Amino acid dipepetide frequency for Pseudomonas kuykendallii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.054AlaAla: 14.054 ± 0.124	1.323AlaCys: 1.323 ± 0.033	6.281AlaAsp: 6.281 ± 0.076	7.916AlaGlu: 7.916 ± 0.088	4.114AlaPhe: 4.114 ± 0.061	9.663AlaGly: 9.663 ± 0.128	2.263AlaHis: 2.263 ± 0.04	5.107AlaIle: 5.107 ± 0.076	3.431AlaLys: 3.431 ± 0.063	15.168AlaLeu: 15.168 ± 0.142	2.899AlaMet: 2.899 ± 0.049	2.833AlaAsn: 2.833 ± 0.064	4.944AlaPro: 4.944 ± 0.071	5.144AlaGln: 5.144 ± 0.077	8.225AlaArg: 8.225 ± 0.098	6.505AlaSer: 6.505 ± 0.077	4.722AlaThr: 4.722 ± 0.064	7.494AlaVal: 7.494 ± 0.079	1.677AlaTrp: 1.677 ± 0.043	2.527AlaTyr: 2.527 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.205CysAla: 1.205 ± 0.036	0.146CysCys: 0.146 ± 0.01	0.511CysAsp: 0.511 ± 0.019	0.56CysGlu: 0.56 ± 0.022	0.33CysPhe: 0.33 ± 0.015	0.974CysGly: 0.974 ± 0.031	0.265CysHis: 0.265 ± 0.014	0.421CysIle: 0.421 ± 0.019	0.245CysLys: 0.245 ± 0.015	1.142CysLeu: 1.142 ± 0.029	0.181CysMet: 0.181 ± 0.013	0.245CysAsn: 0.245 ± 0.014	0.504CysPro: 0.504 ± 0.021	0.351CysGln: 0.351 ± 0.017	0.682CysArg: 0.682 ± 0.024	0.618CysSer: 0.618 ± 0.018	0.449CysThr: 0.449 ± 0.019	0.68CysVal: 0.68 ± 0.023	0.147CysTrp: 0.147 ± 0.01	0.222CysTyr: 0.222 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.432AspAla: 6.432 ± 0.07	0.546AspCys: 0.546 ± 0.02	3.178AspAsp: 3.178 ± 0.048	3.713AspGlu: 3.713 ± 0.066	2.169AspPhe: 2.169 ± 0.043	4.861AspGly: 4.861 ± 0.074	1.069AspHis: 1.069 ± 0.031	2.581AspIle: 2.581 ± 0.049	1.719AspLys: 1.719 ± 0.042	6.134AspLeu: 6.134 ± 0.077	1.143AspMet: 1.143 ± 0.029	1.401AspAsn: 1.401 ± 0.035	2.873AspPro: 2.873 ± 0.049	1.858AspGln: 1.858 ± 0.039	3.245AspArg: 3.245 ± 0.046	2.934AspSer: 2.934 ± 0.052	2.235AspThr: 2.235 ± 0.042	3.557AspVal: 3.557 ± 0.062	1.042AspTrp: 1.042 ± 0.028	1.721AspTyr: 1.721 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.075GluAla: 7.075 ± 0.086	0.438GluCys: 0.438 ± 0.017	2.62GluAsp: 2.62 ± 0.046	3.363GluGlu: 3.363 ± 0.069	1.862GluPhe: 1.862 ± 0.04	4.178GluGly: 4.178 ± 0.063	1.58GluHis: 1.58 ± 0.036	2.755GluIle: 2.755 ± 0.055	2.14GluLys: 2.14 ± 0.051	7.312GluLeu: 7.312 ± 0.08	1.31GluMet: 1.31 ± 0.03	1.559GluAsn: 1.559 ± 0.037	2.65GluPro: 2.65 ± 0.054	3.512GluGln: 3.512 ± 0.062	5.575GluArg: 5.575 ± 0.085	2.798GluSer: 2.798 ± 0.041	2.653GluThr: 2.653 ± 0.045	4.298GluVal: 4.298 ± 0.06	0.738GluTrp: 0.738 ± 0.022	