Amino acid dipepetide frequency for Enterococcus asini ATCC 700915

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.55AlaAla: 7.55 ± 0.141
0.671AlaCys: 0.671 ± 0.032
4.822AlaAsp: 4.822 ± 0.252
5.829AlaGlu: 5.829 ± 0.109
3.515AlaPhe: 3.515 ± 0.067
6.262AlaGly: 6.262 ± 0.108
1.39AlaHis: 1.39 ± 0.044
5.607AlaIle: 5.607 ± 0.093
5.516AlaLys: 5.516 ± 0.103
8.663AlaLeu: 8.663 ± 0.117
2.173AlaMet: 2.173 ± 0.052
3.097AlaAsn: 3.097 ± 0.061
2.687AlaPro: 2.687 ± 0.064
3.814AlaGln: 3.814 ± 0.083
2.842AlaArg: 2.842 ± 0.065
4.304AlaSer: 4.304 ± 0.085
4.905AlaThr: 4.905 ± 0.091
5.75AlaVal: 5.75 ± 0.101
0.752AlaTrp: 0.752 ± 0.029
2.816AlaTyr: 2.816 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.436CysAla: 0.436 ± 0.028
0.092CysCys: 0.092 ± 0.012
0.38CysAsp: 0.38 ± 0.023
0.421CysGlu: 0.421 ± 0.023
0.327CysPhe: 0.327 ± 0.021
0.701CysGly: 0.701 ± 0.034
0.201CysHis: 0.201 ± 0.019
0.358CysIle: 0.358 ± 0.022
0.217CysLys: 0.217 ± 0.021
0.709CysLeu: 0.709 ± 0.03
0.153CysMet: 0.153 ± 0.015
0.246CysAsn: 0.246 ± 0.019
0.334CysPro: 0.334 ± 0.027
0.36CysGln: 0.36 ± 0.025
0.311CysArg: 0.311 ± 0.022
0.409CysSer: 0.409 ± 0.023
0.349CysThr: 0.349 ± 0.022
0.448CysVal: 0.448 ± 0.027
0.062CysTrp: 0.062 ± 0.011
0.316CysTyr: 0.316 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.156AspAla: 4.156 ± 0.248
0.377AspCys: 0.377 ± 0.024
2.471AspAsp: 2.471 ± 0.078
4.249AspGlu: 4.249 ± 0.087
3.085AspPhe: 3.085 ± 0.066
3.579AspGly: 3.579 ± 0.084
1.123AspHis: 1.123 ± 0.04
3.321AspIle: 3.321 ± 0.069
2.876AspLys: 2.876 ± 0.075
5.86AspLeu: 5.86 ± 0.103
1.299AspMet: 1.299 ± 0.048
1.958AspAsn: 1.958 ± 0.061
2.113AspPro: 2.113 ± 0.049
2.507AspGln: 2.507 ± 0.059
2.088AspArg: 2.088 ± 0.053
2.923AspSer: 2.923 ± 0.144
2.812AspThr: 2.812 ± 0.067
3.681AspVal: 3.681 ± 0.081
0.754AspTrp: 0.754 ± 0.034
2.528AspTyr: 2.528 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
6.641GluAla: 6.641 ± 0.111
0.335GluCys: 0.335 ± 0.023
3.674GluAsp: 3.674 ± 0.082
6.136GluGlu: 6.136 ± 0.099
2.501GluPhe: 2.501 ± 0.056
4.038GluGly: 4.038 ± 0.084
1.267GluHis: 1.267 ± 0.045
5.114GluIle: 5.114 ± 0.083
5.604GluLys: 5.604 ± 0.092
7.266GluLeu: 7.266 ± 0.104
2.13GluMet: 2.13 ± 0.057
3.438GluAsn: 3.438 ± 0.076
2.064GluPro: 2.064 ± 0.066
3.286GluGln: 3.286 ± 0.072
3.133GluArg: 3.133 ± 0.078
3.219GluSer: 3.219 ± 0.075
4.112GluThr: 4.112 ± 0.076
5.173GluVal: 5.173 ± 0.088
0.626GluTrp: 0.626 ± 0.025
2.246GluTyr: 2.246 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.655PheAla: 3.655 ± 0.084
0.38PheCys: 0.38 ± 0.019
2.693PheAsp: 2.693 ± 0.058
2.664PheGlu: 2.664 ± 0.064
2.334PhePhe: 2.334 ± 0.065
3.389PheGly: 3.389 ± 0.071
0.915PheHis: 0.915 ± 0.038
2.664PheIle: 2.664 ± 0.078
1.963PheLys: 1.963 ± 0.058
4.758PheLeu: 4.758 ± 0.103
1.078PheMet: 1.078 ± 0.045
1.583PheAsn: 1.583 ± 0.047
1.669PhePro: 1.669 ± 0.051
1.79PheGln: 1.79 ± 0.054
1.643PheArg: 1.643 ± 0.05
2.928PheSer: 2.928 ± 0.069
2.769PheThr: 2.769 ± 0.07
3.289PheVal: 3.289 ± 0.078
0.54PheTrp: 0.54 ± 0.026
1.813PheTyr: 1.813 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
5.459GlyAla: 5.459 ± 0.104
0.55GlyCys: 0.55 ± 0.029
3.653GlyAsp: 3.653 ± 0.089
4.463GlyGlu: 4.463 ± 0.08
3.418GlyPhe: 3.418 ± 0.079
4.862GlyGly: 4.862 ± 0.106
1.346GlyHis: 1.346 ± 0.045
5.613GlyIle: 5.613 ± 0.091
4.884GlyLys: 4.884 ± 0.083
7.016GlyLeu: 7.016 ± 0.119
2.13GlyMet: 2.13 ± 0.062
2.712GlyAsn: 2.712 ± 0.07
1.718GlyPro: 1.718 ± 0.055
2.97GlyGln: 2.97 ± 0.073
2.815GlyArg: 2.815 ± 0.063
3.756GlySer: 3.756 ± 0.079
4.095GlyThr: 4.095 ± 0.069
5.368GlyVal: 5.368 ± 0.097
0.71GlyTrp: 0.71 ± 0.032
2.765GlyTyr: 2.765 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.137HisAla: 1.137 ± 0.039
0.167HisCys: 0.167 ± 0.016
0.982HisAsp: 0.982 ± 0.041
1.207HisGlu: 1.207 ± 0.043
1.131HisPhe: 1.131 ± 0.039
1.38HisGly: 1.38 ± 0.047
0.52HisHis: 0.52 ± 0.03
1.035HisIle: 1.035 ± 0.036
0.86HisLys: 0.86 ± 0.035
2.058HisLeu: 2.058 ± 0.057
0.395HisMet: 0.395 ± 0.027
0.665HisAsn: 0.665 ± 0.032
1.032HisPro: 1.032 ± 0.038
0.974HisGln: 0.974 ± 0.041
0.842HisArg: 0.842 ± 0.035
0.997HisSer: 0.997 ± 0.043
0.957HisThr: 0.957 ± 0.041
1.141HisVal: 1.141 ± 0.042
0.24HisTrp: 0.24 ± 0.018
0.896HisTyr: 0.896 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.806IleAla: 5.806 ± 0.086
0.562IleCys: 0.562 ± 0.028
3.712IleAsp: 3.712 ± 0.079
4.235IleGlu: 4.235 ± 0.083
2.868IlePhe: 2.868 ± 0.074
4.976IleGly: 4.976 ± 0.105
1.251IleHis: 1.251 ± 0.039
4.128IleIle: 4.128 ± 0.095
3.438IleLys: 3.438 ± 0.054
6.615IleLeu: 6.615 ± 0.106
1.566IleMet: 1.566 ± 0.052
2.579IleAsn: 2.579 ± 0.056
3.018IlePro: 3.018 ± 0.065
2.937IleGln: 2.937 ± 0.07
2.743IleArg: 2.743 ± 0.074
3.843IleSer: 3.843 ± 0.083
4.251IleThr: 4.251 ± 0.074
4.507IleVal: 4.507 ± 0.077
0.547IleTrp: 0.547 ± 0.031
2.101IleTyr: 2.101 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
5.23LysAla: 5.23 ± 0.092
0.242LysCys: 0.242 ± 0.019
3.68LysAsp: 3.68 ± 0.085
6.059LysGlu: 6.059 ± 0.097
1.684LysPhe: 1.684 ± 0.054
3.856LysGly: 3.856 ± 0.077
0.896LysHis: 0.896 ± 0.038
4.287LysIle: 4.287 ± 0.074
4.78LysLys: 4.78 ± 0.104
4.956LysLeu: 4.956 ± 0.087
1.921LysMet: 1.921 ± 0.063
2.971LysAsn: 2.971 ± 0.063
1.908LysPro: 1.908 ± 0.058
2.727LysGln: 2.727 ± 0.071
3.052LysArg: 3.052 ± 0.071
2.888LysSer: 2.888 ± 0.072
3.49LysThr: 3.49 ± 0.07
4.063LysVal: 4.063 ± 0.081
0.535LysTrp: 0.535 ± 0.025
1.9LysTyr: 1.9 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
9.971LeuAla: 9.971 ± 0.119
0.714LeuCys: 0.714 ± 0.037
5.292LeuAsp: 5.292 ± 0.082
6.352LeuGlu: 6.352 ± 0.106
4.693LeuPhe: 4.693 ± 0.104
7.066LeuGly: 7.066 ± 0.12
1.836LeuHis: 1.836 ± 0.059
6.099LeuIle: 6.099 ± 0.117
5.817LeuLys: 5.817 ± 0.087
11.257LeuLeu: 11.257 ± 0.196
2.403LeuMet: 2.403 ± 0.059
3.866LeuAsn: 3.866 ± 0.073
4.717LeuPro: 4.717 ± 0.081
4.539LeuGln: 4.539 ± 0.087
4.143LeuArg: 4.143 ± 0.088
6.235LeuSer: 6.235 ± 0.1
6.591LeuThr: 6.591 ± 0.097
7.613LeuVal: 7.613 ± 0.12
0.952LeuTrp: 0.952 ± 0.045
3.198LeuTyr: 3.198 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.28MetAla: 2.28 ± 0.059
0.143MetCys: 0.143 ± 0.013
1.43MetAsp: 1.43 ± 0.045
1.84MetGlu: 1.84 ± 0.054
0.82MetPhe: 0.82 ± 0.034
1.859MetGly: 1.859 ± 0.053
0.376MetHis: 0.376 ± 0.022
1.862MetIle: 1.862 ± 0.055
2.107MetLys: 2.107 ± 0.052
2.213MetLeu: 2.213 ± 0.054
0.785MetMet: 0.785 ± 0.036
1.354MetAsn: 1.354 ± 0.046
1.024MetPro: 1.024 ± 0.04
0.989MetGln: 0.989 ± 0.036
1.005MetArg: 1.005 ± 0.045
1.5MetSer: 1.5 ± 0.047
1.688MetThr: 1.688 ± 0.049
1.837MetVal: 1.837 ± 0.052
0.151MetTrp: 0.151 ± 0.015
0.664MetTyr: 0.664 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.708AsnAla: 2.708 ± 0.07
0.318AsnCys: 0.318 ± 0.021
1.995AsnAsp: 1.995 ± 0.055
2.714AsnGlu: 2.714 ± 0.064
1.754AsnPhe: 1.754 ± 0.048
3.04AsnGly: 3.04 ± 0.064
0.94AsnHis: 0.94 ± 0.035
2.334AsnIle: 2.334 ± 0.063
1.959AsnLys: 1.959 ± 0.057
4.046AsnLeu: 4.046 ± 0.076
1.003AsnMet: 1.003 ± 0.04
1.601AsnAsn: 1.601 ± 0.065
2.139AsnPro: 2.139 ± 0.05
2.439AsnGln: 2.439 ± 0.065
1.91AsnArg: 1.91 ± 0.053
2.065AsnSer: 2.065 ± 0.058
1.977AsnThr: 1.977 ± 0.055
2.661AsnVal: 2.661 ± 0.067
0.516AsnTrp: 0.516 ± 0.025
1.697AsnTyr: 1.697 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.964ProAla: 2.964 ± 0.076
0.194ProCys: 0.194 ± 0.016
2.226ProAsp: 2.226 ± 0.059
3.83ProGlu: 3.83 ± 0.081
1.832ProPhe: 1.832 ± 0.051
2.551ProGly: 2.551 ± 0.07
0.69ProHis: 0.69 ± 0.029
2.342ProIle: 2.342 ± 0.062
2.293ProLys: 2.293 ± 0.054
3.801ProLeu: 3.801 ± 0.079
0.881ProMet: 0.881 ± 0.034
1.488ProAsn: 1.488 ± 0.044
0.853ProPro: 0.853 ± 0.036
1.685ProGln: 1.685 ± 0.046
1.274ProArg: 1.274 ± 0.043
1.923ProSer: 1.923 ± 0.051
2.14ProThr: 2.14 ± 0.053
3.054ProVal: 3.054 ± 0.067
0.371ProTrp: 0.371 ± 0.021
1.419ProTyr: 1.419 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.247GlnAla: 4.247 ± 0.098
0.19GlnCys: 0.19 ± 0.017
2.281GlnAsp: 2.281 ± 0.056
3.898GlnGlu: 3.898 ± 0.08
1.566GlnPhe: 1.566 ± 0.05
3.067GlnGly: 3.067 ± 0.063
0.675GlnHis: 0.675 ± 0.027
2.851GlnIle: 2.851 ± 0.065
3.357GlnLys: 3.357 ± 0.073
4.876GlnLeu: 4.876 ± 0.104
1.229GlnMet: 1.229 ± 0.047
1.708GlnAsn: 1.708 ± 0.051
1.504GlnPro: 1.504 ± 0.04
2.296GlnGln: 2.296 ± 0.078
2.018GlnArg: 2.018 ± 0.056
2.213GlnSer: 2.213 ± 0.063
2.489GlnThr: 2.489 ± 0.071
3.574GlnVal: 3.574 ± 0.071
0.459GlnTrp: 0.459 ± 0.024
1.441GlnTyr: 1.441 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.368ArgAla: 2.368 ± 0.064
0.273ArgCys: 0.273 ± 0.02
1.966ArgAsp: 1.966 ± 0.061
2.974ArgGlu: 2.974 ± 0.073
2.135ArgPhe: 2.135 ± 0.06
2.459ArgGly: 2.459 ± 0.068
0.846ArgHis: 0.846 ± 0.039
2.928ArgIle: 2.928 ± 0.063
2.908ArgLys: 2.908 ± 0.074
4.637ArgLeu: 4.637 ± 0.091
1.187ArgMet: 1.187 ± 0.041
1.756ArgAsn: 1.756 ± 0.054
1.45ArgPro: 1.45 ± 0.047
2.302ArgGln: 2.302 ± 0.072
2.198ArgArg: 2.198 ± 0.06
2.133ArgSer: 2.133 ± 0.053
1.887ArgThr: 1.887 ± 0.055
2.755ArgVal: 2.755 ± 0.073
0.402ArgTrp: 0.402 ± 0.022
1.852ArgTyr: 1.852 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.854SerAla: 3.854 ± 0.082
0.371SerCys: 0.371 ± 0.023
2.835SerAsp: 2.835 ± 0.137
3.734SerGlu: 3.734 ± 0.068
2.824SerPhe: 2.824 ± 0.067
4.408SerGly: 4.408 ± 0.079
1.048SerHis: 1.048 ± 0.039
3.442SerIle: 3.442 ± 0.07
2.926SerLys: 2.926 ± 0.062
6.038SerLeu: 6.038 ± 0.112
1.419SerMet: 1.419 ± 0.045
2.046SerAsn: 2.046 ± 0.065
1.886SerPro: 1.886 ± 0.052
2.633SerGln: 2.633 ± 0.068
2.398SerArg: 2.398 ± 0.054
3.282SerSer: 3.282 ± 0.116
2.915SerThr: 2.915 ± 0.07
3.76SerVal: 3.76 ± 0.069
0.616SerTrp: 0.616 ± 0.03
2.156SerTyr: 2.156 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.59ThrAla: 4.59 ± 0.082
0.372ThrCys: 0.372 ± 0.025
3.127ThrAsp: 3.127 ± 0.066
3.964ThrGlu: 3.964 ± 0.067
2.611ThrPhe: 2.611 ± 0.069
4.566ThrGly: 4.566 ± 0.085
1.078ThrHis: 1.078 ± 0.044
4.239ThrIle: 4.239 ± 0.079
3.563ThrLys: 3.563 ± 0.071
5.992ThrLeu: 5.992 ± 0.093
1.362ThrMet: 1.362 ± 0.044
2.277ThrAsn: 2.277 ± 0.06
2.868ThrPro: 2.868 ± 0.06
2.141ThrGln: 2.141 ± 0.061
1.978ThrArg: 1.978 ± 0.053
3.27ThrSer: 3.27 ± 0.071
3.628ThrThr: 3.628 ± 0.089
4.203ThrVal: 4.203 ± 0.082
0.553ThrTrp: 0.553 ± 0.029
1.985ThrTyr: 1.985 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
7.004ValAla: 7.004 ± 0.118
0.5ValCys: 0.5 ± 0.028
3.927ValAsp: 3.927 ± 0.079
4.332ValGlu: 4.332 ± 0.083
3.061ValPhe: 3.061 ± 0.07
4.858ValGly: 4.858 ± 0.097
1.124ValHis: 1.124 ± 0.045
5.111ValIle: 5.111 ± 0.09
4.208ValLys: 4.208 ± 0.081
7.077ValLeu: 7.077 ± 0.105
1.906ValMet: 1.906 ± 0.052
2.733ValAsn: 2.733 ± 0.06
2.846ValPro: 2.846 ± 0.06
2.303ValGln: 2.303 ± 0.055
2.558ValArg: 2.558 ± 0.062
4.201ValSer: 4.201 ± 0.077
4.968ValThr: 4.968 ± 0.085
5.347ValVal: 5.347 ± 0.1
0.577ValTrp: 0.577 ± 0.022
2.329ValTyr: 2.329 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.574TrpAla: 0.574 ± 0.029
0.084TrpCys: 0.084 ± 0.012
0.515TrpAsp: 0.515 ± 0.025
0.642TrpGlu: 0.642 ± 0.031
0.471TrpPhe: 0.471 ± 0.027
0.698TrpGly: 0.698 ± 0.033
0.229TrpHis: 0.229 ± 0.015
0.509TrpIle: 0.509 ± 0.026
0.445TrpLys: 0.445 ± 0.025
1.301TrpLeu: 1.301 ± 0.042
0.229TrpMet: 0.229 ± 0.018
0.405TrpAsn: 0.405 ± 0.022
0.322TrpPro: 0.322 ± 0.023
0.819TrpGln: 0.819 ± 0.041
0.538TrpArg: 0.538 ± 0.027
0.6TrpSer: 0.6 ± 0.027
0.479TrpThr: 0.479 ± 0.027
0.562TrpVal: 0.562 ± 0.028
0.136TrpTrp: 0.136 ± 0.013
0.357TrpTyr: 0.357 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.337TyrAla: 2.337 ± 0.059
0.296TyrCys: 0.296 ± 0.02
2.103TyrAsp: 2.103 ± 0.057
2.46TyrGlu: 2.46 ± 0.058
1.887TyrPhe: 1.887 ± 0.054
2.683TyrGly: 2.683 ± 0.058
0.864TyrHis: 0.864 ± 0.04
1.839TyrIle: 1.839 ± 0.06
1.403TyrLys: 1.403 ± 0.046
4.213TyrLeu: 4.213 ± 0.091
0.672TyrMet: 0.672 ± 0.032
1.335TyrAsn: 1.335 ± 0.038
1.659TyrPro: 1.659 ± 0.053
2.432TyrGln: 2.432 ± 0.066
1.927TyrArg: 1.927 ± 0.052
1.902TyrSer: 1.902 ± 0.054
1.864TyrThr: 1.864 ± 0.046
2.185TyrVal: 2.185 ± 0.051
0.417TyrTrp: 0.417 ± 0.026
1.613TyrTyr: 1.613 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2389 proteins (736464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski