Amino acid dipepetide frequency for Trinickia symbiotica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.152AlaAla: 18.152 ± 0.16	1.345AlaCys: 1.345 ± 0.031	6.545AlaAsp: 6.545 ± 0.068	6.535AlaGlu: 6.535 ± 0.058	4.424AlaPhe: 4.424 ± 0.053	10.361AlaGly: 10.361 ± 0.084	2.824AlaHis: 2.824 ± 0.041	6.14AlaIle: 6.14 ± 0.057	3.847AlaLys: 3.847 ± 0.052	14.441AlaLeu: 14.441 ± 0.118	3.183AlaMet: 3.183 ± 0.045	3.264AlaAsn: 3.264 ± 0.043	5.823AlaPro: 5.823 ± 0.067	4.841AlaGln: 4.841 ± 0.061	9.659AlaArg: 9.659 ± 0.081	7.704AlaSer: 7.704 ± 0.08	6.38AlaThr: 6.38 ± 0.068	8.866AlaVal: 8.866 ± 0.073	1.656AlaTrp: 1.656 ± 0.031	2.754AlaTyr: 2.754 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.259CysAla: 1.259 ± 0.025	0.143CysCys: 0.143 ± 0.01	0.568CysAsp: 0.568 ± 0.019	0.544CysGlu: 0.544 ± 0.015	0.36CysPhe: 0.36 ± 0.014	1.04CysGly: 1.04 ± 0.028	0.247CysHis: 0.247 ± 0.012	0.415CysIle: 0.415 ± 0.014	0.226CysLys: 0.226 ± 0.012	0.812CysLeu: 0.812 ± 0.022	0.192CysMet: 0.192 ± 0.009	0.244CysAsn: 0.244 ± 0.01	0.462CysPro: 0.462 ± 0.018	0.234CysGln: 0.234 ± 0.011	0.67CysArg: 0.67 ± 0.019	0.553CysSer: 0.553 ± 0.018	0.499CysThr: 0.499 ± 0.016	0.784CysVal: 0.784 ± 0.022	0.108CysTrp: 0.108 ± 0.007	0.239CysTyr: 0.239 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.551AspAla: 7.551 ± 0.074	0.472AspCys: 0.472 ± 0.016	3.214AspAsp: 3.214 ± 0.043	3.699AspGlu: 3.699 ± 0.048	1.952AspPhe: 1.952 ± 0.032	4.652AspGly: 4.652 ± 0.06	1.101AspHis: 1.101 ± 0.023	2.6AspIle: 2.6 ± 0.035	1.497AspLys: 1.497 ± 0.037	5.014AspLeu: 5.014 ± 0.052	1.151AspMet: 1.151 ± 0.025	1.24AspAsn: 1.24 ± 0.028	2.97AspPro: 2.97 ± 0.044	1.473AspGln: 1.473 ± 0.031	3.53AspArg: 3.53 ± 0.042	2.483AspSer: 2.483 ± 0.039	2.609AspThr: 2.609 ± 0.036	4.342AspVal: 4.342 ± 0.054	0.893AspTrp: 0.893 ± 0.023	1.506AspTyr: 1.506 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.054GluAla: 7.054 ± 0.073	0.447GluCys: 0.447 ± 0.017	2.191GluAsp: 2.191 ± 0.036	2.641GluGlu: 2.641 ± 0.044	1.805GluPhe: 1.805 ± 0.034	3.616GluGly: 3.616 ± 0.047	1.46GluHis: 1.46 ± 0.028	2.928GluIle: 2.928 ± 0.043	1.832GluLys: 1.832 ± 0.034	5.733GluLeu: 5.733 ± 0.059	1.272GluMet: 1.272 ± 0.026	1.439GluAsn: 1.439 ± 0.028	2.841GluPro: 2.841 ± 0.042	2.32GluGln: 2.32 ± 0.036	5.392GluArg: 5.392 ± 0.058	2.832GluSer: 2.832 ± 0.042	2.992GluThr: 2.992 ± 0.048	3.562GluVal: 3.562 ± 0.051	0.775GluTrp: 0.775 ± 0.02	1.23GluTyr: 1.23 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.813PheAla: 4.813 ± 0.05	0.441PheCys: 0.441 ± 0.014	2.636PheAsp: 2.636 ± 0.046	2.11PheGlu: 2.11 ± 0.032	1.42PhePhe: 1.42 ± 0.031	3.621PheGly: 3.621 ± 0.048	0.774PheHis: 0.774 ± 0.02	1.605PheIle: 1.605 ± 0.031	1.02PheLys: 1.02 ± 0.022	2.97PheLeu: 2.97 ± 0.045	0.746PheMet: 0.746 ± 0.018	1.094PheAsn: 1.094 ± 0.026	1.56PhePro: 1.56 ± 0.03	0.949PheGln: 0.949 ± 0.024	2.073PheArg: 2.073 ± 0.037	2.314PheSer: 2.314 ± 0.038	1.9PheThr: 1.9 ± 0.031	3.258PheVal: 3.258 ± 0.04	0.496PheTrp: 0.496 ± 0.017	0.913PheTyr: 0.913 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.606GlyAla: 9.606 ± 0.089	0.881GlyCys: 0.881 ± 0.024	4.011GlyAsp: 4.011 ± 0.047	4.417GlyGlu: 4.417 ± 0.049	3.385GlyPhe: 3.385 ± 0.049	6.931GlyGly: 6.931 ± 0.084	1.924GlyHis: 1.924 ± 0.03	4.466GlyIle: 4.466 ± 0.046	3.146GlyLys: 3.146 ± 0.046	7.851GlyLeu: 7.851 ± 0.074	2.121GlyMet: 2.121 ± 0.034	2.473GlyAsn: 2.473 ± 0.051	3.048GlyPro: 3.048 ± 0.043	2.664GlyGln: 2.664 ± 0.04	5.376GlyArg: 5.376 ± 0.059	4.672GlySer: 4.672 ± 0.071	4.778GlyThr: 4.778 ± 0.086	6.584GlyVal: 6.584 ± 0.06	1.369GlyTrp: 1.369 ± 0.028	2.373GlyTyr: 2.373 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.998HisAla: 2.998 ± 0.039	0.266HisCys: 0.266 ± 0.011	1.318HisAsp: 1.318 ± 0.027	1.301HisGlu: 1.301 ± 0.028	0.928HisPhe: 0.928 ± 0.025	2.182HisGly: 2.182 ± 0.034	0.611HisHis: 0.611 ± 0.02	0.936HisIle: 0.936 ± 0.025	0.479HisLys: 0.479 ± 0.019	2.089HisLeu: 2.089 ± 0.035	0.494HisMet: 0.494 ± 0.016	0.503HisAsn: 0.503 ± 0.016	1.443HisPro: 1.443 ± 0.032	0.627HisGln: 0.627 ± 0.017	1.663HisArg: 1.663 ± 0.03	1.092HisSer: 1.092 ± 0.024	1.003HisThr: 1.003 ± 0.024	1.763HisVal: 1.763 ± 0.032	0.382HisTrp: 0.382 ± 0.014	0.687HisTyr: 0.687 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.441IleAla: 7.441 ± 0.07	0.463IleCys: 0.463 ± 0.016	3.75IleAsp: 3.75 ± 0.05	3.595IleGlu: 3.595 ± 0.048	1.454IlePhe: 1.454 ± 0.029	4.975IleGly: 4.975 ± 0.059	0.932IleHis: 0.932 ± 0.021	1.617IleIle: 1.617 ± 0.034	1.353IleLys: 1.353 ± 0.029	3.332IleLeu: 3.332 ± 0.044	0.759IleMet: 0.759 ± 0.023	1.348IleAsn: 1.348 ± 0.027	2.091IlePro: 2.091 ± 0.036	1.147IleGln: 1.147 ± 0.025	2.869IleArg: 2.869 ± 0.036	2.55IleSer: 2.55 ± 0.038	2.286IleThr: 2.286 ± 0.039	4.811IleVal: 4.811 ± 0.055	0.534IleTrp: 0.534 ± 0.018	1.074IleTyr: 1.074 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.515LysAla: 