Amino acid dipepetide frequency for Nocardiopsis alba (strain ATCC BAA-2165 / BE74)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.979AlaAla: 14.979 ± 0.12	0.903AlaCys: 0.903 ± 0.018	7.225AlaAsp: 7.225 ± 0.07	8.956AlaGlu: 8.956 ± 0.08	3.35AlaPhe: 3.35 ± 0.052	10.544AlaGly: 10.544 ± 0.088	2.761AlaHis: 2.761 ± 0.051	3.769AlaIle: 3.769 ± 0.057	1.877AlaLys: 1.877 ± 0.036	13.915AlaLeu: 13.915 ± 0.133	2.425AlaMet: 2.425 ± 0.041	1.589AlaAsn: 1.589 ± 0.028	6.316AlaPro: 6.316 ± 0.069	2.635AlaGln: 2.635 ± 0.045	9.731AlaArg: 9.731 ± 0.084	5.754AlaSer: 5.754 ± 0.062	6.002AlaThr: 6.002 ± 0.065	10.234AlaVal: 10.234 ± 0.106	1.681AlaTrp: 1.681 ± 0.035	2.266AlaTyr: 2.266 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.913CysAla: 0.913 ± 0.024	0.09CysCys: 0.09 ± 0.009	0.425CysAsp: 0.425 ± 0.017	0.392CysGlu: 0.392 ± 0.015	0.205CysPhe: 0.205 ± 0.011	0.827CysGly: 0.827 ± 0.023	0.178CysHis: 0.178 ± 0.011	0.108CysIle: 0.108 ± 0.009	0.064CysLys: 0.064 ± 0.006	0.722CysLeu: 0.722 ± 0.022	0.119CysMet: 0.119 ± 0.008	0.093CysAsn: 0.093 ± 0.007	0.489CysPro: 0.489 ± 0.019	0.137CysGln: 0.137 ± 0.009	0.552CysArg: 0.552 ± 0.017	0.499CysSer: 0.499 ± 0.019	0.365CysThr: 0.365 ± 0.015	0.665CysVal: 0.665 ± 0.02	0.094CysTrp: 0.094 ± 0.008	0.137CysTyr: 0.137 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.356AspAla: 6.356 ± 0.064	0.344AspCys: 0.344 ± 0.015	3.992AspAsp: 3.992 ± 0.063	4.702AspGlu: 4.702 ± 0.056	1.701AspPhe: 1.701 ± 0.032	6.11AspGly: 6.11 ± 0.079	1.828AspHis: 1.828 ± 0.034	1.944AspIle: 1.944 ± 0.041	0.876AspLys: 0.876 ± 0.025	7.269AspLeu: 7.269 ± 0.08	0.984AspMet: 0.984 ± 0.024	0.899AspAsn: 0.899 ± 0.027	5.222AspPro: 5.222 ± 0.07	1.482AspGln: 1.482 ± 0.038	5.793AspArg: 5.793 ± 0.073	2.65AspSer: 2.65 ± 0.046	3.555AspThr: 3.555 ± 0.051	4.864AspVal: 4.864 ± 0.065	0.855AspTrp: 0.855 ± 0.025	1.185AspTyr: 1.185 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	8.25GluAla: 8.25 ± 0.083	0.359GluCys: 0.359 ± 0.018	3.956GluAsp: 3.956 ± 0.065	5.919GluGlu: 5.919 ± 0.085	1.631GluPhe: 1.631 ± 0.032	6.409GluGly: 6.409 ± 0.071	2.02GluHis: 2.02 ± 0.037	2.839GluIle: 2.839 ± 0.045	1.367GluLys: 1.367 ± 0.033	6.799GluLeu: 6.799 ± 0.072	1.122GluMet: 1.122 ± 0.028	1.497GluAsn: 1.497 ± 0.037	3.973GluPro: 3.973 ± 0.057	2.02GluGln: 2.02 ± 0.04	7.721GluArg: 7.721 ± 0.077	3.217GluSer: 3.217 ± 0.046	3.701GluThr: 3.701 ± 0.052	5.438GluVal: 5.438 ± 0.056	0.919GluTrp: 0.919 ± 0.024	1.304GluTyr: 1.304 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.383PheAla: 3.383 ± 0.052	0.239PheCys: 0.239 ± 0.012	2.154PheAsp: 2.154 ± 0.042	1.692PheGlu: 1.692 ± 0.032	0.91PhePhe: 0.91 ± 0.026	3.179PheGly: 3.179 ± 0.045	0.679PheHis: 0.679 ± 0.02	0.796PheIle: 0.796 ± 0.024	0.397PheLys: 0.397 ± 0.014	2.881PheLeu: 2.881 ± 0.048	0.467PheMet: 0.467 ± 0.016	0.534PheAsn: 0.534 ± 0.021	1.459PhePro: 1.459 ± 0.026	0.649PheGln: 0.649 ± 0.021	1.739PheArg: 1.739 ± 0.035	1.746PheSer: 1.746 ± 0.035	1.912PheThr: 1.912 ± 0.036	2.496PheVal: 2.496 ± 0.043	0.44PheTrp: 0.44 ± 0.016	0.59PheTyr: 0.59 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.371GlyAla: 10.371 ± 0.097	0.716GlyCys: 0.716 ± 0.022	5.553GlyAsp: 5.553 ± 0.063	6.44GlyGlu: 6.44 ± 0.074	2.975GlyPhe: 2.975 ± 0.042	8.947GlyGly: 8.947 ± 0.102	2.354GlyHis: 2.354 ± 0.038	3.39GlyIle: 3.39 ± 0.05	1.656GlyLys: 1.656 ± 0.042	9.532GlyLeu: 9.532 ± 0.089	2.232GlyMet: 2.232 ± 0.038	1.612GlyAsn: 1.612 ± 0.036	5.607GlyPro: 5.607 ± 0.074	2.088GlyGln: 2.088 ± 0.037	8.505GlyArg: 8.505 ± 0.078	5.403GlySer: 5.403 ± 0.072	5.948GlyThr: 5.948 ± 0.07	8.191GlyVal: 8.191 ± 0.072	1.513GlyTrp: 1.513 ± 0.035	2.234GlyTyr: 2.234 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.34HisAla: 2.34 ± 0.036	0.177HisCys: 0.177 ± 0.01	1.491HisAsp: 1.491 ± 0.03	1.406HisGlu: 1.406 ± 0.033	0.602HisPhe: 0.602 ± 0.018	2.394HisGly: 2.394 ± 0.039	0.791HisHis: 0.791 ± 0.024	0.652HisIle: 0.652 ± 0.022	0.306HisLys: 0.306 ± 0.014	2.644HisLeu: 2.644 ± 0.043	0.397HisMet: 0.397 ± 0.014	0.367HisAsn: 0.367 ± 0.015	1.825HisPro: 1.825 ± 0.039	0.554HisGln: 0.554 ± 0.02	2.321HisArg: 2.321 ± 0.044	1.048HisSer: 1.048 ± 0.026	1.322HisThr: 1.322 ± 0.033	1.868HisVal: 1.868 ± 0.038	0.366HisTrp: 0.366 ± 0.015	0.493HisTyr: 0.493 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.918IleAla: 4.918 ± 0.069	0.26IleCys: 0.26 ± 0.012	2.705IleAsp: 2.705 ± 0.046	2.414IleGlu: 2.414 ± 0.041	0.815IlePhe: 0.815 ± 0.024	3.849IleGly: 3.849 ± 0.054	0.635IleHis: 0.635 ± 0.02	1.199IleIle: 1.199 ± 0.032	0.574IleLys: 0.574 ± 0.022	2.938IleLeu: 2.938 ± 0.047	0.607IleMet: 0.607 ± 0.02	0.722IleAsn: 0.722 ± 0.023	1.94IlePro: 1.94 ± 0.038	0.665IleGln: 0.665 ± 0.021	2.406IleArg: 2.406 ± 0.04	1.848IleSer: 1.848 ± 0.031	2.327IleThr: 2.327 ± 0.039	3.159IleVal: 3.159 ± 0.056	0.342IleTrp: 0.342 ± 0.015	0.523IleTyr: 0.523 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.118LysAla: 2.118 ± 0.046	0.072LysCys: 0.072 ± 0.007	1.04LysAsp: 1.04 ± 0.031	1.145LysGlu: 1.145 ± 0.027	0.322LysPhe: 0.322 ± 0.016	1.575LysGly: 1.575 ± 0.035	0.319LysHis: 0.319 ± 0.015	0.654LysIle: 0.654 ± 0.022	0.565LysLys: 0.565 ± 0.029	1.232LysLeu: 1.232 ± 0.032	0.335LysMet: 0.335 ± 0.014	0.401LysAsn: 0.401 ± 0.016	0.844LysPro: 0.844 ± 0.025	0.365LysGln: 0.365 ± 0.016	1.33LysArg: 1.33 ± 0.031	0.86LysSer: 0.86 ± 0.027	0.923LysThr: 0.923 ± 0.024	1.594LysVal: 1.594 ± 0.033	0.172LysTrp: 0.172 ± 0.01	0.303LysTyr: 0.303 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.091LeuAla: 13.091 ± 0.117	0.834LeuCys: 0.834 ± 0.02	6.682LeuAsp: 6.682 ± 0.074	5.876LeuGlu: 5.876 ± 0.074	3.112LeuPhe: 3.112 ± 0.052	9.339LeuGly: 9.339 ± 0.095	2.074LeuHis: 2.074 ± 0.043	3.818LeuIle: 3.818 ± 0.064	1.487LeuLys: 1.487 ± 0.037	11.424LeuLeu: 11.424 ± 0.14	1.963LeuMet: 1.963 ± 0.033	1.7LeuAsn: 1.7 ± 0.031	6.407LeuPro: 6.407 ± 0.071	1.77LeuGln: 1.77 ± 0.034	8.718LeuArg: 8.718 ± 0.088	6.283LeuSer: 6.283 ± 0.063	6.495LeuThr: 6.495 ± 0.069	9.366LeuVal: 9.366 ± 0.098	1.467LeuTrp: 1.467 ± 0.03	1.919LeuTyr: 1.919 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.398MetAla: 2.398 ± 0.038	0.148MetCys: 0.148 ± 0.009	1.093MetAsp: 1.093 ± 0.026	1.046MetGlu: 1.046 ± 0.024	0.593MetPhe: 0.593 ± 0.02	1.676MetGly: 1.676 ± 0.034	0.325MetHis: 0.325 ± 0.014	0.829MetIle: 0.829 ± 0.026	0.338MetLys: 0.338 ± 0.015	1.81MetLeu: 1.81 ± 0.034	0.371MetMet: 0.371 ± 0.016	0.509MetAsn: 0.509 ± 0.021	1.141MetPro: 1.141 ± 0.027	0.328MetGln: 0.328 ± 0.013	1.684MetArg: 1.684 ± 0.033	1.581MetSer: 1.581 ± 0.03	1.52MetThr: 1.52 ± 0.029	1.745MetVal: 1.745 ± 0.031	0.254MetTrp: 0.254 ± 0.012	0.317MetTyr: 0.317 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.073AsnAla: 2.073 ± 0.039	0.137AsnCys: 0.137 ± 0.01	1.019AsnAsp: 1.019 ± 0.03	1.058AsnGlu: 1.058 ± 0.028	0.425AsnPhe: 0.425 ± 0.016	1.815AsnGly: 1.815 ± 0.035	0.399AsnHis: 0.399 ± 0.017	0.683AsnIle: 0.683 ± 0.022	0.318AsnLys: 0.318 ± 0.014	1.634AsnLeu: 1.634 ± 0.037	0.331AsnMet: 0.331 ± 0.013	0.395AsnAsn: 0.395 ± 0.02	1.328AsnPro: 1.328 ± 0.035	0.424AsnGln: 0.424 ± 0.018	1.32AsnArg: 1.32 ± 0.029	0.871AsnSer: 0.871 ± 0.025	1.163AsnThr: 1.163 ± 0.03	1.432AsnVal: 1.432 ± 0.032	0.264AsnTrp: 0.264 ± 0.011	0.353AsnTyr: 0.353 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.363ProAla: 6.363 ± 0.072	0.329ProCys: 0.329 ± 0.015	4.606ProAsp: 4.606 ± 0.065	6.074ProGlu: 6.074 ± 0.071	1.705ProPhe: 1.705 ± 0.034	6.445ProGly: 6.445 ± 0.073	1.377ProHis: 1.377 ± 0.03	1.772ProIle: 1.772 ± 0.033	1.006ProLys: 1.006 ± 0.028	5.515ProLeu: 5.515 ± 0.064	1.188ProMet: 1.188 ± 0.027	0.984ProAsn: 0.984 ± 0.026	3.64ProPro: 3.64 ± 0.076	1.228ProGln: 1.228 ± 0.035	4.509ProArg: 4.509 ± 0.069	3.628ProSer: 3.628 ± 0.055	3.452ProThr: 3.452 ± 0.053	5.187ProVal: 5.187 ± 0.059	0.966ProTrp: 0.966 ± 0.026	1.229ProTyr: 1.229 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.759GlnAla: 2.759 ± 0.046	0.112GlnCys: 0.112 ± 0.008	1.116GlnAsp: 1.116 ± 0.028	1.502GlnGlu: 1.502 ± 0.031	0.491GlnPhe: 0.491 ± 0.017	2.268GlnGly: 2.268 ± 0.043	0.42GlnHis: 0.42 ± 0.019	1.024GlnIle: 1.024 ± 0.024	0.356GlnLys: 0.356 ± 0.016	1.834GlnLeu: 1.834 ± 0.036	0.454GlnMet: 0.454 ± 0.017	0.509GlnAsn: 0.509 ± 0.021	1.002GlnPro: 1.002 ± 0.03	0.706GlnGln: 0.706 ± 0.035	1.939GlnArg: 1.939 ± 0.033	1.086GlnSer: 1.086 ± 0.029	1.045GlnThr: 1.045 ± 0.027	2.108GlnVal: 2.108 ± 0.038	0.339GlnTrp: 0.339 ± 0.015	0.418GlnTyr: 0.418 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.504ArgAla: 9.504 ± 0.105	0.532ArgCys: 0.532 ± 0.018	4.671ArgAsp: 4.671 ± 0.067	6.017ArgGlu: 6.017 ± 0.067	2.503ArgPhe: 2.503 ± 0.037	6.7ArgGly: 6.7 ± 0.072	2.094ArgHis: 2.094 ± 0.036	3.46ArgIle: 3.46 ± 0.048	1.443ArgLys: 1.443 ± 0.035	9.02ArgLeu: 9.02 ± 0.094	2.081ArgMet: 2.081 ± 0.031	1.445ArgAsn: 1.445 ± 0.037	5.401ArgPro: 5.401 ± 0.068	1.727ArgGln: 1.727 ± 0.035	8.759ArgArg: 8.759 ± 0.095	5.26ArgSer: 5.26 ± 0.067	5.02ArgThr: 5.02 ± 0.057	7.069ArgVal: 7.069 ± 0.076	1.367ArgTrp: 1.367 ± 0.026	1.794ArgTyr: 1.794 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.217SerAla: 6.217 ± 0.055	0.408SerCys: 0.408 ± 0.017	3.236SerAsp: 3.236 ± 0.051	3.6SerGlu: 3.6 ± 0.056	1.628SerPhe: 1.628 ± 0.032	6.438SerGly: 6.438 ± 0.072	1.139SerHis: 1.139 ± 0.026	1.706SerIle: 1.706 ± 0.032	0.851SerLys: 0.851 ± 0.029	5.423SerLeu: 5.423 ± 0.065	1.242SerMet: 1.242 ± 0.03	0.874SerAsn: 0.874 ± 0.026	3.748SerPro: 3.748 ± 0.048	1.128SerGln: 1.128 ± 0.027	4.249SerArg: 4.249 ± 0.047	3.344SerSer: 3.344 ± 0.064	3.369SerThr: 3.369 ± 0.045	4.578SerVal: 4.578 ± 0.051	0.937SerTrp: 0.937 ± 0.024	1.099SerTyr: 1.099 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	7.069ThrAla: 7.069 ± 0.072	0.405ThrCys: 0.405 ± 0.015	3.795ThrAsp: 3.795 ± 0.054	3.975ThrGlu: 3.975 ± 0.051	1.624ThrPhe: 1.624 ± 0.03	6.302ThrGly: 6.302 ± 0.07	1.215ThrHis: 1.215 ± 0.029	1.94ThrIle: 1.94 ± 0.037	0.845ThrLys: 0.845 ± 0.026	6.001ThrLeu: 6.001 ± 0.063	1.097ThrMet: 1.097 ± 0.024	0.937ThrAsn: 0.937 ± 0.026	3.996ThrPro: 3.996 ± 0.053	1.008ThrGln: 1.008 ± 0.029	4.264ThrArg: 4.264 ± 0.061	3.221ThrSer: 3.221 ± 0.043	3.731ThrThr: 3.731 ± 0.065	5.711ThrVal: 5.711 ± 0.064	0.883ThrTrp: 0.883 ± 0.024	1.128ThrTyr: 1.128 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.126ValAla: 10.126 ± 0.107	0.719ValCys: 0.719 ± 0.023	5.777ValAsp: 5.777 ± 0.068	5.992ValGlu: 5.992 ± 0.067	2.639ValPhe: 2.639 ± 0.042	7.277ValGly: 7.277 ± 0.081	2.04ValHis: 2.04 ± 0.034	3.124ValIle: 3.124 ± 0.055	1.22ValLys: 1.22 ± 0.029	9.569ValLeu: 9.569 ± 0.102	1.665ValMet: 1.665 ± 0.032	1.598ValAsn: 1.598 ± 0.033	5.119ValPro: 5.119 ± 0.059	1.692ValGln: 1.692 ± 0.032	7.108ValArg: 7.108 ± 0.073	4.845ValSer: 4.845 ± 0.059	5.158ValThr: 5.158 ± 0.06	8.357ValVal: 8.357 ± 0.103	1.202ValTrp: 1.202 ± 0.029	1.563ValTyr: 1.563 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.518TrpAla: 1.518 ± 0.034	0.135TrpCys: 0.135 ± 0.009	0.777TrpAsp: 0.777 ± 0.026	0.959TrpGlu: 0.959 ± 0.022	0.51TrpPhe: 0.51 ± 0.019	1.176TrpGly: 1.176 ± 0.027	0.328TrpHis: 0.328 ± 0.015	0.625TrpIle: 0.625 ± 0.017	0.308TrpLys: 0.308 ± 0.015	1.49TrpLeu: 1.49 ± 0.034	0.315TrpMet: 0.315 ± 0.013	0.426TrpAsn: 0.426 ± 0.019	0.703TrpPro: 0.703 ± 0.022	0.362TrpGln: 0.362 ± 0.015	1.393TrpArg: 1.393 ± 0.031	1.036TrpSer: 1.036 ± 0.026	0.955TrpThr: 0.955 ± 0.028	1.047TrpVal: 1.047 ± 0.025	0.367TrpTrp: 0.367 ± 0.017	0.288TrpTyr: 0.288 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.164TyrAla: 2.164 ± 0.037	0.154TyrCys: 0.154 ± 0.01	1.298TyrAsp: 1.298 ± 0.033	1.294TyrGlu: 1.294 ± 0.029	0.604TyrPhe: 0.604 ± 0.018	1.999TyrGly: 1.999 ± 0.038	0.387TyrHis: 0.387 ± 0.015	0.516TyrIle: 0.516 ± 0.019	0.314TyrLys: 0.314 ± 0.015	2.172TyrLeu: 2.172 ± 0.042	0.312TyrMet: 0.312 ± 0.014	0.354TyrAsn: 0.354 ± 0.016	1.044TyrPro: 1.044 ± 0.03	0.519TyrGln: 0.519 ± 0.018	1.828TyrArg: 1.828 ± 0.031	1.033TyrSer: 1.033 ± 0.027	1.186TyrThr: 1.186 ± 0.025	1.678TyrVal: 1.678 ± 0.036	0.287TyrTrp: 0.287 ± 0.014	0.417TyrTyr: 0.417 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5500 proteins (1675371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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