Amino acid dipepetide frequency for Hibiscus latent Fort Pierce virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.442AlaAla: 7.442 ± 1.158
1.55AlaCys: 1.55 ± 0.441
3.101AlaAsp: 3.101 ± 0.511
2.481AlaGlu: 2.481 ± 0.714
3.101AlaPhe: 3.101 ± 0.569
4.341AlaGly: 4.341 ± 0.474
1.24AlaHis: 1.24 ± 0.365
3.721AlaIle: 3.721 ± 0.745
4.341AlaLys: 4.341 ± 1.218
4.031AlaLeu: 4.031 ± 2.472
2.791AlaMet: 2.791 ± 0.876
3.721AlaAsn: 3.721 ± 0.376
1.24AlaPro: 1.24 ± 1.656
2.171AlaGln: 2.171 ± 1.604
3.721AlaArg: 3.721 ± 1.095
4.341AlaSer: 4.341 ± 1.252
5.581AlaThr: 5.581 ± 2.067
6.202AlaVal: 6.202 ± 0.518
0.0AlaTrp: 0.0 ± 0.0
2.171AlaTyr: 2.171 ± 0.608
0.31AlaXaa: 0.31 ± 0.214
Cys
2.791CysAla: 2.791 ± 0.781
0.62CysCys: 0.62 ± 0.183
0.93CysAsp: 0.93 ± 0.295
0.31CysGlu: 0.31 ± 0.621
1.24CysPhe: 1.24 ± 0.365
2.481CysGly: 2.481 ± 0.728
0.0CysHis: 0.0 ± 0.0
2.171CysIle: 2.171 ± 0.414
2.171CysLys: 2.171 ± 0.608
2.171CysLeu: 2.171 ± 0.608
1.24CysMet: 1.24 ± 0.449
0.93CysAsn: 0.93 ± 0.497
0.93CysPro: 0.93 ± 0.295
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.62CysSer: 0.62 ± 0.183
2.171CysThr: 2.171 ± 0.608
2.791CysVal: 2.791 ± 0.884
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.411AspAla: 3.411 ± 1.615
4.651AspCys: 4.651 ± 1.317
3.101AspAsp: 3.101 ± 0.707
5.891AspGlu: 5.891 ± 1.111
3.721AspPhe: 3.721 ± 1.443
2.171AspGly: 2.171 ± 0.912
0.93AspHis: 0.93 ± 0.295
6.202AspIle: 6.202 ± 0.518
5.891AspLys: 5.891 ± 1.089
4.341AspLeu: 4.341 ± 1.21
0.93AspMet: 0.93 ± 0.295
1.24AspAsn: 1.24 ± 1.01
1.24AspPro: 1.24 ± 1.135
0.62AspGln: 0.62 ± 0.183
0.93AspArg: 0.93 ± 0.806
5.271AspSer: 5.271 ± 1.046
6.822AspThr: 6.822 ± 0.736
4.961AspVal: 4.961 ± 1.868
0.0AspTrp: 0.0 ± 0.0
3.721AspTyr: 3.721 ± 1.046
0.0AspXaa: 0.0 ± 0.0
Glu
3.721GluAla: 3.721 ± 0.895
0.0GluCys: 0.0 ± 0.0
2.791GluAsp: 2.791 ± 0.722
0.93GluGlu: 0.93 ± 1.071
2.481GluPhe: 2.481 ± 0.361
2.171GluGly: 2.171 ± 0.608
1.86GluHis: 1.86 ± 0.357
2.481GluIle: 2.481 ± 2.567
4.341GluLys: 4.341 ± 0.734
2.171GluLeu: 2.171 ± 0.414
1.86GluMet: 1.86 ± 0.589
4.031GluAsn: 4.031 ± 0.635
2.171GluPro: 2.171 ± 0.608
1.55GluGln: 1.55 ± 1.489
1.55GluArg: 1.55 ± 0.441
6.202GluSer: 6.202 ± 0.893
3.101GluThr: 3.101 ± 1.436
4.341GluVal: 4.341 ± 0.734
0.62GluTrp: 0.62 ± 0.183
2.171GluTyr: 2.171 ± 0.769
0.0GluXaa: 0.0 ± 0.0
Phe
0.93PheAla: 0.93 ± 0.782
1.86PheCys: 1.86 ± 0.891
4.961PheAsp: 4.961 ± 1.388
3.101PheGlu: 3.101 ± 1.466
2.791PhePhe: 2.791 ± 1.163
1.24PheGly: 1.24 ± 0.438
1.86PheHis: 1.86 ± 0.357
2.791PheIle: 2.791 ± 0.426
5.581PheLys: 5.581 ± 0.852
2.481PheLeu: 2.481 ± 0.728
1.24PheMet: 1.24 ± 0.365
3.411PheAsn: 3.411 ± 1.019
1.24PhePro: 1.24 ± 0.715
2.171PheGln: 2.171 ± 0.748
1.55PheArg: 1.55 ± 0.441
5.581PheSer: 5.581 ± 1.032
4.341PheThr: 4.341 ± 0.734
3.721PheVal: 3.721 ± 0.579
0.31PheTrp: 0.31 ± 0.214
2.171PheTyr: 2.171 ± 0.608
0.0PheXaa: 0.0 ± 0.0
Gly
4.961GlyAla: 4.961 ± 0.877
1.86GlyCys: 1.86 ± 0.589
2.171GlyAsp: 2.171 ± 0.414
2.171GlyGlu: 2.171 ± 0.412
2.791GlyPhe: 2.791 ± 0.814
4.031GlyGly: 4.031 ± 1.434
1.55GlyHis: 1.55 ± 0.441
2.481GlyIle: 2.481 ± 1.059
5.271GlyLys: 5.271 ± 1.095
4.341GlyLeu: 4.341 ± 0.297
1.24GlyMet: 1.24 ± 0.365
3.411GlyAsn: 3.411 ± 0.747
2.791GlyPro: 2.791 ± 0.637
1.86GlyGln: 1.86 ± 0.357
1.86GlyArg: 1.86 ± 1.378
1.55GlySer: 1.55 ± 0.441
2.481GlyThr: 2.481 ± 0.747
1.24GlyVal: 1.24 ± 0.438
1.55GlyTrp: 1.55 ± 0.718
1.55GlyTyr: 1.55 ± 0.441
0.0GlyXaa: 0.0 ± 0.0
His
0.31HisAla: 0.31 ± 0.214
1.86HisCys: 1.86 ± 0.548
0.62HisAsp: 0.62 ± 0.183
0.62HisGlu: 0.62 ± 0.183
3.411HisPhe: 3.411 ± 0.958
1.24HisGly: 1.24 ± 0.365
0.31HisHis: 0.31 ± 0.214
0.93HisIle: 0.93 ± 0.295
0.93HisLys: 0.93 ± 0.806
3.101HisLeu: 3.101 ± 0.837
0.31HisMet: 0.31 ± 0.214
0.62HisAsn: 0.62 ± 1.242
0.31HisPro: 0.31 ± 0.621
0.93HisGln: 0.93 ± 0.295
0.0HisArg: 0.0 ± 0.0
3.411HisSer: 3.411 ± 1.019
2.481HisThr: 2.481 ± 0.73
1.55HisVal: 1.55 ± 0.441
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.101IleAla: 3.101 ± 0.511
2.791IleCys: 2.791 ± 0.481
5.271IleAsp: 5.271 ± 0.611
3.101IleGlu: 3.101 ± 1.738
3.101IlePhe: 3.101 ± 0.569
2.791IleGly: 2.791 ± 0.426
0.93IleHis: 0.93 ± 0.806
2.791IleIle: 2.791 ± 0.944
6.202IleLys: 6.202 ± 0.834
4.651IleLeu: 4.651 ± 2.124
0.62IleMet: 0.62 ± 0.183
1.86IleAsn: 1.86 ± 0.994
2.481IlePro: 2.481 ± 0.73
2.171IleGln: 2.171 ± 0.414
2.171IleArg: 2.171 ± 0.608
4.961IleSer: 4.961 ± 1.158
5.891IleThr: 5.891 ± 0.626
2.791IleVal: 2.791 ± 0.604
0.31IleTrp: 0.31 ± 0.214
2.481IleTyr: 2.481 ± 0.714
0.0IleXaa: 0.0 ± 0.0
Lys
5.891LysAla: 5.891 ± 1.653
0.62LysCys: 0.62 ± 0.183
3.721LysAsp: 3.721 ± 0.714
3.721LysGlu: 3.721 ± 0.745
3.411LysPhe: 3.411 ± 0.509
4.651LysGly: 4.651 ± 0.783
0.93LysHis: 0.93 ± 0.641
4.341LysIle: 4.341 ± 1.215
8.062LysLys: 8.062 ± 1.447
5.581LysLeu: 5.581 ± 1.194
1.86LysMet: 1.86 ± 0.994
4.031LysAsn: 4.031 ± 0.371
2.481LysPro: 2.481 ± 0.728
4.651LysGln: 4.651 ± 0.729
6.202LysArg: 6.202 ± 1.552
3.411LysSer: 3.411 ± 0.499
3.411LysThr: 3.411 ± 0.747
3.101LysVal: 3.101 ± 0.837
0.93LysTrp: 0.93 ± 0.497
2.481LysTyr: 2.481 ± 0.939
0.0LysXaa: 0.0 ± 0.0
Leu
3.721LeuAla: 3.721 ± 1.313
0.93LeuCys: 0.93 ± 0.295
6.512LeuAsp: 6.512 ± 2.102
4.031LeuGlu: 4.031 ± 0.859
2.791LeuPhe: 2.791 ± 0.426
4.961LeuGly: 4.961 ± 1.084
2.171LeuHis: 2.171 ± 0.412
4.341LeuIle: 4.341 ± 1.191
6.822LeuLys: 6.822 ± 1.481
8.062LeuLeu: 8.062 ± 2.842
3.101LeuMet: 3.101 ± 0.447
2.791LeuAsn: 2.791 ± 1.408
3.721LeuPro: 3.721 ± 1.046
3.411LeuGln: 3.411 ± 2.194
3.721LeuArg: 3.721 ± 1.594
7.442LeuSer: 7.442 ± 1.201
5.891LeuThr: 5.891 ± 0.831
4.961LeuVal: 4.961 ± 0.319
1.86LeuTrp: 1.86 ± 0.548
4.651LeuTyr: 4.651 ± 1.324
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
1.55MetAsp: 1.55 ± 0.441
2.481MetGlu: 2.481 ± 0.73
0.31MetPhe: 0.31 ± 0.621
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.24MetIle: 1.24 ± 0.481
3.101MetLys: 3.101 ± 0.883
2.481MetLeu: 2.481 ± 0.73
0.0MetMet: 0.0 ± 0.0
1.24MetAsn: 1.24 ± 0.365
0.0MetPro: 0.0 ± 0.0
0.93MetGln: 0.93 ± 0.295
0.93MetArg: 0.93 ± 0.295
2.791MetSer: 2.791 ± 0.637
1.55MetThr: 1.55 ± 0.418
3.411MetVal: 3.411 ± 0.748
0.31MetTrp: 0.31 ± 0.214
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.651AsnAla: 4.651 ± 1.252
0.31AsnCys: 0.31 ± 0.214
2.481AsnAsp: 2.481 ± 0.728
2.481AsnGlu: 2.481 ± 0.73
2.791AsnPhe: 2.791 ± 0.884
1.55AsnGly: 1.55 ± 0.418
0.62AsnHis: 0.62 ± 0.183
4.961AsnIle: 4.961 ± 1.173
0.93AsnLys: 0.93 ± 0.641
4.961AsnLeu: 4.961 ± 1.927
0.62AsnMet: 0.62 ± 0.585
0.0AsnAsn: 0.0 ± 0.0
2.171AsnPro: 2.171 ± 0.748
1.55AsnGln: 1.55 ± 0.718
2.481AsnArg: 2.481 ± 0.632
2.481AsnSer: 2.481 ± 1.913
2.481AsnThr: 2.481 ± 0.361
4.651AsnVal: 4.651 ± 0.783
0.0AsnTrp: 0.0 ± 0.0
1.55AsnTyr: 1.55 ± 0.418
0.0AsnXaa: 0.0 ± 0.0
Pro
2.481ProAla: 2.481 ± 1.43
1.55ProCys: 1.55 ± 0.477
2.481ProAsp: 2.481 ± 0.728
1.86ProGlu: 1.86 ± 0.548
1.86ProPhe: 1.86 ± 0.548
2.791ProGly: 2.791 ± 0.884
0.62ProHis: 0.62 ± 0.183
2.171ProIle: 2.171 ± 0.414
2.791ProLys: 2.791 ± 0.426
7.442ProLeu: 7.442 ± 1.158
0.0ProMet: 0.0 ± 0.0
1.55ProAsn: 1.55 ± 0.418
1.24ProPro: 1.24 ± 0.365
0.31ProGln: 0.31 ± 0.214
0.93ProArg: 0.93 ± 0.295
1.24ProSer: 1.24 ± 0.365
2.171ProThr: 2.171 ± 3.331
2.481ProVal: 2.481 ± 0.632
0.31ProTrp: 0.31 ± 0.621
0.93ProTyr: 0.93 ± 0.782
0.0ProXaa: 0.0 ± 0.0
Gln
4.341GlnAla: 4.341 ± 2.136
0.62GlnCys: 0.62 ± 0.183
3.411GlnAsp: 3.411 ± 0.748
0.0GlnGlu: 0.0 ± 0.0
0.62GlnPhe: 0.62 ± 0.183
2.171GlnGly: 2.171 ± 1.333
1.86GlnHis: 1.86 ± 0.548
3.101GlnIle: 3.101 ± 0.65
1.86GlnLys: 1.86 ± 0.357
2.481GlnLeu: 2.481 ± 0.669
1.55GlnMet: 1.55 ± 0.441
0.62GlnAsn: 0.62 ± 0.427
1.86GlnPro: 1.86 ± 0.589
2.481GlnGln: 2.481 ± 0.728
1.24GlnArg: 1.24 ± 0.715
2.171GlnSer: 2.171 ± 1.591
2.791GlnThr: 2.791 ± 0.637
1.55GlnVal: 1.55 ± 0.441
0.62GlnTrp: 0.62 ± 0.183
0.31GlnTyr: 0.31 ± 0.621
0.0GlnXaa: 0.0 ± 0.0
Arg
3.101ArgAla: 3.101 ± 0.913
0.93ArgCys: 0.93 ± 0.295
1.86ArgAsp: 1.86 ± 0.872
1.86ArgGlu: 1.86 ± 0.65
2.481ArgPhe: 2.481 ± 0.747
0.62ArgGly: 0.62 ± 0.183
0.62ArgHis: 0.62 ± 0.183
2.171ArgIle: 2.171 ± 0.748
2.481ArgLys: 2.481 ± 0.728
4.031ArgLeu: 4.031 ± 0.742
0.0ArgMet: 0.0 ± 0.0
2.791ArgAsn: 2.791 ± 0.637
2.171ArgPro: 2.171 ± 0.696
1.55ArgGln: 1.55 ± 0.418
1.86ArgArg: 1.86 ± 0.548
3.101ArgSer: 3.101 ± 0.65
4.341ArgThr: 4.341 ± 1.215
4.651ArgVal: 4.651 ± 0.679
0.31ArgTrp: 0.31 ± 0.881
1.86ArgTyr: 1.86 ± 0.548
0.0ArgXaa: 0.0 ± 0.0
Ser
4.341SerAla: 4.341 ± 1.278
0.62SerCys: 0.62 ± 0.427
4.961SerAsp: 4.961 ± 1.718
3.101SerGlu: 3.101 ± 0.447
6.202SerPhe: 6.202 ± 1.332
4.031SerGly: 4.031 ± 2.134
1.24SerHis: 1.24 ± 0.365
5.581SerIle: 5.581 ± 1.071
3.721SerLys: 3.721 ± 0.94
6.512SerLeu: 6.512 ± 0.933
0.31SerMet: 0.31 ± 0.541
5.581SerAsn: 5.581 ± 1.207
2.171SerPro: 2.171 ± 0.748
0.93SerGln: 0.93 ± 0.295
4.651SerArg: 4.651 ± 2.048
2.171SerSer: 2.171 ± 0.748
2.791SerThr: 2.791 ± 0.481
5.581SerVal: 5.581 ± 1.032
1.24SerTrp: 1.24 ± 0.365
3.411SerTyr: 3.411 ± 0.486
0.0SerXaa: 0.0 ± 0.0
Thr
5.891ThrAla: 5.891 ± 2.831
1.24ThrCys: 1.24 ± 0.365
4.031ThrAsp: 4.031 ± 0.772
4.031ThrGlu: 4.031 ± 0.419
4.961ThrPhe: 4.961 ± 0.988
2.791ThrGly: 2.791 ± 0.481
1.24ThrHis: 1.24 ± 0.365
3.411ThrIle: 3.411 ± 0.509
4.031ThrLys: 4.031 ± 0.891
7.442ThrLeu: 7.442 ± 1.159
0.62ThrMet: 0.62 ± 0.427
1.86ThrAsn: 1.86 ± 0.589
3.721ThrPro: 3.721 ± 0.745
6.822ThrGln: 6.822 ± 1.401
2.791ThrArg: 2.791 ± 0.637
3.721ThrSer: 3.721 ± 0.579
4.961ThrThr: 4.961 ± 1.264
6.512ThrVal: 6.512 ± 0.957
0.31ThrTrp: 0.31 ± 0.881
4.031ThrTyr: 4.031 ± 1.137
0.0ThrXaa: 0.0 ± 0.0
Val
4.031ValAla: 4.031 ± 2.111
0.93ValCys: 0.93 ± 0.497
6.822ValAsp: 6.822 ± 0.356
6.512ValGlu: 6.512 ± 0.933
2.481ValPhe: 2.481 ± 0.669
3.721ValGly: 3.721 ± 1.3
4.031ValHis: 4.031 ± 0.744
2.791ValIle: 2.791 ± 0.814
2.171ValLys: 2.171 ± 0.412
6.202ValLeu: 6.202 ± 0.573
2.481ValMet: 2.481 ± 0.73
1.86ValAsn: 1.86 ± 0.65
3.411ValPro: 3.411 ± 0.748
0.31ValGln: 0.31 ± 0.214
4.961ValArg: 4.961 ± 1.461
5.271ValSer: 5.271 ± 0.76
6.202ValThr: 6.202 ± 0.573
4.031ValVal: 4.031 ± 1.461
1.55ValTrp: 1.55 ± 0.708
1.86ValTyr: 1.86 ± 0.65
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.55TrpAsp: 1.55 ± 0.418
1.24TrpGlu: 1.24 ± 0.481
1.86TrpPhe: 1.86 ± 0.548
0.62TrpGly: 0.62 ± 0.183
0.31TrpHis: 0.31 ± 0.621
0.62TrpIle: 0.62 ± 0.183
0.31TrpLys: 0.31 ± 0.214
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.93TrpAsn: 0.93 ± 0.295
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.31TrpSer: 0.31 ± 0.881
0.62TrpThr: 0.62 ± 1.762
1.86TrpVal: 1.86 ± 0.548
0.0TrpTrp: 0.0 ± 0.0
0.62TrpTyr: 0.62 ± 0.817
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.791TyrAla: 2.791 ± 0.781
0.62TyrCys: 0.62 ± 0.183
3.721TyrAsp: 3.721 ± 0.985
0.62TyrGlu: 0.62 ± 0.183
0.93TyrPhe: 0.93 ± 0.641
2.791TyrGly: 2.791 ± 0.781
0.62TyrHis: 0.62 ± 0.427
2.171TyrIle: 2.171 ± 0.769
2.481TyrLys: 2.481 ± 0.361
3.411TyrLeu: 3.411 ± 0.958
1.24TyrMet: 1.24 ± 0.365
1.24TyrAsn: 1.24 ± 0.715
1.86TyrPro: 1.86 ± 0.589
0.93TyrGln: 0.93 ± 0.497
1.24TyrArg: 1.24 ± 0.365
3.101TyrSer: 3.101 ± 1.466
4.341TyrThr: 4.341 ± 1.215
1.24TyrVal: 1.24 ± 1.015
0.62TyrTrp: 0.62 ± 0.183
0.93TyrTyr: 0.93 ± 0.295
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.31XaaGln: 0.31 ± 0.214
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski