Amino acid dipepetide frequency for Bacillus daliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.666AlaAla: 8.666 ± 0.123	0.63AlaCys: 0.63 ± 0.021	4.382AlaAsp: 4.382 ± 0.071	7.051AlaGlu: 7.051 ± 0.097	3.401AlaPhe: 3.401 ± 0.062	6.966AlaGly: 6.966 ± 0.091	1.4AlaHis: 1.4 ± 0.038	4.662AlaIle: 4.662 ± 0.073	4.06AlaLys: 4.06 ± 0.06	7.729AlaLeu: 7.729 ± 0.09	2.273AlaMet: 2.273 ± 0.052	2.376AlaAsn: 2.376 ± 0.049	2.513AlaPro: 2.513 ± 0.055	2.521AlaGln: 2.521 ± 0.05	2.884AlaArg: 2.884 ± 0.055	4.67AlaSer: 4.67 ± 0.073	3.036AlaThr: 3.036 ± 0.06	6.935AlaVal: 6.935 ± 0.095	0.755AlaTrp: 0.755 ± 0.03	2.415AlaTyr: 2.415 ± 0.046	0.001AlaXaa: 0.001 ± 0.001
Cys	0.432CysAla: 0.432 ± 0.02	0.089CysCys: 0.089 ± 0.009	0.305CysAsp: 0.305 ± 0.018	0.392CysGlu: 0.392 ± 0.018	0.251CysPhe: 0.251 ± 0.015	0.655CysGly: 0.655 ± 0.026	0.156CysHis: 0.156 ± 0.015	0.382CysIle: 0.382 ± 0.019	0.249CysLys: 0.249 ± 0.019	0.526CysLeu: 0.526 ± 0.022	0.143CysMet: 0.143 ± 0.011	0.251CysAsn: 0.251 ± 0.016	0.306CysPro: 0.306 ± 0.02	0.167CysGln: 0.167 ± 0.013	0.347CysArg: 0.347 ± 0.02	0.427CysSer: 0.427 ± 0.021	0.352CysThr: 0.352 ± 0.018	0.323CysVal: 0.323 ± 0.017	0.068CysTrp: 0.068 ± 0.008	0.209CysTyr: 0.209 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.763AspAla: 3.763 ± 0.07	0.305AspCys: 0.305 ± 0.016	2.413AspAsp: 2.413 ± 0.059	4.387AspGlu: 4.387 ± 0.075	2.448AspPhe: 2.448 ± 0.054	3.474AspGly: 3.474 ± 0.073	1.213AspHis: 1.213 ± 0.044	4.104AspIle: 4.104 ± 0.067	2.906AspLys: 2.906 ± 0.058	4.865AspLeu: 4.865 ± 0.071	1.483AspMet: 1.483 ± 0.039	2.014AspAsn: 2.014 ± 0.049	2.234AspPro: 2.234 ± 0.052	1.869AspGln: 1.869 ± 0.047	2.32AspArg: 2.32 ± 0.051	2.538AspSer: 2.538 ± 0.052	2.773AspThr: 2.773 ± 0.053	3.53AspVal: 3.53 ± 0.068	0.706AspTrp: 0.706 ± 0.026	2.027AspTyr: 2.027 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.705GluAla: 7.705 ± 0.097	0.3GluCys: 0.3 ± 0.017	4.982GluAsp: 4.982 ± 0.088	11.071GluGlu: 11.071 ± 0.192	2.64GluPhe: 2.64 ± 0.056	5.279GluGly: 5.279 ± 0.084	1.686GluHis: 1.686 ± 0.041	5.763GluIle: 5.763 ± 0.077	6.685GluLys: 6.685 ± 0.091	7.63GluLeu: 7.63 ± 0.1	2.639GluMet: 2.639 ± 0.052	4.449GluAsn: 4.449 ± 0.084	2.22GluPro: 2.22 ± 0.057	3.455GluGln: 3.455 ± 0.068	3.828GluArg: 3.828 ± 0.07	3.938GluSer: 3.938 ± 0.068	4.682GluThr: 4.682 ± 0.082	5.846GluVal: 5.846 ± 0.084	0.955GluTrp: 0.955 ± 0.028	2.297GluTyr: 2.297 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.186PheAla: 3.186 ± 0.066	0.281PheCys: 0.281 ± 0.017	2.303PheAsp: 2.303 ± 0.05	2.988PheGlu: 2.988 ± 0.058	2.329PhePhe: 2.329 ± 0.056	3.222PheGly: 3.222 ± 0.063	1.082PheHis: 1.082 ± 0.034	3.587PheIle: 3.587 ± 0.07	1.959PheLys: 1.959 ± 0.049	4.345PheLeu: 4.345 ± 0.096	1.243PheMet: 1.243 ± 0.033	1.546PheAsn: 1.546 ± 0.041	1.756PhePro: 1.756 ± 0.04	1.831PheGln: 1.831 ± 0.048	1.699PheArg: 1.699 ± 0.038	3.154PheSer: 3.154 ± 0.055	2.75PheThr: 2.75 ± 0.056	2.851PheVal: 2.851 ± 0.06	0.503PheTrp: 0.503 ± 0.023	1.704PheTyr: 1.704 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.616GlyAla: 5.616 ± 0.093	0.529GlyCys: 0.529 ± 0.024	3.4GlyAsp: 3.4 ± 0.063	5.466GlyGlu: 5.466 ± 0.081	3.3GlyPhe: 3.3 ± 0.066	5.057GlyGly: 5.057 ± 0.085	1.345GlyHis: 1.345 ± 0.042	5.618GlyIle: 5.618 ± 0.083	4.482GlyLys: 4.482 ± 0.064	6.283GlyLeu: 6.283 ± 0.091	2.189GlyMet: 2.189 ± 0.054	2.696GlyAsn: 2.696 ± 0.059	1.897GlyPro: 1.897 ± 0.049	1.887GlyGln: 1.887 ± 0.037	2.952GlyArg: 2.952 ± 0.067	4.195GlySer: 4.195 ± 0.067	4.198GlyThr: 4.198 ± 0.065	4.983GlyVal: 4.983 ± 0.076	0.843GlyTrp: 0.843 ± 0.031	2.61GlyTyr: 2.61 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.533HisAla: 1.533 ± 0.039	0.179HisCys: 0.179 ± 0.012	1.036HisAsp: 1.036 ± 0.041	1.542HisGlu: 1.542 ± 0.041	1.06HisPhe: 1.06 ± 0.034	1.527HisGly: 1.527 ± 0.042	0.668HisHis: 0.668 ± 0.027	1.538HisIle: 1.538 ± 0.037	1.005HisLys: 1.005 ± 0.029	2.149HisLeu: 2.149 ± 0.045	0.567HisMet: 0.567 ± 0.023	0.769HisAsn: 0.769 ± 0.031	1.233HisPro: 1.233 ± 0.034	0.889HisGln: 0.889 ± 0.028	0.984HisArg: 0.984 ± 0.031	1.184HisSer: 1.184 ± 0.034	1.139HisThr: 1.139 ± 0.037	1.484HisVal: 1.484 ± 0.038	0.285HisTrp: 0.285 ± 0.016	0.834HisTyr: 0.834 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.711IleAla: 5.711 ± 0.082	0.486IleCys: 0.486 ± 0.023	4.021IleAsp: 4.021 ± 0.064	5.462IleGlu: 5.462 ± 0.07	3.216IlePhe: 3.216 ± 0.076	5.312IleGly: 5.312 ± 0.084	1.656IleHis: 1.656 ± 0.035	5.211IleIle: 5.211 ± 0.088	3.521IleLys: 3.521 ± 0.071	6.395IleLeu: 6.395 ± 0.101	1.737IleMet: 1.737 ± 0.05	2.856IleAsn: 2.856 ± 0.057	3.124IlePro: 3.124 ± 0.056	2.583IleGln: 2.583 ± 0.049	2.909IleArg: 2.909 ± 0.062	4.738IleSer: 4.738 ± 0.07	4.177IleThr: 4.177 ± 0.071	4.771IleVal: 4.771 ± 0.082	0.631IleTrp: 0.631 ± 0.031	2.323IleTyr: 2.323 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.411LysAla: 4.411 ± 0.078	0.231LysCys: 0.231 ± 0.017	3.252LysAsp: 3.252 ± 0.061	6.845LysGlu: 6.845 ± 0.091	1.76LysPhe: 1.76 ± 0.036	3.607LysGly: 3.607 ± 0.061	1.275LysHis: 1.275 ± 0.035	3.787LysIle: 3.787 ± 0.057	5.295LysLys: 5.295 ± 0.093	5.247LysLeu: 5.247 ± 0.07	1.988LysMet: 1.988 ± 0.046	2.754LysAsn: 2.754 ± 0.057	1.964LysPro: 1.964 ± 0.044	2.927LysGln: 2.927 ± 0.056	2.927LysArg: 2.927 ± 0.056	2.952LysSer: 2.952 ± 0.057	3.122LysThr: 3.122 ± 0.054	3.987LysVal: 3.987 ± 0.065	0.589LysTrp: 0.589 ± 0.021	1.75LysTyr: 1.75 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.47LeuAla: 7.47 ± 0.096	0.557LeuCys: 0.557 ± 0.023	4.697LeuAsp: 4.697 ± 0.075	7.506LeuGlu: 7.506 ± 0.08	4.556LeuPhe: 4.556 ± 0.086	6.108LeuGly: 6.108 ± 0.093	2.173LeuHis: 2.173 ± 0.053	6.677LeuIle: 6.677 ± 0.109	5.601LeuLys: 5.601 ± 0.07	10.045LeuLeu: 10.045 ± 0.142	2.47LeuMet: 2.47 ± 0.054	3.687LeuAsn: 3.687 ± 0.054	4.129LeuPro: 4.129 ± 0.069	4.073LeuGln: 4.073 ± 0.066	3.958LeuArg: 3.958 ± 0.065	6.42LeuSer: 6.42 ± 0.073	5.672LeuThr: 5.672 ± 0.085	5.66LeuVal: 5.66 ± 0.088	0.859LeuTrp: 0.859 ± 0.029	3.1LeuTyr: 3.1 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.048MetAla: 2.048 ± 0.047	0.12MetCys: 0.12 ± 0.012	1.448MetAsp: 1.448 ± 0.033	2.513MetGlu: 2.513 ± 0.051	1.121MetPhe: 1.121 ± 0.041	1.641MetGly: 1.641 ± 0.043	0.585MetHis: 0.585 ± 0.023	2.156MetIle: 2.156 ± 0.048	2.496MetLys: 2.496 ± 0.045	2.765MetLeu: 2.765 ± 0.064	0.953MetMet: 0.953 ± 0.035	1.636MetAsn: 1.636 ± 0.04	1.059MetPro: 1.059 ± 0.036	1.264MetGln: 1.264 ± 0.035	1.192MetArg: 1.192 ± 0.029	1.744MetSer: 1.744 ± 0.04	1.669MetThr: 1.669 ± 0.043	1.583MetVal: 1.583 ± 0.04	0.224MetTrp: 0.224 ± 0.014	0.772MetTyr: 0.772 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.88AsnAla: 2.88 ± 0.063	0.226AsnCys: 0.226 ± 0.014	2.078AsnAsp: 2.078 ± 0.046	3.783AsnGlu: 3.783 ± 0.084	1.67AsnPhe: 1.67 ± 0.04	2.775AsnGly: 2.775 ± 0.058	0.834AsnHis: 0.834 ± 0.035	3.158AsnIle: 3.158 ± 0.061	2.467AsnLys: 2.467 ± 0.054	3.302AsnLeu: 3.302 ± 0.056	1.19AsnMet: 1.19 ± 0.032	2.256AsnAsn: 2.256 ± 0.095	1.814AsnPro: 1.814 ± 0.046	1.676AsnGln: 1.676 ± 0.044	1.698AsnArg: 1.698 ± 0.037	2.149AsnSer: 2.149 ± 0.048	2.235AsnThr: 2.235 ± 0.048	2.71AsnVal: 2.71 ± 0.045	0.453AsnTrp: 0.453 ± 0.022	1.473AsnTyr: 1.473 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.082ProAla: 3.082 ± 0.055	0.212ProCys: 0.212 ± 0.015	2.185ProAsp: 2.185 ± 0.049	3.963ProGlu: 3.963 ± 0.068	1.892ProPhe: 1.892 ± 0.042	2.779ProGly: 2.779 ± 0.056	0.867ProHis: 0.867 ± 0.029	2.186ProIle: 2.186 ± 0.052	1.743ProLys: 1.743 ± 0.04	3.633ProLeu: 3.633 ± 0.063	0.89ProMet: 0.89 ± 0.031	1.193ProAsn: 1.193 ± 0.036	1.172ProPro: 1.172 ± 0.035	1.245ProGln: 1.245 ± 0.037	1.189ProArg: 1.189 ± 0.037	2.216ProSer: 2.216 ± 0.05	1.519ProThr: 1.519 ± 0.041	3.274ProVal: 3.274 ± 0.06	0.409ProTrp: 0.409 ± 0.02	1.358ProTyr: 1.358 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.028GlnAla: 3.028 ± 0.05	0.196GlnCys: 0.196 ± 0.014	1.643GlnAsp: 1.643 ± 0.044	3.814GlnGlu: 3.814 ± 0.07	1.528GlnPhe: 1.528 ± 0.042	2.404GlnGly: 2.404 ± 0.049	0.83GlnHis: 0.83 ± 0.027	2.296GlnIle: 2.296 ± 0.044	2.543GlnLys: 2.543 ± 0.062	4.085GlnLeu: 4.085 ± 0.068	1.199GlnMet: 1.199 ± 0.034	1.386GlnAsn: 1.386 ± 0.039	1.224GlnPro: 1.224 ± 0.035	1.991GlnGln: 1.991 ± 0.057	1.681GlnArg: 1.681 ± 0.042	2.08GlnSer: 2.08 ± 0.048	2.005GlnThr: 2.005 ± 0.042	2.383GlnVal: 2.383 ± 0.05	0.464GlnTrp: 0.464 ± 0.02	1.184GlnTyr: 1.184 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.802ArgAla: 2.802 ± 0.053	0.217ArgCys: 0.217 ± 0.014	2.09ArgAsp: 2.09 ± 0.043	3.738ArgGlu: 3.738 ± 0.065	1.865ArgPhe: 1.865 ± 0.047	2.624ArgGly: 2.624 ± 0.054	0.892ArgHis: 0.892 ± 0.031	3.027ArgIle: 3.027 ± 0.057	3.104ArgLys: 3.104 ± 0.051	3.839ArgLeu: 3.839 ± 0.058	1.44ArgMet: 1.44 ± 0.036	1.868ArgAsn: 1.868 ± 0.043	1.368ArgPro: 1.368 ± 0.036	1.577ArgGln: 1.577 ± 0.048	2.155ArgArg: 2.155 ± 0.048	2.439ArgSer: 2.439 ± 0.049	2.252ArgThr: 2.252 ± 0.044	2.655ArgVal: 2.655 ± 0.047	0.503ArgTrp: 0.503 ± 0.023	1.49ArgTyr: 1.49 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.321SerAla: 4.321 ± 0.068	0.354SerCys: 0.354 ± 0.023	2.638SerAsp: 2.638 ± 0.054	4.34SerGlu: 4.34 ± 0.073	3.263SerPhe: 3.263 ± 0.06	4.602SerGly: 4.602 ± 0.072	1.258SerHis: 1.258 ± 0.039	4.379SerIle: 4.379 ± 0.068	3.029SerLys: 3.029 ± 0.058	6.213SerLeu: 6.213 ± 0.082	1.831SerMet: 1.831 ± 0.038	2.153SerAsn: 2.153 ± 0.051	2.217SerPro: 2.217 ± 0.044	2.05SerGln: 2.05 ± 0.046	2.622SerArg: 2.622 ± 0.052	4.147SerSer: 4.147 ± 0.078	2.942SerThr: 2.942 ± 0.057	4.114SerVal: 4.114 ± 0.059	0.743SerTrp: 0.743 ± 0.026	2.239SerTyr: 2.239 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.026ThrAla: 5.026 ± 0.079	0.3ThrCys: 0.3 ± 0.016	2.654ThrAsp: 2.654 ± 0.051	4.172ThrGlu: 4.172 ± 0.073	2.61ThrPhe: 2.61 ± 0.046	4.472ThrGly: 4.472 ± 0.067	1.088ThrHis: 1.088 ± 0.036	3.912ThrIle: 3.912 ± 0.063	2.875ThrLys: 2.875 ± 0.06	5.166ThrLeu: 5.166 ± 0.079	1.496ThrMet: 1.496 ± 0.039	2.18ThrAsn: 2.18 ± 0.051	2.255ThrPro: 2.255 ± 0.05	1.537ThrGln: 1.537 ± 0.039	1.792ThrArg: 1.792 ± 0.041	3.299ThrSer: 3.299 ± 0.054	2.542ThrThr: 2.542 ± 0.053	4.031ThrVal: 4.031 ± 0.064	0.545ThrTrp: 0.545 ± 0.024	1.851ThrTyr: 1.851 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.641ValAla: 4.641 ± 0.068	0.503ValCys: 0.503 ± 0.023	3.492ValAsp: 3.492 ± 0.065	5.237ValGlu: 5.237 ± 0.081	3.109ValPhe: 3.109 ± 0.054	4.021ValGly: 4.021 ± 0.064	1.513ValHis: 1.513 ± 0.041	5.405ValIle: 5.405 ± 0.08	4.169ValLys: 4.169 ± 0.063	6.851ValLeu: 6.851 ± 0.097	1.986ValMet: 1.986 ± 0.049	2.95ValAsn: 2.95 ± 0.046	2.807ValPro: 2.807 ± 0.051	2.489ValGln: 2.489 ± 0.054	2.848ValArg: 2.848 ± 0.053	4.527ValSer: 4.527 ± 0.068	4.429ValThr: 4.429 ± 0.071	4.629ValVal: 4.629 ± 0.068	0.623ValTrp: 0.623 ± 0.025	2.284ValTyr: 2.284 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.655TrpAla: 0.655 ± 0.027	0.065TrpCys: 0.065 ± 0.007	0.501TrpAsp: 0.501 ± 0.024	0.891TrpGlu: 0.891 ± 0.032	0.485TrpPhe: 0.485 ± 0.022	0.666TrpGly: 0.666 ± 0.027	0.226TrpHis: 0.226 ± 0.014	0.8TrpIle: 0.8 ± 0.027	0.852TrpLys: 0.852 ± 0.027	1.123TrpLeu: 1.123 ± 0.036	0.411TrpMet: 0.411 ± 0.02	0.533TrpAsn: 0.533 ± 0.022	0.3TrpPro: 0.3 ± 0.017	0.448TrpGln: 0.448 ± 0.021	0.431TrpArg: 0.431 ± 0.024	0.633TrpSer: 0.633 ± 0.022	0.534TrpThr: 0.534 ± 0.026	0.633TrpVal: 0.633 ± 0.027	0.153TrpTrp: 0.153 ± 0.012	0.336TrpTyr: 0.336 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.35TyrAla: 2.35 ± 0.049	0.251TyrCys: 0.251 ± 0.015	1.851TyrAsp: 1.851 ± 0.047	2.89TyrGlu: 2.89 ± 0.059	1.813TyrPhe: 1.813 ± 0.048	2.356TyrGly: 2.356 ± 0.053	0.861TyrHis: 0.861 ± 0.031	2.19TyrIle: 2.19 ± 0.05	1.631TyrLys: 1.631 ± 0.045	3.229TyrLeu: 3.229 ± 0.058	0.859TyrMet: 0.859 ± 0.027	1.273TyrAsn: 1.273 ± 0.038	1.414TyrPro: 1.414 ± 0.037	1.484TyrGln: 1.484 ± 0.037	1.529TyrArg: 1.529 ± 0.04	2.004TyrSer: 2.004 ± 0.047	1.776TyrThr: 1.776 ± 0.041	2.13TyrVal: 2.13 ± 0.046	0.363TyrTrp: 0.363 ± 0.019	1.393TyrTyr: 1.393 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 3459 proteins (1040143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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