Amino acid dipepetide frequency for Corynebacterium imitans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.535AlaAla: 16.535 ± 0.255	0.966AlaCys: 0.966 ± 0.048	7.391AlaAsp: 7.391 ± 0.105	8.856AlaGlu: 8.856 ± 0.131	3.669AlaPhe: 3.669 ± 0.082	10.328AlaGly: 10.328 ± 0.139	2.641AlaHis: 2.641 ± 0.074	5.164AlaIle: 5.164 ± 0.103	4.212AlaLys: 4.212 ± 0.1	12.294AlaLeu: 12.294 ± 0.174	2.713AlaMet: 2.713 ± 0.071	3.136AlaAsn: 3.136 ± 0.073	5.702AlaPro: 5.702 ± 0.119	4.614AlaGln: 4.614 ± 0.104	7.556AlaArg: 7.556 ± 0.13	6.066AlaSer: 6.066 ± 0.113	7.194AlaThr: 7.194 ± 0.114	9.349AlaVal: 9.349 ± 0.131	1.623AlaTrp: 1.623 ± 0.049	2.583AlaTyr: 2.583 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.04	0.078CysCys: 0.078 ± 0.011	0.407CysAsp: 0.407 ± 0.026	0.405CysGlu: 0.405 ± 0.028	0.234CysPhe: 0.234 ± 0.021	0.72CysGly: 0.72 ± 0.038	0.131CysHis: 0.131 ± 0.012	0.304CysIle: 0.304 ± 0.021	0.164CysLys: 0.164 ± 0.016	0.535CysLeu: 0.535 ± 0.031	0.125CysMet: 0.125 ± 0.014	0.18CysAsn: 0.18 ± 0.017	0.364CysPro: 0.364 ± 0.028	0.174CysGln: 0.174 ± 0.016	0.312CysArg: 0.312 ± 0.025	0.387CysSer: 0.387 ± 0.029	0.483CysThr: 0.483 ± 0.03	0.518CysVal: 0.518 ± 0.03	0.089CysTrp: 0.089 ± 0.012	0.144CysTyr: 0.144 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.283AspAla: 8.283 ± 0.119	0.348AspCys: 0.348 ± 0.026	3.478AspAsp: 3.478 ± 0.082	4.944AspGlu: 4.944 ± 0.098	2.144AspPhe: 2.144 ± 0.064	5.606AspGly: 5.606 ± 0.123	1.102AspHis: 1.102 ± 0.046	2.811AspIle: 2.811 ± 0.068	1.962AspLys: 1.962 ± 0.069	5.372AspLeu: 5.372 ± 0.088	1.275AspMet: 1.275 ± 0.04	1.692AspAsn: 1.692 ± 0.07	3.744AspPro: 3.744 ± 0.068	1.675AspGln: 1.675 ± 0.054	3.417AspArg: 3.417 ± 0.074	2.907AspSer: 2.907 ± 0.061	3.721AspThr: 3.721 ± 0.08	5.059AspVal: 5.059 ± 0.1	0.863AspTrp: 0.863 ± 0.039	1.66AspTyr: 1.66 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	7.976GluAla: 7.976 ± 0.146	0.376GluCys: 0.376 ± 0.027	4.042GluAsp: 4.042 ± 0.094	4.913GluGlu: 4.913 ± 0.12	2.24GluPhe: 2.24 ± 0.059	4.918GluGly: 4.918 ± 0.096	1.822GluHis: 1.822 ± 0.052	3.335GluIle: 3.335 ± 0.077	2.522GluLys: 2.522 ± 0.076	7.227GluLeu: 7.227 ± 0.117	1.476GluMet: 1.476 ± 0.047	1.863GluAsn: 1.863 ± 0.056	3.089GluPro: 3.089 ± 0.092	2.908GluGln: 2.908 ± 0.077	4.687GluArg: 4.687 ± 0.095	2.979GluSer: 2.979 ± 0.062	3.709GluThr: 3.709 ± 0.089	5.756GluVal: 5.756 ± 0.101	0.86GluTrp: 0.86 ± 0.039	1.612GluTyr: 1.612 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	4.206PheAla: 4.206 ± 0.078	0.251PheCys: 0.251 ± 0.021	2.499PheAsp: 2.499 ± 0.06	1.855PheGlu: 1.855 ± 0.055	1.093PhePhe: 1.093 ± 0.049	3.336PheGly: 3.336 ± 0.071	0.682PheHis: 0.682 ± 0.032	1.46PheIle: 1.46 ± 0.051	0.825PheLys: 0.825 ± 0.036	2.795PheLeu: 2.795 ± 0.083	0.646PheMet: 0.646 ± 0.035	0.986PheAsn: 0.986 ± 0.04	1.397PhePro: 1.397 ± 0.042	0.851PheGln: 0.851 ± 0.038	1.686PheArg: 1.686 ± 0.05	1.929PheSer: 1.929 ± 0.057	2.218PheThr: 2.218 ± 0.063	2.546PheVal: 2.546 ± 0.068	0.396PheTrp: 0.396 ± 0.025	0.808PheTyr: 0.808 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	9.254GlyAla: 9.254 ± 0.13	0.625GlyCys: 0.625 ± 0.034	4.632GlyAsp: 4.632 ± 0.095	6.067GlyGlu: 6.067 ± 0.091	2.963GlyPhe: 2.963 ± 0.069	6.835GlyGly: 6.835 ± 0.141	1.703GlyHis: 1.703 ± 0.046	4.377GlyIle: 4.377 ± 0.089	3.399GlyLys: 3.399 ± 0.098	7.654GlyLeu: 7.654 ± 0.119	2.172GlyMet: 2.172 ± 0.052	2.454GlyAsn: 2.454 ± 0.065	3.393GlyPro: 3.393 ± 0.079	2.785GlyGln: 2.785 ± 0.07	4.744GlyArg: 4.744 ± 0.087	4.533GlySer: 4.533 ± 0.091	5.473GlyThr: 5.473 ± 0.102	7.186GlyVal: 7.186 ± 0.109	1.337GlyTrp: 1.337 ± 0.047	2.161GlyTyr: 2.161 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.459HisAla: 2.459 ± 0.076	0.156HisCys: 0.156 ± 0.016	1.302HisAsp: 1.302 ± 0.045	1.342HisGlu: 1.342 ± 0.047	0.68HisPhe: 0.68 ± 0.035	1.884HisGly: 1.884 ± 0.056	0.514HisHis: 0.514 ± 0.031	1.006HisIle: 1.006 ± 0.04	0.515HisLys: 0.515 ± 0.026	1.967HisLeu: 1.967 ± 0.06	0.437HisMet: 0.437 ± 0.029	0.558HisAsn: 0.558 ± 0.031	1.386HisPro: 1.386 ± 0.048	0.573HisGln: 0.573 ± 0.032	1.333HisArg: 1.333 ± 0.042	1.047HisSer: 1.047 ± 0.039	1.351HisThr: 1.351 ± 0.043	1.612HisVal: 1.612 ± 0.053	0.248HisTrp: 0.248 ± 0.019	0.559HisTyr: 0.559 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.287IleAla: 6.287 ± 0.105	0.336IleCys: 0.336 ± 0.025	3.674IleAsp: 3.674 ± 0.085	3.164IleGlu: 3.164 ± 0.085	1.423IlePhe: 1.423 ± 0.048	4.119IleGly: 4.119 ± 0.073	0.85IleHis: 0.85 ± 0.033	2.314IleIle: 2.314 ± 0.064	1.302IleLys: 1.302 ± 0.05	3.647IleLeu: 3.647 ± 0.09	0.905IleMet: 0.905 ± 0.039	1.458IleAsn: 1.458 ± 0.047	2.454IlePro: 2.454 ± 0.068	1.279IleGln: 1.279 ± 0.046	2.451IleArg: 2.451 ± 0.061	2.467IleSer: 2.467 ± 0.066	3.148IleThr: 3.148 ± 0.086	4.033IleVal: 4.033 ± 0.085	0.475IleTrp: 0.475 ± 0.026	0.99IleTyr: 0.99 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.692LysAla: 3.692 ± 0.094	0.118LysCys: 0.118 ± 0.013	2.14LysAsp: 2.14 ± 0.08	2.146LysGlu: 2.146 ± 0.058	0.906LysPhe: 0.906 ± 0.035	2.274LysGly: 2.274 ± 0.058	0.724LysHis: 0.724 ± 0.033	1.411LysIle: 1.411 ± 0.058	1.622LysLys: 1.622 ± 0.074	3.281LysLeu: 3.281 ± 0.074	0.782LysMet: 0.782 ± 0.033	0.972LysAsn: 0.972 ± 0.044	1.712LysPro: 1.712 ± 0.063	1.29LysGln: 1.29 ± 0.049	2.367LysArg: 2.367 ± 0.066	1.589LysSer: 1.589 ± 0.055	1.913LysThr: 1.913 ± 0.065	2.659LysVal: 2.659 ± 0.069	0.388LysTrp: 0.388 ± 0.025	0.749LysTyr: 0.749 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	12.417LeuAla: 12.417 ± 0.182	0.646LeuCys: 0.646 ± 0.031	6.277LeuAsp: 6.277 ± 0.123	5.448LeuGlu: 5.448 ± 0.097	2.783LeuPhe: 2.783 ± 0.067	8.166LeuGly: 8.166 ± 0.129	1.962LeuHis: 1.962 ± 0.054	4.674LeuIle: 4.674 ± 0.092	2.639LeuLys: 2.639 ± 0.069	8.772LeuLeu: 8.772 ± 0.158	1.894LeuMet: 1.894 ± 0.055	2.487LeuAsn: 2.487 ± 0.063	5.199LeuPro: 5.199 ± 0.103	2.548LeuGln: 2.548 ± 0.073	6.413LeuArg: 6.413 ± 0.13	5.395LeuSer: 5.395 ± 0.098	5.682LeuThr: 5.682 ± 0.102	7.886LeuVal: 7.886 ± 0.124	1.019LeuTrp: 1.019 ± 0.037	1.782LeuTyr: 1.782 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.603MetAla: 2.603 ± 0.072	0.15MetCys: 0.15 ± 0.016	1.22MetAsp: 1.22 ± 0.041	1.1MetGlu: 1.1 ± 0.046	0.694MetPhe: 0.694 ± 0.035	1.596MetGly: 1.596 ± 0.049	0.462MetHis: 0.462 ± 0.029	1.056MetIle: 1.056 ± 0.045	0.692MetLys: 0.692 ± 0.03	2.133MetLeu: 2.133 ± 0.061	0.463MetMet: 0.463 ± 0.034	0.599MetAsn: 0.599 ± 0.03	1.206MetPro: 1.206 ± 0.049	0.782MetGln: 0.782 ± 0.031	1.53MetArg: 1.53 ± 0.048	1.505MetSer: 1.505 ± 0.043	1.541MetThr: 1.541 ± 0.039	1.727MetVal: 1.727 ± 0.059	0.286MetTrp: 0.286 ± 0.021	0.365MetTyr: 0.365 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.188AsnAla: 3.188 ± 0.081	0.164AsnCys: 0.164 ± 0.015	1.525AsnAsp: 1.525 ± 0.054	1.654AsnGlu: 1.654 ± 0.049	0.926AsnPhe: 0.926 ± 0.038	2.292AsnGly: 2.292 ± 0.073	0.532AsnHis: 0.532 ± 0.031	1.299AsnIle: 1.299 ± 0.045	0.86AsnLys: 0.86 ± 0.037	2.58AsnLeu: 2.58 ± 0.065	0.62AsnMet: 0.62 ± 0.034	0.877AsnAsn: 0.877 ± 0.048	2.126AsnPro: 2.126 ± 0.071	0.967AsnGln: 0.967 ± 0.038	1.687AsnArg: 1.687 ± 0.056	1.388AsnSer: 1.388 ± 0.048	1.634AsnThr: 1.634 ± 0.052	2.291AsnVal: 2.291 ± 0.067	0.413AsnTrp: 0.413 ± 0.026	0.784AsnTyr: 0.784 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.245ProAla: 6.245 ± 0.124	0.231ProCys: 0.231 ± 0.021	3.503ProAsp: 3.503 ± 0.084	4.704ProGlu: 4.704 ± 0.105	1.681ProPhe: 1.681 ± 0.053	4.698ProGly: 4.698 ± 0.088	1.077ProHis: 1.077 ± 0.042	1.916ProIle: 1.916 ± 0.051	1.771ProLys: 1.771 ± 0.062	4.243ProLeu: 4.243 ± 0.088	0.938ProMet: 0.938 ± 0.036	1.539ProAsn: 1.539 ± 0.046	1.761ProPro: 1.761 ± 0.063	1.808ProGln: 1.808 ± 0.054	2.769ProArg: 2.769 ± 0.07	2.482ProSer: 2.482 ± 0.063	3.148ProThr: 3.148 ± 0.078	4.496ProVal: 4.496 ± 0.092	0.685ProTrp: 0.685 ± 0.037	1.113ProTyr: 1.113 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.203GlnAla: 4.203 ± 0.098	0.167GlnCys: 0.167 ± 0.015	1.637GlnAsp: 1.637 ± 0.054	2.065GlnGlu: 2.065 ± 0.058	1.024GlnPhe: 1.024 ± 0.033	2.346GlnGly: 2.346 ± 0.06	0.685GlnHis: 0.685 ± 0.034	1.675GlnIle: 1.675 ± 0.049	1.018GlnLys: 1.018 ± 0.045	3.912GlnLeu: 3.912 ± 0.089	0.773GlnMet: 0.773 ± 0.038	0.767GlnAsn: 0.767 ± 0.037	1.661GlnPro: 1.661 ± 0.056	1.485GlnGln: 1.485 ± 0.053	2.592GlnArg: 2.592 ± 0.068	1.537GlnSer: 1.537 ± 0.049	1.51GlnThr: 1.51 ± 0.048	2.725GlnVal: 2.725 ± 0.065	0.529GlnTrp: 0.529 ± 0.028	0.747GlnTyr: 0.747 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	7.071ArgAla: 7.071 ± 0.125	0.367ArgCys: 0.367 ± 0.024	3.873ArgAsp: 3.873 ± 0.081	5.068ArgGlu: 5.068 ± 0.107	2.149ArgPhe: 2.149 ± 0.059	4.768ArgGly: 4.768 ± 0.094	1.262ArgHis: 1.262 ± 0.043	3.222ArgIle: 3.222 ± 0.07	2.204ArgLys: 2.204 ± 0.067	5.493ArgLeu: 5.493 ± 0.111	1.628ArgMet: 1.628 ± 0.055	1.747ArgAsn: 1.747 ± 0.05	2.838ArgPro: 2.838 ± 0.065	2.033ArgGln: 2.033 ± 0.053	4.779ArgArg: 4.779 ± 0.109	3.098ArgSer: 3.098 ± 0.066	3.718ArgThr: 3.718 ± 0.075	4.944ArgVal: 4.944 ± 0.089	0.915ArgTrp: 0.915 ± 0.042	1.612ArgTyr: 1.612 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.95SerAla: 5.95 ± 0.097	0.324SerCys: 0.324 ± 0.025	2.652SerAsp: 2.652 ± 0.062	3.157SerGlu: 3.157 ± 0.068	1.816SerPhe: 1.816 ± 0.049	5.048SerGly: 5.048 ± 0.088	1.108SerHis: 1.108 ± 0.043	2.347SerIle: 2.347 ± 0.058	1.692SerLys: 1.692 ± 0.061	4.998SerLeu: 4.998 ± 0.095	1.302SerMet: 1.302 ± 0.047	1.452SerAsn: 1.452 ± 0.051	2.638SerPro: 2.638 ± 0.07	1.796SerGln: 1.796 ± 0.057	3.232SerArg: 3.232 ± 0.072	3.076SerSer: 3.076 ± 0.085	3.486SerThr: 3.486 ± 0.085	4.087SerVal: 4.087 ± 0.079	0.773SerTrp: 0.773 ± 0.034	1.279SerTyr: 1.279 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.972ThrAla: 6.972 ± 0.111	0.439ThrCys: 0.439 ± 0.027	3.689ThrAsp: 3.689 ± 0.074	3.619ThrGlu: 3.619 ± 0.083	2.023ThrPhe: 2.023 ± 0.06	5.419ThrGly: 5.419 ± 0.081	1.268ThrHis: 1.268 ± 0.041	2.933ThrIle: 2.933 ± 0.07	1.866ThrLys: 1.866 ± 0.056	5.736ThrLeu: 5.736 ± 0.104	1.111ThrMet: 1.111 ± 0.045	1.632ThrAsn: 1.632 ± 0.052	4.067ThrPro: 4.067 ± 0.093	1.895ThrGln: 1.895 ± 0.053	3.562ThrArg: 3.562 ± 0.085	3.414ThrSer: 3.414 ± 0.09	4.163ThrThr: 4.163 ± 0.124	5.685ThrVal: 5.685 ± 0.114	0.844ThrTrp: 0.844 ± 0.038	1.461ThrTyr: 1.461 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	10.229ValAla: 10.229 ± 0.146	0.676ValCys: 0.676 ± 0.033	5.852ValAsp: 5.852 ± 0.094	5.607ValGlu: 5.607 ± 0.106	2.615ValPhe: 2.615 ± 0.062	6.492ValGly: 6.492 ± 0.108	1.651ValHis: 1.651 ± 0.056	3.894ValIle: 3.894 ± 0.076	2.395ValLys: 2.395 ± 0.075	7.751ValLeu: 7.751 ± 0.127	1.716ValMet: 1.716 ± 0.059	2.274ValAsn: 2.274 ± 0.072	4.282ValPro: 4.282 ± 0.083	2.216ValGln: 2.216 ± 0.058	5.208ValArg: 5.208 ± 0.104	4.38ValSer: 4.38 ± 0.08	5.537ValThr: 5.537 ± 0.108	7.564ValVal: 7.564 ± 0.141	1.032ValTrp: 1.032 ± 0.037	1.644ValTyr: 1.644 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.49TrpAla: 1.49 ± 0.052	0.124TrpCys: 0.124 ± 0.015	0.786TrpAsp: 0.786 ± 0.038	0.761TrpGlu: 0.761 ± 0.038	0.495TrpPhe: 0.495 ± 0.028	0.863TrpGly: 0.863 ± 0.038	0.315TrpHis: 0.315 ± 0.024	0.657TrpIle: 0.657 ± 0.034	0.425TrpLys: 0.425 ± 0.023	1.473TrpLeu: 1.473 ± 0.052	0.336TrpMet: 0.336 ± 0.02	0.419TrpAsn: 0.419 ± 0.024	0.599TrpPro: 0.599 ± 0.033	0.561TrpGln: 0.561 ± 0.03	0.935TrpArg: 0.935 ± 0.043	0.708TrpSer: 0.708 ± 0.029	0.744TrpThr: 0.744 ± 0.035	1.187TrpVal: 1.187 ± 0.047	0.309TrpTrp: 0.309 ± 0.025	0.275TrpTyr: 0.275 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.563TyrAla: 2.563 ± 0.064	0.18TyrCys: 0.18 ± 0.018	1.487TyrAsp: 1.487 ± 0.052	1.435TyrGlu: 1.435 ± 0.054	0.905TyrPhe: 0.905 ± 0.034	2.037TyrGly: 2.037 ± 0.06	0.439TyrHis: 0.439 ± 0.027	0.923TyrIle: 0.923 ± 0.043	0.651TyrLys: 0.651 ± 0.034	2.227TyrLeu: 2.227 ± 0.057	0.394TyrMet: 0.394 ± 0.023	0.715TyrAsn: 0.715 ± 0.034	1.191TyrPro: 1.191 ± 0.048	0.818TyrGln: 0.818 ± 0.04	1.528TyrArg: 1.528 ± 0.047	1.327TyrSer: 1.327 ± 0.043	1.426TyrThr: 1.426 ± 0.046	1.706TyrVal: 1.706 ± 0.049	0.379TyrTrp: 0.379 ± 0.029	0.584TyrTyr: 0.584 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2011 proteins (654327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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