1.193GluTyr: 1.193 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.436PheAla: 4.436 ± 0.064	0.485PheCys: 0.485 ± 0.019	2.464PheAsp: 2.464 ± 0.044	2.13PheGlu: 2.13 ± 0.044	1.499PhePhe: 1.499 ± 0.035	3.357PheGly: 3.357 ± 0.056	0.771PheHis: 0.771 ± 0.021	1.713PheIle: 1.713 ± 0.042	1.099PheLys: 1.099 ± 0.026	3.358PheLeu: 3.358 ± 0.059	0.743PheMet: 0.743 ± 0.025	1.163PheAsn: 1.163 ± 0.033	1.517PhePro: 1.517 ± 0.036	1.14PheGln: 1.14 ± 0.031	2.004PheArg: 2.004 ± 0.034	2.419PheSer: 2.419 ± 0.042	1.745PheThr: 1.745 ± 0.035	2.643PheVal: 2.643 ± 0.046	0.547PheTrp: 0.547 ± 0.02	1.016PheTyr: 1.016 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.177GlyAla: 8.177 ± 0.11	1.008GlyCys: 1.008 ± 0.031	4.253GlyAsp: 4.253 ± 0.058	5.411GlyGlu: 5.411 ± 0.073	3.353GlyPhe: 3.353 ± 0.046	6.482GlyGly: 6.482 ± 0.135	1.868GlyHis: 1.868 ± 0.046	4.102GlyIle: 4.102 ± 0.053	3.286GlyLys: 3.286 ± 0.057	9.563GlyLeu: 9.563 ± 0.091	2.23GlyMet: 2.23 ± 0.036	2.356GlyAsn: 2.356 ± 0.081	2.61GlyPro: 2.61 ± 0.044	3.416GlyGln: 3.416 ± 0.058	5.406GlyArg: 5.406 ± 0.066	4.858GlySer: 4.858 ± 0.118	3.719GlyThr: 3.719 ± 0.12	6.216GlyVal: 6.216 ± 0.08	1.354GlyTrp: 1.354 ± 0.036	2.451GlyTyr: 2.451 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.487HisAla: 2.487 ± 0.041	0.342HisCys: 0.342 ± 0.014	1.23HisAsp: 1.23 ± 0.033	1.156HisGlu: 1.156 ± 0.029	0.995HisPhe: 0.995 ± 0.029	2.017HisGly: 2.017 ± 0.044	0.549HisHis: 0.549 ± 0.025	0.887HisIle: 0.887 ± 0.025	0.581HisLys: 0.581 ± 0.02	2.572HisLeu: 2.572 ± 0.051	0.494HisMet: 0.494 ± 0.02	0.539HisAsn: 0.539 ± 0.02	1.434HisPro: 1.434 ± 0.038	0.812HisGln: 0.812 ± 0.027	1.371HisArg: 1.371 ± 0.037	1.171HisSer: 1.171 ± 0.027	0.876HisThr: 0.876 ± 0.026	1.252HisVal: 1.252 ± 0.034	0.429HisTrp: 0.429 ± 0.017	0.708HisTyr: 0.708 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.985IleAla: 5.985 ± 0.074	0.456IleCys: 0.456 ± 0.021	3.238IleAsp: 3.238 ± 0.05	3.239IleGlu: 3.239 ± 0.053	1.283IlePhe: 1.283 ± 0.03	4.651IleGly: 4.651 ± 0.066	0.931IleHis: 0.931 ± 0.031	1.77IleIle: 1.77 ± 0.038	1.404IleLys: 1.404 ± 0.033	4.028IleLeu: 4.028 ± 0.067	0.73IleMet: 0.73 ± 0.023	1.527IleAsn: 1.527 ± 0.037	2.152IlePro: 2.152 ± 0.041	1.471IleGln: 1.471 ± 0.037	3.052IleArg: 3.052 ± 0.043	2.625IleSer: 2.625 ± 0.043	2.235IleThr: 2.235 ± 0.045	3.193IleVal: 3.193 ± 0.047	0.437IleTrp: 0.437 ± 0.019	1.07IleTyr: 1.07 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.791LysAla: 3.791 ± 0.081	0.167LysCys: 0.167 ± 0.012	1.562LysAsp: 1.562 ± 0.034	1.484LysGlu: 1.484 ± 0.045	0.748LysPhe: 0.748 ± 0.028	2.417LysGly: 2.417 ± 0.049	0.647LysHis: 0.647 ± 0.022	1.43LysIle: 1.43 ± 0.035	1.195LysLys: 1.195 ± 0.044	3.453LysLeu: 3.453 ± 0.058	0.68LysMet: 0.68 ± 0.025	0.895LysAsn: 0.895 ± 0.028	1.969LysPro: 1.969 ± 0.041	1.37LysGln: 1.37 ± 0.035	2.347LysArg: 2.347 ± 0.047	1.698LysSer: 1.698 ± 0.038	1.658LysThr: 1.658 ± 0.037	2.587LysVal: 2.587 ± 0.049	0.318LysTrp: 0.318 ± 0.016	0.62LysTyr: 0.62 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.296LeuAla: 15.296 ± 0.122	1.261LeuCys: 1.261 ± 0.033	7.143LeuAsp: 7.143 ± 0.079	6.895LeuGlu: 6.895 ± 0.094	4.311LeuPhe: 4.311 ± 0.071	9.948LeuGly: 9.948 ± 0.128	2.484LeuHis: 2.484 ± 0.055	5.526LeuIle: 5.526 ± 0.064	3.917LeuLys: 3.917 ± 0.061	14.372LeuLeu: 14.372 ± 0.168	2.517LeuMet: 2.517 ± 0.049	3.365LeuAsn: 3.365 ± 0.069	6.63LeuPro: 6.63 ± 0.08	4.767LeuGln: 4.767 ± 0.059	8.258LeuArg: 8.258 ± 0.093	7.176LeuSer: 7.176 ± 0.091	5.298LeuThr: 5.298 ± 0.077	8.02LeuVal: 8.02 ± 0.079	1.429LeuTrp: 1.429 ± 0.038	2.579LeuTyr: 2.579 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.497MetAla: 2.497 ± 0.043	0.141MetCys: 0.141 ± 0.01	1.033MetAsp: 1.033 ± 0.03	0.944MetGlu: 0.944 ± 0.029	0.631MetPhe: 0.631 ± 0.022	1.612MetGly: 1.612 ± 0.039	0.496MetHis: 0.496 ± 0.018	1.087MetIle: 1.087 ± 0.026	0.831MetLys: 0.831 ± 0.026	2.693MetLeu: 2.693 ± 0.046	0.469MetMet: 0.469 ± 0.019	0.812MetAsn: 0.812 ± 0.025	1.392MetPro: 1.392 ± 0.037	1.042MetGln: 1.042 ± 0.027	1.593MetArg: 1.593 ± 0.031	1.713MetSer: 1.713 ± 0.034	1.289MetThr: 1.289 ± 0.03	1.408MetVal: 1.408 ± 0.035	0.158MetTrp: 0.158 ± 0.009	0.368MetTyr: 0.368 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.147AsnAla: 3.147 ± 0.073	0.266AsnCys: 0.266 ± 0.015	1.482AsnAsp: 1.482 ± 0.045	1.338AsnGlu: 1.338 ± 0.031	1.004AsnPhe: 1.004 ± 0.029	2.557AsnGly: 2.557 ± 0.077	0.553AsnHis: 0.553 ± 0.019	1.224AsnIle: 1.224 ± 0.034	0.745AsnLys: 0.745 ± 0.026	3.353AsnLeu: 3.353 ± 0.058	0.521AsnMet: 0.521 ± 0.021	0.77AsnAsn: 0.77 ± 0.028	1.89AsnPro: 1.89 ± 0.036	1.094AsnGln: 1.094 ± 0.032	1.846AsnArg: 1.846 ± 0.04	1.409AsnSer: 1.409 ± 0.04	1.273AsnThr: 1.273 ± 0.035	1.826AsnVal: 1.826 ± 0.04	0.417AsnTrp: 0.417 ± 0.015	0.75AsnTyr: 0.75 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.01ProAla: 6.01 ± 0.082	