Amino acid dipepetide frequency for Marseillevirus marseillevirus (GBM)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.222AlaAla: 3.222 ± 0.25
1.103AlaCys: 1.103 ± 0.105
2.217AlaAsp: 2.217 ± 0.13
4.277AlaGlu: 4.277 ± 0.23
2.91AlaPhe: 2.91 ± 0.163
2.509AlaGly: 2.509 ± 0.166
0.771AlaHis: 0.771 ± 0.083
2.431AlaIle: 2.431 ± 0.159
4.677AlaLys: 4.677 ± 0.263
5.283AlaLeu: 5.283 ± 0.282
1.289AlaMet: 1.289 ± 0.122
1.748AlaAsn: 1.748 ± 0.15
1.885AlaPro: 1.885 ± 0.133
1.689AlaGln: 1.689 ± 0.144
2.91AlaArg: 2.91 ± 0.176
4.326AlaSer: 4.326 ± 0.245
2.812AlaThr: 2.812 ± 0.264
3.378AlaVal: 3.378 ± 0.194
0.547AlaTrp: 0.547 ± 0.07
1.357AlaTyr: 1.357 ± 0.138
0.0AlaXaa: 0.0 ± 0.0
Cys
1.113CysAla: 1.113 ± 0.111
0.742CysCys: 0.742 ± 0.091
1.123CysAsp: 1.123 ± 0.123
1.943CysGlu: 1.943 ± 0.167
1.592CysPhe: 1.592 ± 0.16
1.982CysGly: 1.982 ± 0.164
0.449CysHis: 0.449 ± 0.058
0.879CysIle: 0.879 ± 0.094
1.709CysLys: 1.709 ± 0.142
2.451CysLeu: 2.451 ± 0.178
0.4CysMet: 0.4 ± 0.055
0.674CysAsn: 0.674 ± 0.083
1.445CysPro: 1.445 ± 0.169
0.664CysGln: 0.664 ± 0.093
1.24CysArg: 1.24 ± 0.107
2.217CysSer: 2.217 ± 0.2
0.908CysThr: 0.908 ± 0.092
1.455CysVal: 1.455 ± 0.126
0.264CysTrp: 0.264 ± 0.05
0.654CysTyr: 0.654 ± 0.079
0.0CysXaa: 0.0 ± 0.0
Asp
2.783AspAla: 2.783 ± 0.204
1.142AspCys: 1.142 ± 0.12
2.207AspAsp: 2.207 ± 0.168
3.886AspGlu: 3.886 ± 0.23
3.154AspPhe: 3.154 ± 0.176
4.072AspGly: 4.072 ± 0.205
0.508AspHis: 0.508 ± 0.086
3.837AspIle: 3.837 ± 0.238
3.125AspLys: 3.125 ± 0.193
3.31AspLeu: 3.31 ± 0.177
1.094AspMet: 1.094 ± 0.103
1.426AspAsn: 1.426 ± 0.119
1.787AspPro: 1.787 ± 0.142
0.947AspGln: 0.947 ± 0.106
2.197AspArg: 2.197 ± 0.155
2.998AspSer: 2.998 ± 0.185
1.826AspThr: 1.826 ± 0.115
3.759AspVal: 3.759 ± 0.186
0.801AspTrp: 0.801 ± 0.092
1.328AspTyr: 1.328 ± 0.121
0.0AspXaa: 0.0 ± 0.0
Glu
4.472GluAla: 4.472 ± 0.221
1.582GluCys: 1.582 ± 0.159
4.072GluAsp: 4.072 ± 0.215
10.204GluGlu: 10.204 ± 0.614
4.755GluPhe: 4.755 ± 0.245
5.351GluGly: 5.351 ± 0.243
1.845GluHis: 1.845 ± 0.149
4.609GluIle: 4.609 ± 0.211
10.809GluLys: 10.809 ± 0.442
7.069GluLeu: 7.069 ± 0.34
2.363GluMet: 2.363 ± 0.166
4.082GluAsn: 4.082 ± 0.238
1.953GluPro: 1.953 ± 0.157
3.281GluGln: 3.281 ± 0.196
6.493GluArg: 6.493 ± 0.268
4.306GluSer: 4.306 ± 0.205
5.175GluThr: 5.175 ± 0.203
4.062GluVal: 4.062 ± 0.234
1.221GluTrp: 1.221 ± 0.099
2.685GluTyr: 2.685 ± 0.157
0.0GluXaa: 0.0 ± 0.0
Phe
3.623PheAla: 3.623 ± 0.189
2.002PheCys: 2.002 ± 0.201
3.086PheAsp: 3.086 ± 0.167
4.97PheGlu: 4.97 ± 0.259
3.281PhePhe: 3.281 ± 0.209
3.994PheGly: 3.994 ± 0.214
1.035PheHis: 1.035 ± 0.098
2.06PheIle: 2.06 ± 0.136
2.48PheLys: 2.48 ± 0.153
6.767PheLeu: 6.767 ± 0.298
1.123PheMet: 1.123 ± 0.111
0.957PheAsn: 0.957 ± 0.1
2.529PhePro: 2.529 ± 0.17
1.513PheGln: 1.513 ± 0.113
3.095PheArg: 3.095 ± 0.197
5.4PheSer: 5.4 ± 0.241
1.806PheThr: 1.806 ± 0.132
4.872PheVal: 4.872 ± 0.229
1.318PheTrp: 1.318 ± 0.135
1.738PheTyr: 1.738 ± 0.132
0.0PheXaa: 0.0 ± 0.0
Gly
3.388GlyAla: 3.388 ± 0.219
1.582GlyCys: 1.582 ± 0.142
2.763GlyAsp: 2.763 ± 0.161
5.712GlyGlu: 5.712 ± 0.261
2.9GlyPhe: 2.9 ± 0.181
3.613GlyGly: 3.613 ± 0.25
1.201GlyHis: 1.201 ± 0.13
3.935GlyIle: 3.935 ± 0.192
6.913GlyLys: 6.913 ± 0.29
4.179GlyLeu: 4.179 ± 0.203
1.367GlyMet: 1.367 ± 0.111
2.783GlyAsn: 2.783 ± 0.163
1.699GlyPro: 1.699 ± 0.126
1.904GlyGln: 1.904 ± 0.172
3.955GlyArg: 3.955 ± 0.214
4.238GlySer: 4.238 ± 0.217
3.886GlyThr: 3.886 ± 0.241
4.384GlyVal: 4.384 ± 0.242
0.928GlyTrp: 0.928 ± 0.098
2.236GlyTyr: 2.236 ± 0.149
0.0GlyXaa: 0.0 ± 0.0
His
0.81HisAla: 0.81 ± 0.085
0.508HisCys: 0.508 ± 0.065
0.586HisAsp: 0.586 ± 0.094
1.299HisGlu: 1.299 ± 0.13
1.133HisPhe: 1.133 ± 0.111
1.435HisGly: 1.435 ± 0.149
0.322HisHis: 0.322 ± 0.062
1.211HisIle: 1.211 ± 0.106
1.865HisLys: 1.865 ± 0.148
1.875HisLeu: 1.875 ± 0.169
0.332HisMet: 0.332 ± 0.059
0.684HisAsn: 0.684 ± 0.07
0.947HisPro: 0.947 ± 0.1
0.625HisGln: 0.625 ± 0.078
0.898HisArg: 0.898 ± 0.097
1.318HisSer: 1.318 ± 0.122
0.566HisThr: 0.566 ± 0.081
1.045HisVal: 1.045 ± 0.089
0.254HisTrp: 0.254 ± 0.057
0.537HisTyr: 0.537 ± 0.075
0.0HisXaa: 0.0 ± 0.0
Ile
2.431IleAla: 2.431 ± 0.148
1.211IleCys: 1.211 ± 0.103
2.041IleAsp: 2.041 ± 0.136
3.291IleGlu: 3.291 ± 0.201
3.535IlePhe: 3.535 ± 0.196
2.705IleGly: 2.705 ± 0.199
0.996IleHis: 0.996 ± 0.1
2.275IleIle: 2.275 ± 0.159
2.754IleLys: 2.754 ± 0.164
5.439IleLeu: 5.439 ± 0.223
0.664IleMet: 0.664 ± 0.094
1.045IleAsn: 1.045 ± 0.098
2.783IlePro: 2.783 ± 0.187
1.933IleGln: 1.933 ± 0.147
2.578IleArg: 2.578 ± 0.137
5.273IleSer: 5.273 ± 0.256
1.826IleThr: 1.826 ± 0.147
3.271IleVal: 3.271 ± 0.195
0.81IleTrp: 0.81 ± 0.082
1.162IleTyr: 1.162 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
4.179LysAla: 4.179 ± 0.259
1.289LysCys: 1.289 ± 0.13
4.296LysAsp: 4.296 ± 0.225
9.12LysGlu: 9.12 ± 0.395
4.208LysPhe: 4.208 ± 0.209
5.419LysGly: 5.419 ± 0.24
1.836LysHis: 1.836 ± 0.146
4.609LysIle: 4.609 ± 0.215
11.297LysLys: 11.297 ± 0.64
5.986LysLeu: 5.986 ± 0.234
1.963LysMet: 1.963 ± 0.173
4.785LysAsn: 4.785 ± 0.279
2.236LysPro: 2.236 ± 0.186
2.714LysGln: 2.714 ± 0.174
6.034LysArg: 6.034 ± 0.263
4.404LysSer: 4.404 ± 0.273
5.195LysThr: 5.195 ± 0.208
4.589LysVal: 4.589 ± 0.213
0.889LysTrp: 0.889 ± 0.087
3.046LysTyr: 3.046 ± 0.19
0.0LysXaa: 0.0 ± 0.0
Leu
4.423LeuAla: 4.423 ± 0.2
2.724LeuCys: 2.724 ± 0.201
4.306LeuAsp: 4.306 ± 0.218
8.456LeuGlu: 8.456 ± 0.34
5.185LeuPhe: 5.185 ± 0.234
5.253LeuGly: 5.253 ± 0.263
1.582LeuHis: 1.582 ± 0.128
2.695LeuIle: 2.695 ± 0.158
5.79LeuLys: 5.79 ± 0.236
8.72LeuLeu: 8.72 ± 0.336
1.67LeuMet: 1.67 ± 0.125
2.578LeuAsn: 2.578 ± 0.172
4.619LeuPro: 4.619 ± 0.217
3.642LeuGln: 3.642 ± 0.276
5.048LeuArg: 5.048 ± 0.268
8.856LeuSer: 8.856 ± 0.347
3.3LeuThr: 3.3 ± 0.176
5.888LeuVal: 5.888 ± 0.238
1.865LeuTrp: 1.865 ± 0.147
2.324LeuTyr: 2.324 ± 0.137
0.0LeuXaa: 0.0 ± 0.0
Met
1.269MetAla: 1.269 ± 0.119
0.566MetCys: 0.566 ± 0.074
1.24MetAsp: 1.24 ± 0.105
2.314MetGlu: 2.314 ± 0.158
1.103MetPhe: 1.103 ± 0.104
1.211MetGly: 1.211 ± 0.104
0.371MetHis: 0.371 ± 0.059
0.459MetIle: 0.459 ± 0.068
1.543MetLys: 1.543 ± 0.136
1.504MetLeu: 1.504 ± 0.118
0.478MetMet: 0.478 ± 0.073
0.957MetAsn: 0.957 ± 0.105
0.605MetPro: 0.605 ± 0.079
0.889MetGln: 0.889 ± 0.094
1.094MetArg: 1.094 ± 0.109
1.972MetSer: 1.972 ± 0.139
1.172MetThr: 1.172 ± 0.109
1.025MetVal: 1.025 ± 0.11
0.371MetTrp: 0.371 ± 0.06
0.537MetTyr: 0.537 ± 0.07
0.0MetXaa: 0.0 ± 0.0
Asn
1.894AsnAla: 1.894 ± 0.138
0.674AsnCys: 0.674 ± 0.077
1.269AsnAsp: 1.269 ± 0.108
2.207AsnGlu: 2.207 ± 0.146
2.636AsnPhe: 2.636 ± 0.156
2.998AsnGly: 2.998 ± 0.205
0.439AsnHis: 0.439 ± 0.063
3.037AsnIle: 3.037 ± 0.192
2.773AsnLys: 2.773 ± 0.17
3.3AsnLeu: 3.3 ± 0.146
0.771AsnMet: 0.771 ± 0.092
1.474AsnAsn: 1.474 ± 0.124
2.256AsnPro: 2.256 ± 0.193
0.771AsnGln: 0.771 ± 0.079
1.679AsnArg: 1.679 ± 0.136
3.066AsnSer: 3.066 ± 0.165
1.982AsnThr: 1.982 ± 0.24
2.422AsnVal: 2.422 ± 0.146
0.537AsnTrp: 0.537 ± 0.065
1.074AsnTyr: 1.074 ± 0.098
0.0AsnXaa: 0.0 ± 0.0
Pro
1.347ProAla: 1.347 ± 0.127
0.752ProCys: 0.752 ± 0.079
1.816ProAsp: 1.816 ± 0.146
4.169ProGlu: 4.169 ± 0.198
2.275ProPhe: 2.275 ± 0.166
2.314ProGly: 2.314 ± 0.155
0.83ProHis: 0.83 ± 0.094
1.631ProIle: 1.631 ± 0.124
3.71ProLys: 3.71 ± 0.253
3.798ProLeu: 3.798 ± 0.187
0.732ProMet: 0.732 ± 0.084
1.66ProAsn: 1.66 ± 0.145
1.836ProPro: 1.836 ± 0.166
1.504ProGln: 1.504 ± 0.139
2.256ProArg: 2.256 ± 0.175
3.31ProSer: 3.31 ± 0.408
2.099ProThr: 2.099 ± 0.154
1.904ProVal: 1.904 ± 0.137
0.644ProTrp: 0.644 ± 0.088
1.328ProTyr: 1.328 ± 0.125
0.0ProXaa: 0.0 ± 0.0
Gln
1.494GlnAla: 1.494 ± 0.134
0.537GlnCys: 0.537 ± 0.088
1.279GlnAsp: 1.279 ± 0.11
3.544GlnGlu: 3.544 ± 0.223
0.976GlnPhe: 0.976 ± 0.092
2.217GlnGly: 2.217 ± 0.188
0.703GlnHis: 0.703 ± 0.079
1.474GlnIle: 1.474 ± 0.11
4.335GlnLys: 4.335 ± 0.222
2.158GlnLeu: 2.158 ± 0.149
0.898GlnMet: 0.898 ± 0.102
1.767GlnAsn: 1.767 ± 0.139
0.869GlnPro: 0.869 ± 0.103
1.621GlnGln: 1.621 ± 0.141
2.939GlnArg: 2.939 ± 0.182
1.553GlnSer: 1.553 ± 0.118
2.119GlnThr: 2.119 ± 0.181
1.933GlnVal: 1.933 ± 0.188
0.449GlnTrp: 0.449 ± 0.074
0.771GlnTyr: 0.771 ± 0.099
0.0GlnXaa: 0.0 ± 0.0
Arg
2.695ArgAla: 2.695 ± 0.179
1.113ArgCys: 1.113 ± 0.095
2.88ArgAsp: 2.88 ± 0.16
6.454ArgGlu: 6.454 ± 0.311
2.597ArgPhe: 2.597 ± 0.158
3.701ArgGly: 3.701 ± 0.181
1.279ArgHis: 1.279 ± 0.121
3.037ArgIle: 3.037 ± 0.195
6.239ArgLys: 6.239 ± 0.278
4.765ArgLeu: 4.765 ± 0.245
1.279ArgMet: 1.279 ± 0.111
2.92ArgAsn: 2.92 ± 0.19
1.64ArgPro: 1.64 ± 0.142
1.992ArgGln: 1.992 ± 0.126
3.32ArgArg: 3.32 ± 0.219
3.105ArgSer: 3.105 ± 0.189
2.91ArgThr: 2.91 ± 0.198
3.857ArgVal: 3.857 ± 0.201
0.762ArgTrp: 0.762 ± 0.074
2.011ArgTyr: 2.011 ± 0.15
0.0ArgXaa: 0.0 ± 0.0
Ser
3.945SerAla: 3.945 ± 0.181
2.158SerCys: 2.158 ± 0.149
3.164SerAsp: 3.164 ± 0.184
5.81SerGlu: 5.81 ± 0.275
5.214SerPhe: 5.214 ± 0.251
5.654SerGly: 5.654 ± 0.278
1.426SerHis: 1.426 ± 0.147
2.9SerIle: 2.9 ± 0.175
5.849SerLys: 5.849 ± 0.242
7.528SerLeu: 7.528 ± 0.246
1.23SerMet: 1.23 ± 0.114
2.295SerAsn: 2.295 ± 0.175
3.652SerPro: 3.652 ± 0.34
2.822SerGln: 2.822 ± 0.168
4.121SerArg: 4.121 ± 0.227
7.011SerSer: 7.011 ± 0.369
3.125SerThr: 3.125 ± 0.19
5.097SerVal: 5.097 ± 0.258
1.396SerTrp: 1.396 ± 0.111
2.031SerTyr: 2.031 ± 0.157
0.0SerXaa: 0.0 ± 0.0
Thr
2.519ThrAla: 2.519 ± 0.172
1.181ThrCys: 1.181 ± 0.123
1.933ThrAsp: 1.933 ± 0.142
3.925ThrGlu: 3.925 ± 0.213
2.92ThrPhe: 2.92 ± 0.168
2.939ThrGly: 2.939 ± 0.194
0.762ThrHis: 0.762 ± 0.084
2.08ThrIle: 2.08 ± 0.149
4.55ThrLys: 4.55 ± 0.229
4.531ThrLeu: 4.531 ± 0.304
1.015ThrMet: 1.015 ± 0.104
1.992ThrAsn: 1.992 ± 0.224
2.539ThrPro: 2.539 ± 0.21
1.767ThrGln: 1.767 ± 0.156
2.802ThrArg: 2.802 ± 0.176
3.232ThrSer: 3.232 ± 0.221
2.998ThrThr: 2.998 ± 0.221
2.851ThrVal: 2.851 ± 0.159
0.654ThrTrp: 0.654 ± 0.084
1.318ThrTyr: 1.318 ± 0.121
0.0ThrXaa: 0.0 ± 0.0
Val
3.496ValAla: 3.496 ± 0.245
1.758ValCys: 1.758 ± 0.141
3.457ValAsp: 3.457 ± 0.187
5.068ValGlu: 5.068 ± 0.295
4.326ValPhe: 4.326 ± 0.205
3.183ValGly: 3.183 ± 0.176
1.133ValHis: 1.133 ± 0.109
2.539ValIle: 2.539 ± 0.166
4.179ValLys: 4.179 ± 0.183
6.337ValLeu: 6.337 ± 0.232
1.211ValMet: 1.211 ± 0.108
1.709ValAsn: 1.709 ± 0.116
3.193ValPro: 3.193 ± 0.172
2.031ValGln: 2.031 ± 0.137
3.33ValArg: 3.33 ± 0.198
5.839ValSer: 5.839 ± 0.27
2.48ValThr: 2.48 ± 0.185
5.107ValVal: 5.107 ± 0.281
1.23ValTrp: 1.23 ± 0.1
1.933ValTyr: 1.933 ± 0.128
0.0ValXaa: 0.0 ± 0.0
Trp
0.654TrpAla: 0.654 ± 0.076
0.605TrpCys: 0.605 ± 0.105
0.684TrpAsp: 0.684 ± 0.092
1.24TrpGlu: 1.24 ± 0.121
1.357TrpPhe: 1.357 ± 0.116
0.635TrpGly: 0.635 ± 0.096
0.273TrpHis: 0.273 ± 0.054
0.771TrpIle: 0.771 ± 0.092
1.426TrpLys: 1.426 ± 0.111
1.465TrpLeu: 1.465 ± 0.134
0.312TrpMet: 0.312 ± 0.049
0.644TrpAsn: 0.644 ± 0.076
0.244TrpPro: 0.244 ± 0.046
0.322TrpGln: 0.322 ± 0.05
0.976TrpArg: 0.976 ± 0.094
1.582TrpSer: 1.582 ± 0.127
0.889TrpThr: 0.889 ± 0.086
0.928TrpVal: 0.928 ± 0.1
0.244TrpTrp: 0.244 ± 0.044
0.566TrpTyr: 0.566 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.592TyrAla: 1.592 ± 0.122
0.674TyrCys: 0.674 ± 0.078
1.767TyrAsp: 1.767 ± 0.122
2.5TyrGlu: 2.5 ± 0.14
1.592TyrPhe: 1.592 ± 0.118
2.383TyrGly: 2.383 ± 0.201
0.488TyrHis: 0.488 ± 0.062
1.553TyrIle: 1.553 ± 0.137
2.07TyrLys: 2.07 ± 0.148
2.461TyrLeu: 2.461 ± 0.165
0.478TyrMet: 0.478 ± 0.063
1.084TyrAsn: 1.084 ± 0.105
1.201TyrPro: 1.201 ± 0.107
1.006TyrGln: 1.006 ± 0.109
1.592TyrArg: 1.592 ± 0.116
2.422TyrSer: 2.422 ± 0.123
1.435TyrThr: 1.435 ± 0.117
1.709TyrVal: 1.709 ± 0.142
0.635TyrTrp: 0.635 ± 0.075
0.693TyrTyr: 0.693 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 428 proteins (102414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski