: 2.468 ± 0.046
5.702IleGly: 5.702 ± 0.173
1.226IleHis: 1.226 ± 0.028
5.354IleIle: 5.354 ± 0.072
3.773IleLys: 3.773 ± 0.052
6.333IleLeu: 6.333 ± 0.084
1.722IleMet: 1.722 ± 0.037
3.089IleAsn: 3.089 ± 0.045
3.224IlePro: 3.224 ± 0.05
2.161IleGln: 2.161 ± 0.044
3.287IleArg: 3.287 ± 0.05
4.114IleSer: 4.114 ± 0.067
4.575IleThr: 4.575 ± 0.14
5.156IleVal: 5.156 ± 0.08
0.561IleTrp: 0.561 ± 0.018
1.971IleTyr: 1.971 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
5.067LysAla: 5.067 ± 0.068
0.493LysCys: 0.493 ± 0.02
2.394LysAsp: 2.394 ± 0.049
3.555LysGlu: 3.555 ± 0.058
1.59LysPhe: 1.59 ± 0.037
3.128LysGly: 3.128 ± 0.053
0.951LysHis: 0.951 ± 0.028
3.885LysIle: 3.885 ± 0.054
3.368LysLys: 3.368 ± 0.058
5.353LysLeu: 5.353 ± 0.07
1.505LysMet: 1.505 ± 0.037
2.373LysAsn: 2.373 ± 0.045
2.309LysPro: 2.309 ± 0.039
2.434LysGln: 2.434 ± 0.048
2.484LysArg: 2.484 ± 0.048
2.519LysSer: 2.519 ± 0.048
3.102LysThr: 3.102 ± 0.043
3.826LysVal: 3.826 ± 0.051
0.495LysTrp: 0.495 ± 0.02
1.824LysTyr: 1.824 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
11.992LeuAla: 11.992 ± 0.148
1.131LeuCys: 1.131 ± 0.032
4.668LeuAsp: 4.668 ± 0.054
5.368LeuGlu: 5.368 ± 0.074
3.77LeuPhe: 3.77 ± 0.069
7.562LeuGly: 7.562 ± 0.083
1.727LeuHis: 1.727 ± 0.036
6.295LeuIle: 6.295 ± 0.085
5.141LeuLys: 5.141 ± 0.072
10.301LeuLeu: 10.301 ± 0.143
2.344LeuMet: 2.344 ± 0.047
3.856LeuAsn: 3.856 ± 0.057
4.788LeuPro: 4.788 ± 0.068
3.824LeuGln: 3.824 ± 0.058
4.518LeuArg: 4.518 ± 0.076
6.035LeuSer: 6.035 ± 0.085
6.442LeuThr: 6.442 ± 0.088
6.782LeuVal: 6.782 ± 0.087
0.909LeuTrp: 0.909 ± 0.027
2.897LeuTyr: 2.897 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.776MetAla: 2.776 ± 0.045
0.221MetCys: 0.221 ± 0.013
1.205MetAsp: 1.205 ± 0.031
1.424MetGlu: 1.424 ± 0.033
0.842MetPhe: 0.842 ± 0.021
1.937MetGly: 1.937 ± 0.046
0.42MetHis: 0.42 ± 0.017
1.619MetIle: 1.619 ± 0.037
1.47MetLys: 1.47 ± 0.032
2.632MetLeu: 2.632 ± 0.05
0.607MetMet: 0.607 ± 0.023
1.064MetAsn: 1.064 ± 0.028
1.269MetPro: 1.269 ± 0.032
1.024MetGln: 1.024 ± 0.029
1.189MetArg: 1.189 ± 0.032
1.562MetSer: 1.562 ± 0.037
1.487MetThr: 1.487 ± 0.033
1.89MetVal: 1.89 ± 0.04
0.188MetTrp: 0.188 ± 0.011
0.614MetTyr: 0.614 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.145AsnAla: 3.145 ± 0.062
0.494AsnCys: 0.494 ± 0.02
1.647AsnAsp: 1.647 ± 0.037
2.053AsnGlu: 2.053 ± 0.042
1.46AsnPhe: 1.46 ± 0.031
2.748AsnGly: 2.748 ± 0.051
0.741AsnHis: 0.741 ± 0.024
3.108AsnIle: 3.108 ± 0.053
2.225AsnLys: 2.225 ± 0.041
3.756AsnLeu: 3.756 ± 0.068
1.025AsnMet: 1.025 ± 0.029
1.757AsnAsn: 1.757 ± 0.044
2.084AsnPro: 2.084 ± 0.035
1.561AsnGln: 1.561 ± 0.037
2.003AsnArg: 2.003 ± 0.047
2.16AsnSer: 2.16 ± 0.051
2.272AsnThr: 2.272 ± 0.047
2.444AsnVal: 2.444 ± 0.043
0.462AsnTrp: 0.462 ± 0.018
1.447AsnTyr: 1.447 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
5.133ProAla: 5.133 ± 0.08
0.448ProCys: 0.448 ± 0.02
2.501ProAsp: 2.501 ± 0.048
3.126ProGlu: 3.126 ± 0.053
1.629ProPhe: 1.629 ± 0.037
3.734ProGly: 3.734 ± 0.062
0.81ProHis: 0.81 ± 0.027
2.106ProIle: 2.106 ± 0.042
1.536ProLys: 1.536 ± 0.036
4.027ProLeu: 4.027 ± 0.071
0.811ProMet: 0.811 ± 0.024
1.261ProAsn: 1.261 ± 0.03
1.645ProPro: 1.645 ± 0.039
1.582ProGln: 1.582 ± 0.039
1.664ProArg: 1.664 ± 0.035
1.75ProSer: 1.75 ± 0.038
1.774ProThr: 1.774 ± 0.033
4.152ProVal: 4.152 ± 0.054
0.445ProTrp: 0.445 ± 0.02
1.289ProTyr: 1.289 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
5.074GlnAla: 5.074 ± 0.083
0.432GlnCys: 0.432 ± 0.016
1.852GlnAsp: 1.852 ± 0.038
2.628GlnGlu: 2.628 ± 0.046
1.252GlnPhe: 1.252 ± 0.032
2.898GlnGly: 2.898 ± 0.062
0.745GlnHis: 0.745 ± 0.024
2.469GlnIle: 2.469 ± 0.05
1.955GlnLys: 1.955 ± 0.046
4.054GlnLeu: 4.054 ± 0.063
0.992GlnMet: 0.992 ± 0.025
1.401GlnAsn: 1.401 ± 0.041
1.82GlnPro: 1.82 ± 0.042
2.266GlnGln: 2.266 ± 0.049
1.822GlnArg: 1.822 ± 0.034
1.88GlnSer: 1.88 ± 0.042
2.071GlnThr: 2.071 ± 0.042
2.93GlnVal: 2.93 ± 0.055
0.395GlnTrp: 0.395 ± 0.016
1.345GlnTyr: 1.345 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.622ArgAla: 3.622 ± 0.056
0.581ArgCys: 0.581 ± 0.019
2.329ArgAsp: 2.329 ± 0.042
3.533ArgGlu: 3.533 ± 0.065
1.9ArgPhe: 1.9 ± 0.039
3.002ArgGly: 3.002 ± 0.053
1.053ArgHis: 1.053 ± 0.031
3.474ArgIle: 3.474 ± 0.053
2.581ArgLys: 2.581 ± 0.042
5.715ArgLeu: 5.715 ± 0.087
1.299ArgMet: 1.299 ± 0.032
1.826ArgAsn: 1.826 ± 0.029
2.042ArgPro: 2.042 ± 0.045
3.014ArgGln: 3.014 ± 0.056
2.783ArgArg: 2.783 ± 0.06
2.327ArgSer: 2.327 ± 0.046
2.381ArgThr: 2.381 ± 0.045
3.237ArgVal: 3.237 ± 0.046
0.513ArgTrp: 0.513 ± 0.02
1.775ArgTyr: 1.775 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.597SerAla: 4.597 ± 0.084
0.634SerCys: 0.634 ± 0.023
2.365SerAsp: 2.365 ± 0.039
2.769SerGlu: 2.769 ± 0.049
2.236SerPhe: 2.236 ± 0.045
4.74SerGly: 4.74 ± 0.112
1.015SerHis: 1.015 ± 0.03
3.555SerIle: 3.555 ± 0.05
2.43SerLys: 2.43 ± 0.044
5.688SerLeu: 5.688 ± 0.074
1.395SerMet: 1.395 ± 0.034
1.799SerAsn: 1.799 ± 0.043
2.33SerPro: 2.33 ± 0.041
2.134SerGln: 2.134 ± 0.04
2.865SerArg: 2.865 ± 0.051
2.957SerSer: 2.957 ± 0.056
2.741SerThr: 2.741 ± 0.046
3.783SerVal: 3.783 ± 0.06
0.621SerTrp: 0.621 ± 0.023
1.716SerTyr: 1.716 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
6.214ThrAla: 6.214 ± 0.097
0.611ThrCys: 0.611 ± 0.025
2.67ThrAsp: 2.67 ± 0.042
2.895ThrGlu: 2.895 ± 0.047
1.976ThrPhe: 1.976 ± 0.039
7.248ThrGly: 7.248 ± 1.484
0.889ThrHis: 0.889 ± 0.023
3.859ThrIle: 3.859 ± 0.056
2.352ThrLys: 2.352 ± 0.039
5.347ThrLeu: 5.347 ± 0.073
1.303ThrMet: 1.303 ± 0.028
1.997ThrAsn: 1.997 ± 0.04
2.646ThrPro: 2.646 ± 0.05
1.621ThrGln: 1.621 ± 0.031
2.328ThrArg: 2.328 ± 0.043
2.54ThrSer: 2.54 ± 0.046
3.092ThrThr: 3.092 ± 0.059
4.878ThrVal: 4.878 ± 0.075
0.535ThrTrp: 0.535 ± 0.02
1.609ThrTyr: 1.609 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
7.462ValAla: 7.462 ± 0.089
0.922ValCys: 0.922 ± 0.029
3.604ValAsp: 3.604 ± 0.052
4.144ValGlu: 4.144 ± 0.058
2.922ValPhe: 2.922 ± 0.06
4.94ValGly: 4.94 ± 0.071
1.204ValHis: 1.204 ± 0.031
5.551ValIle: 5.551 ± 0.08
3.947ValLys: 3.947 ± 0.061
7.449ValLeu: 7.449 ± 0.095
1.952ValMet: 1.952 ± 0.039
3.098ValAsn: 3.098 ± 0.048
3.123ValPro: 3.123 ± 0.05
2.403ValGln: 2.403 ± 0.044
3.542ValArg: 3.542 ± 0.059
4.196ValSer: 4.196 ± 0.06
4.586ValThr: 4.586 ± 0.17
5.569ValVal: 5.569 ± 0.078
0.663ValTrp: 0.663 ± 0.023
2.268ValTyr: 2.268 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.777TrpAla: 0.777 ± 0.024
0.125TrpCys: 0.125 ± 0.01
0.49TrpAsp: 0.49 ± 0.019
0.634TrpGlu: 0.634 ± 0.021
0.428TrpPhe: 0.428 ± 0.019
0.805TrpGly: 0.805 ± 0.029
0.227TrpHis: 0.227 ± 0.013
0.546TrpIle: 0.546 ± 0.019
0.441TrpLys: 0.441 ± 0.018
1.302TrpLeu: 1.302 ± 0.037
0.243TrpMet: 0.243 ± 0.013
0.399TrpAsn: 0.399 ± 0.018
0.422TrpPro: 0.422 ± 0.016
0.734TrpGln: 0.734 ± 0.023
0.542TrpArg: 0.542 ± 0.02
0.542TrpSer: 0.542 ± 0.021
0.449TrpThr: 0.449 ± 0.018
0.619TrpVal: 0.619 ± 0.023
0.171TrpTrp: 0.171 ± 0.012
0.295TrpTyr: 0.295 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.655TyrAla: 2.655 ± 0.046
0.509TyrCys: 0.509 ± 0.02
1.723TyrAsp: 1.723 ± 0.039
1.754TyrGlu: 1.754 ± 0.037
1.431TyrPhe: 1.431 ± 0.032
2.688TyrGly: 2.688 ± 0.046
0.699TyrHis: 0.699 ± 0.023
2.139TyrIle: 2.139 ± 0.048
1.582TyrLys: 1.582 ± 0.041
3.302TyrLeu: 3.302 ± 0.056
0.738TyrMet: 0.738 ± 0.024
1.353TyrAsn: 1.353 ± 0.038
1.45TyrPro: 1.45 ± 0.034
1.461TyrGln: 1.461 ± 0.034
1.822TyrArg: 1.822 ± 0.036
1.863TyrSer: 1.863 ± 0.038
1.811TyrThr: 1.811 ± 0.035
1.939TyrVal: 1.939 ± 0.038
0.39TyrTrp: 0.39 ± 0.018
1.21TyrTyr: 1.21 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4716 proteins (1486555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski