Amino acid dipepetide frequency for Ignicoccus islandicus DSM 13165

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.831AlaAla: 4.831 ± 0.123	0.675AlaCys: 0.675 ± 0.044	2.34AlaAsp: 2.34 ± 0.076	4.029AlaGlu: 4.029 ± 0.097	3.14AlaPhe: 3.14 ± 0.093	3.776AlaGly: 3.776 ± 0.097	1.06AlaHis: 1.06 ± 0.048	5.886AlaIle: 5.886 ± 0.121	5.25AlaLys: 5.25 ± 0.127	9.633AlaLeu: 9.633 ± 0.178	1.718AlaMet: 1.718 ± 0.066	1.949AlaAsn: 1.949 ± 0.059	2.4AlaPro: 2.4 ± 0.081	1.39AlaGln: 1.39 ± 0.055	3.838AlaArg: 3.838 ± 0.101	4.626AlaSer: 4.626 ± 0.123	3.154AlaThr: 3.154 ± 0.104	5.368AlaVal: 5.368 ± 0.135	0.957AlaTrp: 0.957 ± 0.054	2.735AlaTyr: 2.735 ± 0.086	0.0AlaXaa: 0.0 ± 0.0
Cys	0.463CysAla: 0.463 ± 0.037	0.157CysCys: 0.157 ± 0.017	0.463CysAsp: 0.463 ± 0.033	0.785CysGlu: 0.785 ± 0.051	0.316CysPhe: 0.316 ± 0.028	1.07CysGly: 1.07 ± 0.062	0.243CysHis: 0.243 ± 0.042	0.6CysIle: 0.6 ± 0.041	0.829CysLys: 0.829 ± 0.047	0.764CysLeu: 0.764 ± 0.043	0.193CysMet: 0.193 ± 0.021	0.52CysAsn: 0.52 ± 0.034	0.969CysPro: 0.969 ± 0.058	0.137CysGln: 0.137 ± 0.018	0.359CysArg: 0.359 ± 0.029	0.679CysSer: 0.679 ± 0.044	0.467CysThr: 0.467 ± 0.039	0.718CysVal: 0.718 ± 0.046	0.159CysTrp: 0.159 ± 0.021	0.386CysTyr: 0.386 ± 0.033	0.0CysXaa: 0.0 ± 0.0
Asp	2.966AspAla: 2.966 ± 0.09	0.424AspCys: 0.424 ± 0.037	1.771AspAsp: 1.771 ± 0.072	4.152AspGlu: 4.152 ± 0.095	1.831AspPhe: 1.831 ± 0.073	2.997AspGly: 2.997 ± 0.168	0.636AspHis: 0.636 ± 0.04	2.853AspIle: 2.853 ± 0.085	2.838AspLys: 2.838 ± 0.092	5.648AspLeu: 5.648 ± 0.138	0.995AspMet: 0.995 ± 0.051	1.246AspAsn: 1.246 ± 0.056	2.93AspPro: 2.93 ± 0.102	0.802AspGln: 0.802 ± 0.042	1.875AspArg: 1.875 ± 0.071	2.164AspSer: 2.164 ± 0.076	1.708AspThr: 1.708 ± 0.084	5.031AspVal: 5.031 ± 0.129	0.667AspTrp: 0.667 ± 0.045	2.041AspTyr: 2.041 ± 0.087	0.0AspXaa: 0.0 ± 0.0
Glu	6.077GluAla: 6.077 ± 0.141	0.819GluCys: 0.819 ± 0.056	3.325GluAsp: 3.325 ± 0.083	8.373GluGlu: 8.373 ± 0.178	2.508GluPhe: 2.508 ± 0.091	5.568GluGly: 5.568 ± 0.111	0.901GluHis: 0.901 ± 0.047	6.38GluIle: 6.38 ± 0.147	6.289GluLys: 6.289 ± 0.162	9.619GluLeu: 9.619 ± 0.19	2.142GluMet: 2.142 ± 0.074	2.694GluAsn: 2.694 ± 0.086	2.665GluPro: 2.665 ± 0.076	1.06GluGln: 1.06 ± 0.05	4.725GluArg: 4.725 ± 0.106	3.501GluSer: 3.501 ± 0.097	2.99GluThr: 2.99 ± 0.084	8.467GluVal: 8.467 ± 0.164	0.988GluTrp: 0.988 ± 0.054	2.677GluTyr: 2.677 ± 0.085	0.0GluXaa: 0.0 ± 0.0
Phe	2.349PheAla: 2.349 ± 0.072	0.333PheCys: 0.333 ± 0.03	1.976PheAsp: 1.976 ± 0.074	2.841PheGlu: 2.841 ± 0.082	1.198PhePhe: 1.198 ± 0.064	2.424PheGly: 2.424 ± 0.078	0.663PheHis: 0.663 ± 0.04	2.176PheIle: 2.176 ± 0.061	2.696PheLys: 2.696 ± 0.085	3.812PheLeu: 3.812 ± 0.106	0.81PheMet: 0.81 ± 0.042	1.467PheAsn: 1.467 ± 0.066	1.499PhePro: 1.499 ± 0.052	0.778PheGln: 0.778 ± 0.04	1.557PheArg: 1.557 ± 0.064	2.515PheSer: 2.515 ± 0.081	1.67PheThr: 1.67 ± 0.066	3.021PheVal: 3.021 ± 0.089	0.431PheTrp: 0.431 ± 0.034	1.499PheTyr: 1.499 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	4.373GlyAla: 4.373 ± 0.103	0.778GlyCys: 0.778 ± 0.046	3.234GlyAsp: 3.234 ± 0.105	4.894GlyGlu: 4.894 ± 0.112	2.903GlyPhe: 2.903 ± 0.084	4.279GlyGly: 4.279 ± 0.114	1.034GlyHis: 1.034 ± 0.042	5.66GlyIle: 5.66 ± 0.11	5.698GlyLys: 5.698 ± 0.12	6.631GlyLeu: 6.631 ± 0.142	1.757GlyMet: 1.757 ± 0.071	2.597GlyAsn: 2.597 ± 0.095	2.458GlyPro: 2.458 ± 0.085	1.026GlyGln: 1.026 ± 0.053	3.684GlyArg: 3.684 ± 0.109	4.161GlySer: 4.161 ± 0.101	3.474GlyThr: 3.474 ± 0.094	5.33GlyVal: 5.33 ± 0.145	0.998GlyTrp: 0.998 ± 0.051	2.783GlyTyr: 2.783 ± 0.089	0.0GlyXaa: 0.0 ± 0.0
His	0.978HisAla: 0.978 ± 0.047	0.181HisCys: 0.181 ± 0.021	0.554HisAsp: 0.554 ± 0.036	0.942HisGlu: 0.942 ± 0.048	0.564HisPhe: 0.564 ± 0.038	1.152HisGly: 1.152 ± 0.055	0.361HisHis: 0.361 ± 0.031	0.843HisIle: 0.843 ± 0.041	0.814HisLys: 0.814 ± 0.05	1.617HisLeu: 1.617 ± 0.072	0.33HisMet: 0.33 ± 0.028	0.354HisAsn: 0.354 ± 0.028	1.0HisPro: 1.0 ± 0.05	0.34HisGln: 0.34 ± 0.026	0.689HisArg: 0.689 ± 0.038	0.817HisSer: 0.817 ± 0.045	0.67HisThr: 0.67 ± 0.051	1.487HisVal: 1.487 ± 0.06	0.229HisTrp: 0.229 ± 0.024	0.679HisTyr: 0.679 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	6.421IleAla: 6.421 ± 0.141	0.581IleCys: 0.581 ± 0.042	4.171IleAsp: 4.171 ± 0.111	7.199IleGlu: 7.199 ± 0.155	1.94IlePhe: 1.94 ± 0.069	5.325IleGly: 5.325 ± 0.114	1.046IleHis: 1.046 ± 0.052	4.388IleIle: 4.388 ± 0.128	4.547IleLys: 4.547 ± 0.107	6.554IleLeu: 6.554 ± 0.138	1.296IleMet: 1.296 ± 0.06	2.303IleAsn: 2.303 ± 0.087	3.479IlePro: 3.479 ± 0.102	1.058IleGln: 1.058 ± 0.048	3.971IleArg: 3.971 ± 0.102	4.633IleSer: 4.633 ± 0.114	3.361IleThr: 3.361 ± 0.131	6.303IleVal: 6.303 ± 0.138	0.713IleTrp: 0.713 ± 0.04	2.624IleTyr: 2.624 ± 0.079	0.0IleXaa: 0.0 ± 0.0
Lys	5.457LysAla: 5.457 ± 0.117	1.053LysCys: 1.053 ± 0.062	3.474LysAsp: 3.474 ± 0.087	7.368LysGlu: 7.368 ± 0.177	2.436LysPhe: 2.436 ± 0.076	5.773LysGly: 5.773 ± 0.113	0.836LysHis: 0.836 ± 0.042	4.742LysIle: 4.742 ± 0.134	5.05LysLys: 5.05 ± 0.122	7.992LysLeu: 7.992 ± 0.128	1.624LysMet: 1.624 ± 0.058	2.05LysAsn: 2.05 ± 0.074	3.007LysPro: 3.007 ± 0.089	0.904LysGln: 0.904 ± 0.046	4.927LysArg: 4.927 ± 0.124	3.626LysSer: 3.626 ± 0.1	2.576LysThr: 2.576 ± 0.089	8.151LysVal: 8.151 ± 0.134	1.173LysTrp: 1.173 ± 0.055	3.161LysTyr: 3.161 ± 0.099	0.0LysXaa: 0.0 ± 0.0
Leu	7.802LeuAla: 7.802 ± 0.153	0.798LeuCys: 0.798 ± 0.053	4.923LeuAsp: 4.923 ± 0.111	8.587LeuGlu: 8.587 ± 0.196	3.127LeuPhe: 3.127 ± 0.096	7.628LeuGly: 7.628 ± 0.146	1.53LeuHis: 1.53 ± 0.065	7.698LeuIle: 7.698 ± 0.129	9.108LeuLys: 9.108 ± 0.171	10.823LeuLeu: 10.823 ± 0.21	2.566LeuMet: 2.566 ± 0.083	4.395LeuAsn: 4.395 ± 0.093	4.723LeuPro: 4.723 ± 0.099	2.043LeuGln: 2.043 ± 0.08	6.604LeuArg: 6.604 ± 0.151	7.686LeuSer: 7.686 ± 0.147	4.985LeuThr: 4.985 ± 0.15	7.949LeuVal: 7.949 ± 0.136	1.217LeuTrp: 1.217 ± 0.06	3.699LeuTyr: 3.699 ± 0.1	0.0LeuXaa: 0.0 ± 0.0
Met	1.655MetAla: 1.655 ± 0.058	0.173MetCys: 0.173 ± 0.018	1.154MetAsp: 1.154 ± 0.055	1.973MetGlu: 1.973 ± 0.076	0.639MetPhe: 0.639 ± 0.04	1.641MetGly: 1.641 ± 0.075	0.308MetHis: 0.308 ± 0.028	1.508MetIle: 1.508 ± 0.064	2.171MetLys: 2.171 ± 0.073	1.997MetLeu: 1.997 ± 0.077	0.458MetMet: 0.458 ± 0.037	0.879MetAsn: 0.879 ± 0.046	0.92MetPro: 0.92 ± 0.052	0.347MetGln: 0.347 ± 0.025	1.426MetArg: 1.426 ± 0.058	1.52MetSer: 1.52 ± 0.068	0.947MetThr: 0.947 ± 0.055	1.993MetVal: 1.993 ± 0.067	0.188MetTrp: 0.188 ± 0.019	0.679MetTyr: 0.679 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	2.487AsnAla: 2.487 ± 0.082	0.518AsnCys: 0.518 ± 0.038	1.547AsnAsp: 1.547 ± 0.058	3.111AsnGlu: 3.111 ± 0.089	1.313AsnPhe: 1.313 ± 0.051	2.696AsnGly: 2.696 ± 0.097	0.378AsnHis: 0.378 ± 0.028	1.925AsnIle: 1.925 ± 0.073	2.32AsnLys: 2.32 ± 0.085	3.843AsnLeu: 3.843 ± 0.099	0.689AsnMet: 0.689 ± 0.039	1.077AsnAsn: 1.077 ± 0.062	2.111AsnPro: 2.111 ± 0.071	0.571AsnGln: 0.571 ± 0.04	1.424AsnArg: 1.424 ± 0.063	2.046AsnSer: 2.046 ± 0.08	1.222AsnThr: 1.222 ± 0.06	4.019AsnVal: 4.019 ± 0.1	0.443AsnTrp: 0.443 ± 0.045	1.436AsnTyr: 1.436 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.156ProAla: 2.156 ± 0.073	0.549ProCys: 0.549 ± 0.04	1.985ProAsp: 1.985 ± 0.081	3.436ProGlu: 3.436 ± 0.092	2.019ProPhe: 2.019 ± 0.068	2.778ProGly: 2.778 ± 0.092	0.836ProHis: 0.836 ± 0.041	3.323ProIle: 3.323 ± 0.092	3.306ProLys: 3.306 ± 0.092	5.012ProLeu: 5.012 ± 0.127	0.913ProMet: 0.913 ± 0.048	1.667ProAsn: 1.667 ± 0.069	2.597ProPro: 2.597 ± 0.092	1.144ProGln: 1.144 ± 0.052	2.32ProArg: 2.32 ± 0.069	3.39ProSer: 3.39 ± 0.098	2.101ProThr: 2.101 ± 0.067	3.229ProVal: 3.229 ± 0.097	0.817ProTrp: 0.817 ± 0.049	2.002ProTyr: 2.002 ± 0.075	0.0ProXaa: 0.0 ± 0.0
Gln	1.306GlnAla: 1.306 ± 0.056	0.234GlnCys: 0.234 ± 0.024	0.53GlnAsp: 0.53 ± 0.032	1.229GlnGlu: 1.229 ± 0.063	0.598GlnPhe: 0.598 ± 0.035	1.164GlnGly: 1.164 ± 0.057	0.212GlnHis: 0.212 ± 0.022	1.284GlnIle: 1.284 ± 0.048	1.087GlnLys: 1.087 ± 0.048	2.25GlnLeu: 2.25 ± 0.083	0.61GlnMet: 0.61 ± 0.037	0.532GlnAsn: 0.532 ± 0.049	0.699GlnPro: 0.699 ± 0.049	0.441GlnGln: 0.441 ± 0.039	1.248GlnArg: 1.248 ± 0.058	0.87GlnSer: 0.87 ± 0.043	0.829GlnThr: 0.829 ± 0.052	1.448GlnVal: 1.448 ± 0.056	0.287GlnTrp: 0.287 ± 0.027	0.663GlnTyr: 0.663 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	3.66ArgAla: 3.66 ± 0.096	0.612ArgCys: 0.612 ± 0.046	2.829ArgAsp: 2.829 ± 0.075	5.185ArgGlu: 5.185 ± 0.134	1.711ArgPhe: 1.711 ± 0.071	4.082ArgGly: 4.082 ± 0.112	0.73ArgHis: 0.73 ± 0.046	3.944ArgIle: 3.944 ± 0.1	4.768ArgLys: 4.768 ± 0.122	5.123ArgLeu: 5.123 ± 0.105	1.224ArgMet: 1.224 ± 0.058	2.084ArgAsn: 2.084 ± 0.077	2.159ArgPro: 2.159 ± 0.067	0.72ArgGln: 0.72 ± 0.044	3.303ArgArg: 3.303 ± 0.099	2.966ArgSer: 2.966 ± 0.091	2.154ArgThr: 2.154 ± 0.08	4.238ArgVal: 4.238 ± 0.107	0.663ArgTrp: 0.663 ± 0.041	2.026ArgTyr: 2.026 ± 0.069	0.0ArgXaa: 0.0 ± 0.0
Ser	3.325SerAla: 3.325 ± 0.081	0.593SerCys: 0.593 ± 0.04	2.761SerAsp: 2.761 ± 0.087	4.344SerGlu: 4.344 ± 0.12	2.564SerPhe: 2.564 ± 0.093	3.954SerGly: 3.954 ± 0.104	0.913SerHis: 0.913 ± 0.044	4.949SerIle: 4.949 ± 0.135	5.272SerLys: 5.272 ± 0.11	7.057SerLeu: 7.057 ± 0.15	1.463SerMet: 1.463 ± 0.058	2.47SerAsn: 2.47 ± 0.088	2.747SerPro: 2.747 ± 0.082	1.289SerGln: 1.289 ± 0.057	2.776SerArg: 2.776 ± 0.083	4.421SerSer: 4.421 ± 0.145	2.841SerThr: 2.841 ± 0.091	4.759SerVal: 4.759 ± 0.097	0.795SerTrp: 0.795 ± 0.043	2.313SerTyr: 2.313 ± 0.081	0.0SerXaa: 0.0 ± 0.0
Thr	2.744ThrAla: 2.744 ± 0.09	0.516ThrCys: 0.516 ± 0.04	1.836ThrAsp: 1.836 ± 0.115	2.771ThrGlu: 2.771 ± 0.09	1.858ThrPhe: 1.858 ± 0.076	2.918ThrGly: 2.918 ± 0.076	0.711ThrHis: 0.711 ± 0.041	3.421ThrIle: 3.421 ± 0.142	2.865ThrLys: 2.865 ± 0.093	5.306ThrLeu: 5.306 ± 0.131	0.925ThrMet: 0.925 ± 0.054	1.622ThrAsn: 1.622 ± 0.065	2.496ThrPro: 2.496 ± 0.084	1.01ThrGln: 1.01 ± 0.058	1.889ThrArg: 1.889 ± 0.075	3.046ThrSer: 3.046 ± 0.098	2.453ThrThr: 2.453 ± 0.194	3.756ThrVal: 3.756 ± 0.113	0.564ThrTrp: 0.564 ± 0.037	1.812ThrTyr: 1.812 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	6.375ValAla: 6.375 ± 0.116	0.728ValCys: 0.728 ± 0.048	4.13ValAsp: 4.13 ± 0.106	6.595ValGlu: 6.595 ± 0.152	2.954ValPhe: 2.954 ± 0.082	4.886ValGly: 4.886 ± 0.111	1.383ValHis: 1.383 ± 0.06	7.315ValIle: 7.315 ± 0.119	6.828ValLys: 6.828 ± 0.133	8.558ValLeu: 8.558 ± 0.142	1.797ValMet: 1.797 ± 0.075	3.356ValAsn: 3.356 ± 0.087	4.332ValPro: 4.332 ± 0.105	1.431ValGln: 1.431 ± 0.064	4.978ValArg: 4.978 ± 0.12	5.404ValSer: 5.404 ± 0.119	4.795ValThr: 4.795 ± 0.146	7.674ValVal: 7.674 ± 0.134	0.884ValTrp: 0.884 ± 0.048	3.212ValTyr: 3.212 ± 0.094	0.0ValXaa: 0.0 ± 0.0
Trp	0.689TrpAla: 0.689 ± 0.038	0.133TrpCys: 0.133 ± 0.019	0.653TrpAsp: 0.653 ± 0.037	1.053TrpGlu: 1.053 ± 0.061	0.525TrpPhe: 0.525 ± 0.035	0.776TrpGly: 0.776 ± 0.045	0.19TrpHis: 0.19 ± 0.027	1.017TrpIle: 1.017 ± 0.052	1.258TrpLys: 1.258 ± 0.053	1.236TrpLeu: 1.236 ± 0.053	0.342TrpMet: 0.342 ± 0.033	0.598TrpAsn: 0.598 ± 0.045	0.451TrpPro: 0.451 ± 0.03	0.222TrpGln: 0.222 ± 0.021	0.892TrpArg: 0.892 ± 0.044	0.798TrpSer: 0.798 ± 0.05	0.545TrpThr: 0.545 ± 0.04	0.887TrpVal: 0.887 ± 0.044	0.267TrpTrp: 0.267 ± 0.03	0.489TrpTyr: 0.489 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.638TyrAla: 2.638 ± 0.074	0.424TyrCys: 0.424 ± 0.032	1.92TyrAsp: 1.92 ± 0.088	2.901TyrGlu: 2.901 ± 0.081	1.571TyrPhe: 1.571 ± 0.065	2.865TyrGly: 2.865 ± 0.072	0.629TyrHis: 0.629 ± 0.046	2.0TyrIle: 2.0 ± 0.071	2.388TyrLys: 2.388 ± 0.08	4.417TyrLeu: 4.417 ± 0.107	0.725TyrMet: 0.725 ± 0.041	1.313TyrAsn: 1.313 ± 0.063	1.942TyrPro: 1.942 ± 0.055	0.805TyrGln: 0.805 ± 0.048	1.696TyrArg: 1.696 ± 0.062	2.735TyrSer: 2.735 ± 0.087	1.578TyrThr: 1.578 ± 0.069	3.79TyrVal: 3.79 ± 0.093	0.578TyrTrp: 0.578 ± 0.042	1.66TyrTyr: 1.66 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1510 proteins (415030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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