Amino acid dipepetide frequency for Actinomyces urogenitalis DSM 15434

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.713AlaAla: 18.713 ± 0.227	1.298AlaCys: 1.298 ± 0.044	7.463AlaAsp: 7.463 ± 0.122	7.965AlaGlu: 7.965 ± 0.128	3.168AlaPhe: 3.168 ± 0.06	12.985AlaGly: 12.985 ± 0.172	2.654AlaHis: 2.654 ± 0.057	4.257AlaIle: 4.257 ± 0.085	2.622AlaLys: 2.622 ± 0.073	14.141AlaLeu: 14.141 ± 0.164	3.132AlaMet: 3.132 ± 0.072	2.008AlaAsn: 2.008 ± 0.057	6.377AlaPro: 6.377 ± 0.128	5.424AlaGln: 5.424 ± 0.092	9.778AlaArg: 9.778 ± 0.165	8.095AlaSer: 8.095 ± 0.124	7.669AlaThr: 7.669 ± 0.121	11.492AlaVal: 11.492 ± 0.139	2.168AlaTrp: 2.168 ± 0.068	2.464AlaTyr: 2.464 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.035	0.09CysCys: 0.09 ± 0.012	0.399CysAsp: 0.399 ± 0.023	0.446CysGlu: 0.446 ± 0.023	0.203CysPhe: 0.203 ± 0.015	0.885CysGly: 0.885 ± 0.037	0.194CysHis: 0.194 ± 0.015	0.202CysIle: 0.202 ± 0.015	0.101CysLys: 0.101 ± 0.011	0.86CysLeu: 0.86 ± 0.035	0.139CysMet: 0.139 ± 0.013	0.138CysAsn: 0.138 ± 0.013	0.5CysPro: 0.5 ± 0.031	0.315CysGln: 0.315 ± 0.02	0.483CysArg: 0.483 ± 0.026	0.45CysSer: 0.45 ± 0.025	0.438CysThr: 0.438 ± 0.023	0.658CysVal: 0.658 ± 0.031	0.139CysTrp: 0.139 ± 0.015	0.159CysTyr: 0.159 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.424AspAla: 7.424 ± 0.123	0.377AspCys: 0.377 ± 0.02	3.333AspAsp: 3.333 ± 0.073	3.829AspGlu: 3.829 ± 0.084	1.514AspPhe: 1.514 ± 0.047	5.748AspGly: 5.748 ± 0.102	1.306AspHis: 1.306 ± 0.041	1.729AspIle: 1.729 ± 0.054	1.244AspLys: 1.244 ± 0.048	6.491AspLeu: 6.491 ± 0.113	0.946AspMet: 0.946 ± 0.036	0.988AspAsn: 0.988 ± 0.04	4.054AspPro: 4.054 ± 0.077	1.801AspGln: 1.801 ± 0.051	3.522AspArg: 3.522 ± 0.064	2.895AspSer: 2.895 ± 0.07	2.735AspThr: 2.735 ± 0.054	5.053AspVal: 5.053 ± 0.095	0.87AspTrp: 0.87 ± 0.037	1.332AspTyr: 1.332 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.513GluAla: 8.513 ± 0.13	0.319GluCys: 0.319 ± 0.021	3.549GluAsp: 3.549 ± 0.079	4.023GluGlu: 4.023 ± 0.091	1.123GluPhe: 1.123 ± 0.035	4.655GluGly: 4.655 ± 0.079	1.534GluHis: 1.534 ± 0.051	2.589GluIle: 2.589 ± 0.067	1.302GluLys: 1.302 ± 0.049	6.498GluLeu: 6.498 ± 0.099	1.133GluMet: 1.133 ± 0.041	1.015GluAsn: 1.015 ± 0.04	3.142GluPro: 3.142 ± 0.08	2.555GluGln: 2.555 ± 0.068	4.951GluArg: 4.951 ± 0.092	2.482GluSer: 2.482 ± 0.06	2.766GluThr: 2.766 ± 0.061	5.578GluVal: 5.578 ± 0.089	0.605GluTrp: 0.605 ± 0.032	0.989GluTyr: 0.989 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.999PheAla: 2.999 ± 0.072	0.219PheCys: 0.219 ± 0.016	1.738PheAsp: 1.738 ± 0.053	1.38PheGlu: 1.38 ± 0.044	0.92PhePhe: 0.92 ± 0.038	2.412PheGly: 2.412 ± 0.074	0.517PheHis: 0.517 ± 0.025	1.06PheIle: 1.06 ± 0.039	0.6PheLys: 0.6 ± 0.033	2.502PheLeu: 2.502 ± 0.067	0.509PheMet: 0.509 ± 0.028	0.703PheAsn: 0.703 ± 0.034	1.179PhePro: 1.179 ± 0.045	0.695PheGln: 0.695 ± 0.033	1.356PheArg: 1.356 ± 0.047	1.678PheSer: 1.678 ± 0.046	1.898PheThr: 1.898 ± 0.052	2.187PheVal: 2.187 ± 0.061	0.372PheTrp: 0.372 ± 0.023	0.687PheTyr: 0.687 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.821GlyAla: 10.821 ± 0.14	0.755GlyCys: 0.755 ± 0.034	4.193GlyAsp: 4.193 ± 0.075	5.273GlyGlu: 5.273 ± 0.087	2.485GlyPhe: 2.485 ± 0.056	7.354GlyGly: 7.354 ± 0.123	2.024GlyHis: 2.024 ± 0.057	3.545GlyIle: 3.545 ± 0.079	2.307GlyLys: 2.307 ± 0.067	9.273GlyLeu: 9.273 ± 0.125	2.095GlyMet: 2.095 ± 0.052	1.587GlyAsn: 1.587 ± 0.053	3.885GlyPro: 3.885 ± 0.086	3.657GlyGln: 3.657 ± 0.077	6.612GlyArg: 6.612 ± 0.109	5.523GlySer: 5.523 ± 0.093	5.808GlyThr: 5.808 ± 0.106	7.896GlyVal: 7.896 ± 0.124	1.702GlyTrp: 1.702 ± 0.061	2.272GlyTyr: 2.272 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.534HisAla: 2.534 ± 0.063	0.161HisCys: 0.161 ± 0.012	1.296HisAsp: 1.296 ± 0.036	1.378HisGlu: 1.378 ± 0.041	0.462HisPhe: 0.462 ± 0.027	2.084HisGly: 2.084 ± 0.054	0.609HisHis: 0.609 ± 0.029	0.612HisIle: 0.612 ± 0.027	0.333HisLys: 0.333 ± 0.021	2.436HisLeu: 2.436 ± 0.057	0.431HisMet: 0.431 ± 0.023	0.431HisAsn: 0.431 ± 0.025	1.474HisPro: 1.474 ± 0.042	0.628HisGln: 0.628 ± 0.028	1.55HisArg: 1.55 ± 0.048	0.968HisSer: 0.968 ± 0.036	1.093HisThr: 1.093 ± 0.033	1.747HisVal: 1.747 ± 0.049	0.327HisTrp: 0.327 ± 0.021	0.47HisTyr: 0.47 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.066IleAla: 5.066 ± 0.09	0.314IleCys: 0.314 ± 0.022	2.78IleAsp: 2.78 ± 0.065	2.545IleGlu: 2.545 ± 0.06	0.929IlePhe: 0.929 ± 0.043	3.664IleGly: 3.664 ± 0.086	0.765IleHis: 0.765 ± 0.029	1.612IleIle: 1.612 ± 0.061	0.863IleLys: 0.863 ± 0.033	3.172IleLeu: 3.172 ± 0.08	0.721IleMet: 0.721 ± 0.03	0.899IleAsn: 0.899 ± 0.042	1.911IlePro: 1.911 ± 0.06	1.01IleGln: 1.01 ± 0.036	2.039IleArg: 2.039 ± 0.053	2.117IleSer: 2.117 ± 0.057	2.456IleThr: 2.456 ± 0.062	3.324IleVal: 3.324 ± 0.075	0.428IleTrp: 0.428 ± 0.025	0.673IleTyr: 0.673 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.917LysAla: 2.917 ± 0.068	0.086LysCys: 0.086 ± 0.01	1.457LysAsp: 1.457 ± 0.048	1.311LysGlu: 1.311 ± 0.049	0.383LysPhe: 0.383 ± 0.024	1.697LysGly: 1.697 ± 0.051	0.401LysHis: 0.401 ± 0.023	0.964LysIle: 0.964 ± 0.038	0.762LysLys: 0.762 ± 0.034	1.507LysLeu: 1.507 ± 0.052	0.419LysMet: 0.419 ± 0.024	0.532LysAsn: 0.532 ± 0.026	1.037LysPro: 1.037 ± 0.04	0.656LysGln: 0.656 ± 0.031	1.421LysArg: 1.421 ± 0.059	0.976LysSer: 0.976 ± 0.041	1.279LysThr: 1.279 ± 0.051	1.959LysVal: 1.959 ± 0.056	0.196LysTrp: 0.196 ± 0.017	0.45LysTyr: 0.45 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.716LeuAla: 15.716 ± 0.2	0.722LeuCys: 0.722 ± 0.029	6.569LeuAsp: 6.569 ± 0.097	5.51LeuGlu: 5.51 ± 0.099	2.315LeuPhe: 2.315 ± 0.064	9.282LeuGly: 9.282 ± 0.123	1.887LeuHis: 1.887 ± 0.054	3.78LeuIle: 3.78 ± 0.072	1.782LeuLys: 1.782 ± 0.056	9.809LeuLeu: 9.809 ± 0.173	1.944LeuMet: 1.944 ± 0.052	1.65LeuAsn: 1.65 ± 0.051	5.88LeuPro: 5.88 ± 0.09	2.322LeuGln: 2.322 ± 0.058	7.423LeuArg: 7.423 ± 0.103	6.107LeuSer: 6.107 ± 0.102	7.294LeuThr: 7.294 ± 0.114	9.391LeuVal: 9.391 ± 0.153	1.179LeuTrp: 1.179 ± 0.047	1.66LeuTyr: 1.66 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.59MetAla: 2.59 ± 0.063	0.146MetCys: 0.146 ± 0.014	1.028MetAsp: 1.028 ± 0.033	0.998MetGlu: 0.998 ± 0.042	0.461MetPhe: 0.461 ± 0.026	1.621MetGly: 1.621 ± 0.043	0.347MetHis: 0.347 ± 0.023	0.83MetIle: 0.83 ± 0.031	0.458MetLys: 0.458 ± 0.023	2.013MetLeu: 2.013 ± 0.053	0.44MetMet: 0.44 ± 0.028	0.424MetAsn: 0.424 ± 0.023	1.269MetPro: 1.269 ± 0.044	0.464MetGln: 0.464 ± 0.025	1.578MetArg: 1.578 ± 0.047	1.795MetSer: 1.795 ± 0.049	1.864MetThr: 1.864 ± 0.047	1.733MetVal: 1.733 ± 0.051	0.265MetTrp: 0.265 ± 0.019	0.33MetTyr: 0.33 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.218AsnAla: 2.218 ± 0.053	0.108AsnCys: 0.108 ± 0.014	0.995AsnAsp: 0.995 ± 0.037	0.959AsnGlu: 0.959 ± 0.038	0.479AsnPhe: 0.479 ± 0.025	1.667AsnGly: 1.667 ± 0.069	0.383AsnHis: 0.383 ± 0.021	0.748AsnIle: 0.748 ± 0.034	0.427AsnLys: 0.427 ± 0.029	1.974AsnLeu: 1.974 ± 0.056	0.329AsnMet: 0.329 ± 0.021	0.455AsnAsn: 0.455 ± 0.03	1.456AsnPro: 1.456 ± 0.045	0.595AsnGln: 0.595 ± 0.03	1.101AsnArg: 1.101 ± 0.038	0.812AsnSer: 0.812 ± 0.03	1.041AsnThr: 1.041 ± 0.045	1.475AsnVal: 1.475 ± 0.051	0.25AsnTrp: 0.25 ± 0.02	0.457AsnTyr: 0.457 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.879ProAla: 7.879 ± 0.124	0.31ProCys: 0.31 ± 0.024	3.311ProAsp: 3.311 ± 0.075	3.789ProGlu: 3.789 ± 0.072	1.429ProPhe: 1.429 ± 0.042	5.466ProGly: 5.466 ± 0.113	1.079ProHis: 1.079 ± 0.035	1.551ProIle: 1.551 ± 0.045	0.898ProLys: 0.898 ± 0.034	4.689ProLeu: 4.689 ± 0.087	1.014ProMet: 1.014 ± 0.035	0.814ProAsn: 0.814 ± 0.034	1.982ProPro: 1.982 ± 0.065	2.221ProGln: 2.221 ± 0.049	3.396ProArg: 3.396 ± 0.083	3.664ProSer: 3.664 ± 0.077	3.549ProThr: 3.549 ± 0.077	5.095ProVal: 5.095 ± 0.078	0.89ProTrp: 0.89 ± 0.035	1.112ProTyr: 1.112 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	6.211GlnAla: 6.211 ± 0.102	0.204GlnCys: 0.204 ± 0.014	2.027GlnAsp: 2.027 ± 0.058	2.217GlnGlu: 2.217 ± 0.059	0.64GlnPhe: 0.64 ± 0.026	2.779GlnGly: 2.779 ± 0.058	0.597GlnHis: 0.597 ± 0.028	1.43GlnIle: 1.43 ± 0.049	0.567GlnLys: 0.567 ± 0.029	3.034GlnLeu: 3.034 ± 0.068	0.801GlnMet: 0.801 ± 0.035	0.454GlnAsn: 0.454 ± 0.023	1.849GlnPro: 1.849 ± 0.058	1.107GlnGln: 1.107 ± 0.039	2.533GlnArg: 2.533 ± 0.055	1.426GlnSer: 1.426 ± 0.043	1.81GlnThr: 1.81 ± 0.049	3.836GlnVal: 3.836 ± 0.081	0.614GlnTrp: 0.614 ± 0.03	0.532GlnTyr: 0.532 ± 0.024	0.001GlnXaa: 0.001 ± 0.001
Arg	8.596ArgAla: 8.596 ± 0.132	0.533ArgCys: 0.533 ± 0.027	3.372ArgAsp: 3.372 ± 0.068	4.699ArgGlu: 4.699 ± 0.086	1.89ArgPhe: 1.89 ± 0.052	5.286ArgGly: 5.286 ± 0.101	1.737ArgHis: 1.737 ± 0.051	2.611ArgIle: 2.611 ± 0.063	1.373ArgLys: 1.373 ± 0.051	7.819ArgLeu: 7.819 ± 0.107	1.645ArgMet: 1.645 ± 0.05	1.069ArgAsn: 1.069 ± 0.036	3.915ArgPro: 3.915 ± 0.091	2.858ArgGln: 2.858 ± 0.074	6.978ArgArg: 6.978 ± 0.135	4.507ArgSer: 4.507 ± 0.078	4.268ArgThr: 4.268 ± 0.075	5.487ArgVal: 5.487 ± 0.085	1.252ArgTrp: 1.252 ± 0.043	1.643ArgTyr: 1.643 ± 0.048	0.003ArgXaa: 0.003 ± 0.002
Ser	7.264SerAla: 7.264 ± 0.111	0.5SerCys: 0.5 ± 0.025	2.813SerAsp: 2.813 ± 0.071	2.922SerGlu: 2.922 ± 0.07	1.937SerPhe: 1.937 ± 0.049	5.82SerGly: 5.82 ± 0.107	1.304SerHis: 1.304 ± 0.042	1.959SerIle: 1.959 ± 0.054	1.128SerLys: 1.128 ± 0.042	5.985SerLeu: 5.985 ± 0.102	1.27SerMet: 1.27 ± 0.042	1.015SerAsn: 1.015 ± 0.033	3.448SerPro: 3.448 ± 0.075	2.589SerGln: 2.589 ± 0.061	4.027SerArg: 4.027 ± 0.082	4.122SerSer: 4.122 ± 0.092	3.911SerThr: 3.911 ± 0.085	4.716SerVal: 4.716 ± 0.086	1.189SerTrp: 1.189 ± 0.048	1.427SerTyr: 1.427 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.795ThrAla: 7.795 ± 0.11	0.497ThrCys: 0.497 ± 0.029	3.476ThrAsp: 3.476 ± 0.073	2.982ThrGlu: 2.982 ± 0.07	1.795ThrPhe: 1.795 ± 0.063	5.937ThrGly: 5.937 ± 0.099	1.285ThrHis: 1.285 ± 0.04	2.587ThrIle: 2.587 ± 0.069	1.253ThrLys: 1.253 ± 0.05	6.096ThrLeu: 6.096 ± 0.092	1.18ThrMet: 1.18 ± 0.042	1.193ThrAsn: 1.193 ± 0.043	3.741ThrPro: 3.741 ± 0.079	2.149ThrGln: 2.149 ± 0.054	3.819ThrArg: 3.819 ± 0.073	4.019ThrSer: 4.019 ± 0.083	4.398ThrThr: 4.398 ± 0.092	5.756ThrVal: 5.756 ± 0.094	1.201ThrTrp: 1.201 ± 0.041	1.414ThrTyr: 1.414 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	11.491ValAla: 11.491 ± 0.16	0.785ValCys: 0.785 ± 0.038	5.183ValAsp: 5.183 ± 0.101	5.048ValGlu: 5.048 ± 0.077	2.355ValPhe: 2.355 ± 0.056	6.772ValGly: 6.772 ± 0.117	1.654ValHis: 1.654 ± 0.046	3.95ValIle: 3.95 ± 0.081	1.63ValLys: 1.63 ± 0.058	9.876ValLeu: 9.876 ± 0.151	1.777ValMet: 1.777 ± 0.056	1.646ValAsn: 1.646 ± 0.05	5.156ValPro: 5.156 ± 0.096	2.183ValGln: 2.183 ± 0.048	6.233ValArg: 6.233 ± 0.092	5.567ValSer: 5.567 ± 0.09	6.063ValThr: 6.063 ± 0.099	9.028ValVal: 9.028 ± 0.141	1.187ValTrp: 1.187 ± 0.044	1.66ValTyr: 1.66 ± 0.051	0.001ValXaa: 0.001 ± 0.001
Trp	1.685TrpAla: 1.685 ± 0.051	0.186TrpCys: 0.186 ± 0.016	0.925TrpAsp: 0.925 ± 0.034	0.761TrpGlu: 0.761 ± 0.035	0.488TrpPhe: 0.488 ± 0.025	1.109TrpGly: 1.109 ± 0.04	0.358TrpHis: 0.358 ± 0.023	0.628TrpIle: 0.628 ± 0.033	0.343TrpLys: 0.343 ± 0.025	1.65TrpLeu: 1.65 ± 0.054	0.39TrpMet: 0.39 ± 0.024	0.425TrpAsn: 0.425 ± 0.028	0.79TrpPro: 0.79 ± 0.035	0.677TrpGln: 0.677 ± 0.031	1.241TrpArg: 1.241 ± 0.047	0.994TrpSer: 0.994 ± 0.039	0.967TrpThr: 0.967 ± 0.038	1.189TrpVal: 1.189 ± 0.042	0.379TrpTrp: 0.379 ± 0.024	0.342TrpTyr: 0.342 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.451TyrAla: 2.451 ± 0.066	0.178TyrCys: 0.178 ± 0.015	1.282TyrAsp: 1.282 ± 0.044	1.284TyrGlu: 1.284 ± 0.04	0.635TyrPhe: 0.635 ± 0.032	1.846TyrGly: 1.846 ± 0.045	0.389TyrHis: 0.389 ± 0.025	0.643TyrIle: 0.643 ± 0.029	0.416TyrLys: 0.416 ± 0.025	2.397TyrLeu: 2.397 ± 0.057	0.34TyrMet: 0.34 ± 0.023	0.481TyrAsn: 0.481 ± 0.023	1.093TyrPro: 1.093 ± 0.037	0.764TyrGln: 0.764 ± 0.033	1.503TyrArg: 1.503 ± 0.048	1.149TyrSer: 1.149 ± 0.039	1.265TyrThr: 1.265 ± 0.04	1.645TyrVal: 1.645 ± 0.047	0.315TyrTrp: 0.315 ± 0.024	0.505TyrTyr: 0.505 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2394 proteins (768598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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