Amino acid dipepetide frequency for Flavobacteriaceae bacterium MAR_2010_72

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.257AlaAla: 4.257 ± 0.114	0.563AlaCys: 0.563 ± 0.03	3.432AlaAsp: 3.432 ± 0.111	3.699AlaGlu: 3.699 ± 0.074	3.438AlaPhe: 3.438 ± 0.069	4.209AlaGly: 4.209 ± 0.103	1.177AlaHis: 1.177 ± 0.036	5.805AlaIle: 5.805 ± 0.087	4.44AlaLys: 4.44 ± 0.087	6.625AlaLeu: 6.625 ± 0.103	1.511AlaMet: 1.511 ± 0.04	3.69AlaAsn: 3.69 ± 0.068	1.925AlaPro: 1.925 ± 0.045	2.497AlaGln: 2.497 ± 0.046	1.903AlaArg: 1.903 ± 0.048	4.423AlaSer: 4.423 ± 0.072	3.755AlaThr: 3.755 ± 0.097	4.113AlaVal: 4.113 ± 0.11	0.645AlaTrp: 0.645 ± 0.026	2.565AlaTyr: 2.565 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.508CysAla: 0.508 ± 0.037	0.099CysCys: 0.099 ± 0.01	0.526CysAsp: 0.526 ± 0.046	0.526CysGlu: 0.526 ± 0.053	0.434CysPhe: 0.434 ± 0.024	0.697CysGly: 0.697 ± 0.066	0.185CysHis: 0.185 ± 0.015	0.567CysIle: 0.567 ± 0.023	0.469CysLys: 0.469 ± 0.022	0.687CysLeu: 0.687 ± 0.03	0.144CysMet: 0.144 ± 0.013	0.462CysAsn: 0.462 ± 0.025	0.37CysPro: 0.37 ± 0.03	0.209CysGln: 0.209 ± 0.013	0.184CysArg: 0.184 ± 0.014	0.577CysSer: 0.577 ± 0.036	0.422CysThr: 0.422 ± 0.028	0.428CysVal: 0.428 ± 0.023	0.063CysTrp: 0.063 ± 0.007	0.292CysTyr: 0.292 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.058AspAla: 4.058 ± 0.129	0.519AspCys: 0.519 ± 0.05	3.483AspAsp: 3.483 ± 0.095	3.709AspGlu: 3.709 ± 0.081	3.443AspPhe: 3.443 ± 0.065	4.058AspGly: 4.058 ± 0.151	1.051AspHis: 1.051 ± 0.037	4.478AspIle: 4.478 ± 0.086	3.899AspLys: 3.899 ± 0.075	5.419AspLeu: 5.419 ± 0.081	1.163AspMet: 1.163 ± 0.036	3.389AspAsn: 3.389 ± 0.084	1.888AspPro: 1.888 ± 0.077	1.736AspGln: 1.736 ± 0.046	1.898AspArg: 1.898 ± 0.045	3.306AspSer: 3.306 ± 0.076	2.937AspThr: 2.937 ± 0.084	3.835AspVal: 3.835 ± 0.084	0.823AspTrp: 0.823 ± 0.035	2.987AspTyr: 2.987 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.571GluAla: 4.571 ± 0.089	0.388GluCys: 0.388 ± 0.05	3.598GluAsp: 3.598 ± 0.07	4.021GluGlu: 4.021 ± 0.092	3.018GluPhe: 3.018 ± 0.063	3.601GluGly: 3.601 ± 0.064	1.35GluHis: 1.35 ± 0.044	4.907GluIle: 4.907 ± 0.085	4.648GluLys: 4.648 ± 0.093	6.054GluLeu: 6.054 ± 0.098	1.368GluMet: 1.368 ± 0.036	3.993GluAsn: 3.993 ± 0.067	1.722GluPro: 1.722 ± 0.046	2.408GluGln: 2.408 ± 0.055	2.565GluArg: 2.565 ± 0.064	3.404GluSer: 3.404 ± 0.072	3.75GluThr: 3.75 ± 0.071	4.155GluVal: 4.155 ± 0.068	0.588GluTrp: 0.588 ± 0.026	2.077GluTyr: 2.077 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.841PheAla: 2.841 ± 0.057	0.406PheCys: 0.406 ± 0.019	3.359PheAsp: 3.359 ± 0.059	3.456PheGlu: 3.456 ± 0.067	2.536PhePhe: 2.536 ± 0.065	3.81PheGly: 3.81 ± 0.072	0.825PheHis: 0.825 ± 0.032	3.812PheIle: 3.812 ± 0.084	3.971PheLys: 3.971 ± 0.082	4.351PheLeu: 4.351 ± 0.085	1.158PheMet: 1.158 ± 0.038	3.563PheAsn: 3.563 ± 0.072	1.698PhePro: 1.698 ± 0.042	1.539PheGln: 1.539 ± 0.041	1.632PheArg: 1.632 ± 0.035	3.833PheSer: 3.833 ± 0.071	3.059PheThr: 3.059 ± 0.063	3.012PheVal: 3.012 ± 0.059	0.585PheTrp: 0.585 ± 0.027	2.097PheTyr: 2.097 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.167GlyAla: 4.167 ± 0.073	0.72GlyCys: 0.72 ± 0.055	3.64GlyAsp: 3.64 ± 0.102	3.515GlyGlu: 3.515 ± 0.065	3.752GlyPhe: 3.752 ± 0.062	4.587GlyGly: 4.587 ± 0.103	1.251GlyHis: 1.251 ± 0.04	5.3GlyIle: 5.3 ± 0.088	4.498GlyLys: 4.498 ± 0.087	6.005GlyLeu: 6.005 ± 0.092	1.519GlyMet: 1.519 ± 0.04	3.915GlyAsn: 3.915 ± 0.111	1.5GlyPro: 1.5 ± 0.047	2.061GlyGln: 2.061 ± 0.051	2.118GlyArg: 2.118 ± 0.056	4.185GlySer: 4.185 ± 0.084	4.227GlyThr: 4.227 ± 0.128	4.323GlyVal: 4.323 ± 0.076	0.778GlyTrp: 0.778 ± 0.033	2.755GlyTyr: 2.755 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	0.962HisAla: 0.962 ± 0.033	0.224HisCys: 0.224 ± 0.026	0.917HisAsp: 0.917 ± 0.03	1.005HisGlu: 1.005 ± 0.035	1.104HisPhe: 1.104 ± 0.037	1.141HisGly: 1.141 ± 0.04	0.549HisHis: 0.549 ± 0.027	1.569HisIle: 1.569 ± 0.042	1.263HisLys: 1.263 ± 0.04	1.878HisLeu: 1.878 ± 0.046	0.371HisMet: 0.371 ± 0.021	1.023HisAsn: 1.023 ± 0.033	0.936HisPro: 0.936 ± 0.037	0.773HisGln: 0.773 ± 0.031	0.663HisArg: 0.663 ± 0.028	1.073HisSer: 1.073 ± 0.032	1.009HisThr: 1.009 ± 0.04	1.051HisVal: 1.051 ± 0.036	0.263HisTrp: 0.263 ± 0.018	0.896HisTyr: 0.896 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.581IleAla: 5.581 ± 0.083	0.659IleCys: 0.659 ± 0.026	4.997IleAsp: 4.997 ± 0.078	5.476IleGlu: 5.476 ± 0.083	3.403IlePhe: 3.403 ± 0.064	5.187IleGly: 5.187 ± 0.079	1.369IleHis: 1.369 ± 0.038	5.965IleIle: 5.965 ± 0.103	5.719IleLys: 5.719 ± 0.083	6.921IleLeu: 6.921 ± 0.111	1.451IleMet: 1.451 ± 0.04	4.826IleAsn: 4.826 ± 0.077	3.196IlePro: 3.196 ± 0.066	2.472IleGln: 2.472 ± 0.059	2.462IleArg: 2.462 ± 0.052	5.676IleSer: 5.676 ± 0.081	5.046IleThr: 5.046 ± 0.147	4.846IleVal: 4.846 ± 0.082	0.725IleTrp: 0.725 ± 0.028	2.769IleTyr: 2.769 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.16LysAla: 5.16 ± 0.095	0.298LysCys: 0.298 ± 0.019	4.349LysAsp: 4.349 ± 0.081	5.181LysGlu: 5.181 ± 0.099	2.881LysPhe: 2.881 ± 0.062	4.319LysGly: 4.319 ± 0.078	1.575LysHis: 1.575 ± 0.045	5.347LysIle: 5.347 ± 0.08	5.498LysLys: 5.498 ± 0.1	6.509LysLeu: 6.509 ± 0.101	1.721LysMet: 1.721 ± 0.042	4.525LysAsn: 4.525 ± 0.07	2.408LysPro: 2.408 ± 0.049	2.936LysGln: 2.936 ± 0.067	2.848LysArg: 2.848 ± 0.059	4.616LysSer: 4.616 ± 0.075	4.839LysThr: 4.839 ± 0.089	4.678LysVal: 4.678 ± 0.092	0.718LysTrp: 0.718 ± 0.028	2.604LysTyr: 2.604 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.784LeuAla: 5.784 ± 0.087	0.746LeuCys: 0.746 ± 0.029	5.325LeuAsp: 5.325 ± 0.079	5.963LeuGlu: 5.963 ± 0.095	4.803LeuPhe: 4.803 ± 0.097	6.007LeuGly: 6.007 ± 0.093	1.624LeuHis: 1.624 ± 0.038	7.248LeuIle: 7.248 ± 0.121	7.992LeuLys: 7.992 ± 0.107	8.565LeuLeu: 8.565 ± 0.141	2.098LeuMet: 2.098 ± 0.05	6.147LeuAsn: 6.147 ± 0.076	3.523LeuPro: 3.523 ± 0.063	3.18LeuGln: 3.18 ± 0.062	2.992LeuArg: 2.992 ± 0.064	6.443LeuSer: 6.443 ± 0.082	5.202LeuThr: 5.202 ± 0.077	5.57LeuVal: 5.57 ± 0.084	0.863LeuTrp: 0.863 ± 0.036	3.22LeuTyr: 3.22 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.657MetAla: 1.657 ± 0.047	0.128MetCys: 0.128 ± 0.011	1.154MetAsp: 1.154 ± 0.04	1.261MetGlu: 1.261 ± 0.037	0.915MetPhe: 0.915 ± 0.035	1.249MetGly: 1.249 ± 0.037	0.402MetHis: 0.402 ± 0.022	1.481MetIle: 1.481 ± 0.038	2.053MetLys: 2.053 ± 0.042	2.023MetLeu: 2.023 ± 0.051	0.544MetMet: 0.544 ± 0.027	1.309MetAsn: 1.309 ± 0.038	0.868MetPro: 0.868 ± 0.032	0.796MetGln: 0.796 ± 0.024	0.832MetArg: 0.832 ± 0.031	1.417MetSer: 1.417 ± 0.043	1.18MetThr: 1.18 ± 0.035	1.392MetVal: 1.392 ± 0.042	0.167MetTrp: 0.167 ± 0.014	0.714MetTyr: 0.714 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	4.091AsnAla: 4.091 ± 0.075	0.524AsnCys: 0.524 ± 0.034	3.662AsnAsp: 3.662 ± 0.088	3.769AsnGlu: 3.769 ± 0.06	3.02AsnPhe: 3.02 ± 0.063	4.086AsnGly: 4.086 ± 0.101	1.073AsnHis: 1.073 ± 0.034	4.585AsnIle: 4.585 ± 0.071	4.059AsnLys: 4.059 ± 0.078	5.457AsnLeu: 5.457 ± 0.081	1.345AsnMet: 1.345 ± 0.035	3.991AsnAsn: 3.991 ± 0.095	2.869AsnPro: 2.869 ± 0.068	2.268AsnGln: 2.268 ± 0.053	2.111AsnArg: 2.111 ± 0.047	4.114AsnSer: 4.114 ± 0.088	4.014AsnThr: 4.014 ± 0.084	3.685AsnVal: 3.685 ± 0.064	0.803AsnTrp: 0.803 ± 0.03	3.01AsnTyr: 3.01 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	1.871ProAla: 1.871 ± 0.053	0.208ProCys: 0.208 ± 0.023	2.192ProAsp: 2.192 ± 0.073	2.804ProGlu: 2.804 ± 0.062	1.863ProPhe: 1.863 ± 0.051	2.011ProGly: 2.011 ± 0.061	0.646ProHis: 0.646 ± 0.027	2.775ProIle: 2.775 ± 0.05	2.598ProLys: 2.598 ± 0.058	2.98ProLeu: 2.98 ± 0.057	0.7ProMet: 0.7 ± 0.029	2.595ProAsn: 2.595 ± 0.056	0.913ProPro: 0.913 ± 0.049	1.13ProGln: 1.13 ± 0.036	0.999ProArg: 0.999 ± 0.035	2.364ProSer: 2.364 ± 0.068	2.032ProThr: 2.032 ± 0.058	2.262ProVal: 2.262 ± 0.063	0.378ProTrp: 0.378 ± 0.027	1.434ProTyr: 1.434 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.018GlnAla: 2.018 ± 0.053	0.217GlnCys: 0.217 ± 0.021	1.895GlnAsp: 1.895 ± 0.041	2.042GlnGlu: 2.042 ± 0.046	1.879GlnPhe: 1.879 ± 0.044	1.945GlnGly: 1.945 ± 0.051	0.688GlnHis: 0.688 ± 0.027	2.737GlnIle: 2.737 ± 0.054	2.434GlnLys: 2.434 ± 0.061	3.806GlnLeu: 3.806 ± 0.062	0.826GlnMet: 0.826 ± 0.032	2.246GlnAsn: 2.246 ± 0.05	1.252GlnPro: 1.252 ± 0.035	1.513GlnGln: 1.513 ± 0.043	1.324GlnArg: 1.324 ± 0.039	2.097GlnSer: 2.097 ± 0.048	2.036GlnThr: 2.036 ± 0.052	2.06GlnVal: 2.06 ± 0.048	0.384GlnTrp: 0.384 ± 0.021	1.326GlnTyr: 1.326 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.092ArgAla: 2.092 ± 0.053	0.207ArgCys: 0.207 ± 0.013	1.868ArgAsp: 1.868 ± 0.045	1.96ArgGlu: 1.96 ± 0.054	1.896ArgPhe: 1.896 ± 0.046	1.986ArgGly: 1.986 ± 0.062	0.642ArgHis: 0.642 ± 0.026	2.8ArgIle: 2.8 ± 0.057	2.425ArgLys: 2.425 ± 0.056	3.359ArgLeu: 3.359 ± 0.074	0.844ArgMet: 0.844 ± 0.027	1.913ArgAsn: 1.913 ± 0.046	1.136ArgPro: 1.136 ± 0.04	1.183ArgGln: 1.183 ± 0.041	1.348ArgArg: 1.348 ± 0.041	1.97ArgSer: 1.97 ± 0.044	1.964ArgThr: 1.964 ± 0.05	2.078ArgVal: 2.078 ± 0.052	0.416ArgTrp: 0.416 ± 0.02	1.532ArgTyr: 1.532 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.955SerAla: 3.955 ± 0.079	0.616SerCys: 0.616 ± 0.028	3.633SerAsp: 3.633 ± 0.084	3.852SerGlu: 3.852 ± 0.073	3.644SerPhe: 3.644 ± 0.067	4.712SerGly: 4.712 ± 0.106	1.116SerHis: 1.116 ± 0.031	5.365SerIle: 5.365 ± 0.09	5.071SerLys: 5.071 ± 0.078	5.968SerLeu: 5.968 ± 0.088	1.246SerMet: 1.246 ± 0.034	4.126SerAsn: 4.126 ± 0.083	2.193SerPro: 2.193 ± 0.053	2.264SerGln: 2.264 ± 0.052	2.11SerArg: 2.11 ± 0.048	4.401SerSer: 4.401 ± 0.09	3.855SerThr: 3.855 ± 0.075	3.961SerVal: 3.961 ± 0.074	0.783SerTrp: 0.783 ± 0.03	2.798SerTyr: 2.798 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.757ThrAla: 3.757 ± 0.134	0.375ThrCys: 0.375 ± 0.026	3.33ThrAsp: 3.33 ± 0.1	3.213ThrGlu: 3.213 ± 0.077	3.243ThrPhe: 3.243 ± 0.07	4.032ThrGly: 4.032 ± 0.089	1.099ThrHis: 1.099 ± 0.036	5.393ThrIle: 5.393 ± 0.129	3.871ThrLys: 3.871 ± 0.062	5.744ThrLeu: 5.744 ± 0.07	1.096ThrMet: 1.096 ± 0.035	3.656ThrAsn: 3.656 ± 0.1	2.548ThrPro: 2.548 ± 0.075	1.99ThrGln: 1.99 ± 0.058	1.677ThrArg: 1.677 ± 0.048	4.064ThrSer: 4.064 ± 0.086	3.785ThrThr: 3.785 ± 0.101	4.017ThrVal: 4.017 ± 0.132	0.653ThrTrp: 0.653 ± 0.041	2.664ThrTyr: 2.664 ± 0.102	0.0ThrXaa: 0.0 ± 0.0
Val	4.151ValAla: 4.151 ± 0.087	0.514ValCys: 0.514 ± 0.027	3.688ValAsp: 3.688 ± 0.07	3.94ValGlu: 3.94 ± 0.07	3.348ValPhe: 3.348 ± 0.071	3.935ValGly: 3.935 ± 0.074	0.989ValHis: 0.989 ± 0.033	5.047ValIle: 5.047 ± 0.082	4.32ValLys: 4.32 ± 0.078	6.098ValLeu: 6.098 ± 0.095	1.36ValMet: 1.36 ± 0.042	3.703ValAsn: 3.703 ± 0.064	2.113ValPro: 2.113 ± 0.053	1.81ValGln: 1.81 ± 0.047	1.931ValArg: 1.931 ± 0.052	4.518ValSer: 4.518 ± 0.085	3.862ValThr: 3.862 ± 0.107	4.34ValVal: 4.34 ± 0.069	0.6ValTrp: 0.6 ± 0.024	2.464ValTyr: 2.464 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.628TrpAla: 0.628 ± 0.026	0.092TrpCys: 0.092 ± 0.009	0.62TrpAsp: 0.62 ± 0.027	0.657TrpGlu: 0.657 ± 0.031	0.577TrpPhe: 0.577 ± 0.024	0.646TrpGly: 0.646 ± 0.024	0.248TrpHis: 0.248 ± 0.015	0.789TrpIle: 0.789 ± 0.03	0.77TrpLys: 0.77 ± 0.034	1.03TrpLeu: 1.03 ± 0.031	0.32TrpMet: 0.32 ± 0.017	0.754TrpAsn: 0.754 ± 0.031	0.26TrpPro: 0.26 ± 0.019	0.424TrpGln: 0.424 ± 0.026	0.417TrpArg: 0.417 ± 0.022	0.641TrpSer: 0.641 ± 0.028	0.703TrpThr: 0.703 ± 0.055	0.687TrpVal: 0.687 ± 0.038	0.148TrpTrp: 0.148 ± 0.015	0.47TrpTyr: 0.47 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.563TyrAla: 2.563 ± 0.057	0.346TyrCys: 0.346 ± 0.018	2.411TyrAsp: 2.411 ± 0.05	2.136TyrGlu: 2.136 ± 0.05	2.348TyrPhe: 2.348 ± 0.057	2.598TyrGly: 2.598 ± 0.053	0.81TyrHis: 0.81 ± 0.033	2.779TyrIle: 2.779 ± 0.055	3.013TyrLys: 3.013 ± 0.065	3.815TyrLeu: 3.815 ± 0.065	0.758TyrMet: 0.758 ± 0.029	2.711TyrAsn: 2.711 ± 0.057	1.436TyrPro: 1.436 ± 0.037	1.537TyrGln: 1.537 ± 0.041	1.602TyrArg: 1.602 ± 0.042	2.544TyrSer: 2.544 ± 0.051	2.53TyrThr: 2.53 ± 0.116	2.239TyrVal: 2.239 ± 0.052	0.498TyrTrp: 0.498 ± 0.026	1.785TyrTyr: 1.785 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2943 proteins (1037183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---