Amino acid dipepetide frequency for Candidatus Syntrophoarchaeum butanivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.542AlaAla: 5.542 ± 0.146
1.003AlaCys: 1.003 ± 0.054
3.854AlaAsp: 3.854 ± 0.094
5.26AlaGlu: 5.26 ± 0.126
2.838AlaPhe: 2.838 ± 0.098
5.784AlaGly: 5.784 ± 0.124
1.272AlaHis: 1.272 ± 0.047
6.186AlaIle: 6.186 ± 0.137
3.75AlaLys: 3.75 ± 0.113
7.137AlaLeu: 7.137 ± 0.148
2.049AlaMet: 2.049 ± 0.072
1.744AlaAsn: 1.744 ± 0.062
2.252AlaPro: 2.252 ± 0.084
1.213AlaGln: 1.213 ± 0.057
4.604AlaArg: 4.604 ± 0.105
4.315AlaSer: 4.315 ± 0.118
3.233AlaThr: 3.233 ± 0.086
5.549AlaVal: 5.549 ± 0.107
0.615AlaTrp: 0.615 ± 0.04
2.079AlaTyr: 2.079 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.795CysAla: 0.795 ± 0.049
0.262CysCys: 0.262 ± 0.029
0.739CysAsp: 0.739 ± 0.043
1.001CysGlu: 1.001 ± 0.053
0.407CysPhe: 0.407 ± 0.033
1.611CysGly: 1.611 ± 0.077
0.386CysHis: 0.386 ± 0.054
0.931CysIle: 0.931 ± 0.049
0.567CysLys: 0.567 ± 0.042
0.779CysLeu: 0.779 ± 0.044
0.328CysMet: 0.328 ± 0.027
0.371CysAsn: 0.371 ± 0.029
0.843CysPro: 0.843 ± 0.053
0.183CysGln: 0.183 ± 0.021
0.802CysArg: 0.802 ± 0.043
0.723CysSer: 0.723 ± 0.05
0.626CysThr: 0.626 ± 0.043
0.759CysVal: 0.759 ± 0.043
0.09CysTrp: 0.09 ± 0.012
0.382CysTyr: 0.382 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.659AspAla: 4.659 ± 0.1
0.605AspCys: 0.605 ± 0.037
3.003AspAsp: 3.003 ± 0.103
6.188AspGlu: 6.188 ± 0.145
1.927AspPhe: 1.927 ± 0.069
4.817AspGly: 4.817 ± 0.136
1.064AspHis: 1.064 ± 0.046
4.846AspIle: 4.846 ± 0.082
2.634AspLys: 2.634 ± 0.091
7.196AspLeu: 7.196 ± 0.12
1.405AspMet: 1.405 ± 0.053
1.272AspAsn: 1.272 ± 0.057
3.542AspPro: 3.542 ± 0.093
0.881AspGln: 0.881 ± 0.046
3.836AspArg: 3.836 ± 0.095
2.205AspSer: 2.205 ± 0.072
2.623AspThr: 2.623 ± 0.083
4.537AspVal: 4.537 ± 0.098
0.576AspTrp: 0.576 ± 0.042
1.785AspTyr: 1.785 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
6.064GluAla: 6.064 ± 0.135
0.847GluCys: 0.847 ± 0.045
5.149GluAsp: 5.149 ± 0.098
8.438GluGlu: 8.438 ± 0.183
2.991GluPhe: 2.991 ± 0.091
6.559GluGly: 6.559 ± 0.12
1.455GluHis: 1.455 ± 0.058
8.185GluIle: 8.185 ± 0.17
5.336GluLys: 5.336 ± 0.124
8.158GluLeu: 8.158 ± 0.178
2.716GluMet: 2.716 ± 0.062
2.506GluAsn: 2.506 ± 0.081
2.469GluPro: 2.469 ± 0.07
1.261GluGln: 1.261 ± 0.058
6.94GluArg: 6.94 ± 0.174
3.554GluSer: 3.554 ± 0.081
3.016GluThr: 3.016 ± 0.096
7.166GluVal: 7.166 ± 0.121
0.904GluTrp: 0.904 ± 0.055
2.553GluTyr: 2.553 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.573PheAla: 2.573 ± 0.082
0.456PheCys: 0.456 ± 0.035
2.74PheAsp: 2.74 ± 0.074
3.26PheGlu: 3.26 ± 0.089
1.505PhePhe: 1.505 ± 0.064
3.109PheGly: 3.109 ± 0.085
0.621PheHis: 0.621 ± 0.039
2.833PheIle: 2.833 ± 0.098
1.945PheLys: 1.945 ± 0.071
3.522PheLeu: 3.522 ± 0.121
0.913PheMet: 0.913 ± 0.049
1.195PheAsn: 1.195 ± 0.063
1.367PhePro: 1.367 ± 0.055
0.666PheGln: 0.666 ± 0.036
2.429PheArg: 2.429 ± 0.075
2.363PheSer: 2.363 ± 0.069
1.871PheThr: 1.871 ± 0.06
2.433PheVal: 2.433 ± 0.083
0.328PheTrp: 0.328 ± 0.029
1.247PheTyr: 1.247 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
5.702GlyAla: 5.702 ± 0.13
1.428GlyCys: 1.428 ± 0.065
4.717GlyAsp: 4.717 ± 0.108
6.611GlyGlu: 6.611 ± 0.148
3.491GlyPhe: 3.491 ± 0.085
6.611GlyGly: 6.611 ± 0.157
1.276GlyHis: 1.276 ± 0.06
7.383GlyIle: 7.383 ± 0.153
4.733GlyLys: 4.733 ± 0.108
6.678GlyLeu: 6.678 ± 0.126
2.743GlyMet: 2.743 ± 0.075
1.995GlyAsn: 1.995 ± 0.076
1.814GlyPro: 1.814 ± 0.075
1.123GlyGln: 1.123 ± 0.053
5.104GlyArg: 5.104 ± 0.104
4.668GlySer: 4.668 ± 0.107
3.545GlyThr: 3.545 ± 0.11
7.23GlyVal: 7.23 ± 0.142
1.069GlyTrp: 1.069 ± 0.058
2.989GlyTyr: 2.989 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.301HisAla: 1.301 ± 0.057
0.264HisCys: 0.264 ± 0.027
0.971HisAsp: 0.971 ± 0.044
1.234HisGlu: 1.234 ± 0.047
0.624HisPhe: 0.624 ± 0.036
1.484HisGly: 1.484 ± 0.069
0.47HisHis: 0.47 ± 0.037
1.331HisIle: 1.331 ± 0.054
0.727HisLys: 0.727 ± 0.042
1.975HisLeu: 1.975 ± 0.073
0.361HisMet: 0.361 ± 0.027
0.531HisAsn: 0.531 ± 0.034
1.31HisPro: 1.31 ± 0.06
0.386HisGln: 0.386 ± 0.029
1.211HisArg: 1.211 ± 0.051
0.854HisSer: 0.854 ± 0.042
1.005HisThr: 1.005 ± 0.054
1.014HisVal: 1.014 ± 0.055
0.165HisTrp: 0.165 ± 0.019
0.483HisTyr: 0.483 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.373IleAla: 6.373 ± 0.125
0.897IleCys: 0.897 ± 0.051
5.171IleAsp: 5.171 ± 0.117
7.851IleGlu: 7.851 ± 0.147
3.269IlePhe: 3.269 ± 0.101
6.283IleGly: 6.283 ± 0.128
1.48IleHis: 1.48 ± 0.06
5.847IleIle: 5.847 ± 0.142
4.636IleLys: 4.636 ± 0.095
8.187IleLeu: 8.187 ± 0.164
1.801IleMet: 1.801 ± 0.062
2.51IleAsn: 2.51 ± 0.069
3.96IlePro: 3.96 ± 0.097
1.701IleGln: 1.701 ± 0.062
5.734IleArg: 5.734 ± 0.114
5.305IleSer: 5.305 ± 0.126
4.494IleThr: 4.494 ± 0.112
5.309IleVal: 5.309 ± 0.12
0.635IleTrp: 0.635 ± 0.043
2.442IleTyr: 2.442 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
3.511LysAla: 3.511 ± 0.095
0.479LysCys: 0.479 ± 0.036
3.373LysAsp: 3.373 ± 0.098
5.472LysGlu: 5.472 ± 0.142
1.344LysPhe: 1.344 ± 0.059
4.561LysGly: 4.561 ± 0.1
0.897LysHis: 0.897 ± 0.046
4.62LysIle: 4.62 ± 0.109
3.933LysLys: 3.933 ± 0.115
4.451LysLeu: 4.451 ± 0.124
1.566LysMet: 1.566 ± 0.058
1.947LysAsn: 1.947 ± 0.079
2.16LysPro: 2.16 ± 0.074
1.037LysGln: 1.037 ± 0.048
4.471LysArg: 4.471 ± 0.113
2.454LysSer: 2.454 ± 0.082
2.275LysThr: 2.275 ± 0.076
4.033LysVal: 4.033 ± 0.096
0.499LysTrp: 0.499 ± 0.036
1.568LysTyr: 1.568 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
6.541LeuAla: 6.541 ± 0.149
1.012LeuCys: 1.012 ± 0.044
6.039LeuAsp: 6.039 ± 0.129
7.984LeuGlu: 7.984 ± 0.167
3.561LeuPhe: 3.561 ± 0.102
7.483LeuGly: 7.483 ± 0.143
1.487LeuHis: 1.487 ± 0.062
8.027LeuIle: 8.027 ± 0.141
6.152LeuLys: 6.152 ± 0.142
9.358LeuLeu: 9.358 ± 0.201
2.567LeuMet: 2.567 ± 0.085
3.068LeuAsn: 3.068 ± 0.083
3.802LeuPro: 3.802 ± 0.092
1.658LeuGln: 1.658 ± 0.07
6.423LeuArg: 6.423 ± 0.137
6.4LeuSer: 6.4 ± 0.136
4.618LeuThr: 4.618 ± 0.114
6.028LeuVal: 6.028 ± 0.135
0.691LeuTrp: 0.691 ± 0.046
2.589LeuTyr: 2.589 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
1.988MetAla: 1.988 ± 0.079
0.246MetCys: 0.246 ± 0.022
1.57MetAsp: 1.57 ± 0.057
2.395MetGlu: 2.395 ± 0.067
0.615MetPhe: 0.615 ± 0.04
2.35MetGly: 2.35 ± 0.062
0.461MetHis: 0.461 ± 0.035
2.388MetIle: 2.388 ± 0.077
1.981MetLys: 1.981 ± 0.065
2.237MetLeu: 2.237 ± 0.068
0.99MetMet: 0.99 ± 0.046
0.933MetAsn: 0.933 ± 0.044
1.107MetPro: 1.107 ± 0.052
0.531MetGln: 0.531 ± 0.04
2.422MetArg: 2.422 ± 0.072
1.204MetSer: 1.204 ± 0.048
1.389MetThr: 1.389 ± 0.061
2.081MetVal: 2.081 ± 0.081
0.203MetTrp: 0.203 ± 0.017
0.635MetTyr: 0.635 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.187AsnAla: 2.187 ± 0.076
0.346AsnCys: 0.346 ± 0.03
1.365AsnAsp: 1.365 ± 0.059
2.243AsnGlu: 2.243 ± 0.076
1.089AsnPhe: 1.089 ± 0.053
2.16AsnGly: 2.16 ± 0.074
0.495AsnHis: 0.495 ± 0.032
2.467AsnIle: 2.467 ± 0.096
1.127AsnLys: 1.127 ± 0.056
3.479AsnLeu: 3.479 ± 0.101
0.615AsnMet: 0.615 ± 0.036
0.746AsnAsn: 0.746 ± 0.052
2.038AsnPro: 2.038 ± 0.069
0.605AsnGln: 0.605 ± 0.04
1.977AsnArg: 1.977 ± 0.07
1.206AsnSer: 1.206 ± 0.061
1.36AsnThr: 1.36 ± 0.058
2.042AsnVal: 2.042 ± 0.076
0.294AsnTrp: 0.294 ± 0.028
0.784AsnTyr: 0.784 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.537ProAla: 2.537 ± 0.082
0.526ProCys: 0.526 ± 0.033
3.172ProAsp: 3.172 ± 0.086
3.877ProGlu: 3.877 ± 0.09
1.798ProPhe: 1.798 ± 0.062
3.373ProGly: 3.373 ± 0.092
0.965ProHis: 0.965 ± 0.047
2.578ProIle: 2.578 ± 0.076
1.731ProLys: 1.731 ± 0.067
3.85ProLeu: 3.85 ± 0.094
0.843ProMet: 0.843 ± 0.043
1.014ProAsn: 1.014 ± 0.048
2.151ProPro: 2.151 ± 0.08
0.872ProGln: 0.872 ± 0.047
2.088ProArg: 2.088 ± 0.063
2.56ProSer: 2.56 ± 0.088
1.92ProThr: 1.92 ± 0.072
3.459ProVal: 3.459 ± 0.085
0.472ProTrp: 0.472 ± 0.031
1.462ProTyr: 1.462 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.392GlnAla: 1.392 ± 0.063
0.206GlnCys: 0.206 ± 0.022
0.996GlnAsp: 0.996 ± 0.053
1.398GlnGlu: 1.398 ± 0.052
0.599GlnPhe: 0.599 ± 0.035
1.211GlnGly: 1.211 ± 0.05
0.337GlnHis: 0.337 ± 0.028
1.559GlnIle: 1.559 ± 0.068
1.078GlnLys: 1.078 ± 0.05
1.554GlnLeu: 1.554 ± 0.051
0.633GlnMet: 0.633 ± 0.037
0.567GlnAsn: 0.567 ± 0.038
0.63GlnPro: 0.63 ± 0.038
0.47GlnGln: 0.47 ± 0.042
1.421GlnArg: 1.421 ± 0.062
0.881GlnSer: 0.881 ± 0.042
0.852GlnThr: 0.852 ± 0.045
1.356GlnVal: 1.356 ± 0.053
0.169GlnTrp: 0.169 ± 0.019
0.531GlnTyr: 0.531 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
4.575ArgAla: 4.575 ± 0.108
1.075ArgCys: 1.075 ± 0.059
4.164ArgAsp: 4.164 ± 0.088
6.633ArgGlu: 6.633 ± 0.157
2.878ArgPhe: 2.878 ± 0.08
5.171ArgGly: 5.171 ± 0.124
0.978ArgHis: 0.978 ± 0.047
6.285ArgIle: 6.285 ± 0.117
3.637ArgLys: 3.637 ± 0.098
6.195ArgLeu: 6.195 ± 0.136
2.438ArgMet: 2.438 ± 0.081
1.697ArgAsn: 1.697 ± 0.067
1.927ArgPro: 1.927 ± 0.084
1.166ArgGln: 1.166 ± 0.059
5.415ArgArg: 5.415 ± 0.126
3.893ArgSer: 3.893 ± 0.099
2.555ArgThr: 2.555 ± 0.069
5.456ArgVal: 5.456 ± 0.116
0.917ArgTrp: 0.917 ± 0.055
2.598ArgTyr: 2.598 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
3.554SerAla: 3.554 ± 0.09
0.759SerCys: 0.759 ± 0.05
3.045SerAsp: 3.045 ± 0.087
4.175SerGlu: 4.175 ± 0.1
2.485SerPhe: 2.485 ± 0.084
5.253SerGly: 5.253 ± 0.121
1.062SerHis: 1.062 ± 0.05
4.394SerIle: 4.394 ± 0.103
2.686SerLys: 2.686 ± 0.084
5.241SerLeu: 5.241 ± 0.11
1.511SerMet: 1.511 ± 0.07
1.532SerAsn: 1.532 ± 0.062
2.526SerPro: 2.526 ± 0.091
1.096SerGln: 1.096 ± 0.05
3.92SerArg: 3.92 ± 0.112
3.504SerSer: 3.504 ± 0.097
2.666SerThr: 2.666 ± 0.09
3.579SerVal: 3.579 ± 0.099
0.556SerTrp: 0.556 ± 0.037
1.866SerTyr: 1.866 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
3.233ThrAla: 3.233 ± 0.097
0.615ThrCys: 0.615 ± 0.045
2.467ThrAsp: 2.467 ± 0.078
2.853ThrGlu: 2.853 ± 0.079
1.832ThrPhe: 1.832 ± 0.071
4.494ThrGly: 4.494 ± 0.108
0.881ThrHis: 0.881 ± 0.04
3.927ThrIle: 3.927 ± 0.106
1.832ThrLys: 1.832 ± 0.054
4.57ThrLeu: 4.57 ± 0.096
1.051ThrMet: 1.051 ± 0.047
1.177ThrAsn: 1.177 ± 0.061
2.844ThrPro: 2.844 ± 0.093
0.908ThrGln: 0.908 ± 0.039
2.84ThrArg: 2.84 ± 0.073
2.885ThrSer: 2.885 ± 0.098
2.49ThrThr: 2.49 ± 0.097
3.529ThrVal: 3.529 ± 0.117
0.38ThrTrp: 0.38 ± 0.035
1.353ThrTyr: 1.353 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.266ValAla: 5.266 ± 0.141
1.053ValCys: 1.053 ± 0.066
4.681ValAsp: 4.681 ± 0.118
6.102ValGlu: 6.102 ± 0.12
2.546ValPhe: 2.546 ± 0.075
5.25ValGly: 5.25 ± 0.12
1.164ValHis: 1.164 ± 0.05
6.791ValIle: 6.791 ± 0.134
4.561ValLys: 4.561 ± 0.104
6.791ValLeu: 6.791 ± 0.117
2.108ValMet: 2.108 ± 0.073
2.379ValAsn: 2.379 ± 0.077
2.752ValPro: 2.752 ± 0.081
1.109ValGln: 1.109 ± 0.05
4.93ValArg: 4.93 ± 0.099
4.324ValSer: 4.324 ± 0.104
3.59ValThr: 3.59 ± 0.1
5.824ValVal: 5.824 ± 0.133
0.619ValTrp: 0.619 ± 0.039
2.155ValTyr: 2.155 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.513TrpAla: 0.513 ± 0.041
0.122TrpCys: 0.122 ± 0.017
0.642TrpAsp: 0.642 ± 0.045
0.847TrpGlu: 0.847 ± 0.052
0.384TrpPhe: 0.384 ± 0.032
0.748TrpGly: 0.748 ± 0.041
0.167TrpHis: 0.167 ± 0.019
0.87TrpIle: 0.87 ± 0.05
0.544TrpLys: 0.544 ± 0.039
0.895TrpLeu: 0.895 ± 0.056
0.404TrpMet: 0.404 ± 0.029
0.38TrpAsn: 0.38 ± 0.034
0.208TrpPro: 0.208 ± 0.021
0.219TrpGln: 0.219 ± 0.022
0.685TrpArg: 0.685 ± 0.043
0.45TrpSer: 0.45 ± 0.035
0.348TrpThr: 0.348 ± 0.03
0.786TrpVal: 0.786 ± 0.049
0.163TrpTrp: 0.163 ± 0.019
0.321TrpTyr: 0.321 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.972TyrAla: 1.972 ± 0.065
0.382TyrCys: 0.382 ± 0.03
1.742TyrAsp: 1.742 ± 0.064
2.445TyrGlu: 2.445 ± 0.07
1.195TyrPhe: 1.195 ± 0.057
2.598TyrGly: 2.598 ± 0.074
0.788TyrHis: 0.788 ± 0.043
2.438TyrIle: 2.438 ± 0.078
1.057TyrLys: 1.057 ± 0.053
3.233TyrLeu: 3.233 ± 0.092
0.685TyrMet: 0.685 ± 0.04
1.062TyrAsn: 1.062 ± 0.061
1.543TyrPro: 1.543 ± 0.061
0.752TyrGln: 0.752 ± 0.042
2.404TyrArg: 2.404 ± 0.069
1.663TyrSer: 1.663 ± 0.063
1.685TyrThr: 1.685 ± 0.061
1.828TyrVal: 1.828 ± 0.063
0.35TyrTrp: 0.35 ± 0.03
1.082TyrTyr: 1.082 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1592 proteins (442627 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski