Amino acid dipepetide frequency for Burkholderia sp. Ch1-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.436AlaAla: 17.436 ± 0.132	1.294AlaCys: 1.294 ± 0.027	6.575AlaAsp: 6.575 ± 0.054	6.048AlaGlu: 6.048 ± 0.054	4.287AlaPhe: 4.287 ± 0.039	10.308AlaGly: 10.308 ± 0.074	2.833AlaHis: 2.833 ± 0.037	5.712AlaIle: 5.712 ± 0.049	3.657AlaLys: 3.657 ± 0.047	13.982AlaLeu: 13.982 ± 0.09	3.196AlaMet: 3.196 ± 0.038	3.369AlaAsn: 3.369 ± 0.048	5.76AlaPro: 5.76 ± 0.065	5.417AlaGln: 5.417 ± 0.057	8.858AlaArg: 8.858 ± 0.07	7.451AlaSer: 7.451 ± 0.064	6.425AlaThr: 6.425 ± 0.066	8.873AlaVal: 8.873 ± 0.073	1.672AlaTrp: 1.672 ± 0.029	2.697AlaTyr: 2.697 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.21CysAla: 1.21 ± 0.022	0.125CysCys: 0.125 ± 0.007	0.538CysAsp: 0.538 ± 0.015	0.51CysGlu: 0.51 ± 0.013	0.339CysPhe: 0.339 ± 0.012	0.995CysGly: 0.995 ± 0.025	0.252CysHis: 0.252 ± 0.011	0.412CysIle: 0.412 ± 0.012	0.222CysLys: 0.222 ± 0.009	0.818CysLeu: 0.818 ± 0.022	0.192CysMet: 0.192 ± 0.009	0.251CysAsn: 0.251 ± 0.009	0.439CysPro: 0.439 ± 0.016	0.227CysGln: 0.227 ± 0.011	0.612CysArg: 0.612 ± 0.017	0.525CysSer: 0.525 ± 0.016	0.491CysThr: 0.491 ± 0.015	0.802CysVal: 0.802 ± 0.018	0.129CysTrp: 0.129 ± 0.007	0.228CysTyr: 0.228 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.269AspAla: 7.269 ± 0.062	0.464AspCys: 0.464 ± 0.015	3.002AspAsp: 3.002 ± 0.043	3.412AspGlu: 3.412 ± 0.036	1.949AspPhe: 1.949 ± 0.027	4.473AspGly: 4.473 ± 0.048	1.185AspHis: 1.185 ± 0.024	2.509AspIle: 2.509 ± 0.033	1.547AspLys: 1.547 ± 0.027	5.104AspLeu: 5.104 ± 0.044	1.207AspMet: 1.207 ± 0.024	1.38AspAsn: 1.38 ± 0.026	2.929AspPro: 2.929 ± 0.033	1.64AspGln: 1.64 ± 0.03	3.364AspArg: 3.364 ± 0.035	2.63AspSer: 2.63 ± 0.034	2.82AspThr: 2.82 ± 0.036	4.196AspVal: 4.196 ± 0.048	0.9AspTrp: 0.9 ± 0.017	1.528AspTyr: 1.528 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.52GluAla: 6.52 ± 0.062	0.401GluCys: 0.401 ± 0.014	2.125GluAsp: 2.125 ± 0.027	2.481GluGlu: 2.481 ± 0.04	1.804GluPhe: 1.804 ± 0.026	3.364GluGly: 3.364 ± 0.036	1.443GluHis: 1.443 ± 0.029	2.747GluIle: 2.747 ± 0.036	1.84GluLys: 1.84 ± 0.033	5.498GluLeu: 5.498 ± 0.055	1.189GluMet: 1.189 ± 0.023	1.404GluAsn: 1.404 ± 0.021	2.582GluPro: 2.582 ± 0.041	2.396GluGln: 2.396 ± 0.032	4.838GluArg: 4.838 ± 0.055	2.677GluSer: 2.677 ± 0.028	2.89GluThr: 2.89 ± 0.044	3.537GluVal: 3.537 ± 0.038	0.736GluTrp: 0.736 ± 0.017	1.161GluTyr: 1.161 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.693PheAla: 4.693 ± 0.051	0.422PheCys: 0.422 ± 0.013	2.691PheAsp: 2.691 ± 0.038	2.08PheGlu: 2.08 ± 0.033	1.456PhePhe: 1.456 ± 0.031	3.694PheGly: 3.694 ± 0.044	0.761PheHis: 0.761 ± 0.02	1.607PheIle: 1.607 ± 0.028	0.992PheLys: 0.992 ± 0.021	2.919PheLeu: 2.919 ± 0.037	0.79PheMet: 0.79 ± 0.017	1.198PheAsn: 1.198 ± 0.021	1.577PhePro: 1.577 ± 0.025	1.016PheGln: 1.016 ± 0.02	2.066PheArg: 2.066 ± 0.027	2.318PheSer: 2.318 ± 0.033	1.986PheThr: 1.986 ± 0.024	3.141PheVal: 3.141 ± 0.039	0.519PheTrp: 0.519 ± 0.017	0.981PheTyr: 0.981 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.246GlyAla: 9.246 ± 0.074	0.823GlyCys: 0.823 ± 0.018	3.858GlyAsp: 3.858 ± 0.044	4.29GlyGlu: 4.29 ± 0.045	3.406GlyPhe: 3.406 ± 0.042	6.838GlyGly: 6.838 ± 0.096	1.918GlyHis: 1.918 ± 0.029	4.204GlyIle: 4.204 ± 0.047	3.286GlyLys: 3.286 ± 0.047	7.895GlyLeu: 7.895 ± 0.067	2.196GlyMet: 2.196 ± 0.03	2.446GlyAsn: 2.446 ± 0.044	2.828GlyPro: 2.828 ± 0.043	2.768GlyGln: 2.768 ± 0.034	5.151GlyArg: 5.151 ± 0.048	4.796GlySer: 4.796 ± 0.06	4.668GlyThr: 4.668 ± 0.058	6.673GlyVal: 6.673 ± 0.051	1.399GlyTrp: 1.399 ± 0.024	2.478GlyTyr: 2.478 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.138HisAla: 3.138 ± 0.038	0.261HisCys: 0.261 ± 0.01	1.371HisAsp: 1.371 ± 0.023	1.249HisGlu: 1.249 ± 0.025	0.957HisPhe: 0.957 ± 0.022	2.148HisGly: 2.148 ± 0.032	0.659HisHis: 0.659 ± 0.02	0.966HisIle: 0.966 ± 0.02	0.545HisLys: 0.545 ± 0.015	2.194HisLeu: 2.194 ± 0.028	0.537HisMet: 0.537 ± 0.013	0.548HisAsn: 0.548 ± 0.015	1.387HisPro: 1.387 ± 0.026	0.69HisGln: 0.69 ± 0.018	1.549HisArg: 1.549 ± 0.024	1.148HisSer: 1.148 ± 0.023	1.15HisThr: 1.15 ± 0.027	1.783HisVal: 1.783 ± 0.025	0.411HisTrp: 0.411 ± 0.013	0.667HisTyr: 0.667 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.914IleAla: 6.914 ± 0.064	0.468IleCys: 0.468 ± 0.014	3.428IleAsp: 3.428 ± 0.038	3.268IleGlu: 3.268 ± 0.041	1.507IlePhe: 1.507 ± 0.027	4.722IleGly: 4.722 ± 0.046	0.951IleHis: 0.951 ± 0.024	1.61IleIle: 1.61 ± 0.026	1.384IleLys: 1.384 ± 0.027	3.404IleLeu: 3.404 ± 0.034	0.761IleMet: 0.761 ± 0.019	1.433IleAsn: 1.433 ± 0.027	2.118IlePro: 2.118 ± 0.036	1.281IleGln: 1.281 ± 0.024	2.885IleArg: 2.885 ± 0.034	2.55IleSer: 2.55 ± 0.032	2.434IleThr: 2.434 ± 0.034	4.322IleVal: 4.322 ± 0.044	0.533IleTrp: 0.533 ± 0.016	1.091IleTyr: 1.091 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.622LysAla: 3.622 ± 0.047	0.18LysCys: 0.18 ± 0.009	1.511LysAsp: 1.511 ± 0.028	1.45LysGlu: 1.45 ± 0.028	0.921LysPhe: 0.921 ± 0.019	2.18LysGly: 2.18 ± 0.031	0.693LysHis: 0.693 ± 0.018	1.557LysIle: 1.557 ± 0.031	1.294LysLys: 1.294 ± 0.028	3.414LysLeu: 3.414 ± 0.046	0.78LysMet: 0.78 ± 0.019	0.903LysAsn: 0.903 ± 0.021	1.978LysPro: 1.978 ± 0.033	1.316LysGln: 1.316 ± 0.022	2.417LysArg: 2.417 ± 0.033	1.789LysSer: 1.789 ± 0.03	1.917LysThr: 1.917 ± 0.031	2.388LysVal: 2.388 ± 0.034	0.387LysTrp: 0.387 ± 0.013	0.731LysTyr: 0.731 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.699LeuAla: 13.699 ± 0.09	1.015LeuCys: 1.015 ± 0.022	5.839LeuAsp: 5.839 ± 0.051	5.026LeuGlu: 5.026 ± 0.048	3.622LeuPhe: 3.622 ± 0.043	8.05LeuGly: 8.05 ± 0.068	2.296LeuHis: 2.296 ± 0.029	4.812LeuIle: 4.812 ± 0.053	3.475LeuLys: 3.475 ± 0.044	10.151LeuLeu: 10.151 ± 0.086	2.272LeuMet: 2.272 ± 0.035	2.896LeuAsn: 2.896 ± 0.036	5.697LeuPro: 5.697 ± 0.05	3.514LeuGln: 3.514 ± 0.043	7.098LeuArg: 7.098 ± 0.059	6.392LeuSer: 6.392 ± 0.057	5.622LeuThr: 5.622 ± 0.044	7.255LeuVal: 7.255 ± 0.061	1.113LeuTrp: 1.113 ± 0.023	2.251LeuTyr: 2.251 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.441MetAla: 2.441 ± 0.027	0.187MetCys: 0.187 ± 0.008	0.929MetAsp: 0.929 ± 0.025	0.925MetGlu: 0.925 ± 0.019	0.787MetPhe: 0.787 ± 0.018	1.509MetGly: 1.509 ± 0.025	0.575MetHis: 0.575 ± 0.017	1.096MetIle: 1.096 ± 0.024	1.056MetLys: 1.056 ± 0.02	2.626MetLeu: 2.626 ± 0.037	0.576MetMet: 0.576 ± 0.018	0.935MetAsn: 0.935 ± 0.02	1.478MetPro: 1.478 ± 0.023	1.035MetGln: 1.035 ± 0.023	1.769MetArg: 1.769 ± 0.026	1.809MetSer: 1.809 ± 0.03	1.655MetThr: 1.655 ± 0.026	1.484MetVal: 1.484 ± 0.026	0.218MetTrp: 0.218 ± 0.01	0.407MetTyr: 0.407 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.659AsnAla: 3.659 ± 0.048	0.264AsnCys: 0.264 ± 0.01	1.5AsnAsp: 1.5 ± 0.028	1.354AsnGlu: 1.354 ± 0.024	1.009AsnPhe: 1.009 ± 0.023	2.782AsnGly: 2.782 ± 0.046	0.587AsnHis: 0.587 ± 0.017	1.276AsnIle: 1.276 ± 0.028	0.698AsnLys: 0.698 ± 0.018	2.81AsnLeu: 2.81 ± 0.038	0.605AsnMet: 0.605 ± 0.016	0.866AsnAsn: 0.866 ± 0.027	1.873AsnPro: 1.873 ± 0.028	1.001AsnGln: 1.001 ± 0.024	1.898AsnArg: 1.898 ± 0.029	1.494AsnSer: 1.494 ± 0.041	1.568AsnThr: 1.568 ± 0.026	2.347AsnVal: 2.347 ± 0.047	0.433AsnTrp: 0.433 ± 0.013	0.749AsnTyr: 0.749 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.581ProAla: 6.581 ± 0.066	0.346ProCys: 0.346 ± 0.011	3.192ProAsp: 3.192 ± 0.038	2.938ProGlu: 2.938 ± 0.042	1.883ProPhe: 1.883 ± 0.028	4.097ProGly: 4.097 ± 0.045	1.268ProHis: 1.268 ± 0.023	2.023ProIle: 2.023 ± 0.03	1.437ProLys: 1.437 ± 0.026	5.271ProLeu: 5.271 ± 0.049	1.126ProMet: 1.126 ± 0.022	1.461ProAsn: 1.461 ± 0.024	2.44ProPro: 2.44 ± 0.038	1.986ProGln: 1.986 ± 0.029	2.882ProArg: 2.882 ± 0.039	2.848ProSer: 2.848 ± 0.034	2.597ProThr: 2.597 ± 0.035	4.313ProVal: 4.313 ± 0.041	0.649ProTrp: 0.649 ± 0.016	1.249ProTyr: 1.249 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.604GlnAla: 4.604 ± 0.054	0.292GlnCys: 0.292 ± 0.009	1.401GlnAsp: 1.401 ± 0.025	1.388GlnGlu: 1.388 ± 0.027	1.332GlnPhe: 1.332 ± 0.021	2.492GlnGly: 2.492 ± 0.037	0.942GlnHis: 0.942 ± 0.019	2.059GlnIle: 2.059 ± 0.031	1.167GlnLys: 1.167 ± 0.021	3.908GlnLeu: 3.908 ± 0.038	1.024GlnMet: 1.024 ± 0.024	1.0GlnAsn: 1.0 ± 0.017	2.079GlnPro: 2.079 ± 0.034	2.036GlnGln: 2.036 ± 0.042	3.022GlnArg: 3.022 ± 0.037	2.16GlnSer: 2.16 ± 0.034	2.124GlnThr: 2.124 ± 0.031	2.542GlnVal: 2.542 ± 0.033	0.599GlnTrp: 0.599 ± 0.015	0.979GlnTyr: 0.979 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.99ArgAla: 7.99 ± 0.068	0.625ArgCys: 0.625 ± 0.019	3.78ArgAsp: 3.78 ± 0.043	4.286ArgGlu: 4.286 ± 0.051	3.01ArgPhe: 3.01 ± 0.037	4.564ArgGly: 4.564 ± 0.044	1.881ArgHis: 1.881 ± 0.032	3.659ArgIle: 3.659 ± 0.039	2.226ArgLys: 2.226 ± 0.035	7.186ArgLeu: 7.186 ± 0.061	1.769ArgMet: 1.769 ± 0.026	1.993ArgAsn: 1.993 ± 0.029	3.052ArgPro: 3.052 ± 0.037	2.626ArgGln: 2.626 ± 0.033	5.367ArgArg: 5.367 ± 0.056	3.703ArgSer: 3.703 ± 0.04	3.512ArgThr: 3.512 ± 0.045	5.215ArgVal: 5.215 ± 0.052	1.054ArgTrp: 1.054 ± 0.02	2.038ArgTyr: 2.038 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.158SerAla: 7.158 ± 0.064	0.468SerCys: 0.468 ± 0.014	2.79SerAsp: 2.79 ± 0.033	2.651SerGlu: 2.651 ± 0.036	2.22SerPhe: 2.22 ± 0.03	5.502SerGly: 5.502 ± 0.056	1.287SerHis: 1.287 ± 0.023	2.821SerIle: 2.821 ± 0.036	1.714SerLys: 1.714 ± 0.03	5.887SerLeu: 5.887 ± 0.05	1.418SerMet: 1.418 ± 0.024	1.799SerAsn: 1.799 ± 0.031	2.882SerPro: 2.882 ± 0.034	1.988SerGln: 1.988 ± 0.032	3.824SerArg: 3.824 ± 0.033	3.572SerSer: 3.572 ± 0.047	3.292SerThr: 3.292 ± 0.042	4.613SerVal: 4.613 ± 0.05	0.748SerTrp: 0.748 ± 0.019	1.365SerTyr: 1.365 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	6.154ThrAla: 6.154 ± 0.058	0.459ThrCys: 0.459 ± 0.015	2.722ThrAsp: 2.722 ± 0.035	2.359ThrGlu: 2.359 ± 0.029	1.994ThrPhe: 1.994 ± 0.027	4.804ThrGly: 4.804 ± 0.051	1.325ThrHis: 1.325 ± 0.025	2.633ThrIle: 2.633 ± 0.032	1.287ThrLys: 1.287 ± 0.027	6.524ThrLeu: 6.524 ± 0.054	1.172ThrMet: 1.172 ± 0.021	1.48ThrAsn: 1.48 ± 0.043	3.553ThrPro: 3.553 ± 0.045	2.077ThrGln: 2.077 ± 0.031	3.645ThrArg: 3.645 ± 0.042	3.053ThrSer: 3.053 ± 0.038	3.008ThrThr: 3.008 ± 0.046	4.432ThrVal: 4.432 ± 0.041	0.694ThrTrp: 0.694 ± 0.018	1.312ThrTyr: 1.312 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.511ValAla: 9.511 ± 0.074	0.807ValCys: 0.807 ± 0.018	4.223ValAsp: 4.223 ± 0.041	4.169ValGlu: 4.169 ± 0.04	2.863ValPhe: 2.863 ± 0.036	5.549ValGly: 5.549 ± 0.056	1.544ValHis: 1.544 ± 0.025	3.755ValIle: 3.755 ± 0.039	2.514ValLys: 2.514 ± 0.037	7.945ValLeu: 7.945 ± 0.072	1.867ValMet: 1.867 ± 0.031	2.279ValAsn: 2.279 ± 0.038	4.006ValPro: 4.006 ± 0.045	2.537ValGln: 2.537 ± 0.031	5.14ValArg: 5.14 ± 0.051	4.867ValSer: 4.867 ± 0.05	4.51ValThr: 4.51 ± 0.049	6.266ValVal: 6.266 ± 0.061	0.971ValTrp: 0.971 ± 0.02	1.715ValTyr: 1.715 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.182TrpAla: 1.182 ± 0.022	0.141TrpCys: 0.141 ± 0.007	0.623TrpAsp: 0.623 ± 0.017	0.495TrpGlu: 0.495 ± 0.014	0.556TrpPhe: 0.556 ± 0.015	0.874TrpGly: 0.874 ± 0.02	0.415TrpHis: 0.415 ± 0.013	0.725TrpIle: 0.725 ± 0.017	0.447TrpLys: 0.447 ± 0.015	1.954TrpLeu: 1.954 ± 0.034	0.369TrpMet: 0.369 ± 0.012	0.45TrpAsn: 0.45 ± 0.014	0.662TrpPro: 0.662 ± 0.018	0.692TrpGln: 0.692 ± 0.017	1.193TrpArg: 1.193 ± 0.023	0.843TrpSer: 0.843 ± 0.019	0.699TrpThr: 0.699 ± 0.018	0.915TrpVal: 0.915 ± 0.022	0.231TrpTrp: 0.231 ± 0.01	0.321TrpTyr: 0.321 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.821TyrAla: 2.821 ± 0.039	0.275TyrCys: 0.275 ± 0.01	1.412TyrAsp: 1.412 ± 0.024	1.257TyrGlu: 1.257 ± 0.025	1.005TyrPhe: 1.005 ± 0.02	2.221TyrGly: 2.221 ± 0.031	0.54TyrHis: 0.54 ± 0.015	0.881TyrIle: 0.881 ± 0.018	0.641TyrLys: 0.641 ± 0.017	2.608TyrLeu: 2.608 ± 0.036	0.452TyrMet: 0.452 ± 0.014	0.68TyrAsn: 0.68 ± 0.019	1.266TyrPro: 1.266 ± 0.022	0.904TyrGln: 0.904 ± 0.02	1.959TyrArg: 1.959 ± 0.028	1.374TyrSer: 1.374 ± 0.026	1.317TyrThr: 1.317 ± 0.025	1.943TyrVal: 1.943 ± 0.028	0.391TyrTrp: 0.391 ± 0.013	0.675TyrTyr: 0.675 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7680 proteins (2472543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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