0.351ProCys: 0.351 ± 0.017	2.781ProAsp: 2.781 ± 0.054	3.247ProGlu: 3.247 ± 0.052	1.843ProPhe: 1.843 ± 0.037	4.122ProGly: 4.122 ± 0.06	1.065ProHis: 1.065 ± 0.03	1.999ProIle: 1.999 ± 0.042	1.469ProLys: 1.469 ± 0.038	5.979ProLeu: 5.979 ± 0.078	1.147ProMet: 1.147 ± 0.029	1.326ProAsn: 1.326 ± 0.03	2.124ProPro: 2.124 ± 0.046	2.228ProGln: 2.228 ± 0.046	3.022ProArg: 3.022 ± 0.047	2.639ProSer: 2.639 ± 0.045	2.167ProThr: 2.167 ± 0.045	3.662ProVal: 3.662 ± 0.05	0.748ProTrp: 0.748 ± 0.025	1.191ProTyr: 1.191 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.716GlnAla: 5.716 ± 0.082	0.303GlnCys: 0.303 ± 0.015	1.782GlnAsp: 1.782 ± 0.034	1.92GlnGlu: 1.92 ± 0.044	1.26GlnPhe: 1.26 ± 0.025	3.132GlnGly: 3.132 ± 0.048	0.984GlnHis: 0.984 ± 0.026	1.858GlnIle: 1.858 ± 0.039	1.142GlnLys: 1.142 ± 0.029	5.252GlnLeu: 5.252 ± 0.075	1.015GlnMet: 1.015 ± 0.027	1.066GlnAsn: 1.066 ± 0.032	2.434GlnPro: 2.434 ± 0.04	2.285GlnGln: 2.285 ± 0.053	3.917GlnArg: 3.917 ± 0.063	2.07GlnSer: 2.07 ± 0.044	1.805GlnThr: 1.805 ± 0.042	3.348GlnVal: 3.348 ± 0.05	0.574GlnTrp: 0.574 ± 0.022	0.853GlnTyr: 0.853 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.053ArgAla: 7.053 ± 0.087	0.649ArgCys: 0.649 ± 0.021	3.855ArgAsp: 3.855 ± 0.056	4.721ArgGlu: 4.721 ± 0.064	2.944ArgPhe: 2.944 ± 0.051	4.57ArgGly: 4.57 ± 0.057	1.862ArgHis: 1.862 ± 0.041	3.529ArgIle: 3.529 ± 0.054	2.011ArgLys: 2.011 ± 0.04	9.443ArgLeu: 9.443 ± 0.124	1.698ArgMet: 1.698 ± 0.035	1.871ArgAsn: 1.871 ± 0.038	3.044ArgPro: 3.044 ± 0.054	3.693ArgGln: 3.693 ± 0.058	5.206ArgArg: 5.206 ± 0.081	3.589ArgSer: 3.589 ± 0.044	2.78ArgThr: 2.78 ± 0.043	4.868ArgVal: 4.868 ± 0.069	1.127ArgTrp: 1.127 ± 0.029	2.157ArgTyr: 2.157 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.32SerAla: 6.32 ± 0.08	0.465SerCys: 0.465 ± 0.017	2.822SerAsp: 2.822 ± 0.051	3.122SerGlu: 3.122 ± 0.049	2.115SerPhe: 2.115 ± 0.039	5.374SerGly: 5.374 ± 0.119	1.217SerHis: 1.217 ± 0.03	2.595SerIle: 2.595 ± 0.043	1.591SerLys: 1.591 ± 0.037	7.192SerLeu: 7.192 ± 0.089	1.332SerMet: 1.332 ± 0.03	1.592SerAsn: 1.592 ± 0.047	2.682SerPro: 2.682 ± 0.043	2.19SerGln: 2.19 ± 0.043	3.782SerArg: 3.782 ± 0.052	3.254SerSer: 3.254 ± 0.063	2.68SerThr: 2.68 ± 0.063	3.929SerVal: 3.929 ± 0.066	0.785SerTrp: 0.785 ± 0.022	1.396SerTyr: 1.396 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.804ThrAla: 4.804 ± 0.069	0.424ThrCys: 0.424 ± 0.019	2.193ThrAsp: 2.193 ± 0.052	2.156ThrGlu: 2.156 ± 0.044	1.71ThrPhe: 1.71 ± 0.038	3.984ThrGly: 3.984 ± 0.071	0.964ThrHis: 0.964 ± 0.024	1.697ThrIle: 1.697 ± 0.04	0.949ThrLys: 0.949 ± 0.029	6.736ThrLeu: 6.736 ± 0.127	0.718ThrMet: 0.718 ± 0.026	1.059ThrAsn: 1.059 ± 0.032	2.969ThrPro: 2.969 ± 0.049	1.72ThrGln: 1.72 ± 0.034	3.185ThrArg: 3.185 ± 0.042	2.527ThrSer: 2.527 ± 0.053	2.19ThrThr: 2.19 ± 0.052	3.095ThrVal: 3.095 ± 0.061	0.644ThrTrp: 0.644 ± 0.021	1.165ThrTyr: 1.165 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.932ValAla: 7.932 ± 0.086	0.714ValCys: 0.714 ± 0.023	4.067ValAsp: 4.067 ± 0.057	4.529ValGlu: 4.529 ± 0.059	2.606ValPhe: 2.606 ± 0.046	5.286ValGly: 5.286 ± 0.07	1.396ValHis: 1.396 ± 0.036	3.633ValIle: 3.633 ± 0.053	2.165ValLys: 2.165 ± 0.042	8.124ValLeu: 8.124 ± 0.102	1.619ValMet: 1.619 ± 0.035	1.989ValAsn: 1.989 ± 0.035	3.316ValPro: 3.316 ± 0.043	2.583ValGln: 2.583 ± 0.045	4.67ValArg: 4.67 ± 0.061	4.11ValSer: 4.11 ± 0.064	3.397ValThr: 3.397 ± 0.063	5.254ValVal: 5.254 ± 0.066	0.841ValTrp: 0.841 ± 0.022	1.517ValTyr: 1.517 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.223TrpAla: 1.223 ± 0.028	0.143TrpCys: 0.143 ± 0.01	0.593TrpAsp: 0.593 ± 0.022	0.589TrpGlu: 0.589 ± 0.02	0.526TrpPhe: 0.526 ± 0.022	0.89TrpGly: 0.89 ± 0.024	0.384TrpHis: 0.384 ± 0.017	0.65TrpIle: 0.65 ± 0.022	0.445TrpLys: 0.445 ± 0.018	2.208TrpLeu: 2.208 ± 0.048	0.358TrpMet: 0.358 ± 0.016	0.444TrpAsn: 0.444 ± 0.019	0.707TrpPro: 0.707 ± 0.025	0.851TrpGln: 0.851 ± 0.03	1.141TrpArg: 1.141 ± 0.032	0.827TrpSer: 0.827 ± 0.024	0.602TrpThr: 0.602 ± 0.02	0.881TrpVal: 0.881 ± 0.027	0.23TrpTrp: 0.23 ± 0.013	0.335TrpTyr: 0.335 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.65TyrAla: 2.65 ± 0.047	0.25TyrCys: 0.25 ± 0.014	1.323TyrAsp: 1.323 ± 0.029	1.175TyrGlu: 1.175 ± 0.03	0.944TyrPhe: 0.944 ± 0.03	2.044TyrGly: 2.044 ± 0.042	0.551TyrHis: 0.551 ± 0.021	0.912TyrIle: 0.912 ± 0.028	0.672TyrLys: 0.672 ± 0.025	3.11TyrLeu: 3.11 ± 0.048	0.404TyrMet: 0.404 ± 0.016	0.655TyrAsn: 0.655 ± 0.025	1.281TyrPro: 1.281 ± 0.03	1.19TyrGln: 1.19 ± 0.034	2.144TyrArg: 2.144 ± 0.037	1.496TyrSer: 1.496 ± 0.038	1.119TyrThr: 1.119 ± 0.031	1.537TyrVal: 1.537 ± 0.032	0.386TyrTrp: 0.386 ± 0.017	0.705TyrTyr: 0.705 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4331 proteins (1397955 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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