Amino acid dipepetide frequency for Frankia sp. EUN1f

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.431AlaAla: 23.431 ± 0.155	1.091AlaCys: 1.091 ± 0.024	9.095AlaAsp: 9.095 ± 0.064	7.955AlaGlu: 7.955 ± 0.066	3.435AlaPhe: 3.435 ± 0.043	15.66AlaGly: 15.66 ± 0.106	2.598AlaHis: 2.598 ± 0.032	4.005AlaIle: 4.005 ± 0.047	1.842AlaLys: 1.842 ± 0.03	13.483AlaLeu: 13.483 ± 0.092	2.463AlaMet: 2.463 ± 0.031	2.047AlaAsn: 2.047 ± 0.032	7.475AlaPro: 7.475 ± 0.068	3.77AlaGln: 3.77 ± 0.041	11.344AlaArg: 11.344 ± 0.063	6.836AlaSer: 6.836 ± 0.054	8.006AlaThr: 8.006 ± 0.061	12.45AlaVal: 12.45 ± 0.099	1.806AlaTrp: 1.806 ± 0.027	2.285AlaTyr: 2.285 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.022	0.098CysCys: 0.098 ± 0.005	0.474CysAsp: 0.474 ± 0.015	0.389CysGlu: 0.389 ± 0.013	0.235CysPhe: 0.235 ± 0.009	0.914CysGly: 0.914 ± 0.02	0.191CysHis: 0.191 ± 0.009	0.169CysIle: 0.169 ± 0.008	0.07CysLys: 0.07 ± 0.006	0.794CysLeu: 0.794 ± 0.017	0.113CysMet: 0.113 ± 0.007	0.12CysAsn: 0.12 ± 0.007	0.51CysPro: 0.51 ± 0.014	0.238CysGln: 0.238 ± 0.009	0.663CysArg: 0.663 ± 0.015	0.449CysSer: 0.449 ± 0.013	0.429CysThr: 0.429 ± 0.014	0.636CysVal: 0.636 ± 0.017	0.148CysTrp: 0.148 ± 0.008	0.16CysTyr: 0.16 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.534AspAla: 7.534 ± 0.063	0.417AspCys: 0.417 ± 0.013	3.925AspAsp: 3.925 ± 0.044	3.779AspGlu: 3.779 ± 0.044	1.451AspPhe: 1.451 ± 0.025	6.498AspGly: 6.498 ± 0.054	1.513AspHis: 1.513 ± 0.025	2.03AspIle: 2.03 ± 0.035	0.715AspLys: 0.715 ± 0.02	7.017AspLeu: 7.017 ± 0.055	0.695AspMet: 0.695 ± 0.019	0.909AspAsn: 0.909 ± 0.021	4.884AspPro: 4.884 ± 0.045	1.794AspGln: 1.794 ± 0.027	5.178AspArg: 5.178 ± 0.047	2.599AspSer: 2.599 ± 0.03	2.895AspThr: 2.895 ± 0.038	5.246AspVal: 5.246 ± 0.049	0.913AspTrp: 0.913 ± 0.018	1.088AspTyr: 1.088 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.471GluAla: 6.471 ± 0.062	0.343GluCys: 0.343 ± 0.012	2.228GluAsp: 2.228 ± 0.033	2.397GluGlu: 2.397 ± 0.041	1.383GluPhe: 1.383 ± 0.02	3.306GluGly: 3.306 ± 0.04	1.459GluHis: 1.459 ± 0.026	2.568GluIle: 2.568 ± 0.033	1.038GluLys: 1.038 ± 0.019	6.248GluLeu: 6.248 ± 0.061	0.804GluMet: 0.804 ± 0.018	0.983GluAsn: 0.983 ± 0.019	3.472GluPro: 3.472 ± 0.042	2.063GluGln: 2.063 ± 0.028	5.01GluArg: 5.01 ± 0.052	2.4GluSer: 2.4 ± 0.031	2.699GluThr: 2.699 ± 0.032	4.318GluVal: 4.318 ± 0.043	0.697GluTrp: 0.697 ± 0.015	0.909GluTyr: 0.909 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.609PheAla: 3.609 ± 0.044	0.283PheCys: 0.283 ± 0.012	2.096PheAsp: 2.096 ± 0.027	1.376PheGlu: 1.376 ± 0.023	0.757PhePhe: 0.757 ± 0.016	3.117PheGly: 3.117 ± 0.035	0.576PheHis: 0.576 ± 0.014	0.713PheIle: 0.713 ± 0.018	0.331PheLys: 0.331 ± 0.01	2.369PheLeu: 2.369 ± 0.033	0.357PheMet: 0.357 ± 0.012	0.508PheAsn: 0.508 ± 0.013	1.39PhePro: 1.39 ± 0.025	0.645PheGln: 0.645 ± 0.015	1.821PheArg: 1.821 ± 0.028	1.442PheSer: 1.442 ± 0.025	1.824PheThr: 1.824 ± 0.03	2.333PheVal: 2.333 ± 0.034	0.392PheTrp: 0.392 ± 0.012	0.56PheTyr: 0.56 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.868GlyAla: 11.868 ± 0.081	0.789GlyCys: 0.789 ± 0.018	5.278GlyAsp: 5.278 ± 0.052	4.674GlyGlu: 4.674 ± 0.047	2.754GlyPhe: 2.754 ± 0.035	9.846GlyGly: 9.846 ± 0.114	2.179GlyHis: 2.179 ± 0.029	3.385GlyIle: 3.385 ± 0.037	1.646GlyLys: 1.646 ± 0.032	9.701GlyLeu: 9.701 ± 0.069	1.815GlyMet: 1.815 ± 0.026	1.602GlyAsn: 1.602 ± 0.028	6.112GlyPro: 6.112 ± 0.064	3.049GlyGln: 3.049 ± 0.035	8.676GlyArg: 8.676 ± 0.064	6.04GlySer: 6.04 ± 0.055	6.282GlyThr: 6.282 ± 0.058	7.794GlyVal: 7.794 ± 0.071	1.803GlyTrp: 1.803 ± 0.026	2.141GlyTyr: 2.141 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.484HisAla: 2.484 ± 0.031	0.194HisCys: 0.194 ± 0.009	1.309HisAsp: 1.309 ± 0.023	1.039HisGlu: 1.039 ± 0.02	0.563HisPhe: 0.563 ± 0.016	2.255HisGly: 2.255 ± 0.031	0.662HisHis: 0.662 ± 0.017	0.65HisIle: 0.65 ± 0.016	0.207HisLys: 0.207 ± 0.009	2.354HisLeu: 2.354 ± 0.034	0.263HisMet: 0.263 ± 0.01	0.36HisAsn: 0.36 ± 0.011	1.888HisPro: 1.888 ± 0.029	0.657HisGln: 0.657 ± 0.018	2.15HisArg: 2.15 ± 0.03	1.044HisSer: 1.044 ± 0.024	1.172HisThr: 1.172 ± 0.022	1.581HisVal: 1.581 ± 0.025	0.302HisTrp: 0.302 ± 0.011	0.403HisTyr: 0.403 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.001IleAla: 5.001 ± 0.053	0.306IleCys: 0.306 ± 0.01	2.518IleAsp: 2.518 ± 0.039	2.039IleGlu: 2.039 ± 0.028	0.792IlePhe: 0.792 ± 0.02	3.587IleGly: 3.587 ± 0.044	0.672IleHis: 0.672 ± 0.016	1.112IleIle: 1.112 ± 0.021	0.504IleLys: 0.504 ± 0.014	2.687IleLeu: 2.687 ± 0.035	0.505IleMet: 0.505 ± 0.015	0.727IleAsn: 0.727 ± 0.017	1.941IlePro: 1.941 ± 0.032	0.723IleGln: 0.723 ± 0.014	2.726IleArg: 2.726 ± 0.032	2.023IleSer: 2.023 ± 0.031	2.284IleThr: 2.284 ± 0.031	3.132IleVal: 3.132 ± 0.037	0.4IleTrp: 0.4 ± 0.013	0.616IleTyr: 0.616 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.91LysAla: 1.91 ± 0.028	0.076LysCys: 0.076 ± 0.005	0.744LysAsp: 0.744 ± 0.022	0.696LysGlu: 0.696 ± 0.018	0.34LysPhe: 0.34 ± 0.012	1.09LysGly: 1.09 ± 0.024	0.298LysHis: 0.298 ± 0.011	0.785LysIle: 0.785 ± 0.02	0.392LysLys: 0.392 ± 0.013	1.354LysLeu: 1.354 ± 0.023	0.265LysMet: 0.265 ± 0.01	0.319LysAsn: 0.319 ± 0.012	0.909LysPro: 0.909 ± 0.021	0.419LysGln: 0.419 ± 0.011	0.997LysArg: 0.997 ± 0.023	0.735LysSer: 0.735 ± 0.016	0.875LysThr: 0.875 ± 0.024	1.396LysVal: 1.396 ± 0.026	0.16LysTrp: 0.16 ± 0.008	0.283LysTyr: 0.283 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	15.964LeuAla: 15.964 ± 0.108	0.808LeuCys: 0.808 ± 0.019	6.694LeuAsp: 6.694 ± 0.063	4.315LeuGlu: 4.315 ± 0.043	2.554LeuPhe: 2.554 ± 0.032	9.173LeuGly: 9.173 ± 0.069	2.053LeuHis: 2.053 ± 0.025	3.145LeuIle: 3.145 ± 0.037	1.179LeuLys: 1.179 ± 0.023	10.583LeuLeu: 10.583 ± 0.09	1.355LeuMet: 1.355 ± 0.021	1.532LeuAsn: 1.532 ± 0.025	6.39LeuPro: 6.39 ± 0.051	1.848LeuGln: 1.848 ± 0.028	9.108LeuArg: 9.108 ± 0.07	5.119LeuSer: 5.119 ± 0.043	6.616LeuThr: 6.616 ± 0.047	9.112LeuVal: 9.112 ± 0.066	1.207LeuTrp: 1.207 ± 0.021	1.536LeuTyr: 1.536 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.086MetAla: 2.086 ± 0.032	0.13MetCys: 0.13 ± 0.007	0.758MetAsp: 0.758 ± 0.018	0.606MetGlu: 0.606 ± 0.017	0.507MetPhe: 0.507 ± 0.014	1.127MetGly: 1.127 ± 0.021	0.31MetHis: 0.31 ± 0.01	0.797MetIle: 0.797 ± 0.016	0.308MetLys: 0.308 ± 0.01	1.61MetLeu: 1.61 ± 0.026	0.275MetMet: 0.275 ± 0.011	0.394MetAsn: 0.394 ± 0.013	1.136MetPro: 1.136 ± 0.024	0.34MetGln: 0.34 ± 0.01	1.385MetArg: 1.385 ± 0.023	1.253MetSer: 1.253 ± 0.022	1.447MetThr: 1.447 ± 0.026	1.294MetVal: 1.294 ± 0.024	0.196MetTrp: 0.196 ± 0.01	0.251MetTyr: 0.251 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.16AsnAla: 2.16 ± 0.029	0.151AsnCys: 0.151 ± 0.009	0.93AsnAsp: 0.93 ± 0.021	0.759AsnGlu: 0.759 ± 0.018	0.431AsnPhe: 0.431 ± 0.013	1.842AsnGly: 1.842 ± 0.033	0.359AsnHis: 0.359 ± 0.01	0.687AsnIle: 0.687 ± 0.016	0.261AsnLys: 0.261 ± 0.01	1.72AsnLeu: 1.72 ± 0.027	0.261AsnMet: 0.261 ± 0.009	0.414AsnAsn: 0.414 ± 0.014	1.4AsnPro: 1.4 ± 0.028	0.498AsnGln: 0.498 ± 0.015	1.408AsnArg: 1.408 ± 0.02	0.885AsnSer: 0.885 ± 0.021	1.054AsnThr: 1.054 ± 0.023	1.315AsnVal: 1.315 ± 0.022	0.249AsnTrp: 0.249 ± 0.01	0.371AsnTyr: 0.371 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.547ProAla: 10.547 ± 0.095	0.371ProCys: 0.371 ± 0.013	4.78ProAsp: 4.78 ± 0.044	3.698ProGlu: 3.698 ± 0.04	1.632ProPhe: 1.632 ± 0.026	7.349ProGly: 7.349 ± 0.072	1.226ProHis: 1.226 ± 0.023	1.674ProIle: 1.674 ± 0.03	0.889ProLys: 0.889 ± 0.022	5.078ProLeu: 5.078 ± 0.046	0.993ProMet: 0.993 ± 0.018	0.998ProAsn: 0.998 ± 0.021	4.548ProPro: 4.548 ± 0.073	1.467ProGln: 1.467 ± 0.026	4.641ProArg: 4.641 ± 0.053	3.696ProSer: 3.696 ± 0.045	4.105ProThr: 4.105 ± 0.046	5.664ProVal: 5.664 ± 0.048	0.872ProTrp: 0.872 ± 0.017	1.07ProTyr: 1.07 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.892GlnAla: 3.892 ± 0.039	0.176GlnCys: 0.176 ± 0.009	1.178GlnAsp: 1.178 ± 0.022	1.219GlnGlu: 1.219 ± 0.025	0.679GlnPhe: 0.679 ± 0.016	1.938GlnGly: 1.938 ± 0.031	0.596GlnHis: 0.596 ± 0.017	1.241GlnIle: 1.241 ± 0.021	0.401GlnLys: 0.401 ± 0.013	2.922GlnLeu: 2.922 ± 0.034	0.455GlnMet: 0.455 ± 0.013	0.472GlnAsn: 0.472 ± 0.014	1.973GlnPro: 1.973 ± 0.031	0.948GlnGln: 0.948 ± 0.024	2.454GlnArg: 2.454 ± 0.03	1.221GlnSer: 1.221 ± 0.02	1.42GlnThr: 1.42 ± 0.024	2.565GlnVal: 2.565 ± 0.032	0.415GlnTrp: 0.415 ± 0.012	0.487GlnTyr: 0.487 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	10.918ArgAla: 10.918 ± 0.074	0.687ArgCys: 0.687 ± 0.019	4.752ArgAsp: 4.752 ± 0.042	4.272ArgGlu: 4.272 ± 0.045	2.439ArgPhe: 2.439 ± 0.033	6.481ArgGly: 6.481 ± 0.053	2.167ArgHis: 2.167 ± 0.03	3.327ArgIle: 3.327 ± 0.046	1.073ArgLys: 1.073 ± 0.024	9.279ArgLeu: 9.279 ± 0.071	1.775ArgMet: 1.775 ± 0.023	1.427ArgAsn: 1.427 ± 0.025	6.02ArgPro: 6.02 ± 0.056	2.502ArgGln: 2.502 ± 0.029	9.082ArgArg: 9.082 ± 0.077	4.719ArgSer: 4.719 ± 0.044	4.907ArgThr: 4.907 ± 0.046	6.32ArgVal: 6.32 ± 0.055	1.523ArgTrp: 1.523 ± 0.023	1.802ArgTyr: 1.802 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.522SerAla: 7.522 ± 0.055	0.425SerCys: 0.425 ± 0.013	3.036SerAsp: 3.036 ± 0.035	2.388SerGlu: 2.388 ± 0.033	1.56SerPhe: 1.56 ± 0.027	6.368SerGly: 6.368 ± 0.06	0.99SerHis: 0.99 ± 0.021	1.698SerIle: 1.698 ± 0.03	0.75SerLys: 0.75 ± 0.02	4.683SerLeu: 4.683 ± 0.044	1.07SerMet: 1.07 ± 0.02	0.882SerAsn: 0.882 ± 0.022	3.788SerPro: 3.788 ± 0.049	1.352SerGln: 1.352 ± 0.024	4.268SerArg: 4.268 ± 0.044	3.37SerSer: 3.37 ± 0.043	3.587SerThr: 3.587 ± 0.042	4.29SerVal: 4.29 ± 0.043	0.938SerTrp: 0.938 ± 0.021	1.137SerTyr: 1.137 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.88ThrAla: 8.88 ± 0.066	0.489ThrCys: 0.489 ± 0.013	3.616ThrAsp: 3.616 ± 0.043	2.884ThrGlu: 2.884 ± 0.036	1.698ThrPhe: 1.698 ± 0.027	6.77ThrGly: 6.77 ± 0.063	1.089ThrHis: 1.089 ± 0.02	2.13ThrIle: 2.13 ± 0.03	0.813ThrLys: 0.813 ± 0.02	5.403ThrLeu: 5.403 ± 0.043	1.002ThrMet: 1.002 ± 0.021	1.042ThrAsn: 1.042 ± 0.02	4.111ThrPro: 4.111 ± 0.051	1.331ThrGln: 1.331 ± 0.025	4.369ThrArg: 4.369 ± 0.042	3.788ThrSer: 3.788 ± 0.042	4.136ThrThr: 4.136 ± 0.055	5.742ThrVal: 5.742 ± 0.045	0.882ThrTrp: 0.882 ± 0.02	1.149ThrTyr: 1.149 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.884ValAla: 11.884 ± 0.087	0.725ValCys: 0.725 ± 0.016	5.609ValAsp: 5.609 ± 0.052	4.647ValGlu: 4.647 ± 0.044	2.278ValPhe: 2.278 ± 0.032	7.366ValGly: 7.366 ± 0.061	1.82ValHis: 1.82 ± 0.027	3.165ValIle: 3.165 ± 0.037	1.083ValLys: 1.083 ± 0.02	9.165ValLeu: 9.165 ± 0.073	1.25ValMet: 1.25 ± 0.023	1.723ValAsn: 1.723 ± 0.029	5.359ValPro: 5.359 ± 0.048	1.832ValGln: 1.832 ± 0.026	7.039ValArg: 7.039 ± 0.06	4.571ValSer: 4.571 ± 0.04	5.69ValThr: 5.69 ± 0.052	8.341ValVal: 8.341 ± 0.067	1.04ValTrp: 1.04 ± 0.021	1.343ValTyr: 1.343 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.651TrpAla: 1.651 ± 0.027	0.176TrpCys: 0.176 ± 0.008	0.822TrpAsp: 0.822 ± 0.021	0.697TrpGlu: 0.697 ± 0.016	0.427TrpPhe: 0.427 ± 0.011	0.972TrpGly: 0.972 ± 0.023	0.377TrpHis: 0.377 ± 0.012	0.547TrpIle: 0.547 ± 0.015	0.272TrpLys: 0.272 ± 0.011	1.67TrpLeu: 1.67 ± 0.028	0.291TrpMet: 0.291 ± 0.011	0.343TrpAsn: 0.343 ± 0.01	0.895TrpPro: 0.895 ± 0.019	0.53TrpGln: 0.53 ± 0.015	1.406TrpArg: 1.406 ± 0.026	0.978TrpSer: 0.978 ± 0.021	0.892TrpThr: 0.892 ± 0.019	1.002TrpVal: 1.002 ± 0.017	0.312TrpTrp: 0.312 ± 0.011	0.304TrpTyr: 0.304 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.153TyrAla: 2.153 ± 0.03	0.176TyrCys: 0.176 ± 0.009	1.237TyrAsp: 1.237 ± 0.027	0.97TyrGlu: 0.97 ± 0.02	0.584TyrPhe: 0.584 ± 0.015	1.775TyrGly: 1.775 ± 0.031	0.403TyrHis: 0.403 ± 0.013	0.467TyrIle: 0.467 ± 0.014	0.268TyrLys: 0.268 ± 0.01	2.172TyrLeu: 2.172 ± 0.032	0.203TyrMet: 0.203 ± 0.009	0.353TyrAsn: 0.353 ± 0.012	1.096TyrPro: 1.096 ± 0.024	0.65TyrGln: 0.65 ± 0.016	1.747TyrArg: 1.747 ± 0.027	0.934TyrSer: 0.934 ± 0.02	1.003TyrThr: 1.003 ± 0.023	1.397TyrVal: 1.397 ± 0.025	0.308TyrTrp: 0.308 ± 0.011	0.428TyrTyr: 0.428 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8160 proteins (2647754 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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