3.515 ± 0.056	0.165LysCys: 0.165 ± 0.01	1.402LysAsp: 1.402 ± 0.032	1.435LysGlu: 1.435 ± 0.031	0.872LysPhe: 0.872 ± 0.023	2.184LysGly: 2.184 ± 0.038	0.677LysHis: 0.677 ± 0.019	1.55LysIle: 1.55 ± 0.037	1.146LysLys: 1.146 ± 0.037	3.261LysLeu: 3.261 ± 0.043	0.771LysMet: 0.771 ± 0.021	0.817LysAsn: 0.817 ± 0.023	1.904LysPro: 1.904 ± 0.034	1.173LysGln: 1.173 ± 0.024	2.495LysArg: 2.495 ± 0.041	1.692LysSer: 1.692 ± 0.031	1.818LysThr: 1.818 ± 0.036	2.197LysVal: 2.197 ± 0.042	0.355LysTrp: 0.355 ± 0.014	0.715LysTyr: 0.715 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.239LeuAla: 14.239 ± 0.106	0.989LeuCys: 0.989 ± 0.023	5.874LeuAsp: 5.874 ± 0.058	5.211LeuGlu: 5.211 ± 0.055	3.519LeuPhe: 3.519 ± 0.044	8.07LeuGly: 8.07 ± 0.072	2.214LeuHis: 2.214 ± 0.034	4.672LeuIle: 4.672 ± 0.055	3.09LeuLys: 3.09 ± 0.045	9.501LeuLeu: 9.501 ± 0.102	2.164LeuMet: 2.164 ± 0.038	2.542LeuAsn: 2.542 ± 0.037	5.645LeuPro: 5.645 ± 0.068	3.023LeuGln: 3.023 ± 0.042	7.111LeuArg: 7.111 ± 0.07	6.319LeuSer: 6.319 ± 0.063	5.497LeuThr: 5.497 ± 0.054	7.658LeuVal: 7.658 ± 0.065	1.102LeuTrp: 1.102 ± 0.028	2.121LeuTyr: 2.121 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.458MetAla: 2.458 ± 0.036	0.175MetCys: 0.175 ± 0.01	0.91MetAsp: 0.91 ± 0.024	0.969MetGlu: 0.969 ± 0.024	0.708MetPhe: 0.708 ± 0.021	1.56MetGly: 1.56 ± 0.033	0.553MetHis: 0.553 ± 0.016	1.098MetIle: 1.098 ± 0.023	1.01MetLys: 1.01 ± 0.021	2.563MetLeu: 2.563 ± 0.035	0.59MetMet: 0.59 ± 0.018	0.883MetAsn: 0.883 ± 0.019	1.445MetPro: 1.445 ± 0.027	0.933MetGln: 0.933 ± 0.023	1.929MetArg: 1.929 ± 0.033	1.688MetSer: 1.688 ± 0.029	1.618MetThr: 1.618 ± 0.026	1.412MetVal: 1.412 ± 0.029	0.218MetTrp: 0.218 ± 0.011	0.401MetTyr: 0.401 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.527AsnAla: 3.527 ± 0.048	0.272AsnCys: 0.272 ± 0.012	1.416AsnAsp: 1.416 ± 0.03	1.436AsnGlu: 1.436 ± 0.03	0.968AsnPhe: 0.968 ± 0.021	2.621AsnGly: 2.621 ± 0.048	0.521AsnHis: 0.521 ± 0.018	1.244AsnIle: 1.244 ± 0.029	0.649AsnLys: 0.649 ± 0.02	2.634AsnLeu: 2.634 ± 0.037	0.528AsnMet: 0.528 ± 0.017	0.769AsnAsn: 0.769 ± 0.025	1.733AsnPro: 1.733 ± 0.031	0.84AsnGln: 0.84 ± 0.023	1.784AsnArg: 1.784 ± 0.035	1.335AsnSer: 1.335 ± 0.038	1.354AsnThr: 1.354 ± 0.031	2.333AsnVal: 2.333 ± 0.04	0.433AsnTrp: 0.433 ± 0.016	0.727AsnTyr: 0.727 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.336ProAla: 6.336 ± 0.065	0.371ProCys: 0.371 ± 0.016	3.176ProAsp: 3.176 ± 0.043	3.088ProGlu: 3.088 ± 0.039	1.941ProPhe: 1.941 ± 0.034	4.118ProGly: 4.118 ± 0.045	1.277ProHis: 1.277 ± 0.028	2.297ProIle: 2.297 ± 0.035	1.406ProLys: 1.406 ± 0.027	5.067ProLeu: 5.067 ± 0.061	1.088ProMet: 1.088 ± 0.025	1.429ProAsn: 1.429 ± 0.027	2.592ProPro: 2.592 ± 0.051	1.749ProGln: 1.749 ± 0.033	3.157ProArg: 3.157 ± 0.043	3.062ProSer: 3.062 ± 0.046	2.641ProThr: 2.641 ± 0.042	4.114ProVal: 4.114 ± 0.049	0.663ProTrp: 0.663 ± 0.02	1.344ProTyr: 1.344 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.251GlnAla: 4.251 ± 0.056	0.28GlnCys: 0.28 ± 0.014	1.187GlnAsp: 1.187 ± 0.026	1.325GlnGlu: 1.325 ± 0.027	1.223GlnPhe: 1.223 ± 0.024	2.227GlnGly: 2.227 ± 0.035	0.791GlnHis: 0.791 ± 0.021	1.835GlnIle: 1.835 ± 0.032	0.976GlnLys: 0.976 ± 0.025	3.504GlnLeu: 3.504 ± 0.047	0.96GlnMet: 0.96 ± 0.022	0.84GlnAsn: 0.84 ± 0.022	1.821GlnPro: 1.821 ± 0.036	1.637GlnGln: 1.637 ± 0.033	2.747GlnArg: 2.747 ± 0.041	1.961GlnSer: 1.961 ± 0.033	1.891GlnThr: 1.891 ± 0.036	2.313GlnVal: 2.313 ± 0.036	0.543GlnTrp: 0.543 ± 0.016	0.883GlnTyr: 0.883 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.716ArgAla: 8.716 ± 0.092	0.664ArgCys: 0.664 ± 0.022	3.779ArgAsp: 3.779 ± 0.049	4.709ArgGlu: 4.709 ± 0.053	3.059ArgPhe: 3.059 ± 0.043	4.886ArgGly: 4.886 ± 0.048	1.89ArgHis: 1.89 ± 0.035	3.968ArgIle: 3.968 ± 0.047	2.093ArgLys: 2.093 ± 0.033	7.593ArgLeu: 7.593 ± 0.069	1.868ArgMet: 1.868 ± 0.033	1.903ArgAsn: 1.903 ± 0.034	3.271ArgPro: 3.271 ± 0.044	2.456ArgGln: 2.456 ± 0.037	5.865ArgArg: 5.865 ± 0.07	3.698ArgSer: 3.698 ± 0.055	3.556ArgThr: 3.556 ± 0.039	5.263ArgVal: 5.263 ± 0.057	1.109ArgTrp: 1.109 ± 0.026	2.112ArgTyr: 2.112 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.075SerAla: 7.075 ± 0.078	0.5SerCys: 0.5 ± 0.016	2.923SerAsp: 2.923 ± 0.042	2.763SerGlu: 2.763 ± 0.044	2.21SerPhe: 2.21 ± 0.036	5.423SerGly: 5.423 ± 0.078	1.232SerHis: 1.232 ± 0.029	2.887SerIle: 2.887 ± 0.042	1.561SerLys: 1.561 ± 0.03	5.818SerLeu: 5.818 ± 0.065	1.479SerMet: 1.479 ± 0.026	1.701SerAsn: 1.701 ± 0.039	2.997SerPro: 2.997 ± 0.045	1.757SerGln: 1.757 ± 0.034	3.92SerArg: 3.92 ± 0.046	3.575SerSer: 3.575 ± 0.055	3.114SerThr: 3.114 ± 0.048	4.329SerVal: 4.329 ± 0.057	0.7SerTrp: 0.7 ± 0.022	1.349SerTyr: 1.349 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.026ThrAla: 6.026 ± 0.065	0.451ThrCys: 0.451 ± 0.013	2.612ThrAsp: 2.612 ± 0.04	2.368ThrGlu: 2.368 ± 0.034	2.022ThrPhe: 2.022 ± 0.037	4.774ThrGly: 4.774 ± 0.063	1.238ThrHis: 1.238 ± 0.027	2.808ThrIle: 2.808 ± 0.037	1.362ThrLys: 1.362 ± 0.031	6.243ThrLeu: 6.243 ± 0.063	1.184ThrMet: 1.184 ± 0.025	1.439ThrAsn: 1.439 ± 0.035	3.301ThrPro: 3.301 ± 0.045	1.681ThrGln: 1.681 ± 0.029	3.533ThrArg: 3.533 ± 0.04	3.038ThrSer: 3.038 ± 0.047	2.966ThrThr: 2.966 ± 0.049	4.416ThrVal: 4.416 ± 0.052	0.663ThrTrp: 0.663 ± 0.017	1.234ThrTyr: 1.234 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.762ValAla: 9.762 ± 0.091	0.837ValCys: 0.837 ± 0.024	4.44ValAsp: 4.44 ± 0.051	4.343ValGlu: 4.343 ± 0.049	2.842ValPhe: 2.842 ± 0.039	5.774ValGly: 5.774 ± 0.065	1.58ValHis: 1.58 ± 0.027	3.775ValIle: 3.775 ± 0.05	2.429ValLys: 2.429 ± 0.041	7.72ValLeu: 7.72 ± 0.075	1.77ValMet: 1.77 ± 0.03	2.129ValAsn: 2.129 ± 0.036	4.028ValPro: 4.028 ± 0.05	2.243ValGln: 2.243 ± 0.033	5.332ValArg: 5.332 ± 0.057	4.635ValSer: 4.635 ± 0.059	4.534ValThr: 4.534 ± 0.058	6.428ValVal: 6.428 ± 0.064	0.942ValTrp: 0.942 ± 0.022	1.736ValTyr: 1.736 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.193TrpAla: 1.193 ± 0.03	0.143TrpCys: 0.143 ± 0.009	0.597TrpAsp: 0.597 ± 0.019	0.524TrpGlu: 0.524 ± 0.017	0.559TrpPhe: 0.559 ± 0.018	0.866TrpGly: 0.866 ± 0.022	0.397TrpHis: 0.397 ± 0.012	0.692TrpIle: 0.692 ± 0.018	0.417TrpLys: 0.417 ± 0.016	1.844TrpLeu: 1.844 ± 0.036	0.362TrpMet: 0.362 ± 0.016	0.457TrpAsn: 0.457 ± 0.018	0.653TrpPro: 0.653 ± 0.021	0.614TrpGln: 0.614 ± 0.017	1.275TrpArg: 1.275 ± 0.03	0.806TrpSer: 0.806 ± 0.021	0.708TrpThr: 0.708 ± 0.019	0.9TrpVal: 0.9 ± 0.022	0.246TrpTrp: 0.246 ± 0.013	0.307TrpTyr: 0.307 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.773TyrAla: 2.773 ± 0.043	0.296TyrCys: 0.296 ± 0.013	1.398TyrAsp: 1.398 ± 0.028	1.351TyrGlu: 1.351 ± 0.027	1.061TyrPhe: 1.061 ± 0.027	2.195TyrGly: 2.195 ± 0.04	0.522TyrHis: 0.522 ± 0.017	0.845TyrIle: 0.845 ± 0.024	0.608TyrLys: 0.608 ± 0.02	2.569TyrLeu: 2.569 ± 0.039	0.441TyrMet: 0.441 ± 0.015	0.608TyrAsn: 0.608 ± 0.017	1.288TyrPro: 1.288 ± 0.028	0.836TyrGln: 0.836 ± 0.019	2.078TyrArg: 2.078 ± 0.034	1.301TyrSer: 1.301 ± 0.025	1.214TyrThr: 1.214 ± 0.028	1.946TyrVal: 1.946 ± 0.034	0.374TyrTrp: 0.374 ± 0.013	0.676TyrTyr: 0.676 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5982 proteins (1928138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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